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  1. Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknow...

    Authors: Takashi Ariizumi, Akira Ogose, Hiroyuki Kawashima, Tetsuo Hotta, Hajime Umezu and Naoto Endo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:44
    Content type: Research Published on:

  2. Tumor cells need large energy and nucleic acids to proliferate and grow. For most of their energy needs, cancer cells depend more on glycolysis. For most of their nucleic acids needs, cancer cells depend more ...

    Authors: Hui Chen, Jian-Xin Yue, Shou-Hua Yang, Hui Ding, Rong-Wei Zhao and Song Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:43
    Content type: Research Published on:

  3. Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. ...

    Authors: Ramachandran Meenakshisundaram and Claudia Gragnoli
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:42
    Content type: Research Published on:

  4. The study aimed to calculate chest-wall skin dose associated with different frequencies of bolus applications in post-mastectomy three-dimensional conformal radiotherapy (3D-CRT) and to provide detailed inform...

    Authors: Fundagul Andic, Yasemin Ors, Rima Davutoglu, Sule Baz Cifci, Emine Burcin Ispir and Mehmet Ertugrul Erturk
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:41
    Content type: Research Published on:

  5. The role of angiogenesis in the pathogenesis of renal cell carcinoma is well recognized, however, the influence of tumor cells in this activity has not yet been fully clarified. The aim of this study was to an...

    Authors: Gordana orević, Koviljka Matušan-Ilijaš, Emina Babarović, Ita Hadžisejdić, Maja Grahovac, Blaženka Grahovac and Nives Jonjić
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:40
    Content type: Research Published on:

  6. Studies on activated cell-signaling pathways responsible for neoplastic transformation are numerous in solid tumors and in adult leukemias. Despite of positive results in the evolution of pediatric hematopoiet...

    Authors: Velia D'Angelo, Stefania Crisci, Fiorina Casale, Raffaele Addeo, Maria Giuliano, Elvira Pota, Paola Finsinger, Alfonso Baldi, Roberto Rondelli, Alberto Abbruzzese, Michele Caraglia and Paolo Indolfi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:39
    Content type: Research Published on:

  7. The paper reports a quantitative analysis of the perfusion maps of 22 patients, affected by gliomas or by metastasis, with the aim of characterizing the malignant tissue with respect to the normal tissue. The ...

    Authors: Anna Maria Di Nallo, Antonello Vidiri, Simona Marzi, Alessandra Mirri, Alessandra Fabi, Carmine Maria Carapella, Andrea Pace and Marcello Crecco
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:38
    Content type: Research Published on:

  8. The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single ...

    Authors: Michal Kowalski, Karolina Przybylowska, Pawel Rusin, Jurek Olszewski, Alina Morawiec-Sztandera, Anna Bielecka-Kowalska, Wioletta Pietruszewska, Wojciech Mlynarski, Szemraj Janusz and Ireneusz Majsterek
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:37
    Content type: Research Published on:

  9. Secretory pituitary adenomas are very common brain tumors. Historically, the treatment armamentarium for secretory pituitary adenomas included neurosurgery, medical management, and fractionated radiotherapy. I...

    Authors: Heng Wan, Ohye Chihiro and Shubin Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:36
    Content type: Research Published on:

  10. Serum levels of IGF-I in patients affected with multiple myeloma (MM) have been scarcely studied. The present study is aimed to explore this point comparing 55 healthy subjects, 71 monoclonal gammopaties of un...

    Authors: Claudia Greco, Gaetano Vitelli, Giuseppe Vercillo, Rosa Vona, Diana Giannarelli, Isabella Sperduti, Francesco Pisani, Ettore Capoluongo, Maria Concetta Petti and Franco Ameglio
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:35
    Content type: Research Published on:

  11. This phase II study was designed to evaluate the activity and safety of a combination of epirubicin, oxaliplatin and docetaxel in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma.

    Authors: Luigi Di Lauro, Laura Giacinti, Maria Grazia Arena, Domenico Sergi, Silvia Ileana Fattoruso, Diana Giannarelli and Massimo Lopez
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:34
    Content type: Research Published on:

  13. It has been suggested that polymorphisms in glutathione-S-transferases (GST) could predispose to prostate cancer through a heritable deficiency in detoxification pathways for environmental carcinogens. Yet, studi...

    Authors: Monika Sivoňová, Iveta Waczulíková, Dušan Dobrota, Tatiana Matáková, Jozef Hatok, Peter Račay and Ján Kliment
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:32
    Content type: Case study Published on:

  14. The sustained growth of tumors necessitates neovascularization. As one of the potent endogenous vascular inhibitors, endostatin has been widely used in antiangiogenesis therapy for tumor. Cisplatin is normally...

    Authors: Rui Z Bai, Yang Wu, Quan Liu, Ke Xie, Yu Q Wei, Yong S Wang, Kang Liu, Yan Luo, Jing M Su, Bing Hu, Ji Y Liu, Qiu Li, Ting Niu, Zhi W Zhao and Li Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:31
    Content type: Research Published on:

  15. In experimental systems, interference with coagulation can affect tumor biology. We suggested that abnormal coagulation could be a negative predictor for response to immunotherapy and survival among patients w...

    Authors: Ilya V Tsimafeyeu, Lev V Demidov, Albina V Madzhuga, Oksana V Somonova and Anna L Yelizarova
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:30
    Content type: Research Published on:

  16. Survivin is a structurally and functionally unique member of the inhibitor of apoptosis protein (IAP) family. It plays an important role, not only in regulating mitosis but also in inhibiting apoptosis. The cu...

    Authors: Yu-Qing Chen, Cheng-Ling Zhao and Wei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:29
    Content type: Research Published on:

  17. The Akt/PKB family of kinases is frequently activated in human cancers, including oral squamous cell carcinoma (OSCC). Akt-induced epithelial-to-mesenchymal transition (EMT) involves downregulation of E-cadher...

    Authors: Kyoung-Ok Hong, Ji-Hong Kim, Ji-Soo Hong, Hye-Jung Yoon, Jae-Il Lee, Sam-Pyo Hong and Seong-Doo Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:28
    Content type: Research Published on:

  18. The aim of this study is to comparatively elucidate the underlying molecular pathways and clinicopathological criteria in schistosomal bladder tumor (SBT) versus non-schistosomal bladder tumor (NSBT).

    Authors: Ahmed S Abdulamir, Rand R Hafidh, Haider S Kadhim and Fatimah Abubakar
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:27
    Content type: Research Published on:

  19. The cytogenetic characteristics of osteosarcoma (OS) remain controversial. The establishment of a new human OS cell line may improve the characterization. We report the establishment of a new human osteosarcom...

    Authors: Taketoshi Yasuda, Masahiko Kanamori, Shigeharu Nogami, Takeshi Hori, Takeshi Oya, Kayo Suzuki and Tomoatsu Kimura
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:26
    Content type: Research Published on:

  20. Knowledge of differences in the cellular physiology of malignant and non-malignant cells is a prerequisite for the development of cancer treatments that effectively kill cancer without damaging normal cells. C...

    Authors: Albrecht Bergner, Julia Kellner, Amanda Tufman and Rudolf M Huber
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:25
    Content type: Research Published on:

  21. c-FLIP can be considered as a tumor-progression factor in regard to its anti-apoptotic functions. In the present study, we intended to investigate the expression of c-FLIP in human HCC tissues, and its relatio...

    Authors: Xilin Du, Guoqiang Bao, Xianli He, Huadong Zhao, Fang Yu, Qing Qiao, Jianguo Lu and Qingjiu Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:24
    Content type: Research Published on:

  22. Recent data have redefined the concept of inflammation as a critical component of tumor progression. However, there has been little development on cases where inflammation on or near a wound and a tumor exist ...

    Authors: Yue-mei Ma, Tao Sun, Yi-xin Liu, Nan Zhao, Qiang Gu, Dan-fang Zhang, Shuo Qie, Chun-sheng Ni, Yi Liu and Bao-cun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:23
    Content type: Research Published on:

  23. p53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High survivin expression in non-small cell lung cancer is related with poor prognosis. To investigate...

    Authors: Shin-ichi Yamashita, Masao Chujo, Michiyo Miyawaki, Keita Tokuishi, Kentaro Anami, Satoshi Yamamoto and Katsunobu Kawahara
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:22
    Content type: Research Published on:

  24. Our aim was to detect lymphatic endothelial marker podoplanin, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and vascular endothelial growth factor receptor-3 (VEGFR)-3 and study the prognostic r...

    Authors: Jian-guo Sun, Yan Wang, Zheng-tang Chen, Wen-lei Zhuo, Bo Zhu, Rong-xia Liao and Shao-xiang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:21
    Content type: Research Published on:

  25. Hepatocellular carcinoma (HCC) is the most common tumor in the adult liver, with high relapse and mortality rates despite diverse treatment modalities. In this study, nicotinamide N-methyltransferase (NNMT), a...

    Authors: Jongmin Kim, Seok Joo Hong, Eun Kyung Lim, Yun-Suk Yu, Seung Whan Kim, Ji Hyeon Roh, In-Gu Do, Jae-Won Joh and Dae Shick Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:20
    Content type: Research Published on:

  26. Astrocyte elevated gene-1 (AEG-1) was originally characterized as a HIV-1-inducible gene in primary human fetal astrocyte. Recent studies highlight a potential role of AEG-1 in promoting tumor progression and met...

    Authors: Haiyan Liu, Xianrang Song, Chunxi Liu, Li Xie, Ling Wei and Ruopeng Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:19
    Content type: Research Published on:

  27. Peritoneal carcinomatosis (PC) from epithelial tumors is a fatal diagnosis without efficient treatment. Trifunctional antibodies (trAb) are novel therapeutic approaches leading to a concerted anti-tumor activi...

    Authors: Michael A Ströhlein, Robert Siegel, Michael Jäger, Horst Lindhofer, Karl-Walter Jauch and Markus M Heiss
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:18
    Content type: Research Published on:

  28. The survival of patients with locally advanced head and neck cancer is still poor, with 5-year survival rates of 24–35%. The identification of prognostic and predictive markers at the molecular and cellular le...

    Authors: Eva Henriksson, Elisabeth Kjellén, Bo Baldetorp, Pär-Ola Bendahl, Åke Borg, Eva Brun, Fredrik Mertens, Tomas Ohlsson, Karin Rennstam, Johan Wennerberg and Peter Wahlberg
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:17
    Content type: Research Published on:

  29. It is well established that cancer cells can fuse with endothelial cells to form hybrid cells spontaneously, which facilitates cancer cells traversing the endothelial barrier to form metastases. However, up to...

    Authors: Ze Jun Lu, Ya Qiong Ren, Guo Ping Wang, Qi Song, Mei Li, Sa Sa Jiang, Tao Ning, Yong Song Guan, Jin Liang Yang and Feng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:16
    Content type: Research Published on:

  31. Epstein-Barr virus (EBV) has been shown to be associated with gastric cancer. However, inconsistent findings have been reported regarding the distribution of EBV infected cells (in normal gastric epithelium vs...

    Authors: Camtu D Truong, Wei Feng, Wei Li, T Khoury, Q Li, S Alrawi, Yingyan Yu, Keping Xie, James Yao and Dongfeng Tan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:14
    Content type: Case study Published on:

  32. Key role of angiogenesis in tumor growth and metastasis based on accumulating evidence and recent progress of immunotherapy have led us to investigate vaccine therapy targeting tumor angiogenesis.

    Authors: Kenta Yoshiura, Toshihide Nishishita, Takashi Nakaoka, Naohide Yamashita and Naomi Yamashita
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:13
    Content type: Research Published on:

  35. Genetic polymorphisms of DNA repair enzymes in the base excision repair (BER) pathway, may lead to genetic instability and lung cancer carcinogenesis. We investigated the interactions among the gene polymorphi...

    Authors: Aiko Miyaishi, Kayo Osawa, Yasunori Osawa, Natsuko Inoue, Kana Yoshida, Mayumi Kasahara, Akimitsu Tsutou, Yoshiki Tabuchi, Kazuo Sakamoto, Noriaki Tsubota and Juro Takahashi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:10
    Content type: Research Published on:

  36. KiSS-1 was identified as a metastasis-suppressing gene in melanoma cells. The KiSS-1 gene product (metastin) was isolated from human placenta as the ligand of GPR54, a G-protein-coupled receptor. The role of meta...

    Authors: Kazuyuki Nagai, Ryuichiro Doi, Fumihiko Katagiri, Tatsuo Ito, Atsushi Kida, Masayuki Koizumi, Toshihiko Masui, Yoshiya Kawaguchi, Kenji Tomita, Shinya Oishi, Nobutaka Fujii and Shinji Uemoto
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:9
    Content type: Research Published on:

  37. Lamin A/C is very important in DNA replication, RNA dependent transcription and nuclear stabilization. Reduced or absent lamin A/C expression has been found to be a common feature of a variety of different can...

    Authors: Zhengrong Wu, Lirong Wu, Desheng Weng, Dazhi Xu, Jian Geng and Fei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:8
    Content type: Research Published on:

  38. Chondrosarcomas and chordomas are usually chemoresistant bone tumors and may have a poor prognosis when advanced. They are usually associated with worsening pain difficult to control.

    Authors: Liliana Montella, Raffaele Addeo, Vincenzo Faiola, Gregorio Cennamo, Rosario Guarrasi, Elena Capasso, Rosanna Mamone, Michele Caraglia and Salvatore Del Prete
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:7
    Content type: Case report Published on:

  39. A number of studies have previously shown that the over expression of different ribosomal proteins might play an important role in cancer (i.e. S3a, L10, L16). We have previously reported that RPS2, a 33 Kda r...

    Authors: Min Wang, Youji Hu and Mark E Stearns
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:6
    Content type: Research Published on:

  40. Eukaryotic initiation factor 4E (eIF4E) is elevated in many cancers and is a prognostic indicator in breast cancer. Many pro-tumorigenic proteins are selectively translated via eIF4E, including c-Myc, cyclin D...

    Authors: Heather E Kleiner, Prasad Krishnan, Jesse Tubbs, Mark Smith, Carol Meschonat, Runhua Shi, Mary Lowery-Nordberg, Patrick Adegboyega, Marcia Unger, James Cardelli, Quyen Chu, J Michael Mathis, John Clifford, Arrigo De Benedetti and Benjamin DL Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:5
    Content type: Research Published on:

  41. Melanin synthesis, the elective trait of melanocytes, is regulated by tyrosinase activity. In tyrosinase-positive amelanotic melanomas this rate limiting enzyme is inactive because of acidic endo-melanosomal p...

    Authors: Fabio Di Domenico, Cesira Foppoli, Carla Blarzino, Marzia Perluigi, Francesca Paolini, Salvatrice Morici, Raffaella Coccia, Chiara Cini and Federico De Marco
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:4
    Content type: Research Published on:

  42. Sirolimus is recently reported to have antitumour effects on a large variety of cancers. The present study was performed to investigate sirolimus's ability to inhibit growth in T24 bladder cancer cells.

    Authors: Rosario Pinto-Leite, Pedro Botelho, Eufemia Ribeiro, Paula A Oliveira and Lucios Santos
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:3
    Content type: Research Published on:

  43. This study aimed to analyze three-dimensional (3D) dosimetric data of conventional two-dimensional (2D) palliative spinal bone irradiation using different reference points and treatment plans with respect to t...

    Authors: Fundagul Andic, Sule Baz Cifci, Yasemin Ors, Umar Niang, Ahmet Dirier and Mustafa Adli
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:2
    Content type: Research Published on:

  44. To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to tre...

    Authors: Gustavo Arruda Viani, Gustavo Borges Manta, Ellen Carrara Fonseca, Ligia Issa De fendi, Sergio Luis Afonso and Eduardo Jose Stefano
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:1
    Content type: Research Published on:

  45. Microsatellite instability (MSI) at tri- or tetranucleotide repeat markers (elevated microsatellite alterations at selected tetranucleotide repeat, EMAST) has been recently described. But, the underlying genet...

    Authors: Yoo Duk Choi, Jin Choi, Jo Heon Kim, Ji Shin Lee, Jae Hyuk Lee, Chan Choi, Ho Sun Choi, Min Cheol Lee, Chang Soo Park, Sang Woo Juhng and Jong Hee Nam
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:88
    Content type: Research Published on:

  46. To investigate, in vitro, the regulatory effects of tumor-suppressing gene PTEN on mTOR (mammalian target of rapamycin) signaling pathway, the effects of transfected PTEN and rapamycin on the growth inhibition, a...

    Authors: Zhi Y Cheng, Xiao L Guo, Xiao Y Yang, Zhi Y Niu, Shi H Li, Su Y Wang, Hao Chen and Ling Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:87
    Content type: Research Published on:

  47. The antiangiogenic agent cilengitide disrupts integrin binding to the extracellular matrix leading to apoptosis of activated endothelial cells. Integrins are also widely expressed in malignant glioma and integ...

    Authors: Leticia Oliveira-Ferrer, Jessica Hauschild, Walter Fiedler, Carsten Bokemeyer, Johannes Nippgen, Ilhan Celik and Gunter Schuch
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:86
    Content type: Research Published on:

  48. Gliomas represent the most frequent neoplasm of the central nervous system. Unfortunately, surgical cure of it is practically impossible and their clinical course is primarily determined by the biological beha...

    Authors: Mingyu Zhang, Tao Song, Liang Yang, Ruokun Chen, Lei Wu, Zhuanyi Yang and Jiasheng Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:85
    Content type: Research Published on:

  49. HPV vaccine is an exciting promise of the preventive medicine. Although HPV-immunization programs still reveal a number of unanswered questions, they represent a novel opportunity for primary prevention agains...

    Authors: Luciano Mariani and Sonia Pagliusi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:84
    Content type: Editorial Published on:

  50. Lipocalin 2, an iron binding protein, is abnormally expressed in some malignant human cancers and may play an important role in tumor metastasis. However, the roles of lipocalin 2 in breast cancer formation an...

    Authors: Han Shi, Yuchao Gu, Jing Yang, Liang Xu, Wenyi Mi and Wengong Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:83
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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