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  1. The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal tran...

    Authors: Samantha Kaufhold, Hermes Garbán and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:84
  2. Long non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development and progression. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a novel long non-codin...

    Authors: Yonghao Zhan, Junhao Lin, Yuchen Liu, Mingwei Chen, Xiaoying Chen, Chengle Zhuang, Li Liu, Wen Xu, Zhicong Chen, Anbang He, Qiaoxia Zhang, Xiaojuan Sun, Guoping Zhao and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:83

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:185

  3. Increasing evidence supports the association of CTNND1 with tumor development and progression. However, the mechanism and clinical significance of CTNND1 deregulation in hepatocellular carcinoma (HCC) remains ...

    Authors: Bo Tang, Fang Tang, Zhenran Wang, Guangying Qi, Xingsi Liang, Bo Li, Shengguang Yuan, Jie Liu, Shuiping Yu and Songqing He
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:82
  4. It was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells. We showed in an ...

    Authors: Dana Hamam, Mohamed Abdouh, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:80
  5. Tumor cells use aerobic glycolysis to rapidly generate ATP and growth substrate which expenses a large amount of glucose. However, how tumor cells take in enough glucose from the tumor microenvironment of insu...

    Authors: Shixiong Lei, Jiandong Yang, Chong Chen, Jiachen Sun, Liu Yang, Haili Tang, Tao Yang, An Chen, Huadong Zhao, Yan Li and Xilin Du
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:79
  6. Glioblastoma multiforme is the most aggressive malignant primary brain tumor, characterized by rapid growth and extensive infiltration to neighboring normal brain parenchyma. Both PI3K/Akt and JNK pathways are...

    Authors: Hua-Fu Zhao, Jing Wang, Hao-Ran Jiang, Zhong-Ping Chen and Shing-Shun Tony To
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:78
  7. Lung cancer is the most common malignancies worldwide. However, the detailed molecular mechanisms underlying lung cancer progression are still not completely clear. MicroRNAs are small noncoding RNAs which occ...

    Authors: Wei Chen, Jun Wang, Sulai Liu, Shaoqiang Wang, Yuanda Cheng, Wolong Zhou, Chaojun Duan and Chunfang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:76
  8. Recent evidence has proven that long noncoding RNAs (lncRNAs) play important roles in cancer biology, while few lncRNAs have been characterized in NSCLC. Here, we characterized a novel lncRNA, SBF2 antisense R...

    Authors: Junjie Lv, Mantang Qiu, Wenjia Xia, Chao Liu, Youtao Xu, Jie Wang, Xuechun Leng, Su Huang, Rong Zhu, Ming Zhao, Fengqing Ji, Lin Xu, Keping Xu and Rong Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:75
  9. Gene-based virotherapy mediated by oncolytic viruses is currently experiencing a renaissance in cancer therapy. However, relatively little attention has been given to the potentiality of dual gene virotherapy ...

    Authors: Adel Galal El-Shemi, Ahmad Mohammed Ashshi, Youjin Na, Yan Li, Mohammed Basalamah, Faisal Ahmad Al-Allaf, Eonju Oh, Bo-Kyeong Jung and Chae-Ok YUN
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:74

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:96

  10. Chemotherapy with docetaxel (Doc) remains the standard treatment for metastatic and castration-resistance prostate cancer (CRPC). However, the clinical success of Doc is limited by its chemoresistance and side...

    Authors: Piwen Wang, Susanne M. Henning, Clara E. Magyar, Yahya Elshimali, David Heber and Jaydutt V. Vadgama
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:73
  11. Abnormal DNA methylation/demethylation is recognized as a hallmark of cancer. TET (ten-eleven translocation) family members are novel DNA demethylation related proteins that dysregulate in multiple malignances...

    Authors: Zhongxue Ye, Jie Li, Xi Han, Huilian Hou, He Chen, Xia Zheng, Jiaojiao Lu, Lijie Wang, Wei Chen, Xu Li and Le Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:72
  12. Hepatocellular carcinoma (HCC) accounts for 75 % of liver cancers and is the second most lethal cancer, associated with its multiple etiologies, poor prognosis and resistance to chemotherapy drugs. Chemotherap...

    Authors: Zheng Hu, Guixiang Lv, Yongning Li, Enze Li, Haixia Li, Qi Zhou, Bin Yang and Wenwu Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:71
  13. Aberrant expression of the RON receptor tyrosine kinase, a member of the MET proto-oncogene family, in breast cancer and non-small cell lung cancer (NSCLC) has therapeutic implication. Here we evaluated the ef...

    Authors: Liang Feng, Hang-Ping Yao, Sharad Sharma, Yong-Qing Zhou, Jianwei Zhou, Ruiwen Zhang and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:70

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:95

  14. MicroRNA-138 (miR-138) has been proven to be a tumor suppressor gene in various types of tumors. However, the expression and the role of miR-138 in human osteosarcoma are still poorly understood. We investigat...

    Authors: Baoen Jiang, Weidong Mu, Jiangquan Wang, Jianshu Lu, Shanyong Jiang, Liang Li, Haining Xu and Hongyan Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:69
  15. Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated in the regulation of cell proliferation, invasive migration and survival. However, PHB expression and its biolo...

    Authors: Yang Cao, Haibin Liang, Fei Zhang, Zhou Luan, Shuai Zhao, Xu-an Wang, Shibo Liu, Runfa Bao, Yijun Shu, Qiang Ma, Jian Zhu and Yingbin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:68
  16. Hepatocellular carcinoma (HCC) remains a major public health problem worldwide. The identification of effective chemotherapeutic targets for advanced HCC patients is urgently required. In this study, we invest...

    Authors: Qunying Zhuang, Tengjian Zhou, Chengyong He, Shili Zhang, Yang Qiu, Bing Luo, Ran Zhao, Hengchuan Liu, Yuchun Lin and Zhongning Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:67
  17. Circulating tumor cells (CTCs) hold great potential in both clinical application and basic research for the managements of cancer. However, it remains to be an enormous challenge to obtain efficient detection ...

    Authors: Yang Gao, Yayun Zhu, Zhenzhen Zhang, Cheng Zhang, Xinyu Huang and Zhou Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:66
  18. Endothelial progenitor cells (EPCs) can migrate to the tumor tissue and enhance the angiogenesis of hepatocellular carcinoma (HCC); thus, they are associated with a poor prognosis. However, the specific molecu...

    Authors: Yi Wang, Haitao Yu, Yunfeng Shan, Chonglin Tao, Fang Wu, Zhengping Yu, Pengyi Guo, Jianfei Huang, Junjian Li, Qiandong Zhu, Fuxiang Yu, Qitong Song, Hongqi Shi, Mengtao Zhou and Gang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:65
  19. B-Acute lymphoblastic leukemia (B-ALL) represents a hematologic malignancy with poor clinical outcome and low survival rates in adult patients. Remission rates in Hispanic population are almost 30 % lower and ...

    Authors: Nataly Cruz-Rodriguez, Alba L. Combita, Leonardo J. Enciso, Sandra M. Quijano, Paula L. Pinzon, Olga C. Lozano, Juan S. Castillo, Li Li, Jose Bareño, Claudia Cardozo, Julio Solano, Maria V. Herrera, Jennifer Cudris and Jovanny Zabaleta
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:64
  20. Sonic hedgehog (SHH) plays critical roles in cell growth and development. Tumor cells express SHH, which can promote cell proliferation and epithelial-to-mesenchymal transition. However, the autocrine SHH path...

    Authors: Zhai Ertao, Chen Jianhui, Chen Chuangqi, Qin Changjiang, Chen Sile, He Yulong, Wu Hui and Cai Shirong
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:63
  21. The Hippo signaling acts as a tumor-suppressor pathway that negatively regulates TAZ and YAP. Increasing evidence supports the activation of TAZ and YAP in breast cancer. Moreover, the Hippo pathway is involve...

    Authors: Patrizia Vici, Cristiana Ercolani, Anna Di Benedetto, Laura Pizzuti, Luigi Di Lauro, Francesca Sperati, Irene Terrenato, Teresa Gamucci, Clara Natoli, Franco Di Filippo, Claudio Botti, Maddalena Barba, Marcella Mottolese, Ruggero De Maria and Marcello Maugeri-Saccà
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:62
  22. Evidences indicate that inflammatory process plays pivotal role in tumor disease. Soluble epoxide hydrolase inhibitors (sEHIs) have been shown to participate in anti-inflammation and tumorigenesis by protectin...

    Authors: Junyang Li, Chao Tang, Liwen Li, Rujun Li and Youwu Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:61
  23. We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) att...

    Authors: Hongtuan Zhang, Shadan Li, Xiong Yang, Baomin Qiao, Zhihong Zhang and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:60
  24. Ursolic acid (UA), a natural pentacyclic triterpenoid, exerts anti-tumor effects in various cancer types including hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying this remain large...

    Authors: LiJun Yang, Qing Tang, Jingjing Wu, Yuqing Chen, Fang Zheng, Zhenhui Dai and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:59

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:81

  25. Microtubule Targeting Agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are widely used in the treatment of various cancers. As with most chemotherapeutic agents, adverse effects and drug resi...

    Authors: Mohadeseh Hasanpourghadi, Chandrabose Karthikeyan, Ashok Kumar Pandurangan, Chung Yeng Looi, Piyush Trivedi, Kinue Kobayashi, Kozo Tanaka, Won Fen Wong and Mohd Rais Mustafa
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:58
  26. Gastric cancer remains a major cause of mortality and morbidity worldwide. In recent years, gene-based therapeutic strategies were confirmed promising in cancer inhibition and attracted great attention. RNA in...

    Authors: Hao Peng, Huawei Yang, Liwei Song, Zheng Zhou, Jinwen Sun, Yunfeng Du, Keyu Lu, Tao Li, Aiguo Yin, Jianhua Xu and Shidong Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:57
  27. DNA topoisomerase I (Top1) is a DNA unwinding protein and the specific target of the camptothecin class of chemotherapeutic drugs. One of these, irinotecan, acting through its active metabolite SN-38, is used ...

    Authors: Niels Frank Jensen, Keli Agama, Amit Roy, David Hersi Smith, Thomas D. Pfister, Maria Unni Rømer, Hong-Liang Zhang, James H. Doroshow, Birgitta R. Knudsen, Jan Stenvang, Nils Brünner and Yves Pommier
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:56
  28. The CXCL12/CXCR4 pathway regulates tumor cell proliferation, metastasis, angiogenesis and the tumor-microenvironment cross-talk in several solid tumors, including glioblastoma (GBM), the most common and fatal ...

    Authors: Laura Mercurio, Maria Antonietta Ajmone-Cat, Serena Cecchetti, Alessandro Ricci, Giuseppina Bozzuto, Agnese Molinari, Isabella Manni, Bianca Pollo, Stefania Scala, Giulia Carpinelli and Luisa Minghetti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:55
  29. Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored t...

    Authors: Liangliang Zhao, Yayan Bi, Junjie Kou, Jialan Shi and Daxun Piao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:54
  30. Previous study showed that dsP53-285 has the capacity to induce tumor suppressor gene p53 expression by targeting promoter in non-human primates’ cells. And it is well known that TP53 gene is frequently mutant...

    Authors: Chenghe Wang, Qiangqiang Ge, Qingsong Zhang, Zhong Chen, Jia Hu, Fan Li and Zhangqun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:53
  31. Activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) presents aggressive clinical courses and poor prognosis. Targeting key pathways may raise the possibility of improving clinical outcomes.

    Authors: Zhen Jin, Kai Qing, Yuan Ouyang, Zhao Liu, Wenfang Wang, Xiaoyang Li, Zizhen Xu and Junmin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:52
  32. CC-chemokine receptor 7 (CCR7), which plays an important role in cell directional movement, is highly expressed in various cancers and positively related to lymph node metastasis. The inflammatory cytokine tum...

    Authors: HaiJie Hong, CaiLong He, SiYuan Zhu, YanHui Zhang, XiaoQian Wang, FeiFei She and YanLing Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:51
  33. The aim of this analysis was to investigate the potential impact of Ki67 assay in a series of patients affected by early stage invasive lobular carcinoma (ILC) undergone surgery.

    Authors: Luisa Carbognin, Isabella Sperduti, Matteo Brunelli, Lisa Marcolini, Rolando Nortilli, Sara Pilotto, Ilaria Zampiva, Sara Merler, Elena Fiorio, Elisa Filippi, Erminia Manfrin, Francesca Pellini, Franco Bonetti, Giovanni Paolo Pollini, Giampaolo Tortora and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:50
  34. The achievement of complete response (CR) significantly correlates with a better clinical outcome in multiple myeloma (MM) patients treated with autologous stem cell transplant (ASCT). The depth of response is...

    Authors: Iole Cordone, Francesco Marchesi, Serena Masi, Valentina Summa, Francesco Pisani, Roberta Merola, Giovanni Cigliana, Giulia Orlandi, Svitlana Gumenyuk, Francesca Palombi, Atelda Romano, Antonio Spadea, Daniela Renzi, Elena Papa, Marco Canfora, Laura Conti…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:49
  35. Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. An isoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed t...

    Authors: Koichi Fujisawa, Shuji Terai, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki, Toshihiko Matsumoto, Kazuhito Yamaguchi, Yuji Owada, Hiroshi Nishina, Takafumi Noma and Isao Sakaida
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:48
  36. MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive.

    Authors: Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang and Jin-Shui Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:47

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:61

  37. Progressive loss of skeletal muscle, termed muscle wasting, is a hallmark of cancer cachexia and contributes to weakness, reduced quality of life, as well as poor response to therapy. Previous studies have ind...

    Authors: Xiu-yan Huang, Zi-li Huang, Ju-hong Yang, Yong-hua Xu, Jiu-Song Sun, Qi Zheng, Chunyao Wei, Wei Song and Zhou Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:46

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:77

  38. A widespread decrease of mature microRNAs is often observed in human malignancies giving them potential to act as tumor suppressors. Thus, microRNAs may be potential targets for cancer therapy. The global miRN...

    Authors: Aymone Gurtner, Emmanuela Falcone, Francesca Garibaldi and Giulia Piaggio
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:45
  39. Ewing’s sarcoma is an aggressive bone and soft tissue tumor with a high incidence in children and adolescents. Due to its high malignancy and poor prognosis, identification of novel biomarkers for intervention...

    Authors: Chongmin Ren, Tingting Ren, Kang Yang, Shidong Wang, Xing Bao, Fan Zhang and Wei Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:44
  40. Acting as inflammatory mediators, tumor oncogenes or suppressors, microRNAs are involved in cell survival, death, epithelial–mesenchymal transition and metastasis, etc. Investigating the communication between ...

    Authors: Yudan Chi and Dongming Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:43
  41. Mortalin/GRP75 is a ubiquitous mitochondrial chaperone which related to the cytosolic heat shock protein 70 (HSP70), and plays a role in carcinogenesis. This study aims to investigate the Mortalin expression i...

    Authors: Haidan Jin, Meiying Ji, Liyan Chen, Qixiang Liu, Shuanlong Che, Ming Xu and Zhenhua Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:42
  42. N-Hydroxyphthalimide (NHPI), an important chemical raw material, was found to have potent and selective anti-proliferative effect on human breast carcinoma BT-20 cells, human colon ade...

    Authors: Min Wang, Ankun Zhou, Tao An, Lingmei Kong, Chunlei Yu, Jianmei Liu, Chengfeng Xia, Hongyu Zhou and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:41
  43. Atractylenolide I (ATR-1), an active component of Rhizoma Atractylodis Macrocephalae, possesses cytotoxicity against various carcinomas. However, little is known about the effects of ATR-1on bladder cancer. In th...

    Authors: Rui Yu, Bi-xia Yu, Jun-feng Chen, Xiu-yi Lv, Ze-jun Yan, Yue Cheng and Qi Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:40

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:249

  44. Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote tumor development and to be a good target for cancer treatment. Most studies to date have used human mesothel...

    Authors: Emmanuel Zervos, Steven Agle, Andrew G. Freistaedter, Gwendolyn J. B. Jones and Rachel L. Roper
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:39
  45. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Recurrence and metastasis after curative resection remain critical obstacles in HCC treatment. CD146 predicted p...

    Authors: Guoqing Jiang, Long Zhang, Qin Zhu, Dousheng Bai, Chuanyong Zhang and Xuehao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:38
  46. KDM5B is a jmjc domain-containing histone demethylase which remove tri-, di-, and monomethyl groups from histone H3 lysine 4 (H3K4). KDM5B has been determined as an oncogene in many malignancies. However, its ...

    Authors: Dong Wang, Sheng Han, Rui Peng, Chenyu Jiao, Xing Wang, Xinxiang Yang, Renjie Yang and Xiangcheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:37
  47. Aquaporins (AQP) are water channel proteins that enable fluid fluxes across cell membranes, important for homeostasis of the tissue environment and for cell migration. AQP1 knockout mouse models of human cance...

    Authors: Hilary S. Dorward, Alice Du, Maressa A. Bruhn, Joseph Wrin, Jinxin V. Pei, Andreas Evdokiou, Timothy J. Price, Andrea J. Yool and Jennifer E. Hardingham
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:36
  48. Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common and is strongly associated with mortality. It is therefore critical to identify new targe...

    Authors: Xiaodong Feng, Yuchen Jiang, Liang Xie, Lu Jiang, Jing Li, Chongkui Sun, Hao Xu, Ruinan Wang, Min Zhou, Yu Zhou, Hongxia Dan, Zhiyong Wang, Ning Ji, Peng Deng, Ga Liao, Ning Geng…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:35

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