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  1. Chordoma was a typically slow-growing tumor. The therapeutic approach to chordoma had traditionally relied mainly on surgical therapy. And the main reason for therapeutic failure was resistance to chemotherapy...

    Authors: Zhengang Ji, Hua Long, Yunsheng Hu, Xiuchun Qiu, Xiang Chen, Zhao Li, Degang Fan, Baoan Ma and Qingyu Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:158
    Content type: Research Published on:

  2. The present report was designed to investigate the origins of elevated oxidative stress measured in cancer patients in our previous work related to a case-control study (17 cases, 43 controls) on oesophageal c...

    Authors: Stéphanie Lagadu, Mathilde Lechevrel, François Sichel, Jean Breton, Didier Pottier, Rémy Couderc, Fathi Moussa and Virginie Prevost
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:157
    Content type: Research Published on:

  3. This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells.

    Authors: Nan Li, Weixing Guo, Jie Shi, Jie Xue, Huasheng Hu, Dong Xie, Mengchao Wu and Shuqun Cheng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:156
    Content type: Research Published on:

  4. Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers and might be associated with cancer risk ...

    Authors: Ruixing Zhang, Rui Wang, Fengbin Zhang, Chensi Wu, Haiyan Fan, Yan Li, Cuiju Wang and Zhanjun Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:155
    Content type: Research Published on:

  5. Molecular therapies that target genetic abnormalities in leukemic cells and their affected signaling pathways have been emerging in pediatric acute lymphoblastic leukemia (ALL). Glycogen synthase kinase-3β (GS...

    Authors: Yanni Hu, Xiaoyan Gu, Ruiyan Li, Qing Luo and Youhua Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:154
    Content type: Research Published on:

  6. Pleomorphic malignant fibrous histiocytoma (MFH) is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a m...

    Authors: Jun Nishio, Hiroshi Iwasaki, Kazuki Nabeshima, Masako Ishiguro, Teruto Isayama and Masatoshi Naito
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:153
    Content type: Research Published on:

  7. Noninvasive and tissue-specific technologies of gene transfection would be valuable in clinical gene therapy. This present study was designed to determine whether it could enhance gene transfection in vivo by the...

    Authors: Zhi-Yi Chen, Kun Liang and Ri-Xiang Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:152
    Content type: Research Published on:

  8. MicroRNAs are important gene regulators that potentially play a profound role in tumorigenesis. Increasing evidence indicates that miR-145 is a tumor suppressor capable of inhibiting breast and colon cancer ce...

    Authors: Zhe Chen, Huazong Zeng, Yong Guo, Pei Liu, Hui Pan, Anmei Deng and Jian Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:151
    Content type: Research Published on:

  9. Glucocorticoid (GC) resistance is frequently seen in acute lymphoblastic leukemia of T-cell lineage (T-ALL). In this study we investigate the potential and mechanism of using rapamycin to restore the sensitivi...

    Authors: Ling Gu, Chenyan Zhou, Huajun Liu, Ju Gao, Qiang Li, Dezhi Mu and Zhigui Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:150
    Content type: Research Published on:

  10. Management of peritoneal dissemination is the most critical problem in gastric cancer. This study was performed to investigate the inhibitory effects of valproic acid (VPA) on a highly peritoneal-seeding cell ...

    Authors: Yasumichi Yagi, Sachio Fushida, Shinichi Harada, Jun Kinoshita, Isamu Makino, Katsunobu Oyama, Hidehiro Tajima, Hideto Fujita, Hiroyuki Takamura, Itasu Ninomiya, Takashi Fujimura, Tetsuo Ohta, Masakazu Yashiro and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:149
    Content type: Research Published on:

  11. Colloidal silver has been used as an antimicrobial and disinfectant agent. However, there is scarce information on its antitumor potential. The aim of this study was to determine if colloidal silver had cytoto...

    Authors: Moisés A Franco-Molina, Edgar Mendoza-Gamboa, Crystel A Sierra-Rivera, Ricardo A Gómez-Flores, Pablo Zapata-Benavides, Paloma Castillo-Tello, Juan Manuel Alcocer-González, Diana F Miranda-Hernández, Reyes S Tamez-Guerra and Cristina Rodríguez-Padilla
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:148
    Content type: Research Published on:

  12. Deletions within the short arm of chromosome 7 are observed in approximately 25% of adult and 10% of Wilms pediatric renal tumors. Within Wilms tumors, the region of interest has been delineated to a 2-Mb mini...

    Authors: Kimberly R Blish, Kathryn A Clausen, Gregory A Hawkins, A Julian Garvin, Mark C Willingham, Julie C Turner, Frank M Torti and Suzy V Torti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:147
    Content type: Research Published on:

  13. Epidemiological studies have clearly validated the association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with chronic HBV infection are at increased risk of HCC, in...

    Authors: Zhong-Jun Wu, Yu Zhu, De-Rong Huang and Zhi-Qiang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:146
    Content type: Research Published on:

  14. Norcantharidin, the demethylated analog of cantharidin derived from a traditional Chinese medicine, Mylabris, has been used in the treatment of anti-cancer effects. However, the detailed mechanisms underlying ...

    Authors: Cheng Chang, You-Qing Zhu, Juan-juan Mei, Shi-quan Liu and Jun Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:145
    Content type: Research Published on:

  15. Real-time reverse transcription PCR (qRT-PCR) is frequently used for gene expression quantification due to its methodological reproducibility and sensitivity. The gene expression is quantified by normalization...

    Authors: Lise Aa Sørby, Solveig N Andersen, Ida RK Bukholm and Morten B Jacobsen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:144
    Content type: Research Published on:

  16. The Polycomb group (PcG) genes are a class of regulators responsible for maintaining homeotic gene expression throughout cell division. PcG expression is deregulated in some types of human cancer. Both Bmi-1 and ...

    Authors: You-Wei Lu, Jin Li and Wei-Jian Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:143
    Content type: Research Published on:

  17. Radiotherapy has been shown to be an effective for the treatment human glioma and consists of 30 fractions of 2 Gy each for 6-7 weeks in the tumor volume with margins. However. in preclinical studies, many dif...

    Authors: Sandrine Vinchon-Petit, Delphine Jarnet, Eric Jadaud, Loïc Feuvret, Emmanuel Garcion and Philippe Menei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:142
    Content type: Research Published on:

  18. To study on expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocarcinoma (GC).

    Authors: Ji-wei Yu, Peng Zhang, Ju-gang Wu, Sheng-hua Wu, Xiao-qiang Li, Shi-ting Wang, Rui-qi Lu, Xiao-chun Ni and Bo-jian Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:141
    Content type: Research Published on:

  19. HBO1 (histone acetyltransferase binding to ORC1) is a histone acetyltransferase (HAT) which could exert oncogenic function in breast cancer. However, the biological role and underlying mechanism of HBO1 in bre...

    Authors: Wen-zhong Wang, Hai-ou Liu, Yi-hong Wu, Yi Hong, Jun-wu Yang, Ye-heng Liu, Wei-bin Wu, Lei Zhou, Lin-lin Sun, Jie-jie Xu, Xiao-jing Yun and Jian-xin Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:140
    Content type: Research Published on:

  20. Peritoneal dissemination is one of the main causes of death in gastric cancer patients. Transforming growth factor-beta1 (TGF-β1), one of the most potent fibrotic stimuli for mesothelial cells, may play a key ...

    Authors: Zhi-Dong Lv, Di Na, Fu-Nan Liu, Zong-Min Du, Zhe Sun, Zhen Li, Xiao-Yang Ma, Zhen-Ning Wang and Hui-Mian Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:139
    Content type: Research Published on:

  21. Gliomas represent the most common primary malignant brain tumors, yet little is known about the molecular pathogenesis of these tumors. The highly-regulated Wnt signal transduction pathway is essential for nor...

    Authors: Youxin Zhou, Fang Liu, Qinian Xu and Xiuyun Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:138
    Content type: Research Published on:

  22. Platinum-based chemotherapy has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it has high toxicity. In China, Shenqi Fuzheng, a newly developed injection concocted from Chinese m...

    Authors: Ju Dong, Shi-Yue Su, Min-Yan Wang and Zhen Zhan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:137
    Content type: Research Published on:

  23. The CIP2A protein is a recently characterized oncoprotein which inhibits protein phosphatase 2A activity. Expression of CIP2A has been detected in several carcinomas, but its expression and significance in pro...

    Authors: Markku H Vaarala, Marja-Riitta Väisänen and Ari Ristimäki
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:136
    Content type: Research Published on:

  24. Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are ass...

    Authors: Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:135
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:22

  25. The possibility that autologous NK cells could serve as an effective treatment modality for solid tumors has long been considered. However, implementation is hampered by (i) the small number of NK cells in per...

    Authors: Caroline J Voskens, Ryuko Watanabe, Sandra Rollins, Dario Campana, Kenichiro Hasumi and Dean L Mann
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:134
    Content type: Research Published on:

  26. The esophageal cancer related gene 4 (ECRG4) was initially identified and cloned in our laboratory from human normal esophageal epithelium (GenBank accession no.AF325503). ECRG4 was a new tumor suppressor gene...

    Authors: Linwei Li, Chunpeng Zhang, Xiaoyan Li, ShihHsin Lu and Yun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:133
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:19

  27. We have compared mutation analysis by DNA sequencing and Amplification Refractory Mutation Systemâ„¢ (ARMSâ„¢) for their ability to detect mutations in clinical biopsy specimens.

    Authors: Gillian Ellison, Emma Donald, Gael McWalter, Lucy Knight, Lynn Fletcher, James Sherwood, Mireille Cantarini, Maria Orr and Georgina Speake
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:132
    Content type: Research Published on:

  28. Studies have shown that Dickkopf-1 (DKK-1) is involved in tumorigenesis. Recently, we found that 9 out of 12 human glioma cell lines had high level of DKK-1 protein while the other 3 had very low or non-detect...

    Authors: Youxin Zhou, Wenshuai Li, Qinian Xu and Yulun Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:131
    Content type: Research Published on:

  29. Hepatocellular carcinoma (HCC) is frequently preceded by hepatitis virus infection or alcohol abuse. Genetic backgrounds may increase susceptibility to HCC from these exposures.

    Authors: Ruixing Zhang, Fengbin Zhang, Cuiju Wang, Shunxiang Wang, Yih-Horng Shiao and Zhanjun Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:130
    Content type: Research Published on:

  30. Human 8-oguanine glycosylase 1(hOGG1), voltage-dependent anion channel 1(VDAC1), hexokinase 2(HK-2), represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aim...

    Authors: Peng Guo-Qing, Yang Yuan, Zhong Cai-Gao, Yin Hongling, Hu Gonghua and Tian Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:129
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:53

  31. Colorectal cancer (CRC) screening is key to CRC prevention and mortality reduction, but patient compliance with CRC screening is low. We previously reported a blood-based test for CRC that utilizes a seven-gen...

    Authors: Kok-Thye Yip, Prashanta K Das, David Suria, Chun-Ren Lim, Guey-Hooi Ng and Choong-Chin Liew
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:128
    Content type: Research Published on:

  32. Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibi...

    Authors: Yasuhiro Kidera, Masanobu Tsubaki, Yuzuru Yamazoe, Kaori Shoji, Haruyuki Nakamura, Mitsuhiko Ogaki, Takao Satou, Tatsuki Itoh, Misako Isozaki, Junichi Kaneko, Yoshihiro Tanimori, Masashi Yanae and Shozo Nishida
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:127
    Content type: Research Published on:

  33. Lung cancer is a malignant carcinoma which has the highest morbidity and mortality in Chinese population. Gefitinib, a tyrosine kinase (TK) inhibitor of epidermal growth factor receptor (EGFR), displays anti-t...

    Authors: Yong-Mei Yin, Yi-Ting Geng, Yong-Feng Shao, Xiao-Li Hu, Wei Li, Yong-Qian Shu and Zhao-Xia Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:126
    Content type: Research Published on:

  34. Several studies demonstrated that epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates to the response to tyrosine kinase inhibitors in non small cell lung cancer (NSCLC) and to anti-EGFR ...

    Authors: Giovanni Simone, Anita Mangia, Andrea Malfettone, Vincenza Rubini, Michele Siciliano, Anna Di Benedetto, Irene Terrenato, Flavia Novelli and Marcella Mottolese
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:125
    Content type: Research Published on:

  35. Epithelial ovarian cancer is one of the most malignant cancers in women because metastasis occurs in the most of patients by the time of diagnosis. Cancer cells have strong capacity to form angiogenesis or vas...

    Authors: Pengfei Zhu, Yanxia Ning, Liangqing Yao, Mo Chen and Congjian Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:124
    Content type: Research Published on:

  36. RhoA and RhoC have been proved to be over-expressed in many solid cancers, including colorectal cancer. The reduction of RhoA and RhoC expression by RNA interference (RNAi) resulted growth inhibition of cancer ce...

    Authors: Haibo Wang, Gang Zhao, Xiangping Liu, Aihua Sui, Kun Yang, Ruyong Yao, Zongbao Wang and Qiang Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:123
    Content type: Research Published on:

  37. To investigate the mechanisms of multidrug resistance of brain tumors, to identify the site of cellular expression of P-gp in human brains in situ and to morphologically determine whether an association may ex...

    Authors: Zhenhua Guo, Jin Zhu, Lihua Zhao, Qing Luo and Xianqing Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:122
    Content type: Research Published on:

  38. Anti-CD20 monoclonal antibody treatment has not only increased survival and cure rates in many non-Hodgkin lymphomas, but also has prompted an explosion in the development of novel antibodies and biologically ...

    Authors: Yihu Zheng, Kang Yu, Jimei Du, Lei Jiang, Shenghui Zhang, Yixiang Han, Panpan Yu and Yingxia Tan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:121
    Content type: Research Published on:

  39. The advent of global gene expression profiling has generated unprecedented insight into our molecular understanding of cancer, including breast cancer. For example, human breast cancer patients display signifi...

    Authors: Robin M Hallett, Anna Dvorkin, Christine M Gabardo and John A Hassell
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:120
    Content type: Research Published on:

  40. Slug, Snail, and Twist are transcription factors that regulate the expression of tumor suppressors such as E-cadherin. In this study, we aimed to examine the expression of these transcription factors in human ...

    Authors: Qinchao Yu, Kejun Zhang, Xinsheng Wang, Xiangping Liu and Zemi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:119
    Content type: Research Published on:

  41. Drug resistance remains a great challenge in the treatment of gastric cancer. The goal of this study was to explore the anti-tumor effects and mechanism of cytokine-induced killer (CIK) cell combined with oxal...

    Authors: Qun Zhao, Hui Zhang, Yong Li, Jun Liu, Xiaojie Hu and Liqiao Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:118
    Content type: Research Published on:

  42. Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. Heterozygous carriers of ATM-mutations have an increased ri...

    Authors: Lin-Bo Gao, Xin-Min Pan, Hong Sun, Xia Wang, Li Rao, Li-Juan Li, Wei-Bo Liang, Mei-Li Lv, Wen-Zhong Yang and Lin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:117
    Content type: Research Published on:

  43. Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hype...

    Authors: Jang Hyun Lee, Jae-Kyung Pyon, Dong Wook Kim, Sang Han Lee, Hae Seon Nam, Chul Han Kim, Sang Gue Kang, Yoon Jin Lee, Mi Youn Park, Dong Jun Jeong and Moon Kyun Cho
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:116
    Content type: Research Published on:

  44. To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods.

    Authors: Xingguo Zhong, Maoming Xiong, Xiangling Meng and Renhua Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:115
    Content type: Research Published on:

  45. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus. It was found that CBX7 expression was upregul...

    Authors: Xiao-Wei Zhang, Li Zhang, Wei Qin, Xiao-Hong Yao, Lei-Zhen Zheng, Xin Liu, Jin Li and Wei-Jian Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:114
    Content type: Research Published on:

  47. Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of se...

    Authors: Xiao-yun Mao, Chui-feng Fan, Hua-chuan Zheng, Jing Wei, Fan Yao and Feng Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:112
    Content type: Research Published on:

  48. GTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities. However, the ...

    Authors: Zhen Qian, Jun Qian, Jiang Lin, Dong-ming Yao, Qin Chen, Run-bi Ji, Yun Li, Gao-fei Xiao and Jian-yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:111
    Content type: Research Published on:

  49. The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. C...

    Authors: Cheng-Jeng Tai, Chung-Huei Hsu, Shing-Chuan Shen, Woan-Ruoh Lee and Ming-Chung Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:110
    Content type: Review Published on:

  50. The incidence of malignant melanoma (MM) was occurring at a faster rate than for most neoplasm worldwide, and melanoma metastasis is still the most formidable problem. So it is necessarily to find some biomark...

    Authors: Man Li, Baogang Zhang, Baocun Sun, Xuan Wang, Xinchao Ban, Tao Sun, Zhiyong Liu and Xiulan Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:109
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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