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  1. Total thyroidectomy is the treatment of choice in the majority of thyroid malignancies, preventing the risk of reoperative surgery due to recurrences. In order to assess the usefulness of such an approach, exp...

    Authors: Guglielmo Ardito, Luca Revelli, Alma Boninsegna, Alessandro Sgambato, Francesca Moschella, Maria Cristina Marzola, Erica Giustozzi, Nicola Avenia, Mauro Castelli and Domenico Rubello
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:77
    Content type: Research Published on:

  2. Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and un...

    Authors: Xian-ping Liu, Sheng-tao Zhou, Xing-yi Li, Xian-cheng Chen, Xia Zhao, Zhi-yong Qian, Li-na Zhou, Zhi-yong Li, Yu-mei Wang, Qian Zhong, Tao Yi, Zheng-yu Li, Xiang He and Yu-quan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:76
    Content type: Research Published on:

  3. Recent studies have shown that microRNAs (miRNAs) play roles in tumorigenesis and are reliable classifiers of certain cancer types and subtypes. However, the role of miRNAs in the pathogenesis and diagnosis of...

    Authors: Liqin Du, Jeoffrey J Schageman, Irnov, Luc Girard, Scott M Hammond, John D Minna, Adi F Gazdar and Alexander Pertsemlidis
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:75
    Content type: Research Published on:

  4. To retrospectively compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multidetector-row computed tomography (MDCT) in the assessment of the mandibular invasion by squamous cell carcinoma (...

    Authors: Antonello Vidiri, Antonino Guerrisi, Raul Pellini, Valentina Manciocco, Renato Covello, Oreste Mattioni, Isabella Guerrisi, Salvatore Di Giovanni, Giuseppe Spriano and Marcello Crecco
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:73
    Content type: Research Published on:

  5. SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis.

    Authors: Jian-fang Liang, Hong-kun Wang, Hong Xiao, Ning Li, Cai-xia Cheng, Yu-ze Zhao, Yan-bo Ma, Jian-zhong Gao, Rui-bing Bai and Hui-xia Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:71
    Content type: Research Published on:

  6. Intra-arterial radioembolization with yttrium-90 microspheres ( 90Y-RE) is an increasingly used therapy for patients with unresectable liver malignancies. Over the last decade, radioactive holmium-166 poly(L-lact...

    Authors: Maarten LJ Smits, Johannes FW Nijsen, Maurice AAJ van den Bosch, Marnix GEH Lam, Maarten AD Vente, Julia E Huijbregts, Alfred D van het Schip, Mattijs Elschot, Wouter Bult, Hugo WAM de Jong, Pieter CW Meulenhoff and Bernard A Zonnenberg
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:70
    Content type: Research Published on:

  7. Positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism. We have analyzed the effect ...

    Authors: Seong-Jang Kim, Sang-Hyun Hwang, In Joo Kim, Min Ki Lee, Chang Hun Lee, Sang-Yull Lee and Eun Yup Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:69
    Content type: Research Published on:

  8. This study aimed to investigate the efficacy of prophylactic amifostine in reducing the risk of severe radiation colitis in cancer patients receiving radical radiotherapy to the pelvis.

    Authors: Konstantinos H Katsanos, Evangelos Briasoulis, Pericles Tsekeris, Anna Batistatou, Maria Bai, Christos Tolis, Antonio Capizzello, Ioannis Panelos, Vasileios Karavasilis, Dimitrios Christodoulou and Epameinondas V Tsianos
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:68
    Content type: Research Published on:

  9. Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and pe...

    Authors: Qiong Yang, De-Rong Xie, Zhi-Min Jiang, Wen Ma, Yuan-Dong Zhang, Zhuo-Fei Bi and Deng-Lin Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:67
    Content type: Research Published on:

  10. The prognosis of gastric cancer patients is difficult to predict because of defects in establishing the surgical-pathological features. Cancer-associated fibroblasts (CAFs) have been found to play prominent ro...

    Authors: Kangkang Zhi, Xiaojun Shen, Hao Zhang and Jianwei Bi
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:66
    Content type: Research Published on:

  11. In the province of Cadiz (Spain), the adjusted mortality rate for gastric cancer in the coastal town of Barbate is 10/100.000 inhabitants, whereas in the inland town of Ubrique, the rate is twice as high. The ...

    Authors: Juan-Bosco Lopez-Saez, Victoria Gómez-Biondi, Germán Santamaría-Rodriguez, Margarita Dominguez-Villar, Antonio Amaya-Vidal, Antonio Lorenzo-Peñuelas and Avelino Senra-Varela
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:65
    Content type: Research Published on:

  12. This study aimed to examine whether EBV seropositive patients with lung cancer have an altered virus-specific CTL response, as compared to age-matched healthy controls and whether any variation in this respons...

    Authors: Vaios Karanikas, Maria Zamanakou, Faye Soukou, Theodora Kerenidi, Ioannis Tsougos, Kiki Theodorou, Panagiotis Georgoulias, Konstantinos I Gourgoulianis and Anastasios E Germenis
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:64
    Content type: Research Published on:

  13. in recent years, Livin, a new member of IAPs family, is found to be a key molecule in cancers. Researchers consider Livin may become a new target for tumor therapy; however, the role of it in bladder cancer is...

    Authors: Liu Chuan, Wu Xiaohou, Luo Chunli, Hu Zili, Yin Zhikang, He Yunfeng, Du Hu, Zhang Weili, Jiang Qing and Lin Yanjun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:63
    Content type: Research Published on:

  14. The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare t...

    Authors: Gregory E Rice, Tracey A Edgell and Dominic J Autelitano
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:62
    Content type: Research Published on:

  15. CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. CD147 has been implicated in numerous physiological and pathological activities. Enriched on the surface of many tumo...

    Authors: Bo Wang, Yong-Fei Xu, Bang-Shun He, Yu-Qin Pan, Li-Rong Zhang, Chan Zhu, Li-Li Qu and Shu-Kui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:61
    Content type: Research Published on:

  16. Survival of laryngeal squamous cell carcinoma (LSCC) patients has remained unchanged over recent years due to its uncontrolled recurrence and local lymph node metastasis. Vasculogenic mimicry (VM) is an altern...

    Authors: Wei Wang, Peng Lin, Chunrong Han, Wenjuan Cai, Xiulan Zhao and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:60
    Content type: Research Published on:

  17. Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to ...

    Authors: Jie Yin, Guowei Chen, Yucun Liu, Si Liu, Pengyuan Wang, Yuanlian Wan, Xin Wang, Jing Zhu and Hongqiao Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:59
    Content type: Research Published on:

  18. Although the addition of bevacizumab to 1st line chemotherapy provides a significant survival benefit for advanced colorectal cancer, the magnitudes of both advantages and toxicities have not been extensively inv...

    Authors: Fotios Loupakis, Emilio Bria, Vanja Vaccaro, Federica Cuppone, Michele Milella, Paolo Carlini, Chiara Cremolini, Lisa Salvatore, Alfredo Falcone, Paola Muti, Isabella Sperduti, Diana Giannarelli and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:58
    Content type: Research Published on:

  19. Constitutively decreased TGFBR1 allelic expression is emerging as a potent modifier of colorectal cancer risk in mice and humans. This phenotype was first observed in mice, then in lymphoblastoid cell lines from ...

    Authors: Boris Pasche, Kari B Wisinski, Maureen Sadim, Virginia Kaklamani, Michael J Pennison, Qinghua Zeng, Naresh Bellam, Jacquelyn Zimmerman, Nengjun Yi, Kui Zhang, John Baron, Daniel O Stram and M Geoffrey Hayes
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:57
    Content type: Research Published on:

  20. VEGF is a well-validated target for antiangiogenic intervention in cancer. To date, RNAi technology has been proven to be a promising approach for targeted therapy. DDP is frequently used as a first-line drug ...

    Authors: Yong P Ma, Yang Yang, Shuang Zhang, Xiang Chen, Na Zhang, Wei Wang, Zhi X Cao, Yu Jiang, Xia Zhao, Yu Q Wei and Hong X Deng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:56
    Content type: Research Published on:

  21. It has been demonstrated that certain NK-1 antagonists could reduce proliferation of several cancer cell lines, however, it is unknown whether SR140333 exerts proliferation inhibition in breast cancer cell line.

    Authors: Wei-Qing Huang, Ji-Gang Wang, Lei Chen, Hong-Jun Wei and Hua Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:55
    Content type: Research Published on:

  22. DNA-damage-inducible transcript 3 (DDIT3), a candidate tumor suppressor gene (TSG), has been found involved in the regulation of cellular growth and differentiation. The epigenetic changes of TSGs are recently re...

    Authors: Ya-li Wang, Jun Qian, Jiang Lin, Dong-ming Yao, Zhen Qian, Zhao-hui Zhu and Jian-yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:54
    Content type: Research Published on:

  23. MUC5AC is a secretory mucin normally expressed in the surface muconous cells of stomach and bronchial tract. It has been known that MUC5AC de novo expression occurred in the invasive ductal carcinoma and pancreat...

    Authors: Sadaaki Yamazoe, Hiroaki Tanaka, Tetsuji Sawada, Ryosuke Amano, Nobuya Yamada, Masaichi Ohira and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:53
    Content type: Research Published on:

  24. Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required. In this study we generated a novel 'suicide gene' armed on...

    Authors: Ju-Feng Zhang, Fang Wei, Hui-Ping Wang, Hui-Ming Li, Wei Qiu, Peng-Kang Ren, Xia-Fang Chen and Qian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:52
    Content type: Research Published on:

  25. Signal transducer and activator of transcription 3 (Stat3) is a member of the Janus-activated kinase(Jak)/Stat signaling pathway. Abnormal activation of Stat3 plays a critical role in metastasis and invasion i...

    Authors: Chen Huang, Guang Yang, Tao Jiang, Kejian Huang, Jun Cao and Zhengjun Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:51
    Content type: Research Published on:

  27. Fas/FasL system is a major regulator of apoptosis. The mechanisms by which Fas mediates cisplatin resistance remain unclear. The aim of this study is to explore the effect of Fas over-expression on cisplatin r...

    Authors: Wei Wu, Hai-dong Wang, Wei Guo, Kang Yang, Yun-ping Zhao, Yao-guang Jiang and Ping He
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:49
    Content type: Research Published on:

  28. Glypican 3 (GPC-3) is an oncofoetal protein that is expressed in most hepatocellular carcinomas (HCC). Since it is a potential target for T cell immunotherapy, we investigated the generation of functional, GPC...

    Authors: James O'Beirne, Farzin Farzaneh and Phillip M Harrison
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:48
    Content type: Research Published on:

  29. The main hindrance to the diffusion of proton therapy facilities is the high cost for gantry installations. An alternative technical option is provided by fixed-beam treatment rooms, where the patient is rotat...

    Authors: Salvatore Devicienti, Lidia Strigari, Marco D'Andrea, Marcello Benassi, Vincenzo Dimiccoli and Maurizio Portaluri
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:47
    Content type: Review Published on:

  30. A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin exp...

    Authors: Dan-Dan Yu, Chun-Ting Wang, Hua-Shan Shi, Zhi-Yong Li, Li Pan, Qing-Zhong Yuan, Fei Leng, Yuan Wen, Xiang Chen and Yu-Quan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:46
    Content type: Research Published on:

  31. We performed expression profiling of two neuroblastoma cell lines, SK-N-BE(2) and SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and cyclooxygenases (C...

    Authors: Petr Chlapek, Martina Redova, Karel Zitterbart, Marketa Hermanova, Jaroslav Sterba and Renata Veselska
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:45
    Content type: Research Published on:

  33. To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features.

    Authors: Xiang Hu, Ai-Xi Yu, Bai-Wen Qi, Tao Fu, Gang Wu, Min Zhou, Jun Luo and Jun-Hua Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:43
    Content type: Research Published on:

  34. Calcifying epithelioma of Malherbe, or Pilomatricoma, is considered an uncommon cutaneous neoplasia, normally occurring in children as a solitary, firm, asymptomatic, hard, subcutaneous, slowly growing nodule ...

    Authors: Francesco M Solivetti, Fulvia Elia, Alessandra Drusco, Chiara Panetta, Ada Amantea and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:42
    Content type: Research Published on:

  35. In our previous study, it was well defined that IGFBP7 was an important tumor suppressor gene in colorectal cancer (CRC). We aimed to uncover the downstream molecules responsible for IGFBP7's behaviour in this st...

    Authors: Wenjing Ruan, Yinghong Wang, Yu Ma, Xiaoming Xing, Jie Lin, Jing Cui and Maode Lai
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:41
    Content type: Research Published on:

  36. The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated...

    Authors: Vanessa F Bernardes, Frederico O Gleber-Netto, Sílvia F Sousa, Tarcília A Silva and Maria Cássia F Aguiar
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:40
    Content type: Research Published on:

  37. Definitions of basal-like breast cancer phenotype vary, and microarray-based expression profiling analysis remains the gold standard for the identification of these tumors. Immunohistochemical identification o...

    Authors: Radzislaw Kordek, Piotr Potemski, Renata Kusinska, Elzbieta Pluciennik and Andrzej Bednarek
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:39
    Content type: Research Published on:

  38. The objective of this study was to evaluate the efficacy and safety of pemetrexed plus cisplatin/carboplatin in locally advanced or metastatic non-small cell lung cancer (NSCLC) patients previously treated wit...

    Authors: Guan-Zhong Zhang, Shun-Chang Jiao and Zhao-Ting Meng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:38
    Content type: Research Published on:

  39. To investigate whether dendritic cell (DC) precursors, recruited by injection of chemokine ligand 3 (CCL3) and CCL20, induce anti-tumor immunity against gastric cancer induced by a DC vaccine expressing melanoma ...

    Authors: Songbing He, Liang Wang, Yugang Wu, Dechun Li and Yanyun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:37
    Content type: Research Published on:

  40. Analysis of gene expression and gene mutation may add information to be different from ordinary pathological tissue diagnosis. Since samples obtained endoscopically are very small, it is desired that more sens...

    Authors: Koji Nonogaki, Akihiro Itoh, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroshi Matsubara, Yuya Itoh, Yosuke Nakamura, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Masatoshi Ishigami, Yoshiaki Katano, Hidemi Goto and Yoshiki Hirooka
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:36
    Content type: Research Published on:

  41. This study explored the response of nasopharyngeal carcinoma cells to TGF-β1-induced growth suppression and investigated the roles of the TGF-β/Smad signaling pathway in nasopharyngeal carcinoma cells.

    Authors: Jian Xiao, Qi Xiang, Ye-Chen Xiao, Zhi-Jian Su, Zhi-Feng Huang, Qi-Hao Zhang, Yi Tan, Xiao-Kun Li and Ya-Dong Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:35
    Content type: Research Published on:

  44. PIK3CA is one of the genes most frequently mutated in human cancers and it is a potential target for personalized therapy. The aim of this study was to assess the frequency and type of PIK3CA mutations in gastric...

    Authors: Stefano Barbi, Ivana Cataldo, Giovanni De Manzoni, Samantha Bersani, Simona Lamba, Silvia Mattuzzi, Alberto Bardelli and Aldo Scarpa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:32
    Content type: Research Published on:

  45. In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved in pr...

    Authors: Ke Zheng, Hong-Yuan Li, Xin-Liang Su, Xiao-Yi Wang, Tian Tian, Fan Li and Guo-Sheng Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:31
    Content type: Research Published on:

  46. The past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal...

    Authors: Razvan T Radulescu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:30
    Content type: Review Published on:

  47. MicroRNAs are non-coding RNA molecules that posttranscriptionally regulate expression of target genes and have been implicated in the progress of cancer proliferation, differentiation and apoptosis. The aim of...

    Authors: Bao Song, Chuanxi Wang, Jie Liu, Xingwu Wang, Liyan Lv, Ling Wei, Li Xie, Yan Zheng and Xianrang Song
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:29
    Content type: Research Published on:

  48. The secreted protein acidic and rich in cysteine (SPARC) plays a pivotal role in regulating cell-matrix interactions and tumor angiogenesis, proliferation, and migration. Detection of SPARC gene methylation may b...

    Authors: Jun Gao, Jian Song, Haojie Huang, Zhaoshen Li, Yiqi Du, Jia Cao, Minghui Li, Shunli Lv, Han Lin and Yanfang Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:28
    Content type: Research Published on:

  49. Circulating bone marrow-derived endothelial progenitor cells (EPCs) have been reported to participate in tumor angiogenesis and growth; however, the role of circulating EPCs in tumor progression is controversi...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Weiqi Li, Zhen Cai, Shilong Xiong and Jie Bao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:27
    Content type: Research Published on:

  50. Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of var...

    Authors: Zhuanyi Yang, Ying Wang, Jiasheng Fang, Fenghua Chen, Jinfang Liu, Jun Wu and Yanjin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:26
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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