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  1. Non-coding RNA molecules, such as microRNAs, may play an important role in carcinogenesis. Recent studies have indicated that microRNAs are involved in initiation and progression of various malignancies. Howev...

    Authors: Tao Yu, Xiao-yi Wang, Ren-guo Gong, An Li, Sen Yang, Yu-tang Cao, Yu-ming Wen, Chang-mei Wang and Xin-zhu Yi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:64
    Content type: Research Published on:

  2. An increasing number of studies have shown that ERK and PI3-K/AKT signaling pathways are involved in various human cancers including hepatocellular carcinoma and cholangiocarcinoma. However, few studies have e...

    Authors: Qinglong Li and Zhulin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:65
    Content type: Research Published on:

  3. Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the society. Many randomized phase III trial...

    Authors: Emilio Bria, Massimo Di Maio, Paolo Carlini, Federica Cuppone, Diana Giannarelli, Francesco Cognetti and Michele Milella
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:66
    Content type: Review Published on:

  4. The α6β4 integrin is overexpressed in the basal subtype of breast cancer and plays an important role in tumor cell motility and invasion. EGFR is also overexpressed in the basal subtype of breast cancer, and c...

    Authors: Michael Z Gilcrease, Xiao Zhou, Xiaolin Lu, Wendy A Woodward, Brian E Hall and Phillip J Morrissey
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:67
    Content type: Research Published on:

  5. Chemo-radiotherapy, a combination of chemotherapy and radiotherapy, is the most frequent treatment for patients with esophageal cancer. In the process of radiotherapy, the radiosensitive cancer will become a r...

    Authors: Li Xie, Xianrang Song, Jinming Yu, Ling Wei, Bao Song, Xingwu Wang and Liyan Lv
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:68
    Content type: Research Published on:

  7. Insulin-like growth factor binding protein (IGFBPs) have been as potential tumor suppressors in the occurrence and development of tumors. Cellular Fas-associated death domain-like interleukin-1β-converting enz...

    Authors: Xue-Jing Hou, You-Zhong Zhang, Xin Liu, Li-Hua Meng and Yun-Bo Qiao
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:70
    Content type: Research Published on:

  8. Hepatocellular carcinoma (HCC) is a lethal malignancy with high rate of metastasis and poor prognosis. There are no effective managements to block metastasis of HCC. Programmed cell death 4 (PDCD4) is found to...

    Authors: Shuhong Zhang, Jianfeng Li, Ying Jiang, Yijun Xu and Chengyong Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:71
    Content type: Research Published on:

  9. The relapse of cancer after radiotherapy is a clinical knotty problem. Previous studies have demonstrated that the elevation of several factors is likely in some way to lead to the development of treatment tol...

    Authors: Degang Shi, Genming Shi, Gang Huang, Jiren Zhang and Eric Lartigau
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:72
    Content type: Research Published on:

  10. Reactive oxygen species (ROS) are closely associated with the intracellular signal cascade, thus strongly implicating involvement in tumor progression. However, the mechanism by which ROS are generated and how...

    Authors: Kyung Hee Lee, Sang Woon Kim and Jae-Ryong Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:73
    Content type: Research Published on:

  11. Centromere protein H (CENP-H) is one of the fundamental components of the human active kinetochore. Recently, CENP-H was identified to be associated with tumorigenesis. This study was aimed to investigate the ...

    Authors: Wen-Ting Liao, Chun-Ping Yu, Dong-Hui Wu, Ling Zhang, Li-Hua Xu, Gui-Xiang Weng, Mu-Sheng Zeng, Li-Bing Song and Jin-Song Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:74
    Content type: Research Published on:

  12. Angiogenesis plays an important role in tumor growth, invasion, and eventually metastasis. Antiangiogenic strategies have been proven to be a promising approach for clinical therapy for a variety of tumors. As...

    Authors: Li-Ping Yang, Ping Cheng, Xing-Chen Peng, Hua-Shan Shi, Wei-Hong He, Feng-Yu Cui, Shun-Tao Luo, Yu-Quan Wei and Li Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:75
    Content type: Research Published on:

  13. We observed that paclitaxel altered the pharmacokinetic properties of gemcitabine in patients with non-small cell lung cancer (NSCLC) and limited the accumulation of gemcitabine and its metabolites in various ...

    Authors: Stacy S Shord and Shitalben R Patel
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:76
    Content type: Research Published on:

  14. opioid and somatostatin receptors (SSTRs) that can assemble as heterodimer were individually reported to modulate malignant cell proliferation and to favour apoptosis. Materials and methods: SSTRs and opioid r...

    Authors: Céline Kerros, Thibault Cavey, Brigitte Sola, Philippe Jauzac and Stéphane Allouche
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:77
    Content type: Research Published on:

  15. FBG2 (F-BOX6) gene is an important member in ubiquitin metabolic system F-BOX family, and forms E3 complex with the other members in the family. But its role in gastric cancer is still not clear. In the presen...

    Authors: Lin Zhang, Yanhong Hou, Mengwei Wang, Benyan Wu and Nan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:78
    Content type: Research Published on:

  17. The incidence of hepatocellular carcinoma is increasing in many countries. The estimated number of new cases annually is over 500,000, and the yearly incidence comprises between 2.5 and 7% of patients with liv...

    Authors: AlaaEddeen M Seufi, Safinz S Ibrahim, Tarek K Elmaghraby and Elsayed E Hafez
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:80
    Content type: Research Published on:

  18. Colorectal cancer is a one of the most common alimentary malignancies. Survivin has been proved by many studies to be an ideal target for cancer gene therapy because of its strong anti-apoptotic effect. The re...

    Authors: Wei Shen, Chun-Yi Wang, Xue-Hu Wang and Zhong-Xue Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:81
    Content type: Research Published on:

  19. MircoRNAs(miRNAs) are short, endogenously non-coding RNAs. The abnormal expression of miRNAs may be valuable for the diagnosis and treatment of tumors.

    Authors: Hongchun Luo, Hongbin Zhang, Zhenzhen Zhang, Xia Zhang, Bo Ning, Jinjun Guo, Na Nie, Bo Liu and Xiaoling Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:82
    Content type: Research Published on:

  20. The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy...

    Authors: Reiko Ashida, Bunzo Nakata, Minoru Shigekawa, Nobumasa Mizuno, Akira Sawaki, Kosei Hirakawa, Tetsuo Arakawa and Kenji Yamao
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:83
    Content type: Research Published on:

  21. Intracellular levels of zinc have shown a strong inverse correlation to growth and malignancy of prostate cancer. To date, studies of zinc supplementation in prostate cancer have been equivocal and have not ac...

    Authors: Maulik R Shah, Christopher L Kriedt, Nathan H Lents, Mary K Hoyer, Nimah Jamaluddin, Claudette Klein and Joseph Baldassare
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:84
    Content type: Research Published on:

  22. No satisfactory biomarkers are currently available to screen for nasopharyngeal carcinoma (NPC). We have developed and evaluated surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (S...

    Authors: Yuan-Jiao Huang, Chao Xuan, Bei-Bei Zhang, Ming Liao, Kai-Feng Deng, Min He and Jin-Min Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:85
    Content type: Research Published on:

  23. We aimed to determine the incidence of women's breast cancer in Italy without using statistical approximations.

    Authors: Prisco Piscitelli, Antonio Santoriello, Franco M Buonaguro, Massimo Di Maio, Giovanni Iolascon, Francesca Gimigliano, Alessandra Marinelli, Alessandro Distante, Giuseppe Serravezza, Emiliano Sordi, Katia Cagossi, Fabrizio Artioli, Michele Santangelo, Alfredo Fucito, Raffaele Gimigliano, Maria Luisa Brandi…
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:86
    Content type: Research Published on:

  24. To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis.

    Authors: Lara CV Harrison, Tiina Luukkaala, Hannu Pertovaara, Tuomas O Saarinen, Tomi T Heinonen, Ritva Järvenpää, Seppo Soimakallio, Pirkko-Liisa I Kellokumpu-Lehtinen, Hannu J Eskola and Prasun Dastidar
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:87
    Content type: Research Published on:

  26. Lung cancer is the leading cause of death from cancer worldwide. Conventional studies mainly think that insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) may promote and inhibit tumor gr...

    Authors: Bo Chen, Shan Liu, Wei Xu, Xueli Wang, Weihong Zhao and Jianqing Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:89
    Content type: Research Published on:

  27. Type 2 diabetes (T2D) is associated with obesity and has been shown recently to be associated with tumors/cancer. HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. We have previously shown th...

    Authors: Ramachandran Meenakshisundaram, Nunzia Piumelli, Laura Pierpaoli and Claudia Gragnoli
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:90
    Content type: Research Published on:

  28. Platinum-based neoadjuvant chemotherapy (NAC) is new therapeutic strategy for locally advanced cervical carcinoma, but the variables used to predict NAC response are still infrequently reported. The aim of our...

    Authors: Xiao-Dong Cheng, Wei-Guo Lu, Feng Ye, Xiao-Yun Wan and Xing Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:91
    Content type: Research Published on:

  29. Selenite is a promising anticancer agent which has been shown to induce apoptosis in malignant mesothelioma cells in a phenotype-dependent manner, where cells of the chemoresistant sarcomatoid phenotype are mo...

    Authors: Gustav Nilsonne, Eric Olm, Adam Szulkin, Filip Mundt, Agnes Stein, Branka Kocic, Anna-Klara Rundlöf, Aristi P Fernandes, Mikael Björnstedt and Katalin Dobra
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:92
    Content type: Research Published on:

  31. Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that t...

    Authors: Xiaoxiang Guan, Hui Zhao, Jiangong Niu, Dongfeng Tan, Jaffer A Ajani and Qingyi Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:94
    Content type: Research Published on:

  32. To compare intracavitary brachytherapy (ICBT) planning methods for cervical cancer, based on either orthogonal radiographs (conventional plan) or CT sections (CT plan); the comparison focused on target volume ...

    Authors: Cem Onal, Gungor Arslan, Erkan Topkan, Berrin Pehlivan, Melek Yavuz, Ezgi Oymak and Aydin Yavuz
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:95
    Content type: Research Published on:

  33. Resveratrol is a non flavonoid polyphenol compound present in many plants and fruits and, at especially high concentrations, in the grape berries of Vitis vinifera. This compound has a strong bioactivity and its ...

    Authors: Valerio Berardi, Francesca Ricci, Mauro Castelli, Gaspare Galati and Gianfranco Risuleo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:96
    Content type: Research Published on:

  34. The prognostic value of HER2 expression in patients with advanced non-small cell lung cancer remains controversial. The relationship between HER2 expression, and platinum resistance and patient survival, was i...

    Authors: Zuleyha Calikusu, Yesim Yildirim, Zafer Akcali, Hakan Sakalli, Nebil Bal, Ilker Unal and Ozgur Ozyilkan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:97
    Content type: Research Published on:

  36. Imatinib, a tyrosine kinase inhibitor currently approved for treatment of several malignancies, has been shown to be a substrate for multiple efflux-transporter proteins, including ABCB1 (P-glycoprotein) and A...

    Authors: Erin R Gardner, Nicola F Smith, William D Figg and Alex Sparreboom
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:99
    Content type: Research Published on:

  37. Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in ...

    Authors: Huaifu Li, Guofeng Ruan, Zhijun Li, Ziwei Liu, Xiaoqing Zheng, Hao zheng, Guangming Cheng, Benyi Li and Ming Zhan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:100
    Content type: Research Published on:

  38. Authors: Huang Hao, Yu Nancai, Fu Lei, Wei Xiong, Su Wen, Huang Guofu, Wu yanxia, Huang Hanju, Liu Qian and Xiao Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:101
    Content type: Retraction Note Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2008 27:27

  39. Opioid analgesics are generally used to combat the pain associated with cancerous conditions. These agents not only inhibit respiratory function and cause constipation, but also induce other significant side e...

    Authors: Hyo-Jeong Lee, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Kwan-Hyun Kim, Sun-Hyung Kim, Keun-Sung Lee, Hee-Jae Jung and Sung-Hoon Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:102
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2009 28:137

  40. A reliable and precise classification is essential for successful diagnosis and treatment of cancer. Gene expression microarrays have provided the high-throughput platform to discover genomic biomarkers for ca...

    Authors: Peng Guan, Desheng Huang, Miao He and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:103
    Content type: Research Published on:

  41. Non-synonymous single nucleotide polymorphisms (SNPs) within vital DNA repair genes may cause reduction of activity leaving the genome unrepaired resulting in genomic instability and cancer.

    Authors: Amit Kumar Mitra, Neetu Singh, Vivek Kumar Garg, Rashmi Chaturvedi, Mandira Sharma and Srikanta Kumar Rath
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:104
    Content type: Research Published on:

  42. Osteosarcoma is a highly malignant bone tumor and is the most commonly encountered malignant bone tumor in children and adolescents. Furthermore, significant numbers of patients eventually develop pulmonary me...

    Authors: Zeng Feng Xin, Yang Kyung Kim and Sung Taek Jung
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:105
    Content type: Research Published on:

  43. Genetic instability is known as a cause of oncogenesis. Though Rad18 is reported to function in a post replication mismatch repair system, the relation between the status of Rad18 and human tumorigenesis has n...

    Authors: Tadahiko Nakamura, Shinji Ishikawa, Yoshikatsu Koga, Youhei Nagai, Yu Imamura, Kouei Ikeda, Takeshi Mori, Hiroaki Nomori and Hideo Baba
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:106
    Content type: Review Published on:

  44. Liver cancr is a heterogeneous disease in terms of etiology, biologic and clinical behavior. Very little is known about how many genes concur at the molecular level of tumor development, progression and aggres...

    Authors: Yue-Fang Liu, Bin-Shan Zha, Hui-Lin Zhang, Xiao-Jing Zhu, Yu-Hua Li, Jin Zhu, Xiao-Hong Guan, Zhen-Qing Feng and Jian-Ping Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:107
    Content type: Research Published on:

  45. Barrett's mucosa is the precursor of esophageal adenocarcinoma. The molecular mechanisms behind Barrett's carcinogenesis are largely unknown. Experimental models of longstanding esophageal reflux of duodenal-g...

    Authors: Giuseppe Ingravallo, Luigi Dall'Olmo, Daniela Segat, Matteo Fassan, Claudia Mescoli, Emanuela Dazzo, Carlo Castoro, Lorenzo Polimeno, Christian Rizzetto, Maurizio David Baroni, Giovanni Zaninotto, Ermanno Ancona and Massimo Rugge
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:108
    Content type: Research Published on:

  46. Combination chemotherapy with oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) has become a standard regimen for colorectal cancer. An increase of adverse events with combination chemotherapy is predicted i...

    Authors: Shinichi Sugimoto, Kuniyuki Katano, Akiyoshi Kanazawa, Hiroshi Yoshimura, Akihiko Kidani, Hiroshi Takeda, Masato Makino, Nobuhiro Ozaki, Tsuneo Tanaka and Masahide Ikeguchi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:109
    Content type: Research Published on:

  47. Despite multidisciplinary treatment, lung cancer remains a highly lethal disease due to poor response to chemotherapy. The identification of therapeutic agents with synergistic effects with traditional drugs i...

    Authors: Hecheng Li, XiaoLi Zhu, Yawei Zhang, Jiaqing Xiang and Haiquan Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:110
    Content type: Research Published on:

  48. APMCF1 is a novel human gene first cloned from apoptotic MCF-7 cells. Our previous study found ectogenic APMCF1 could induce G1 arrest in hepatocarcinoma cell line HHCC. In order to search its broad expression...

    Authors: Yaqing Zhang, Qinlong Li, Feng Zhu, Jihong Cui, Kainan Li, Qing Li, Ruian Wang, Wenyong Wang, Weihua Wang and Wei Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:111
    Content type: Research Published on:

  49. Liver cancer is a common malignancy with a high mortality rate. Given the poor prognosis associated with this cancer, many patients seek additional therapies that may improve quality of life or survival. Sever...

    Authors: Ping Wu, Jean Jacques Dugoua, Oghenowede Eyawo and Edward J Mills
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:112
    Content type: Research Published on:

  50. The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperativ...

    Authors: Enrico P Spugnini, Gennaro Citro and Alfonso Baldi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:114
    Content type: Review Published on:

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Journal of Experimental & Clinical Cancer Research

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