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  1. The secreted protein acidic and rich in cysteine (SPARC) plays a pivotal role in regulating cell-matrix interactions and tumor angiogenesis, proliferation, and migration. Detection of SPARC gene methylation may b...

    Authors: Jun Gao, Jian Song, Haojie Huang, Zhaoshen Li, Yiqi Du, Jia Cao, Minghui Li, Shunli Lv, Han Lin and Yanfang Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:28
    Content type: Research Published on:

  2. Circulating bone marrow-derived endothelial progenitor cells (EPCs) have been reported to participate in tumor angiogenesis and growth; however, the role of circulating EPCs in tumor progression is controversi...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Weiqi Li, Zhen Cai, Shilong Xiong and Jie Bao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:27
    Content type: Research Published on:

  3. Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of var...

    Authors: Zhuanyi Yang, Ying Wang, Jiasheng Fang, Fenghua Chen, Jinfang Liu, Jun Wu and Yanjin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:26
    Content type: Research Published on:

  4. Giant cell tumor is an infrequent and unpredictable bony lesion. Although numerous attempts have been made to predict the behaviour of GCT, there are no definite biological or histological parameters to determ...

    Authors: Faisham W Ismail, Aminudin M Shamsudin, Zulmi Wan, Salzihan M Daud and Mutum S Samarendra
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:25
    Content type: Research Published on:

  5. Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commo...

    Authors: Fang-Zhen Shen, Bing-Yuan Zhang, Yu-Jie Feng, Zhuo-Xia Jia, Bing An, Chang-Chang Liu, Xi-Yun Deng, Anil D Kulkarni and Yun Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:24
    Content type: Review Published on:

  6. Anti-HER-2 antibodies targeting distinct epitopes have different biological functions on cancer cells. In a previous study, we demonstrated that anti-HER-2 engineering antibody ChA21 was able to bind to subdom...

    Authors: AnLi Zhang, Hua Xue, XiaoGuang Ling, Yi Gao, Feng Yang, LianSheng Cheng, Jing Liu and Qiang Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:23
    Content type: Research Published on:

  7. It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PP...

    Authors: Takayuki Yoshizaki, Wataru Motomura, Sachie Tanno, Shima Kumei, Yumiko Yoshizaki, Satoshi Tanno and Toshikatsu Okumura
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:22
    Content type: Research Published on:

  8. Taurolidine (TRD) represents an anti-infective substance with anti-neoplastic activity in many malignant cell lines. So far, the knowledge about the cell death inducing mechanisms and pathways activated by TRD...

    Authors: Ansgar M Chromik, Adrien Daigeler, Daniel Bulut, Annegret Flier, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Peter R Ritter, Ulrich Mittelkötter, Stephan A Hahn and Waldemar Uhl
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:21
    Content type: Research Published on:

  9. To retrospectively review the incidence, treatment efficacy, we followed up newly diagnosed chronic myelogenous leukemia (CML) patients residing in Shanghai during 2001-2006.

    Authors: Ai-Hua Wang, Yan-Yan Wang, Yu Yao, Zi-Zhen Xu, Li Zhou, Li Wang, Li Zhang, Yu Chen, Zhi-Xiang Shen, Jiong Hu and Jun-Min Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:20
    Content type: Research Published on:

  11. Hereditary hemochromatosis (HH) is an autosomal recessive disorder mainly associated with homozygosity for the C282Y and H63D mutations in the hemochromatosis (HFE) gene. The reports about the C282Y and H63D m...

    Authors: Fei Jin, Li-Shuai Qu and Xi-Zhong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:18
    Content type: Research Published on:

  12. To better search for potential markers for hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify potential metastasis biomarkers associated with HCC.

    Authors: Long Wu, Chun-Wei Peng, Jin-Xuan Hou, Yan-Hua Zhang, Chuang Chen, Liang-Dong Chen and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:17
    Content type: Research Published on:

  13. The chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis. This study investigated the expression of CXCR4, CCR7, CXCL12, CCL21, and EGFR to illustrate the role of these b...

    Authors: Yixin Liu, Ru Ji, Jingyong Li, Qiang Gu, Xiulan Zhao, Tao Sun, Jinjing Wang, Jiangbo Li, Qiuyue Du and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:16
    Content type: Research Published on:

  14. The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer.

    Authors: Bunzo Nakata, Ryosuke Amano, Shigetomi Nakao, Tatsuro Tamura, Osamu Shinto, Toshiki Hirakawa, Yoshihiro Okita, Nobuya Yamada and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:15
    Content type: Research Published on:

  16. Genome-wide RNA interference screening study revealed that loss of expression of insulin-like growth factor binding protein 7 (IGFBP7) is a critical step in development of a malignant melanoma (MM), and this s...

    Authors: Rong-Yi Chen, Hong-Xiang Chen, Jia-Xi Lin, Wei-Bing She, Ping Jiang, Li Xu and Ya-Ting Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:13
    Content type: Research Published on:

  17. Prospective, randomized, pilot clinical study was conducted to evaluate the beneficial effects of inositol hexaphosphate (IP6) + Inositol in breast cancer patients treated with adjuvant therapy.

    Authors: Ivan Bačić, Nikica Družijanić, Robert Karlo, Ivan Škifić and Stjepan Jagić
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:12
    Content type: Research Published on:

  18. The Sézary syndrome is an aggressive leukemic form of cutaneous T cell lymphoma and there is no cure of this disease. Until now there is no true animal model for Sézary syndrome, by which new drugs against the...

    Authors: Udo Doebbeling
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:11
    Content type: Research Published on:

  19. SIAH proteins are the human members of an highly conserved family of E3 ubiquitin ligases. Several data suggest that SIAH proteins may have a role in tumor suppression and apoptosis. Previously, we reported th...

    Authors: Heriberto Bruzzoni-Giovanelli, Plinio Fernandez, Lucía Veiga, Marie-Pierre Podgorniak, Darren J Powell, Marco M Candeias, Samia Mourah, Fabien Calvo and Mónica Marín
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:10
    Content type: Research Published on:

  20. Accelerated hypofractionation is an attractive approach for adjuvant whole breast radiotherapy. In this study we evaluated the adverse effects at least 3 years post an accelerated hypofractionated whole breast...

    Authors: Paola Pinnarò, Antonella Soriani, Valeria Landoni, Carolina Giordano, Maria Papale, Annelisa Marsella, Laura Marucci, Giorgio Arcangeli and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:9
    Content type: Research Published on:

  21. Survivin is known playing a role in drug resistance. However, its role in bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are conflicting reports for the effect of bortezo...

    Authors: Xiang Ling, Diane Calinski, Asher A Chanan-Khan, Muxiang Zhou and Fengzhi Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:8
    Content type: Research Published on:

  22. The knowledge of Epidermal growth factor receptor (EGFR) expression in metastases of NSCLC was limited. In receptor-mediated targeted nuclide radiotherapy, tumor cells are killed with delivered radiation and t...

    Authors: Chuangzhou Rao, Qiongge Hu, Jianhua Ma, Jian Li, Chen Zhang, Li Shen and Qichun Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:7
    Content type: Research Published on:

  23. The Tientsin Albino 2 (TA2) mouse is an inbred strain originating from the Kunming strain. It has a high incidence of spontaneous breast cancer without the need for external inducers or carcinogens. Until now,...

    Authors: Yanjun Gu, Shiwu Zhang, Qiang Wu, Shaoyan Xu, Yanfen Cui, Zhengduo Yang, Xiulan Zhao and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:6
    Content type: Research Published on:

  24. Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several ...

    Authors: Corinne Bézu, Charles Coutant, Marcos Ballester, Jean-Guillaume Feron, Roman Rouzier, Serge Uzan and Emile Daraï
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:5
    Content type: Review Published on:

  25. Endometriosis is a common disease characterized by the presence of a functional endometrium outside the uterine cavity, causing pelvic pain, dysmenorrheal, and infertility. This disease has been associated to ...

    Authors: Daniel E Machado, Plínio T Berardo, Celia Y Palmero and Luiz E Nasciutti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:4
    Content type: Research Published on:

  26. bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth. Correspondingly, gliomas have been shown to have reduced, or ...

    Authors: Biao Zhang, Xuequan Feng, Jinhuan Wang, Xinnu Xu, Hongsheng Liu and Na Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:3
    Content type: Research Published on:

  27. Renal cell carcinoma (RCC) is a cancer of increasing incidence and mortality. Currently, there are no immunohistochemical prognostic markers for RCCs in routine use. The aim of this study was to examine for th...

    Authors: Hanna Ronkainen, Saila Kauppila, Pasi Hirvikoski and Markku H Vaarala
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:2
    Content type: Research Published on:

  28. The aim of this study is to examine the safety and distribution of Ad-EGFP-MDR1, an adenovirus encoding human multidurg resistance gene (human MDR1), in the mice colon carcinoma model.

    Authors: ZhenZhen Zhao, Wei Liu, YuXi Su, Jin Zhu, GaiHuan Zheng, Qing Luo and XianQing Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:1
    Content type: Research Published on:

  29. Epigenetic silencing of tumor suppressor genes associated with promoter methylation is considered to be a hallmark of oncogenesis. RASSF1A is a candidate tumor suppressor gene which was found to be inactivated...

    Authors: Tao Wang, Hongli Liu, Yeshan Chen, Wei Liu, Jing Yu and Gang Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:160
    Content type: Research Published on:

  30. The results from the published studies on the association between hypoxia-inducible factor -1α (HIF-1α) polymorphisms and cancer risk are conflicting. In this meta-analysis, we aimed to investigate the associatio...

    Authors: Tongfeng Zhao, Jing Lv, Jiangpei Zhao and Marius Nzekebaloudou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:159
    Content type: Research Published on:

  31. Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cad...

    Authors: Ken Sasaki, Shoji Natsugoe, Sumiya Ishigami, Masataka Matsumoto, Hiroshi Okumura, Tetsuro Setoyama, Yasuto Uchikado, Yoshiaki Kita, Kiyokazu Tamotsu, Akihiko Sakamoto, Tetsuhiro Owaki and Takashi Aikou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:158
    Content type: Research Published on:

  32. Despite the fact that genetic counseling in oncology provides information regarding objective risks, it can be found a contrast between the subjective and objective risk.

    Authors: Anita Caruso, Cristina Vigna, Bruna Marozzo, Fabio M Sega, Isabella Sperduti, Francesco Cognetti and Antonella Savarese
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:157
    Content type: Research Published on:

  33. CENP-E, one of spindle checkpoint proteins, plays a crucial role in the function of spindle checkpoint. Once CENP-E expression was interrupted, the chromosomes can not separate procedurally, and may result in ...

    Authors: Zijie Liu, Kang Ling, Xia Wu, Ju Cao, Bin Liu, Suyan Li, Qiong Si, Yan Cai, Chen Yan, Yan Zhang and Yaguang Weng
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:156
    Content type: Research Published on:

  34. Bladder cancer is the ninth most common malignancy in the world. Successful clinical management remains a challenge. In order To search for novel targeted and efficacious treatment, we sought to investigate an...

    Authors: Wei Tang, Yunfeng He, Shengcai Zhou, Yongping Ma and Geli Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:155
    Content type: Research Published on:

  35. Lewis y antigen is difucosylated oligosaccharide and is carried by glycoconjugates at cell surface. Elevated expression of Lewis y has been found in 75% of ovarian tumor, and the high expression level is corre...

    Authors: Juanjuan Liu, Bei Lin, Yingying Hao, Yue Qi, Liancheng Zhu, Feifei Li, Dawo Liu, Jianping Cong, Shulan Zhang and Masao Iwamori
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:154
    Content type: Research Published on:

  36. Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are sus...

    Authors: Zhihua Yin, Meng Su, Xuelian Li, Mingchuan Li, Rui Ma, Qincheng He and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:153
    Content type: Research Published on:

  37. mTOR signaling pathway and its downstream serine/threonine kinase p70S6k were frequently activated in human cancers. The dysregulation of the mTOR pathway has been found to be a contributing factor of a variet...

    Authors: Li Xiao, Yi C Wang, Wu S Li and Yan Du
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:152
    Content type: Research Published on:

  38. Many experimental data evidence that over-expression of various growth factors cause disorders in cell proliferation. The role of the Fibroblast Growth Factors (FGF) in growth control is indisputable: in parti...

    Authors: Gianfranco Risuleo, Marina Ciacciarelli, Mauro Castelli and Gaspare Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:151
    Content type: Research Published on:

  39. Gene targeted therapy refers to any therapy focused on one of the many biological features of the tumor. Such features are mediated by specific genes that are involved in tumor metastasis, recurrence, poor res...

    Authors: Jun Wan, Jinben Ma, Ju Mei and Genfa Shan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:150
    Content type: Research Published on:

  40. More studies based on gene expression data have been reported in great detail, however, one major challenge for the methodologists is the choice of classification methods. The main purpose of this research was...

    Authors: Desheng Huang, Yu Quan, Miao He and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:149
    Content type: Research Published on:

  41. Carotid body tumours (CBTs) are very rare lesions which should be treated as soon as possible even when benign since small tumour size permits easier removal and lower incidence of perioperative complications ...

    Authors: Ombretta Martinelli, Luigi Irace, Rita Massa, Sara Savelli, Fabrizia Giannoni, Roberto Gattuso, Bruno Gossetti, Fabrizio Benedetti-Valentini and Luciano Izzo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:148
    Content type: Research Published on:

  42. Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are i...

    Authors: Sepideh Afshar, Tove Olafsen, Anna M Wu and Sherie L Morrison
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:147
    Content type: Research Published on:

  43. Carbohydrates embedded in the plasma membrane are one of the main actors involved in the communication of cells with the microenvironment. Neuraminic sialic acids are glycocalyx sugars that play important role...

    Authors: Mariano R Gabri, Laura L Otero, Daniel E Gomez and Daniel F Alonso
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:146
    Content type: Research Published on:

  44. To establish a relationship between esophageal squamous cell diseases and the expression of human telomerase reverse transcriptase (hTERT) and Eyes absent 4 (EYA4) mRNA in peripheral blood mononuclear cells.

    Authors: Hao Li, Tao Yu Diao, Zhi Ying Zhou, Fang Yan Yang, Qing Ma and Qing Hui Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:145
    Content type: Review Published on:

  45. To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and th...

    Authors: Wen-Qing Hu, Chun-Wei Peng and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:144
    Content type: Research Published on:

  46. Despite aggressive therapy, advanced stage neuroblastoma patients have poor survival rates. Although angiogenesis correlates with advanced tumour stage and plays an important role in determining the tumour res...

    Authors: Gordana Jakovljević, Srđana Čulić, Jasminka Stepan, Aleksandra Bonevski and Sven Seiwerth
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:143
    Content type: Research Published on:

  47. Studies of treatment with octreotide of patients with hepatocellular carcinoma (HCC) gave conflicting results. We analyzed retrospectively the survival of our patients treated with octreotide monotherapy and c...

    Authors: Maximilian Schöniger-Hekele, Joachim Kettenbach, Markus Peck-Radosavljevic and Christian Müller
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:142
    Content type: Research Published on:

  48. The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated.

    Authors: Zhaohui Wei, Naiyao Chen, Hongxing Guo, Xueming Wang, Fangyun Xu, Qian Ren, ShiHong Lu, Bin Liu, Lei Zhang and Hui Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:141
    Content type: Research Published on:

  50. Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and...

    Authors: Qing-lei Wang, Bing-hui Li, Bin Liu, Ya-bin Liu, Yue-Ping Liu, Sui-Bing Miao, Yi Han, Jin-Kun Wen and Mei Han
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:139
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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