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  1. Coiled-Coil Domain Containing 88A (CCDC88A) was identified as a substrate of the serine/threonine kinase Akt that is capable of binding to the actin cytoskeleton. The aim of this study was to investigate the p...

    Authors: Aki Tanouchi, Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Ken Dabanaka, Masashi Kimura, Ryohei Watanabe, Takuhiro Kohsaki, Takahiro Shimizu, Motoaki Saito, Kazuhiro Hanazaki and Toshiji Saibara
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:190
  2. Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the ‘right’ tre...

    Authors: Luca Pompili, Manuela Porru, Carla Caruso, Annamaria Biroccio and Carlo Leonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:189
  3. Nasopharyngeal carcinoma (NPC) is among the most common squamous cell carcinoma in South China and Southeast Asia. Radiotherapy is the primary treatment for NPC. However, radioresistance acts as a significant ...

    Authors: Teng Huang, Li Yin, Jing Wu, Jia-Jia Gu, Jian-Zhong Wu, Dan Chen, Hong-Liang Yu, Kai Ding, Nan Zhang, Ming-Yu Du, Lu-Xi Qian, Zhi-Wei Lu and Xia He
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:188
  4. The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair...

    Authors: Zhen Mei, Xian Zhang, Jiarong Yi, Junjie Huang, Jian He and Yongguang Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:182
  5. The role of long non-coding RNAs (lncRNAs) in colorectal cancer (CRC) progression has not fully been elucidated. This study was designed to report the identification of a novel lncRNA, lnc-GNAT1-1, and its fun...

    Authors: Chunxiang Ye, Zhanlong Shen, Bo Wang, Yansen Li, Tao Li, Yang Yang, Kewei Jiang, Yingjiang Ye and Shan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:187
  6. Release of exosomes have been shown to play critical roles in drug resistance by delivering cargo. Targeting the transfer of exosomes from resistant cells to sensitive cells may be an approach to overcome some...

    Authors: Xiaohong Wang, Chengfeng Xu, Yitong Hua, Leitao Sun, Kai Cheng, Zhongming Jia, Yong Han, Jianli Dong, Yuzhen Cui and Zhenlin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:186
  7. Authors: Andrea Prodosmo, Amelia Buffone, Manlio Mattioni, Agnese Barnabei, Agnese Persichetti, Aurora De Leo, Marialuisa Appetecchia, Arianna Nicolussi, Anna Coppa, Salvatore Sciacchitano, Carolina Giordano, Paola Pinnarò, Giuseppe Sanguineti, Lidia Strigari, Gabriele Alessandrini, Francesco Facciolo…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:185

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:135

  8. The aim of this study was to investigate the effect of downregulating Hedgehog pathway by GANT61 on human glioma cells, examine the consequent changes of temozolomide (TMZ)-induced effects and explore the mole...

    Authors: Jianlong Li, Jinquan Cai, Shihong Zhao, Kun Yao, Ying Sun, Yongli Li, Lingchao Chen, Ruiyan Li, Xiuwei Zhai, Junhe Zhang and Chuanlu Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:184
  9. Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cance...

    Authors: Wang Liu, Yu Lu, Xiaoping Chai, Xiao Liu, Tong Zhu, Xihan Wu, Yanfen Fang, Xuan Liu and Xiongwen Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:183
  10. Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the...

    Authors: Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu and Hongbing Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:181
  11. The integration of human papilloma virus (HPV) into host genome is one of the critical steps that lead to the progression of precancerous lesion into cancer. However, the mechanisms and consequences of such in...

    Authors: Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen and Fang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:180
  12. DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins...

    Authors: Aniello Cerrato, Francesco Morra and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:179
  13. Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vi...

    Authors: Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai and Ming Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:178
  14. miRNAs are critical post-transcriptional regulators of gene expression and key mediators of tumourigenesis. miR-501-5p is newly identified to be involved in the tumor progression, but its biological role and m...

    Authors: Dongmei Fan, Baoqi Ren, Xiaojun Yang, Jia Liu and Zhengzheng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:177
  15. Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent oncogene overe...

    Authors: Mahmoud Alhosin, Ziad Omran, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Hani Choudhry, Marc Mousli and Christian Bronner
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:174
  16. Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclea...

    Authors: Xi Zhang, Peng Jiang, Ling Shuai, Kai Chen, Zhonghu Li, Yujun Zhang, Yan Jiang and Xiaowu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:176
  17. Gastric cancer (GC) is characterized by the excessive deposition of extracellular matrix, which is thought to contribute to this tumor’s malignant behavior. Epithelial-mesenchymal transition (EMT) is regarded ...

    Authors: Yang Chong, Dong Tang, Qingquan Xiong, Xuetong Jiang, Chuanqi Xu, Yuqin Huang, Jie Wang, Huaicheng Zhou, Youquan Shi, Xiaoqing Wu and Daorong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:175
  18. The metastatic cascade is a complex and multistep process with many potential barriers. Recently, miR-193a has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-onco...

    Authors: Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu and Chengshui Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:173

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:31

  19. Interleukin-7 receptor (IL-7R) is involved in the abnormal function of solid tumors, but the role and regulatory mechanisms of IL-7R in HBV-related hepatocellular carcinoma (HCC) are still unclear.

    Authors: Fanyun Kong, Wei Hu, Kai Zhou, Xiao Wei, Yanbo Kou, Hongjuan You, Kuiyang Zheng and Renxian Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:172
  20. TRIM62 (tripartite motif containing 62) has been found to act as a tumor suppressor of several cancers. However, its precise biological role and related mechanism remain unknown in cervical cancer (CC).

    Authors: Tian-Yu Liu, Jian Chen, Chun-Liang Shang, Hong-Wei Shen, Jia-Ming Huang, Yan-Chun Liang, Wei Wang, Yun-He Zhao, Duo Liu, Man Shu, Lu-Yan Guo, Zheng Hu and Shu-Zhong Yao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:170
  21. Clinicians are confronted with an increasing number of patients with thyroid nodules. Reliable preoperative diagnosis of thyroid nodules remains a challenge because of inconclusive cytological examination of f...

    Authors: Qing-Xuan Wang, En-Dong Chen, Ye-Feng Cai, Quan Li, Yi-Xiang Jin, Wen-Xu Jin, Ying-Hao Wang, Zhou-Ci Zheng, Lu Xue, Ou-Chen Wang and Xiao-Hua Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:169

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:18

  22. Developing safe and effective cancer vaccine formulations is a primary focus in the field of cancer immunotherapy. Dendritic cells (DC) are currently employed as cellular vaccine in clinical trials of tumor im...

    Authors: Soodabeh Iranpour, Vahid Nejati, Nowruz Delirezh, Pouria Biparva and Sadegh Shirian
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:168
  23. Embelin is a potent dual inhibitor of 5-lipoxigenase (5-LOX) and microsomal prostaglandin E2 synthase (mPGES)-1 that suppresses proliferation of human glioma cells and induces apoptosis by inhibiting XIAP and ...

    Authors: S. Zappavigna, M. Scuotto, A. M. Cossu, D. Ingrosso, M. De Rosa, C. Schiraldi, R. Filosa and M. Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:167
  24. Accumulating researches have shown that epithelial-mesenchymal transition (EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates...

    Authors: Lan Wei, Kuangfa Li, Xueli Pang, Bianqin Guo, Min Su, Yunxiu Huang, Nian Wang, Feihu Ji, Changli Zhong, Junhong Yang, Zhiqian Zhang, Yulin Jiang, Yifeng Liu and Tingmei Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:166
  25. Aberrant expression of Retinoic acid receptor γ (RARγ) is implicated in cancer development. Our previous study identified that RARγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth....

    Authors: Wen-Juan Gan, Jing-Ru Wang, Xiao-Li Zhu, Xiao-Shun He, Peng-Da Guo, Shen Zhang, Xiu-Ming Li, Jian-Ming Li and Hua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:164
  26. Recently, tumor initiating cells (TICs), which possess self-renewal and other stem cell properties, are regarded as the cause of tumor initiation, recurrence and metastasis. The isolation and identification of...

    Authors: Yanhui Zhang, Baocun Sun, Xiulan Zhao, Huizhi Sun, Wei Cui, Zhiyong Liu, Xin Yao and Xueyi Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:163
  27. Gliomas are the most common type of primary brain tumour in the central nervous system of adults. The long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) is transcribed from the 5′ tip of t...

    Authors: Li-Min Xu, Lei Chen, Feng Li, Run Zhang, Zong-yang Li, Fan-Fan Chen and Xiao-Dan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:162
  28. Osteosarcoma is the most prevalent primary malignant bone tumor, but treatment is difficult and prognosis remains poor. Recently, large-dose chemotherapy has been shown to improve outcome but this approach can...

    Authors: Baochang Qi, Tiecheng Yu, Chengxue Wang, Tiejun Wang, Jihang Yao, Xiaomeng Zhang, Pengfei Deng, Yongning Xia, Wolfgang G. Junger and Dahui Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:161
  29. Long non-coding RNA (lncRNA) H19 has been reported to involve in many kinds of human cancers and functions as an oncogene. Our previous study found that H19 was over-expressed in gallbladder cancer (GBC) and w...

    Authors: Shou-Hua Wang, Fei Ma, Zhao-hui Tang, Xiao-Cai Wu, Qiang Cai, Ming-Di Zhang, Ming-Zhe Weng, Di Zhou, Jian-Dong Wang and Zhi-Wei Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:160

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:55

  30. Exosomes are carriers of intercellular information and regulate the tumor microenvironment. They play an important role in drug resistance by transporting RNA molecules and proteins. However, their effects on ...

    Authors: Zhen Qu, Junhua Wu, Junyi Wu, Dongjun Luo, Chunping Jiang and Yitao Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:159
  31. LCL161, a novel Smac mimetic, is known to have anti-tumor activity and improve chemosensitivity in various cancers. However, the function and mechanisms of the combination of LCL161 and paclitaxel in non-small...

    Authors: Chengcheng Yang, Huangzhen Wang, Boxiang Zhang, Yimeng Chen, Yamin Zhang, Xin Sun, Guodong Xiao, Kejun Nan, Hong Ren and Sida Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:158
  32. Among several types of tumor, lung cancer is considered one of the most fatal and still the main cause of cancer-related deaths. Although chemotherapeutic agents can improve survival and quality of life compar...

    Authors: Mohanad Aldarouish and Cailian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:157
  33. Exosomes are nanoscale extracellular membrane vesicles that are created by the fusion of an intracellular multivesicular body with the cell membrane. They are widely distributed in serum, urine, saliva and oth...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:156
  34. Genetically induced hepatocellular carcinoma (HCC) models are generally used to investigate carcinogenesis pathways, but very few attempts were made to valorize them for pharmacological testing. This study des...

    Authors: Mihaela Ignat, Cherif Youssef Akladios, Véronique Lindner, Konstantin Khetchoumian, Marius Teletin, Didier Muttter, Pierre Marc Aprahamian and Jacques Marescaux
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:155
  35. Authors: Corina Buta, Eva Benabou, Marie Lequoy, Hélène Régnault, Dominique Wendum, Fatiha Merabtene, Hamza Chettouh, Lynda Aoudjehane, Filomena Conti, Yves Chrétien, Olivier Scatton, Olivier Rosmorduc, Françoise Praz, Laetitia Fartoux and Christèle Desbois-Mouthon
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:154

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:126

  36. Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of ce...

    Authors: Roberta Visconti, Rosa Della Monica and Domenico Grieco
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:153
  37. Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of cancers. Recently, TLE3 together with many other gen...

    Authors: Run-Wei Yang, Ying-Yue Zeng, Wen-Ting Wei, Yan-Mei Cui, Hui-Ying Sun, Yue-Long Cai, Xin-Xin Nian, Yun-Teng Hu, Yu-Ping Quan, Sheng-Lu Jiang, Meng Wang, Ya-Li Zhao, Jun-Feng Qiu, Ming-Xuan Li, Jia-Huan Zhang, Mei-Rong He…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:152

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:277

  38. Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcin...

    Authors: Jian Gao, Camilla H. Ulekleiv and Trond S. Halstensen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:151
  39. Breast cancer is one of the leading cause of cancer-related deaths in women worldwide and increasing rapidly in developing countries. In the present study, we investigated the potential role and association of...

    Authors: Nirmala Jagadish, Sumit Agarwal, Namita Gupta, Rukhsar Fatima, Sonika Devi, Vikash Kumar, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya and Anil Suri
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:150
  40. Hsp90 proteins are important therapeutic targets for many anti-cancer drugs in clinical trials. Geldanamycin (GA) was identified as the first natural inhibitor of Hsp90, increasing evidence suggests that GA wa...

    Authors: Zhirui Zhang, Hong-Mei Li, Can Zhou, Qixiang Li, Linyan Ma, Zixuan Zhang, Yiming Sun, Lirong Wang, Xudong Zhang, Bing Zhu, Young-Soo Hong, Cheng-Zhu Wu and Hao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:149
  41. Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate its biological fun...

    Authors: Guohe Song, Shifeng Xu, Hong Zhang, Yupeng Wang, Chao Xiao, Tao Jiang, Leilei Wu, Tao Zhang, Xing Sun, Lin Zhong, Chongzhi Zhou, Zhaowen Wang, Zhihai Peng, Jian Chen and Xiaoliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:148
  42. Chemo-resistance is still a major obstacle in efforts to overcome acute myeloid leukemia (AML). An emerging concept has proposed that interactions between the bone marrow (BM) microenvironment and leukemia cel...

    Authors: Yuanmei Zhai, Jing Zhang, Hui Wang, Wei Lu, Sihong Liu, Yehua Yu, Wei Weng, Zhiyong Ding, Qi Zhu and Jun Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:147
  43. We have previously shown that the eukaryotic elongation factor subunit 1B gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit “C” (POLR2C), alone or complexed, in the pol II enzyme....

    Authors: Cinzia Pisani, Annalisa Onori, Francesca Gabanella, Francesca Delle Monache, Antonella Borreca, Martine Ammassari-Teule, Maurizio Fanciulli, Maria Grazia Di Certo, Claudio Passananti and Nicoletta Corbi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:146
  44. The recently identified phenomenon of double-stranded RNA (dsRNA)-mediated gene activation (RNAa) has been studied extensively, as it is present in humans, mice, and Caenorhabditis elegans, suggesting that dsRNA-...

    Authors: Huan-Lei Wu, Sen-Mao Li, Jia Hu, Xiao Yu, Hua Xu, Zhong Chen and Zhang-Qun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:145
  45. WNT5A (-/-) mammary tissue has been shown to exhibit increased ductal elongation, suggesting elevated mammary cell migration. Increased epithelial cell migration/invasion has often but not always been linked t...

    Authors: Chandra Prakash Prasad, Shivendra Kumar Chaurasiya, William Guilmain and Tommy Andersson
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:144
  46. Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) a...

    Authors: Yohei Takeda, Masahiro Azuma, Misako Matsumoto and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:143
  47. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the role and molecular mechanism of lncRNA XIST in gastric cancer is still unknown.

    Authors: Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu, Le-zong Chen, Zhao-lei Zeng, Dong-sheng Zhang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, De-shen Wang, Da-zhi Xu, Zhi-wei Zhou, Helene Pelicano, Peng Huang, Dan Xie, Feng-hua Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:142

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:208

  48. Interleukin-1 receptor associated kinase 1 (IRAK1), as a down-stream of toll-like receptor (TLR) signaling, plays important roles in series of malignancies. However, the role of IRAK1 in hepatocellular carcino...

    Authors: Ning Li, Jinhua Jiang, Jing Fu, Ting Yu, Bibo Wang, Wenhao Qin, An Xu, Mengchao Wu, Yao Chen and Hongyang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:140

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