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  1. The helix-loop-helix transcription factor Id-1 (an inhibitor of differentiation and DNA binding) plays a role in development and progression of many tumours. Id-1 is known to exert its effects on the epidermal...

    Authors: Ibrahim Meteoglu, Nezih Meydan and Muhan Erkus
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:69
    Content type: Research Published on:

  2. Cisplatin, a platinum based anticancer drug has played a vital role in the treatment of cancers by chemical agents, but in view of the serious toxicity including nephrotoxicity of cisplatin, various other plat...

    Authors: Shipra Pal, Arpita Sengupta Sadhu, Swarup Patra and Kalyan K Mukherjea
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:68
    Content type: Research Published on:

  3. The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma.

    Authors: Marcello Pace, Riccardo Gattai, Maria Matteini, Erminia Macera Mascitelli and Paolo Bechi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:67
    Content type: Research Published on:

  4. The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model.

    Authors: Won Park, Young Taek Oh, Jae Ho Han and Hongryull Pyo
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:66
    Content type: Research Published on:

  5. Metatypical cell carcinoma can be considered as a new entity of skin cancer, being an intermediate typology between basal cell carcinomas and squamous cell carcinomas. The behaviour of the metatypical cell car...

    Authors: Mauro Tarallo, Emanuele Cigna, Riccardo Frati, Sergio Delfino, Daniele Innocenzi, Umberto Fama, Annamaria Corbianco and Nicolò Scuderi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:65
    Content type: Review Published on:

  6. Thymidine phosphorylase (TP) is identical with platelet-derived endothelial cell growth factor (PD-ECGF) which promotes angiogenesis. The aim of this study was to evaluate the cytosol activity of TP in tumor s...

    Authors: Elżbieta Miszczak-Zaborska, Robert Kubiak, Andrzej Bieńkiewicz and Jacek Bartkowiak
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:64
    Content type: Research Published on:

  7. Interferon-γ-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects.

    Authors: Kai Mei, Lian Wang, Ling Tian, Jingrui Yu, Zhixuan Zhang and Yuquan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:63
    Content type: Research Published on:

  9. Endostatin and anastellin, fragments of collagen type XVIII and fibronectin, respectively, belong to a family of endogenous inhibitors of angiogenesis which inhibit tumor growth and metastasis in a number of m...

    Authors: David M Neskey, Anthony Ambesi, Kevin M Pumiglia and Paula J McKeown-Longo
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:61
    Content type: Research Published on:

  12. Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic ...

    Authors: Enrico P Spugnini, Ivan Dotsinsky, Nikolay Mudrov, Gennaro Citro, Alfredo D'Avino and Alfonso Baldi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:58
    Content type: Research Published on:

  13. We explore the use of a clinical orthovoltage X-ray treatment unit as a small-animal radiation therapy system in a tumoral model of cervical cancer.

    Authors: Luis-Alberto Medina, Blanca-Ivone Herrera-Penilla, Mario-Alberto Castro-Morales, Patricia García-López, Rafael Jurado, Enrique Pérez-Cárdenas, José Chanona-Vilchis and María-Ester Brandan
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:57
    Content type: Research Published on:

  14. Treatment failure after radiotherapy of head and neck squamous cell carcinoma (HNSCC) could be a significant problem. Our objective is to sensitize SCCVII cells to ionizing radiation in vitro and in vivo through ...

    Authors: Jian Zou, Xiaoming Qiao, Huiping Ye, Yuqiong Yang, Xuelian Zheng, Houyu Zhao and Shixi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:56
    Content type: Research Published on:

  15. The RON receptor tyrosine kinase regulates epithelial cell homeostasis and tumorigenesis by transducing multiple signals through its functional domains. The present study was to determine the significance of t...

    Authors: Yi Lu, Hang-Ping Yao and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:55
    Content type: Research Published on:

  16. The activity of dihydropyrimidine dehydrogenase (DPD), the key enzyme of pyrimidine catabolism, is thought to be an important determinant for the occurrence of severe toxic reactions to 5-fluorouracil (5-FU), ...

    Authors: Ursula Amstutz, Simone Farese, Stefan Aebi and Carlo R Largiadèr
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:54
    Content type: Research Published on:

  17. Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa ...

    Authors: Ibrahim Meteoglu, Ibrahim H Erdogdu, Nezih Meydan, Muhan Erkus and Sabri Barutca
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:53
    Content type: Research Published on:

  18. PET (Positron Emission Tomography) is a nuclear medicine imaging method, frequently used in oncology during the last years. It is a non-invasive technique that provides quantitative in vivo assessment of physi...

    Authors: Evelina Miele, Gian Paolo Spinelli, Federica Tomao, Angelo Zullo, Filippo De Marinis, Giulia Pasciuti, Luigi Rossi, Federica Zoratto and Silverio Tomao
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:52
    Content type: Review Published on:

  19. p27Kip1 plays a major role as a negative regulator of the cell cycle. The regulation of p27Kip1 degradation is mediated by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependen...

    Authors: Zheng Liu, Qiang Fu, Jiaju Lv, Facheng Wang and Kejia Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:51
    Content type: Research Published on:

  20. CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells a...

    Authors: Ai-Rong Qian, Wei Zhang, Jian-Ping Cao, Peng-Fei Yang, Xiang Gao, Zhe Wang, Hui-Yun Xu, Yuan-Yuan Weng and Peng Shang
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:50
    Content type: Research Published on:

  21. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interactions between polymorphisms of repair genes and tobacco...

    Authors: Mayumi Kasahara, Kayo Osawa, Kana Yoshida, Aiko Miyaishi, Yasunori Osawa, Natsuko Inoue, Akimitsu Tsutou, Yoshiki Tabuchi, Kenichi Tanaka, Masahiro Yamamoto, Etsuji Shimada and Juro Takahashi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:49
    Content type: Research Published on:

  22. Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to...

    Authors: Gustavo Martinez-Ruiz, Vilma Maldonado, Gisela Ceballos-Cancino, Juan P Reyes Grajeda and Jorge Melendez-Zajgla
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:48
    Content type: Review Published on:

  24. Metastasis in breast cancer is a vital concern in treatment because most women with primary breast cancer have micrometastases to distant sites at diagnosis. As a member of the inhibitor of apoptosis protein (...

    Authors: Xing-Chen Peng, Li Yang, Li-Ping Yang, Yong-Qiu Mao, Han-Shuo Yang, Ji-Yan Liu, Dong-Mei Zhang, li-Juan Chen and Yu-Quan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:46
    Content type: Research Published on:

  25. Lung cancer is the commonest cause of cancer death in developed countries. Adenocarcinoma is becoming the most common form of lung cancer. Cigarette smoking is the main risk factor for lung cancer. Long-term c...

    Authors: David Stav, Ilan Bar and Judith Sandbank
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:45
    Content type: Research Published on:

  26. Reactive oxygen species (ROS) are intricately involved in tumor progression through effects on proliferation, apoptosis and metastasis. But how ROS works is not well understood. In previous study, we found PUM...

    Authors: Xinying Wang, Jing Wang, Shiyong Lin, Yan Geng, Jide Wang and Bo Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:44
    Content type: Research Published on:

  27. Valid interview data is critical to the final results of the study. The purpose of this study was to investigate the reliability of epidemiological data obtained in non-smoking female lung cancer case-control ...

    Authors: Desheng Huang, Peng Guan, Hailong Shi, Qincheng He and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:43
    Content type: Research Published on:

  28. To investigate the feasibility of gene therapy in treating Epstein-Barr virus (EBV)-associated cancer by employing the suicide gene, herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV), which uses t...

    Authors: Yang Lifang, Tang Min, Ai Midan and Cao Ya
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:42
    Content type: Research Published on:

  29. To compare computed tomography (CT) with co-registered positron emission tomography-computed tomography (PET-CT) as the basis for delineating gross tumor volume (GTV) in unresectable, locally advanced pancreat...

    Authors: Erkan Topkan, Ali A Yavuz, Mehmet Aydin, Cem Onal, Fuat Yapar and Melek N Yavuz
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:41
    Content type: Research Published on:

  30. β-(1,3)/(1,6) D-glucan, a component of the fungal cell wall, has been shown to stimulate the immune system, enhance hematopoiesis, amplify killing of opsonized tumor cells and increase neutrophil chemotaxis an...

    Authors: Alan B Weitberg
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:40
    Content type: Research Published on:

  31. Patients with hereditary non-poliposys colorectal cancer (HNPCC) have better prognosis than sporadic colorectal cancer (CRC). Aim of our retrospective study was to compare the overall survival between sporadic...

    Authors: Vittoria Stigliano, Daniela Assisi, Maurizio Cosimelli, Raffaele Palmirotta, Diana Giannarelli, Marcella Mottolese, Lupe Sanchez Mete, Raffaello Mancini and Vincenzo Casale
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:39
    Content type: Case study Published on:

  32. Lung cancer remains a major health challenge in the world. Survival for patients with stage I disease ranges between 40–70%. This suggests that a significant proportion of patients with stage I NSCLC may actua...

    Authors: Mara Campioni, Vincenzo Ambrogi, Eugenio Pompeo, Gennaro Citro, Mauro Castelli, Enrico P Spugnini, Antonio Gatti, Pierluigi Cardelli, Laura Lorenzon, Alfonso Baldi and Tommaso C Mineo
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:38
    Content type: Research Published on:

  33. The management of hormone-refractory prostate cancer (HRPC) still remains as an important challenge of daily oncology practice. Docetaxel has proved to be a first line treatment choice. All-trans retinoic acid...

    Authors: Yuksel Kucukzeybek, Mustafa K Gul, Ercument Cengiz, Cigdem Erten, Burcak Karaca, Gurbuz Gorumlu, Harika Atmaca, Selim Uzunoglu, Bulent Karabulut, Ulus A Sanli and Ruchan Uslu
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:37
    Content type: Research Published on:

  35. Infected cells recognize viral replication as a DNA damage stress and elicit the host surveillance mechanism to anti-virus infection. Modulation of the activity of tumor suppressor p53 is a key event in the re...

    Authors: Lina Sun, Ge Zhang, Zongfang Li, Tusheng Song, Chen Huang and Lusheng Si
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:35
    Content type: Research Published on:

  36. Reported data indicate that cancer cells have increased rates of glucose metabolism, as determined by 18FDG-PET imaging in patients with malignancies. The results of many studies have demonstrated that the exp...

    Authors: Paola Parente, Antonella Coli, Guido Massi, Antonella Mangoni, Manuela M Fabrizi and Giulio Bigotti
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:34
    Content type: Research Published on:

  37. Follicular dendritic cell (FDC) sarcoma is a rare neoplasm arising in lymph nodes but also in extranodal sites from accessory cells of the immune system that are essential for the function of antigen presentat...

    Authors: Francesco Pisani, Mirella Marino, Steno Sentinelli and Maria Concetta Petti
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:33
    Content type: Case report Published on:

  39. Many kinds of Chinese herb had been confirmed to have the character of anti-tumor, clinical reports about anti-tumor effects of Chinese herb had also been found in recent years, but most of the reports were fo...

    Authors: Yun Lu, Chang-Sheng Li and Qian Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:31
    Content type: Review Published on:

  40. To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus.

    Authors: Eiji Toyoda, Ryuichiro Doi, Kazuhiro Kami, Tomohiko Mori, Daisuke Ito, Masayuki Koizumi, Atsushi Kida, Kazuyuki Nagai, Tatsuo Ito, Toshihiko Masui, Michihiko Wada, Masatoshi Tagawa and Shinji Uemoto
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:30
    Content type: Research Published on:

  41. The detection of sub-clinical breast lesions has increased with screening mammography. Biopsy techniques can offer precision and agility in its execution, as well as patient comfort. This trial compares radiog...

    Authors: Marcelo Moreno, Janete Eunice Wiltgen, Benito Bodanese, Ricardo Ludwig Schmitt, Bianca Gutfilen and Lea Mirian Barbosa da Fonseca
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:29
    Content type: Research Published on:

  42. Deaths after percutaneous ethanol injection (PEI) into hepatocellular carcinoma (HCC) may occur within a few hours to a few days following the procedure because of hemoperitoneum and haemorrhage from oesophage...

    Authors: Enrico M Zardi, Francesco Di Matteo, Daniele Santini, Valentina Uwechie, Pierfilippo Crucitti, Massimiliano Carassiti, Antonio Picardi, Eleonora Perrella, Marco Caricato, Giuseppe Tonini, Roberto Coppola and Antonella Afeltra
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:28
    Content type: Review Published on:

  43. The c-Myc and human telomerase reverse transcriptase gene (hTERT) gene are frequently deregulated and overexpressed in malignancy. hTERT activity is induced by c-Myc and strategies designed to inhibit c-Myc ex...

    Authors: Huang Hao, Yu Nancai, Fu Lei, Wei Xiong, Su Wen, Huang Guofu, Wu yanxia, Huang Hanju, Liu Qian and Xiao Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:27
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2009 28:101

  44. To evaluate the relationship between Aberrant Crypt Foci (ACF) and tumorigenesis, we observed the sequential development from ACF to tumor in the colon of azoxymethane-exposed wistar rats.

    Authors: Qing Lu, Bo Jiang, Chen Lin and Tao Shan
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:26
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2008 27:47

  45. A novel human nuclear receptor interaction protein (NRIP) has recently been discovered by Chen SL et al, which may play a role in enhancing the transcriptional activity of steroid nuclear receptors in prostate...

    Authors: Chih-Ping Han, Ming-Yung Lee, Shu-Ling Tzeng, Chung-Chin Yao, Po-Hui Wang, Ya-Wen Cheng, Show-Li Chen, Teresa S Wu, Yeu-Sheng Tyan and Lai-Fong Kok
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:25
    Content type: Research Published on:

  46. DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methyl...

    Authors: Hong Fan, Feng Zhang, Jiabo Hu, Dongsheng Liu and Zhujiang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:24
    Content type: Research Published on:

  47. Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane. Expression of the heparanase gene is associated with...

    Authors: Xin Hong, Feng Jiang, Steven N Kalkanis, Zheng Gang Zhang, Xuepeng Zhang, Xuguang Zheng, Hao Jiang, Tom Mikkelsen and Michael Chopp
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:23
    Content type: Research Published on:

  48. Homeodomain-interacting protein kinase-2 (HIPK2) plays an essential role in restraining tumor progression as it may regulate, by itself or within multiprotein complexes, many proteins (mainly transcription fac...

    Authors: Rosa Puca, Lavinia Nardinocchi and Gabriella D'Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:22
    Content type: Research Published on:

  49. Cancer and its therapies increase the risk of venous thromboembolism. Compared to patients without cancer, patients with cancer anticoagulated for venous thromboembolism are more likely to develop recurrent th...

    Authors: Elie A Akl, Maddalena Barba, Sandeep Rohilla, Irene Terrenato, Francesca Sperati, Paola Muti and Holger J Schünemann
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:21
    Content type: Research Published on:

  50. The objective was to understand the influence of Survivin plasmid with short hairpin RNA (shRNA) on the cell cycle, invasion, and the silencing effect of Survivin gene in the SW480 cell of colorectal carcinoma.

    Authors: Liu Zhonghong, Lin Lianjie, Zheng Changqing, He Ying, Jin Yu and Lin Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:20
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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