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  1. Large immunogenomic analyses have demonstrated the prognostic role of the functional orientation of the tumor microenvironment in adult solid tumors, this variable has been poorly explored in the pediatric cou...

    Authors: Shimaa Sherif, Jessica Roelands, William Mifsud, Eiman I. Ahmed, Christophe M. Raynaud, Darawan Rinchai, Abbirami Sathappan, Ata Maaz, Ayman Saleh, Erdener Ozer, Khalid A. Fakhro, Borbala Mifsud, Vésteinn Thorsson, Davide Bedognetti and Wouter R. L. Hendrickx
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:199
  2. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-022-02409-y.

    Authors: Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao and Jun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:197
  3. Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcino...

    Authors: Kohei Okuyama and Souichi Yanamoto
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:196
  4. DNA-based vaccines represent a simple, safe and promising strategy for harnessing the immune system to fight infectious diseases as well as various forms of cancer and thus are considered an important tool in ...

    Authors: Antonella Conforti, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Clay Shorrock, James A. Hayward, Yuhua Sun, Ben Minghwa Liang, Fabio Palombo, Brian Viscount and Luigi Aurisicchio
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:195
  5. Acquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting agent, has been a huge obstacle in treatment for metastatic castration-resistant prostate cancer (mCRPC). Recently, strategies tar...

    Authors: Liang Chen, Yarong Song, Teng Hou, Xuexiang Li, Lulin Cheng, Yunxue Li and Yifei Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:194
  6. Understanding the intricate signaling network involved in triple-negative breast cancer (TNBC) represents a challenge for developing novel therapeutic approaches. Here, we aim to provide novel mechanistic insi...

    Authors: Damiano Cosimo Rigiracciolo, Nijiro Nohata, Rosamaria Lappano, Francesca Cirillo, Marianna Talia, Sendi Rafael Adame-Garcia, Nadia Arang, Simone Lubrano, Ernestina Marianna De Francesco, Antonino Belfiore, J. Silvio Gutkind and Marcello Maggiolini
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:193
  7. Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of th...

    Authors: Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:192
  8. Downregulation of epithelial markers and upregulation of mesenchymal markers are the characteristics of the epithelial to mesenchymal transition (EMT) program, which provides the metastatic advantage of breast...

    Authors: Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen and Hai Rao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:191
  9. MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in differen...

    Authors: Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:190
  10. Deregulation of FGF19-FGFR4 signaling is found in several cancers, including hepatocellular carcinoma (HCC), nominating it for therapeutic targeting. FGF401 is a potent, selective FGFR4 inhibitor with antitumo...

    Authors: Stephen L. Chan, Martin Schuler, Yoon-Koo Kang, Chia-Jui Yen, Julien Edeline, Su Pin Choo, Chia-Chi Lin, Takuji Okusaka, Karl-Heinz Weiss, Teresa Macarulla, Stéphane Cattan, Jean-Frederic Blanc, Kyung-Hun Lee, Michela Maur, Shubham Pant, Masatoshi Kudo…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:189
  11. Circular RNAs (circRNAs) are essential participants in the development and progression of various malignant tumors. Previous studies have shown that cell migration-inducing protein (CEMIP) accelerates prostate...

    Authors: Ying Yu, Yarong Song, Lulin Cheng, Liang Chen, Bing Liu, Dingheng Lu, Xuexiang Li, Yunxue Li, Fang Lv and Yifei Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:188
  12. Circular RNA (circRNA) is a novel class noncoding RNA (ncRNA) that plays a critical role in various cancers, including prostate cancer (PCa). However, the clinical significance, biological function, and molecu...

    Authors: Lifeng Ding, Ruyue Wang, Qiming Zheng, Danyang Shen, Huan Wang, Zeyi Lu, Wenqin Luo, Haiyun Xie, Liangliang Ren, Minxiao Jiang, Chenhao Yu, Zhenwei Zhou, Yudong Lin, Haohua Lu, Dingwei Xue, Wenjing Su…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:187
  13. Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset of them derived clinical benefit and evidenced the need to identify reliable predictiv...

    Authors: Diego de Miguel-Perez, Alessandro Russo, Oscar Arrieta, Murat Ak, Feliciano Barron, Muthukumar Gunasekaran, Priyadarshini Mamindla, Luis Lara-Mejia, Christine B. Peterson, Mehmet E. Er, Vishal Peddagangireddy, Francesco Buemi, Brandon Cooper, Paolo Manca, Rena G. Lapidus, Ru-Ching Hsia…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:186
  14. Epidermal growth factor receptor (EGFR) inhibitors, including cetuximab and panitumumab, are valuable therapeutics for colorectal cancer (CRC), but resistance to these inhibitors is common. The reason for such...

    Authors: Lu Yang, Arup Bhattacharya, Yun Li, Sandra Sexton, Xiang Ling, Fengzhi Li and Yuesheng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:184
  15. High-grade serous ovarian carcinoma (HGSOC) is clinically dominant and accounts for ~ 80% deaths in all types of ovarian cancer. The delayed diagnosis, rapid development, and wide dissemination of HGSOC collec...

    Authors: Yanhua Du, Xiang Xu, Siang Lv, Han Liu, Hong Sun and Jun Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:185
  16. Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of human iCCA. Carcinogenic changes and therapeu...

    Authors: Leticia Colyn, Gloria Alvarez-Sola, M. Ujue Latasa, Iker Uriarte, Jose M. Herranz, Maria Arechederra, George Vlachogiannis, Colin Rae, Antonio Pineda-Lucena, Andrea Casadei-Gardini, Federica Pedica, Luca Aldrighetti, Angeles López-López, Angeles López-Gonzálvez, Coral Barbas, Sergio Ciordia…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:183
  17. Previous in vitro hepatocyte differentiation model showed that TROY was specifically expressed in liver progenitor cells and a small proportion of hepatocellular carcinoma cells, suggesting that TROY may parti...

    Authors: Beilei Liu, Xiaona Fang, Dora Lai-Wan Kwong, Yu Zhang, Krista Verhoeft, Lanqi Gong, Baifeng Zhang, Jie Chen, Qianqian Yu, Jie Luo, Ying Tang, Tuxiong Huang, Fei Ling, Li Fu, Qian Yan and Xin-Yuan Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:182
  18. Authors: Ilaria Martinelli, Chiara Modica, Cristina Chiriaco, Cristina Basilico, James M. Hughes, Simona Corso, Silvia Giordano, Paolo M. Comoglio and Elisa Vigna
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:180

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:112

  19. Prostate cancer (PC) is the most commonly diagnosed male malignancy and an important cause of mortality. Androgen deprivation therapy is the first line treatment but, unfortunately, a large part of patients ev...

    Authors: Lidia Chellini, Marco Pieraccioli, Claudio Sette and Maria Paola Paronetto
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:178
  20. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1098-y.

    Authors: Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang and Jie Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:177
  21. Authors: Ji Hye Im, Keon Wook Kang, Sun Young Kim, Yoon Gyoon Kim, Yong Jin An, Sunghyouk Park, Byung Hwa Jung, Song-Yi Choi, Jin-Sun Lee and Keon Wook Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:176

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:295

  22. The distant metastasis is the primary cause of cancer morbidity and mortality for bladder cancer (BLCA) paitents. All the recommended therapy for it largely depends on how far the cancer has invaded. It has be...

    Authors: Ming Chi, Jiao Liu, Chenxue Mei, Yaxing Shi, Nanqi Liu, Xuefeng Jiang, Chang Liu, Nan Xue, Hong Hong, Jisheng Xie, Xun Sun, Bo Yin, Xin Meng and Biao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:175
  23. Hypoxia and inflammation tumor microenvironment (TME) play a crucial role in tumor development and progression. Although increased understanding of TME contributed to gastric cancer (GC) progression and progno...

    Authors: Haiyan Piao, Lingfeng Fu, Yuxin Wang, Yang Liu, Yue Wang, Xiangyu Meng, Dong Yang, Xiang Xiao and Jun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:174
  24. The ETS transcription factor GABPA has long been thought of as an oncogenic factor and recently suggested as a target for cancer therapy due to its critical effect on telomerase activation, but the role of GAB...

    Authors: Zhiqing Fang, Ning Zhang, Xiaotian Yuan, Xiangling Xing, Xiaofeng Li, Xin Qin, Zhengfang Liu, Shiyong Neo, Cheng Liu, Feng Kong, Magnus Björkholm, Yidong Fan and Dawei Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:173
  25. Lung cancer is the leading cause of cancer death, partially owing to its extensive heterogeneity. The analysis of intertumor heterogeneity has been limited by an inability to concurrently obtain tissue from sy...

    Authors: Runzhe Chen, Jun Li, Junya Fujimoto, Lingzhi Hong, Xin Hu, Kelly Quek, Ming Tang, Akash Mitra, Carmen Behrens, Chi-Wan Chow, Peixin Jiang, Latasha D. Little, Curtis Gumbs, Xingzhi Song, Jianhua Zhang, Dongfeng Tan…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:172
  26. RNA-binding proteins (RBPs) and circular RNAs (circRNAs) play important roles in glioblastoma multiforme (GBM). Aerobic glycolysis is a metabolic characteristic of GBM. However, the roles of RBPs and circRNAs ...

    Authors: Jian Song, Jian Zheng, Xiaobai Liu, Weiwei Dong, Chunqing Yang, Di Wang, Xuelei Ruan, Yubo Zhao, Libo Liu, Ping Wang, Mengyang Zhang and Yunhui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:171
  27. Melanoma is a type of malignant tumor with high aggressiveness and poor prognosis. At present, metastasis of melanoma is still an important cause of death in melanoma patients. However, the potential functions...

    Authors: Qingfeng Shang, Haizhen Du, Xiaowen Wu, Qian Guo, Fenghao Zhang, Ziqi Gong, Tao Jiao, Jun Guo and Yan Kong
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:170
  28. Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer because of its aggressive biological characteristics and no effective targeted agents. However, the mechanism underlying its aggr...

    Authors: Zhaorui Miao, Qianhua Cao, Ruocen Liao, Xingyu Chen, Xiaoli Li, Longchang Bai, Chenglong Ma, Xinyue Deng, Zhijun Dai, Jun Li and Chenfang Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:169
  29. Triple negative breast cancer (TNBC) is highly malignant and has a worse prognosis, compared with other subtypes of breast cancer due to the absence of therapeutic targets. KIF23 plays a crucial role in the tu...

    Authors: Zhi Li, Hai-Yan Yang, Xiao-Lan Zhang, Xu Zhang, Yu-Zhou Huang, Xin-Yuan Dai, Liang Shi, Guo-Ren Zhou, Ji-Fu Wei and Qiang Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:168
  30. Interleukin-6 (IL-6) has been reported to be critical in oral squamous cell carcinoma (OSCC). However, the set of pathways that IL-6 might activate in OSCC are not fully understood.

    Authors: Li Xiao, Xue Li, Peilin Cao, Wei Fei, Hao Zhou, Na Tang and Yi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:166
  31. Circular RNAs (circRNAs) are noncoding RNAs with stable structures with high expression and tissue-specific expression. Studies have shown that circRNA dysregulation is closely related to the progression of tu...

    Authors: Meiqin Yang, Haoran Hu, Sufang Wu, Jianyi Ding, Bo Yin, Baoyou Huang, Fang Li, Xiaoqing Guo and Lingfei Han
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:165
  32. Circular RNAs (circRNAs) function as crucial regulators in multiple cancers, including hepatocellular carcinoma (HCC). However, the roles of circRNAs in HCC remains largely unknown.

    Authors: Yachong Liu, Jia Song, Hongwei Zhang, Zhibin Liao, Furong Liu, Chen Su, Weijian Wang, Mengzhen Han, Lu Zhang, He Zhu, Zhanguo Zhang, Huifang Liang, Lei Zhang, Bixiang Zhang and Xiaoping Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:164
  33. Inevitably developed resistance of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) limited its clinical benefit on non-small cell lung cancer (NSCLC). Upfront comb...

    Authors: Luyao Ao, Shencun Fang, Kexin Zhang, Yang Gao, Jiawen Cui, Wenjing Jia, Yunlong Shan, Jingwei Zhang, Guangji Wang, Jiali Liu and Fang Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:163
  34. The high postoperative recurrence rate and refractoriness of relapsed tumors are still a conundrum for the clinical management of osteosarcoma (OS). New therapeutic options are urgently needed. Depriving the n...

    Authors: Qingxin Fan, Jing Zuo, Hailong Tian, Canhua Huang, Edouard C. Nice, Zheng Shi and Qingquan Kong
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:162
  35. Neuroblastoma is a deadly childhood cancer, and MYCN-amplified neuroblastoma (MNA-NB) patients have the worst prognoses and are therapy-resistant. While retinoic acid (RA) is beneficial for some neuroblastoma pat...

    Authors: Silvia Lampis, Salvatore Raieli, Luca Montemurro, Damiano Bartolucci, Camilla Amadesi, Sonia Bortolotti, Silvia Angelucci, Anna Lisa Scardovi, Giammario Nieddu, Lucia Cerisoli, Francesca Paganelli, Sabrina Valente, Matthias Fischer, Alberto Maria Martelli, Gianandrea Pasquinelli, Andrea Pession…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:160
  36. Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it controls the correct segregation of chromosomes during mitosis. Many studies have focused on the biological role of CDC20...

    Authors: Samantha Bruno, Andrea Ghelli Luserna di Rorà, Roberta Napolitano, Simona Soverini, Giovanni Martinelli and Giorgia Simonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:159
  37. Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. Wiskott–Aldrich syndrome protein family member 2 (WASF2) is an integral member of the actin cytoskeleton pathway, which pl...

    Authors: Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A Son, Jung Hwan Yoon, Jae Youn Cheong, Hyo Jung Cho, Ho Chul Kang, Jung Woo Eun and Soon Sun Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:158
  38. Epithelial-to-mesenchymal transition (EMT) encompasses a highly dynamic and complex key process which leads to metastatic progression. In high-grade serous ovarian carcinoma (HG-SOC), endothelin-1 (ET-1)/endot...

    Authors: Rosanna Sestito, Piera Tocci, Celia Roman, Valeriana Di Castro and Anna Bagnato
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:157
  39. Circular RNAs (circRNAs) play an important role in the progression of non-small cell lung cancer (NSCLC), especially under tumor hypoxia. However, the precise functions and underlying mechanisms of dysregulate...

    Authors: Dong Wu, Tingting Chen, Xuanna Zhao, Dan Huang, Jiawei Huang, Yujie Huang, Qiu Huang, Zhu Liang, Chunyuan Chen, Min Chen, Dongming Li, Bin Wu and Lixia Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:156
  40. The overall response rate to checkpoint blockade remains unsatisfactory, partially due to the immune-suppressive tumor microenvironment. A retinoic acid-related orphan receptor γt (RORγt) agonist (LYC-55716) i...

    Authors: Li Xia, Enming Tian, Mingcheng Yu, Chenglong Liu, Lian Shen, Yafei Huang, Zhongen Wu, Jinlong Tian, Ker Yu, Yonghui Wang, Qiong Xie and Di Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:155
  41. Osteosarcoma (OS) is a malignant bone tumor mostly occurring in children and adolescents, while chemotherapy resistance often develops and the mechanisms involved remain challenging to be fully investigated.

    Authors: Mingrui Du, Jintao Gu, Chenlin Liu, Nannan Liu, Zhe Yu, Chengpei Zhou, Wei Heng, Zhengcong Cao, Feilong Wei, Kailong Zhu, Yingwen Wang, Wei Zhang, Xiaochang Xue, Yong Zhang and Jixian Qian
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:154
  42. Chemoresistance of pancreatic cancer is the main reason for the poor treatment effect of pancreatic cancer patients. Exploring chemotherapy resistance-related genes has been a difficult and hot topic of oncolo...

    Authors: Zhi-Wen Chen, Jian-Fei Hu, Zu-Wei Wang, Cheng-Yu Liao, Feng-Ping Kang, Cai-Feng Lin, Yi Huang, Long Huang, Yi-Feng Tian and Shi Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:153
  43. Extracellular vesicles (EVs) derived from tumor-associated macrophages are implicated in the progression and metastasis of gastric cancer (GC) via the transfer of molecular cargo RNAs. We aimed to decipher the...

    Authors: Yi Cao, Yi Tu, Jianbo Xiong, Shengxing Tan, Lianghua Luo, Ahao Wu, Xufeng Shu, Zhigang Jie and Zhengrong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:152
  44. Cancer mortality is mainly caused by organ failure and thrombotic events. It has been demonstrated that NETosis, a chromatin release mechanism implemented by neutrophils, may contribute to these lethal systemi...

    Authors: Livia Ronchetti, Irene Terrenato, Margherita Ferretti, Giacomo Corrado, Frauke Goeman, Sara Donzelli, Chiara Mandoj, Roberta Merola, Ashanti Zampa, Mariantonia Carosi, Giovanni Blandino, Laura Conti, Anna Maria Lobascio, Marcello Iacobelli, Enrico Vizza, Giulia Piaggio…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:151
  45. Oral squamous cell carcinoma (OSCC) is one of the common cancers worldwide. The lack of specific biomarkers and therapeutic targets leads to delayed diagnosis and hence the poor prognosis of OSCC patients. Thu...

    Authors: Yan Dong, Liyan Xue, Yan Zhang, Caiyun Liu, Yanguang Zhang, Na Jiang, Xiaoyan Ma, Fangyu Chen, Lingxia Li, Liyuan Yu, Xuefeng Liu, Shujuan Shao, Shufang Guan, Jian Zhang, Qingchun Xiao, Hui Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:150
  46. Cyclin-dependent kinase 16 (CDK16) is an atypical PCTAIRE kinase, and its activity is dependent on the Cyclin Y (CCNY) family. Ccnys have been reported to regulate mammary stem cell activity and mammary gland ...

    Authors: Xiao Li, Jinpeng Li, Liming Xu, Wei Wei, Anyi Cheng, Lingxian Zhang, Mengna Zhang, Gaosong Wu and Cheguo Cai
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:149

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