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  1. CD133-positive cells in hepatocellular carcinoma (HCC) exhibit cancer stem cell (CSC)-like properties as well as resistance to chemotherapeutic agents and ionizing radiation; however, their function remains un...

    Authors: Yeonhwa Song, Jaewoo Jang, Tae-Hoon Shin, Sang Mun Bae, Jin-sun Kim, Kang Mo Kim, Seung-Jae Myung, Eun Kyung Choi and Haeng Ran Seo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:38
  2. Non-small cell lung cancer (NSCLC) is the most commonly diagnosed type of lung cancer that is associated with poor prognosis. In this study we explored the potential role of p53-induced gene 3 (PIG3) in the pr...

    Authors: Ming Li, Shanhu Li, Biao Liu, Meng-Meng Gu, Shitao Zou, Bei-Bei Xiao, Lan Yu, Wei-Qun Ding, Ping-Kun Zhou, Jundong Zhou and Zeng-Fu Shang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:39
  3. Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F family member, was reported to associate with progr...

    Authors: Jing Sun, Run Shi, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma and Chuan Su
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:40
  4. Cancer stem cells (CSCs) are correlated with the initiation, chemoresistance and relapse of tumors. Notch pathway has been reported to function in CSCs maintenance, but whether it is involved in renal cell car...

    Authors: Wei Xiao, Zhiyong Gao, Yixing Duan, Wuxiong Yuan and Yang Ke
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:41
  5. Growing evidence suggests that hepatitis C virus (HCV) contributes to hepatocellular carcinoma (HCC) by directly modulating oncogenic signaling pathways. Protein phosphatase magnesium-dependent 1A (PPM1A) has ...

    Authors: Yali Zhou, Yan Zhao, Yaoying Gao, Wenjun Hu, Yan Qu, Ning Lou, Ying Zhu, Xiaoping Zhang and Hongmei Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:42
  6. Drug resistance and disease progression are still the major obstacles in the treatment of chronic myeloid leukemia (CML). Increasing researches have demonstrated that autophagy becomes activated when cancer ce...

    Authors: Ziyuan Lu, Na Xu, Bolin He, Chengyun Pan, Yangqing Lan, Hongsheng Zhou and Xiaoli Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:43
  7. Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found in plant extracts which are wide...

    Authors: Dong Xu, Junzhe Jin, Hao Yu, Zheming Zhao, Dongyan Ma, Chundong Zhang and Honglei Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:44
  8. Accumulating evidence indicates that microRNA-27a (miR-27a) is involved in carcinogenesis and tumor progression. However, the exact function and molecular mechanism of miR-27a in gastric cancer remain unclear.

    Authors: Lei Ding, Shanyong Zhang, Mu Xu, Renwen Zhang, Pengcheng Sui and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:45
  9. The transcription factor sex-determining region Y-box protein 3 (SOX3) plays important roles in various types of cancer. However, its expression and function have not yet been elucidated in osteosarcoma (OS).

    Authors: Manle Qiu, Daoyun Chen, Chaoyong Shen, Ji Shen, Huakun Zhao and Yaohua He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:46
  10. Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various tumor types. Previous work has demonstrated that curcumin inhibits cancer cell growth by targeting multiple si...

    Authors: Lihua Wang, Xiwen Chen, Zhuanyun Du, Gefei Li, Mayun Chen, Xi Chen, Guang Liang and Tongke Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:47
  11. Epithelial–mesenchymal transition (EMT) and dysregulated microRNAs (miRNAs) have important roles in driving chemoresistance. We previously reported that iASPP is a key EMT inducer and could increase cisplatin ...

    Authors: Ying Xiong, Fei Sun, Peixin Dong, Hidemichi Watari, Junming Yue, Min-fei Yu, Chun-yan Lan, Yin Wang and Ze-biao Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:48
  12. RNA-binding protein 38 (RBM38) is a member of the RNA recognition motif (RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming regulatory loops with relevant genes. c-Myc is an...

    Authors: Xiao-Xia Li, Liang Shi, Xu-Jie Zhou, Jing Wu, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Lei Zhu, Ji-Fu Wei and Qiang Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:49
  13. Itraconazole has been proved therapeutically effective against a variety of human cancers. This study assessed the effect of itraconazole on the Hedgehog (Hh) pathway and proliferation of human gastric cancer ...

    Authors: Qiang Hu, Yi-Chao Hou, Jiao Huang, Jing-Yuan Fang and Hua Xiong
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:50
  14. P73 antisense RNA 1 T (non-protein coding), also known as TP73-AS1, is a long non-coding RNA (lncRNA) which is involved in cell proliferation and the development of tumors. However, the exact effects and molec...

    Authors: Shaling Li, Yan Huang, Yun Huang, Yongming Fu, Daolin Tang, Rui Kang, Rongrong Zhou and Xue-gong Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:51
  15. Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to che...

    Authors: Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K. Keppler and Walter Berger
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:52
  16. Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates ...

    Authors: Peiming Zheng, Lei Chen, Xiangliang Yuan, Qin Luo, Yi Liu, Guohua Xie, Yanhui Ma and Lisong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:53
  17. Numerous studies have shown that long non-coding RNAs (lncRNAs) play key roles during multiple cancer processes, such as cell proliferation, apoptosis, migration and invasion. The previous studies found that N...

    Authors: Zhiliang Lu, Yuan Li, Jingnan Wang, Yun Che, Shouguo Sun, Jianbing Huang, Zhaoli Chen and Jie He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:54
  18. Through high-throughput next-generation sequencing of promoters of solute carrier and ATP-binding cassette genes, which encode drug transporters, we aimed to identify SNPs associated with the response to imati...

    Authors: Monika Jaruskova, Nikola Curik, Rajna Hercog, Vaclava Polivkova, Eliska Motlova, Vladimir Benes, Hana Klamova, Pavla Pecherkova, Petra Belohlavkova, Filip Vrbacky and Katerina Machova Polakova
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:55
  19. Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors. Our previous study has shown that Gab2 induces epithelial-to-mese...

    Authors: Chenbo Ding, Junmin Luo, Xiaobo Fan, Longmei Li, Shanshan Li, Kunming Wen, Jihong Feng and Guoqiu Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:56
  20. BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2. Due to these common targets b...

    Authors: Sabine Heublein, Doris Mayr, Alfons Meindl, Alexandra Kircher, Udo Jeschke and Nina Ditsch
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:57
  21. Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK...

    Authors: Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang and Hua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:58
  22. MicroRNAs are endogenously expressed, small non-coding RNAs that modulate gene expression by targeting specific mRNAs, resulting in translational repression or mRNA degradation. Although miR-584-5p has been re...

    Authors: Qing Li, Zheng Li, Song Wei, Weizhi Wang, Zheng Chen, Lei Zhang, Liang Chen, Bowen Li, Guangli Sun, Jianghao Xu, Qiang Li, Lu Wang, Zhipeng Xu, Yiwen Xia, Diancai Zhang, Hao Xu…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:59
  23. The incidence and mortality rates of hepatocellular carcinoma (HCC) have steadily increased in recent years. A hypoxic microenvironment is one of the most important characteristics of solid tumors which has be...

    Authors: Meili Wang, Xiulan Zhao, Dongwang Zhu, Tieju Liu, Xiaohui Liang, Fang Liu, Yanhui Zhang, Xueyi Dong and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:60
  24. Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS). MM is a biologically complex ...

    Authors: Anna Shvartsur, Kevin B. Givechian, Hermes Garban and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:62
  25. Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment a challenge. Forkhead box M1 (FOXM1) is an oncogene aberrantly expressed in many solid cancers including serous ...

    Authors: Renata A. Tassi, Paola Todeschini, Eric R. Siegel, Stefano Calza, Paolo Cappella, Laura Ardighieri, Moris Cadei, Mattia Bugatti, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Laura Tassone, Donatella Guarino, Concetta Santonocito, Ettore D. Capoluongo, Luca Beltrame…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:63
  26. As a relatively conservative transcriptional regulator in biological evolution, heat shock factor 1 (HSF1) is activated by, and regulates the expression of heat shock proteins (HSPs) in response to a variety o...

    Authors: Wenjin Liang, Yong Liao, Jing Zhang, Qi Huang, Wei Luo, Jidong Yu, Jianhua Gong, Yi Zhou, Xuan Li, Bo Tang, Songqing He and Jinghong Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:64
  27. AHNAK, also known as desmoyokin, is a giant protein with the molecular size of approximately 700 kDa and exerts diverse functions in different types of cancer.

    Authors: Bo Chen, Jin Wang, Danian Dai, Qingyu Zhou, Xiaofang Guo, Zhi Tian, Xiaojia Huang, Lu Yang, Hailin Tang and Xiaoming Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:65
  28. The involvement of lipid metabolism in tumourigenesis and the progression of clear cell renal cell carcinoma (ccRCC) have been reported. However, the role of phospholipid profile alterations in ccRCC has not y...

    Authors: Yiqing Du, Qiang Wang, Xingzhong Zhang, Xiaofeng Wang, Caipeng Qin, Zhengzuo Sheng, Huaqi Yin, Changtao Jiang, Jing Li and Tao Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:66
  29. Chemotherapy resistance is one of the major factors contributing to mortality from human epithelial ovarian cancer (EOC). Identifying drugs that can effectively kill chemotherapy-resistant EOC cells would be a...

    Authors: Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur and Mark W. Nachtigal
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:67
  30. Patients with metastatic or relapsed gallbladder cancer generally have a poor prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat gallbladder cancer.

    Authors: Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong and Yingbin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:68

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:124

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:385

  31. Authors: Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:69

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:193

  32. Fibronectin (FN) is associated with tumorigenesis and progression in bladder cancer, however, the underlying mechanisms causing this remain largely unknown. Furthermore, cancerous inhibitor of protein phosphat...

    Authors: Fengbin Gao, Tianyuan Xu, Xianjin Wang, Shan Zhong, Shanwen Chen, Minguang Zhang, Xiaohua Zhang, Yifan Shen, Xiaojing Wang, Chen Xu and Zhoujun Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:70
  33. The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Authors: Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr. and Aldo Venuti
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:71
  34. Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development is complex. Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the mos...

    Authors: Hong Yuan, Zi-Ming Li, Jiaxiang Shao, Wen-Xiang Ji, Weiliang Xia and Shun Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:72
  35. Epidemiologic data in volcanic areas suggest that environmental factors might be involved in the increase of thyroid cancer (TC) incidence. Recent reports indicate that several heavy metals and metalloids are ...

    Authors: Emilia Luca, Laura Fici, Anna Ronchi, Ferdinando Marandino, Esther Diana Rossi, Maria Emiliana Caristo, Pasqualino Malandrino, Marco Russo, Alfredo Pontecorvi, Riccardo Vigneri and Fabiola Moretti
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:73
  36. Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms implic...

    Authors: Zoltán Hujber, Gábor Petővári, Norbert Szoboszlai, Titanilla Dankó, Noémi Nagy, Csilla Kriston, Ildikó Krencz, Sándor Paku, Olivér Ozohanics, László Drahos, András Jeney and Anna Sebestyén
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:74
  37. Increasing evidence has indicated an important role for estrogen receptor beta 1 (ERβ1) in breast cancer. However, the role of ERβ1 in the metastasis of androgen receptor (AR)-positive triple-negative breast c...

    Authors: Wei Song, Lin Tang, Yumei Xu, Qian Sun, Fang Yang and Xiaoxiang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:75
  38. Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistanc...

    Authors: Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio and Emilio Ciusani
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:76
  39. Bladder cancer (BCa) is the ninth most common form of cancer in the world. There is a continuing need not only for improving the accuracy of diagnostic markers but also for the development of new treatment str...

    Authors: Nana Pei, Yingying Mao, Pengfei Wan, Xinglu Chen, Andrew Li, Huiying Chen, Jinlong Li, Renqiang Wan, Yanling Zhang, Hongyan Du, Baihong Chen, Guangyu Jiang, Minghan Xia, Colin Sumners, Guixue Hu, Dongsheng Gu…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:77
  40. Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cance...

    Authors: Haiyan Chen, Qian Xiao, Yeting Hu, Liubo Chen, Kai Jiang, Yang Tang, Yinuo Tan, Wangxiong Hu, Zhanhuai Wang, Jinjie He, Yue Liu, Yibo Cai, Qi Yang and Kefeng Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:78
  41. Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract. Currently, resistance to traditional chemotherapy is a gre...

    Authors: Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng and Jinbao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:79
  42. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    Authors: A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:80
  43. 5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored the role of NLRP...

    Authors: Xiaodong Feng, Qingqiong Luo, Han Zhang, Han Wang, Wantao Chen, Guangxun Meng and Fuxiang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:81
  44. MicroRNAs (miRs) are involved in tumor progression by regulating tumor cells and tumor microenvironment. MiR21 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological impact on tumor micro...

    Authors: Zhong Zheng, Peng-Peng Xu, Li Wang, Hui-Jin Zhao, Xiang-Qin Weng, Hui-Juan Zhong, Bin Qu, Jie Xiong, Yan Zhao, Xue-Feng Wang, Anne Janin and Wei-Li Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:82
  45. This study examined the ability of lipopolysaccharide (LPS) to affect glioma and glioma stem-like cells (GSCs) in vitro and to induce antitumor immunity in vivo and the role of TLR4 in these processes.

    Authors: Sheng Han, Chao Wang, Xiaofei Qin, Junzhe Xia and Anhua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:83
  46. Oesophageal cancer is one of the most common malignancies worldwide,and oesophageal squamous cell carcinoma (ESCC) is the predominant histological type both globally and in China. Collagen triple helix repeat ...

    Authors: Chunni Wang, Zitong Li, Fei Shao, Xueying Yang, Xiaoli Feng, Susheng Shi, Yibo Gao and Jie He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:84
  47. PHF21B is newly identified to be involved in the tumor progression; however, its biological role and molecular mechanism in prostate cancer have not been defined. This study is aimed to study the role of PHF21...

    Authors: Qiji Li, Liping Ye, Wei Guo, Min Wang, Shuai Huang and Xinsheng Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:85
  48. Homeobox B7 (HOXB7) has been identified associated with poor prognosis of hepatocellular carcinoma (HCC). However, the specific mechanism by which HOXB7 promotes the malignant progression of HCC remains to be ...

    Authors: Hong-bo Huan, Da-peng Yang, Xu-dong Wen, Xue-jiao Chen, Liang Zhang, Li-li Wu, Ping Bie and Feng Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:86
  49. Endoplasmic reticulum (ER) calcium storage and release play important roles in B lymphocyte maturation, survival, antigen-dependent cell activation and immunoglobulin synthesis. Calcium is accumulated in the e...

    Authors: Lamia Aït Ghezali, Atousa Arbabian, Hervé Roudot, Jean-Philippe Brouland, Fanny Baran-Marszak, Evelyn Salvaris, Andrew Boyd, Hans G. Drexler, Agnes Enyedi, Remi Letestu, Nadine Varin-Blank and Bela Papp
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:87

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