Skip to main content

Articles

Page 36 of 76

  1. In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic. Overexpression of Melanoma associated antigen A3...

    Authors: Biswajit Das and Shantibhusan Senapati
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:294
  2. Glioma is one of the most aggressive malignant brain tumors which is characterized with highly infiltrative growth and poor prognosis. NKAP (NF-κB activating protein) is a widely expressed 415-amino acid nucle...

    Authors: Guangyan Gu, Taihong Gao, Lu Zhang, Xiuyang Chen, Qi Pang, Yanan Wang, Dan Wang, Jie Li and Qian Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:291
  3. This commentary wishes to highlight the latest discoveries in the mutant p53 field that have been discussed in the 8th p53 Mutant Workshop 2019, held in Lyon. TP53 mutant (mutp53) proteins are involved in the pat...

    Authors: Silvia Di Agostino, Giulia Fontemaggi, Sabrina Strano, Giovanni Blandino and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:290
  4. Glioblastoma (GBM) cells with stem cell-like properties are called glioma stem cells (GSCs). GSCs display highly treatment resistance and are responsible for tumor recurrence. Napabucasin (BBI608), a novel sma...

    Authors: Dongfeng Han, Tianfu Yu, Nan Dong, Bo Wang, Fei Sun and Dehua Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:289
  5. In the original publication of this article [1], there is a mistake in Figure 7. The tags of TGF-beta and calycosin in Western blotting electrophoresis images are reversed.

    Authors: Qun Wang, Weijun Lu, Tao Yin and Li Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:288

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:240

  6. Drug resistance represents the major reason of pharmacological treatment failure. It is supported by a broad spectrum of mechanisms, whose molecular bases have been frequently correlated to aberrant protein ph...

    Authors: Christian Borgo and Maria Ruzzene
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:287
  7. CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.

    Authors: Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guanyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:286
  8. Anti-angiogenic therapies demonstrate anti-tumor effects by decreasing blood supply to tumors and inhibiting tumor growth. However, anti-angiogenic therapy may leads to changes in tumor microenvironment and in...

    Authors: Weilong Zhong, Wendong Yang, Yuan Qin, Wenguang Gu, Yinyin Xue, Yuanhao Tang, Hengwei Xu, Hongzhi Wang, Chao Zhang, Changhua Wang, Bo Sun, Yanrong Liu, Huijuan Liu, Honggang Zhou, Shuang Chen, Tao Sun…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:285
  9. In the original publication of this article [1], there are two errors.

    Authors: Xihong Liu, Peiyuan Zhao, Xiujuan Wang, Lei Wang, Yingjun Zhu, Yadi Song and Wei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:284

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:184

  10. Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin-17 (...

    Authors: Bing Yang, Aiwen Wu, Yingqi Hu, Cuijian Tao, Ji Ming Wang, Youyong Lu and Rui Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:283
  11. Lung cancer is the most common cause of cancer-related mortality worldwide despite diagnostic improvements and the development of targeted therapies, notably including epidermal growth factor receptor (EGFR) t...

    Authors: Yi-Ying Wu, Hung-Chang Wu, Jia-En Wu, Kuo-Yen Huang, Shuenn-Chen Yang, Si-Xuan Chen, Chao-Jung Tsao, Keng-Fu Hsu, Yuh-Ling Chen and Tse-Ming Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:282
  12. Discoidin domain receptor-1 (DDR1) tyrosine kinase is highly expressed in a variety of human cancers and involved in various steps of tumorigenesis. However, the precise mechanisms underlying the abnormal expr...

    Authors: Sung-Tau Chou, Hsuan-Yu Peng, Kuan-Chi Mo, Yuan-Ming Hsu, Guan-Hsun Wu, Jenn-Ren Hsiao, Su-Fang Lin, Horng-Dar Wang and Shine-Gwo Shiah
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:281
  13. Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level i...

    Authors: Rui Yang, Na Liu, Ling Chen, Yiqun Jiang, Ying Shi, Chao Mao, Yating Liu, Min Wang, Weiwei Lai, Haosheng Tang, Menghui Gao, Desheng Xiao, Xiang Wang, Fenglei Yu, Ya Cao, Qin Yan…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:280
  14. A better understanding of locally advanced cervical cancer (LACC) is mandatory for further improving the rates of disease control, since a significant proportion of patients still fail to respond or undergo re...

    Authors: Marianna Buttarelli, Gabriele Babini, Giuseppina Raspaglio, Flavia Filippetti, Alessandra Battaglia, Alessandra Ciucci, Gabriella Ferrandina, Marco Petrillo, Carmela Marino, Mariateresa Mancuso, Anna Saran, Maria Elena Villani, Angiola Desiderio, Chiara D’Ambrosio, Andrea Scaloni, Giovanni Scambia…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:279
  15. Partial epithelial mesenchymal transition (p-EMT) was found to play a potential role in the initial stage of metastasis in human head and neck squamous cell carcinoma (HNSCC). Some long noncoding RNAs (lncRNAs...

    Authors: Hong-Gang Xiong, Hao Li, Yao Xiao, Qi-Chao Yang, Lei-Lei Yang, Lei Chen, Lin-Lin Bu, Wen-Feng Zhang, Jia-Li Zhang and Zhi-Jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:278
  16. The deubiquitinating enzyme ubiquitin-specific protease 3 (USP3) plays a crucial role in numerous biological processes. The aberrant expression of USP3 may have an important role in tumor development. However,...

    Authors: Xiaosheng Wu, Mengwei Liu, Huiqiong Zhu, Jing Wang, Weiyu Dai, Jiaying Li, Danping Zhu, Weimei Tang, Yizhi Xiao, Jianjiao Lin, Wenjing Zhang, Yong Sun, Yi Zhang, Yaying Chen, Guoxin Li, Aimin Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:277
  17. The E2A gene, which encodes two basic helix–loop–helix transcription factors, E12 and E47, regulates colorectal cancer progression and epithelial-mesenchymal transition. However, whether E2A regulates the tumo...

    Authors: Hongchao Zhao, Chunlin Zhao, Haohao Li, Danhua Zhang and Guanghui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:276
  18. The current chemotherapy regimens may extend survival for patients with metastatic bladder cancer (BCa) for a few months, but eventually most patients succumb to disease because they develop resistance to thei...

    Authors: Chi-Ping Huang, Jinbo Chen, Chi-Cheng Chen, Guodong Liu, Yong Zhang, Edward Messing, Shuyuan Yeh and Chawnshang Chang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:275
  19. Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive properties. However, the mechanism and the eff...

    Authors: Yujia Wang, Yue Jing, Liang Ding, Xiaoxin Zhang, Yuxian Song, Sheng Chen, Xingxing Zhao, Xiaofeng Huang, Yumei Pu, Zhiyong Wang, Yanhong Ni and Qingang Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:274
  20. DEPTOR is an endogenous inhibitor of mTORC1 and mTORC2 that plays a vital role in the progression of human malignances. However, the biological function of DEPTOR in HCC metastasis and the underlying molecular...

    Authors: Jin Chen, Haidan Zhu, Qiumeng Liu, Deng Ning, Zhaoqi Zhang, Long Zhang, Jie Mo, Pengcheng Du, Xu Liu, Shasha Song, Yawei Fan, Huifang Liang, Jikui Liu, Bixiang Zhang and Xiaoping Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:273
  21. Development of resistance to inhibitors of BRAF (BRAFi) and MEK (MEKi) remains a great challenge for targeted therapy in patients with BRAF-mutant melanoma. Here, we explored the role of miRNAs in melanoma acq...

    Authors: Simona Caporali, Adriana Amaro, Lauretta Levati, Ester Alvino, Pedro Miguel Lacal, Simona Mastroeni, Federica Ruffini, Laura Bonmassar, Gian Carlo Antonini Cappellini, Nadia Felli, Alessandra Carè, Ulrich Pfeffer and Stefania D’Atri
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:272
  22. Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and mitochondria. Sequence corresponding to CHTM1 is a...

    Authors: Mansi Babbar, Ying Huang, Christopher M. Curtiss and M. Saeed Sheikh
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:271
  23. Gliomas represent the most common type of malignant brain tumor, among which, glioblastoma remains a clinical challenge with limited treatment options and dismal prognosis. It has been shown that the dysregula...

    Authors: Fangling Cheng and Dongsheng Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:270
  24. Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this succes...

    Authors: Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner and Michael von Bergwelt-Baildon
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:268
  25. FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associat...

    Authors: Kyoung Min Kim, Usama Khamis Hussein, See-Hyoung Park, Mi Ae Kang, Young Jae Moon, Zhongkai Zhang, Yiping Song, Ho Sung Park, Jun Sang Bae, Byung-Hyun Park, Sang Hoon Ha, Woo Sung Moon, Jung Ryul Kim and Kyu Yun Jang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:267
  26. Glioblastoma (GBM) is an aggressive brain tumor with universal recurrence and poor prognosis. The recurrence is largely driven by chemoradiation resistant cancer stem cells (CSCs). Epidermal growth factor rece...

    Authors: Raghupathy Vengoji, Muzafar A. Macha, Rama Krishna Nimmakayala, Satyanarayana Rachagani, Jawed A. Siddiqui, Kavita Mallya, Santhi Gorantla, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra and Nicole Shonka
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:266
  27. Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clinically. In this study, we sought to explore whether ivermectin (IVM), a macrolide ...

    Authors: Lu Jiang, Pan Wang, Ying-Jian Sun and Yi-Jun Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:265
  28. Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to asse...

    Authors: Xiaocheng Cao, Lihua Liu, Qing Yuan, Xiang Li, Yinghong Cui, Kaiqun Ren, Chang Zou, A. Chen, Chang Xu, Yebei Qiu, Meifang Quan, Jiansong Zhang, Jianguo Cao and Xiangding Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:264
  29. Hepatocellular carcinoma (HCC) is the most common tumors in the worldwide, it develops resistance to radiotherapy during treatment, understanding the regulatory mechanisms of radioresistance generation is the ...

    Authors: Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li and Binsheng Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:263

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:387

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:336

  30. Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considere...

    Authors: Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:262
  31. Although the prognosis of patients with occult hepatitis B virus (HBV) infection (OBI) is usually benign, a small portion may undergo cirrhosis and subsequently hepatocellular carcinoma (HCC). We studied the m...

    Authors: Xiao-Ping Chen, Xin Long, Wen-long Jia, Han-Jie Wu, Jing Zhao, Hui-Fang Liang, Arian Laurence, Jun Zhu, Dong Dong, Yan Chen, Long Lin, Yu-Dong Xia, Wei-Yang Li, Gui-Bo Li, Zhi-Kun Zhao, Kui Wu…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:261

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:480

  32. Lung cancer is still the main cause of cancer death worldwide despite the availability of targeted therapies and immune-checkpoint inhibitors combined with chemotherapy. Cancer cell heterogeneity and primary o...

    Authors: Federica Giordano, Valentina Vaira, Diego Cortinovis, Sara Bonomo, Joyce Goedmakers, Federica Brena, Annamaria Cialdella, Leonarda Ianzano, Irene Forno, Maria Grazia Cerrito, Roberto Giovannoni, Gian Luca Ferri, Ennio Tasciotti, Silve Vicent, Francesco Damarco, Silvano Bosari…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:260
  33. USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear.

    Authors: Xiaojun Man, Chiyuan Piao, Xuyong Lin, Chuize Kong, Xiaolu Cui and Yuanjun Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:259
  34. Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play significant roles in metastatic progression and ch...

    Authors: Hyun Ju Hwang, Min-Suk Oh, Dong Woo Lee and Hyo-Jeong Kuh
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:258
  35. We reported that horizontal transfer of malignant traits to target cells is a potential pathway to explain cancer dissemination. Although these results were encouraging, they were never corroborated by data sh...

    Authors: Mohamed Abdouh, Matteo Floris, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:257
  36. Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies, including breast cancer (B...

    Authors: Xue Gao, Tao Qin, Jun Mao, Jun Zhang, Shujun Fan, Ying Lu, Zhigang Sun, Qingqing Zhang, Bo Song and Lianhong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:256

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:202

  37. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mut...

    Authors: Ping Chen, Han-Peng Huang, Yi Wang, Jun Jin, Wei-Guo Long, Kan Chen, Xiao-Hui Zhao, Chen-Guo Chen and Jian Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:254
  38. Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is a strong rationale for combining them with targeted therapy. Inhibition of MAPK pathway may have pleiotropic ef...

    Authors: Carminia Maria Della Corte, Giusi Barra, Vincenza Ciaramella, Raimondo Di Liello, Giovanni Vicidomini, Silvia Zappavigna, Amalia Luce, Marianna Abate, Alfonso Fiorelli, Michele Caraglia, Mario Santini, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello and Floriana Morgillo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:253
  39. Optimal therapeutic strategies for hepatocellular carcinoma (HCC) patients are still challenging due to the high recurrence rate after surgical resection and chemotherapy resistance. Growing evidence shows tha...

    Authors: Jie Zhao, Ann Wozniak, Abby Adams, Josiah Cox, Anusha Vittal, Jordan Voss, Brian Bridges, Steven A. Weinman and Zhuan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:252
  40. Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identificati...

    Authors: Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:251
  41. Colorectal cancer (CRC) is the third most frequent cancer and the second leading cause of cancer-related death worldwide. Increasing evidence indicates that the deregulation of long noncoding RNAs (lncRNAs) co...

    Authors: Kaili Luo, Jingwen Geng, Qinkai Zhang, Yesha Xu, Xunzhu Zhou, Zheng Huang, Ke-Qing Shi, Chenwei Pan and Jianmin Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:249
  42. Glioma is the most common and lethal type of malignant brain tumor. Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processe...

    Authors: Yichen Song, Lianqi Shao, Yixue Xue, Xuelei Ruan, Xiaobai Liu, Chunqing Yang, Jian Zheng, Shuyuan Shen, Jiajia Chen, Zhen Li and Yunhui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:248
  43. Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. Little is known about its invasion and metastasis mechanism so far.

    Authors: Hui Shen, Min He, Ruirong Lin, Ming Zhan, Sunwang Xu, Xince Huang, Chu Xu, Wei Chen, Yanhua Yao, Man Mohan and Jian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:247
  44. Prostate cancer (PCa) is considered one of the most prevalent malignancy globally, and metastasis is a major cause of death. Apigenin (API) is a dietary flavonoid which exerts an antimetastatic effect in vario...

    Authors: Ming-Hsien Chien, Yung-Wei Lin, Yu-Ching Wen, Yi-Chieh Yang, Michael Hsiao, Junn-Liang Chang, Hsiang-Ching Huang and Wei-Jiunn Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:246
  45. Cisplatin is the first-line chemotherapy used against most upper aerodigestive tract carcinomas. In head and neck cancer, sensitivity to cisplatin remains the key issue in treatment response and outcome. Genet...

    Authors: Wei-Min Chang, Yu-Chan Chang, Yi-Chieh Yang, Sze-Kwan Lin, Peter Mu-Hsin Chang and Michael Hsiao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:245
  46. The chemotherapy-resistance of triple-negative breast cancer (TNBC) remains a major challenge. The Nek2B kinase and β-catenin serve as crucial regulators of mitotic processes. The aim of this study was to test...

    Authors: Honghong Shen, Wenpeng Yan, Jinyang Yuan, Ziyue Wang and Chen Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:243
  47. Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic stress that triggers paracrine, adaptive responses...

    Authors: Svenja Offer, Julien A. Menard, Julio Enríquez Pérez, Kelin G. de Oliveira, Vineesh Indira Chandran, Maria C. Johansson, Anna Bång-Rudenstam, Peter Siesjö, Anna Ebbesson, Ingrid Hedenfalk, Pia C. Sundgren, Anna Darabi and Mattias Belting
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:241

Annual Journal Metrics

  • 2022 Citation Impact
    11.3 - 2-year Impact Factor
    11.5 - 5-year Impact Factor
    1.870 - SNIP (Source Normalized Impact per Paper)
    2.413 - SJR (SCImago Journal Rank)

    2023 Speed
    4 days submission to first editorial decision for all manuscripts (Median)
    100 days submission to accept (Median)

    2023 Usage 
    3,003,080 downloads
    3,022 Altmetric mentions