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  1. Epithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gynecological malignancies due to diagnosis at advanced stage and high recurrence rate. Recurrence in ...

    Authors: Brittney S. Harrington, Rahul Kamdar, Franklin Ning, Soumya Korrapati, Michael W. Caminear, Lidia F. Hernandez, Donna Butcher, Elijah F. Edmondson, Nadia Traficante, Joy Hendley, Madeline Gough, Rebecca Rogers, Rohan Lourie, Jyoti Shetty, Bao Tran, Fathi Elloumi…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:270
  2. Important roles of INHBB in various malignancies are increasingly identified. The underlying mechanisms in gastric cancer (GC) microenvironment are still greatly unexplored.

    Authors: Yangbing Jin, Qu Cai, Lingquan Wang, Jun Ji, Ying Sun, Jinling Jiang, Chao Wang, Junwei Wu, Benyan Zhang, Liqin Zhao, Feng Qi, Beiqin Yu and Jun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:269
  3. Dysregulated epithelial–mesenchymal transition (EMT) is involved in cervical cancer metastasis and associated with histone acetylation. However, the underlying molecular mechanisms of histone acetylation in ce...

    Authors: Xiaohui Yang, Fei Sun, Yueying Gao, MengYongwei Li, Mian Liu, Yunjian Wei, Qiuling Jie, Yibing Wang, Jiaoqi Mei, Jingjing Mei, Linna Ma, Yuechuan Shi, Manling Chen, Yongsheng Li, Qi Li, Mingyao Liu…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:268
  4. Long non-coding RNAs (LncRNAs) have been extensively studied to play essential roles in tumor progression. However, more in-depth studies are waiting to be solved on how lncRNAs regulate the progression of hep...

    Authors: Fan Wang, Yuhang Hu, Hongda Wang, Ping Hu, Hewei Xiong, Zhu Zeng, Shengbo Han, Decai Wang, Jie Wang, Yong Zhao, Yan Huang, Wenfeng Zhuo, Guozheng Lv and Gang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:267
  5. Authors: Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:266

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:179

  6. Spindle and kinetochore-associated complex subunit 3 (SKA3) plays an important role in cell proliferation by regulating the separation of chromosomes and their division into daughter cells. Previous studies de...

    Authors: Yananlan Chen, Xiao Xu, Yirui Wang, Yaodong Zhang, Tao Zhou, Wangjie Jiang, Ziyi Wang, Jiang Chang, Shuochen Liu, Ruixiang Chen, Jijun Shan, Jifei Wang, Yuming Wang, Changxian Li and Xiangcheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:265
  7. Disseminated tumor cells (DTCs) can enter a dormant state and cause no symptoms in cancer patients. On the other hand, the dormant DTCs can reactivate and cause metastases progression and lethal relapses. In p...

    Authors: Ruihua Liu, Shang Su, Jing Xing, Ke Liu, Yawei Zhao, Mary Stangis, Diego P. Jacho, Eda D. Yildirim-Ayan, Cara M. Gatto-Weis, Bin Chen and Xiaohong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:264
  8. RNA N6-Methyladenosine (m6A) modification is implicated in the progression of human cancers including cholangiocarcinoma (CCA). METTL16 is recently identified as a new RNA methyltransferase responsible for m6A...

    Authors: Nianli Liu, Jinqiang Zhang, Weina Chen, Wenbo Ma and Tong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:263
  9. Pancreatitis is known to be an important risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the exact molecular mechanisms of how inflammation promotes PDAC are still not fully understood. Regna...

    Authors: Junya Okabe, Takahiro Kodama, Yu Sato, Satoshi Shigeno, Takayuki Matsumae, Kazuma Daiku, Katsuhiko Sato, Teppei Yoshioka, Minoru Shigekawa, Masaya Higashiguchi, Shogo Kobayashi, Hayato Hikita, Tomohide Tatsumi, Toru Okamoto, Takashi Satoh, Hidetoshi Eguchi…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:262
  10. Epstein-Barr virus (EBV) is the first discovered human tumor virus that is associated with a variety of malignancies of both lymphoid and epithelial origin including nasopharyngeal carcinoma (NPC). The EBV-enc...

    Authors: Chaoliang Liao, Min Li, Xue Chen, Chenpeng Tang, Jing Quan, Ann M. Bode, Ya Cao and Xiangjian Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:261
  11. In the era of personalized medicine, the establishment of preclinical models of cancer that faithfully recapitulate original tumors is essential to potentially guide clinical decisions.

    Authors: Lucie Thorel, Pierre-Marie Morice, Hippolyte Paysant, Romane Florent, Guillaume Babin, Cécilia Thomine, Marion Perréard, Edwige Abeilard, Florence Giffard, Emilie Brotin, Christophe Denoyelle, Céline Villenet, Shéhérazade Sebda, Mélanie Briand, Florence Joly, Enora Dolivet…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:260
  12. Acute myeloid leukemia (AML) is a malignant blood cancer with marked cellular heterogeneity due to altered maturation and differentiation of myeloid blasts, the possible causes of which are transcriptional or ...

    Authors: Edoardo Peroni, Maria Luigia Randi, Antonio Rosato and Stefano Cagnin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:259
  13. Liver metastasis (LM) is one of the most common distant metastases of gastric cancer (GC). However, the mechanisms underlying the LM of GC (GC-LM) remain poorly understood. This study aimed to identify the tum...

    Authors: Li Xie, Shengkui Qiu, Chen Lu, Chao Gu, Jihuan Wang, Jialun Lv, Lang Fang, Zetian Chen, Ying Li, Tianlu Jiang, Yiwen Xia, Weizhi Wang, Bowen Li and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:258
  14. Authors: Fei Teng, Ju-Xiang Zhang, Qi-Meng Chang, Xu-Bo Wu, Wei-Guo Tang, Jian-Fa Wang, Jin-Feng Feng, Zi-Ping Zhang and Zhi-Qiu Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:257

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:235

  15. Our previous study first showed that ATR-binding long noncoding RNA (lncRNA) is necessary for ATR function and promotes cancer resistance. However, the specific lncRNAs instrumental in ATR activation remain la...

    Authors: Yuanyuan Chen, Hui Shen, Tingting Liu, Kun Cao, Zhijie Wan, Zhipeng Du, Hang Wang, Yue Yu, Shengzhe Ma, Edward Lu, Wei Zhang, Jianming Cai, Fu Gao and Yanyong Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:256
  16. Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc. Existing studies mainly focused on the roles of stress-induced a...

    Authors: Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li and Jian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:255
  17. The upregulation of antioxidant mechanisms is a common occurrence in cancer cells, as they strive to maintain balanced redox state and prevent oxidative damage. This includes the upregulation of the cystine/gl...

    Authors: Roberto Ruiu, Chiara Cossu, Antonella Iacoviello, Laura Conti, Elisabetta Bolli, Luca Ponzone, Jolanda Magri, Alekya Rumandla, Enzo Calautti and Federica Cavallo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:254
  18. Chimeric antigen receptor (CAR)-T immunotherapy fails to treat solid tumors due in part to immunosuppressive microenvironment. Excess lactate produced by tumor glycolysis increases CAR-T immunosuppression. The...

    Authors: Ting Sun, Bin Liu, Yanyan Li, Jie Wu, Yufei Cao, Shuangyu Yang, Huiling Tan, Lize Cai, Shiqi Zhang, Xinyue Qi, Dingjia Yu and Wei Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:253
  19. NONO-TFE3 rearranged renal cell carcinoma (NONO-TFE3 rRCC) is one of a subtype of TFE3 rRCCs with high malignancy and poor prognosis. Compared with clear cell RCC, NONO-TFE3 rRCC shows a preference for mitochondr...

    Authors: Yi Chen, Yanwen Lu, Lei Yang, Wenliang Ma, Yuhan Dong, Shuoming Zhou, Ning Liu, Weidong Gan and Dongmei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:252
  20. Clinical drawback in checkpoint inhibitors immunotherapy (ICI) of metastatic melanoma (MM) is monitoring clinical benefit. Soluble forms of PD1(sPD1) and PD-L1(sPD-L1) and extracellular vesicles (EVs) expressi...

    Authors: Simona Serratì, Roberta Di Fonte, Letizia Porcelli, Simona De Summa, Ivana De Risi, Livia Fucci, Eustachio Ruggieri, Tommaso Maria Marvulli, Sabino Strippoli, Rossella Fasano, Tania Rafaschieri, Gabriella Guida, Michele Guida and Amalia Azzariti
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:251
  21. Ewing sarcoma (ES) is an aggressive childhood bone and soft tissue cancer. KIAA1429 is one type of N6-methyladenosine (m6A) writer that plays a tumor-progressive role in various cancers, but the role of KIAA1429 ...

    Authors: Kezhe Tan, Wenjie Lu, Feng Chen, Hao Shi, Yingxuan Ma, Zhou Chen, Wei Wu, Zhibao Lv and Jialin Mo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:250
  22. Hypoxia is one of most typical features in the tumor microenvironment of solid tumor and an inducer of endoplasmic reticulum (ER) stress, and HIF-1α functions as a key transcription factor regulator to promote...

    Authors: Hongyu Yuan, Zitong Zhao, Jing Xu, Ruiping Zhang, Liying Ma, Jing Han, Weihong Zhao, Mingzhou Guo and Yongmei Song
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:249
  23. The most common site of metastasis in colorectal cancer (CRC) is the liver and liver metastases occur in more than 50% of patients during diagnosis or treatment. The occurrence of metastasis depends on a serie...

    Authors: Guangshun Sun, Siqi Zhao, Zhongguo Fan, Yuliang Wang, Hanyuan Liu, Hengsong Cao, Guoqiang Sun, Tian Huang, Hongzhou Cai, Hong Pan, Dawei Rong, Yun Gao and Weiwei Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:248
  24. Tumor biopsy is often not available or difficult to obtain in patients with solid tumors. Investigation of the peripheral immune system allows for in-depth and dynamic profiling of patient immune response prio...

    Authors: Nicole J. Toney, Jeffrey Schlom and Renee N. Donahue
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:247
  25. Gastric cancer (GC) is one of the most prevalent malignant tumors of the digestive system. As a hallmark of cancer, energy-related metabolic reprogramming is manipulated by multiple factors, including long non...

    Authors: Cong Zhang, Huixia Wang, Qingwei Liu, Suli Dai, Guo Tian, Xintong Wei, Xiaoya Li, Lianmei Zhao and Baoen Shan
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:246
  26. Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of the most important innate immune...

    Authors: Wentao Zeng, Fei Li, Shikai Jin, Ping-Chih Ho, Pu-Ste Liu and Xin Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:245
  27. Glioblastoma (GBM) is the most malignant among gliomas with an inevitable lethal outcome. The elucidation of the physiology and regulation of this tumor is mandatory to unravel novel target and effective thera...

    Authors: Alberto Visioli, Nadia Trivieri, Gandino Mencarelli, Fabrizio Giani, Massimiliano Copetti, Orazio Palumbo, Riccardo Pracella, Maria Grazia Cariglia, Chiara Barile, Luigi Mischitelli, Amata Amy Soriano, Pietro Palumbo, Federico Legnani, Francesco DiMeco, Leonardo Gorgoglione, Graziano Pesole…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:244
  28. Authors: Lifa Huang, Xu Li, Hui Ye, Yajun Liu, Xiaolong Liang, Chao Yang, Lin Hua, Zhaoxian Yan and Xin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:243

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:63

  29. Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains unclarified.

    Authors: Chengbin Wang, Minjie Zhang, Yingliang Liu, Daming Cui, Liang Gao and Yang Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:242
  30. Authors: Yulin Peng, Yan Wang, Ning Tang, Dongdong Sun, Yulong Lan, Zhenlong Yu, Xinyu Zhao, Lei Feng, Baojing Zhang, Lingling Jin, Fabiao Yu, Xiaochi Ma and Chuanzhu Lv
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:241

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:248

  31. Authors: Yi Zhang, Qinshan Li, Honglin Liu, Hongting Tang, Hanlin Yang, Daoqiu Wu, Yuying Huang, Licheng Li, Lihong Liu and Mengxing Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:240

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:219

  32. Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis. The underlying functions and mechanisms of circular RNA and SUMOylation in the development of ICC remain poorly understood.

    Authors: Junhao Zheng, Yali Wang, Liye Tao, Jingwei Cai, Zefeng Shen, Yang Liu, Haoyu Pan, Shihao Li, Yeling Ruan, Tianyi Chen, Zhengtao Ye, Kainan Lin, Yin Sun, Junjie Xu and Xiao Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:239
  33. Gemcitabine (GEM)-based chemotherapy is the first-line option for pancreatic ductal adenocarcinoma (PDAC). However, the development of drug resistance limits its efficacy, and the specific mechanisms remain la...

    Authors: Chunhua She, Chao Wu, Weihua Guo, Yongjie Xie, Shouyi Li, Weishuai Liu, Chao Xu, Hui Li, Pei Cao, Yanfang Yang, Xiuchao Wang, Antao Chang, Yukuan Feng and Jihui Hao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:238
  34. Chemotherapeutic agents are used to control tumor proliferation. However, their influence in the pre-metastatic niche of target organs has not been well studied. Oxaliplatin (OXA) is a drug applied in standard...

    Authors: Yuanyuan Ma, Chang Guo, Xijun Wang, Xundong Wei and Jie Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:237
  35. Fusobacterium nucleatum (Fn) acts as a procarcinogenic bacterium in colorectal carcinoma (CRC) by regulating the inflammatory tumor microenvironment (TME). Neutrophil extracellular traps (NETs), which can be gene...

    Authors: Xuehua Kong, Yu Zhang, Linwei Xiang, Yan You, Yaqian Duan, Yuqing Zhao, Shue Li, Rui Wu, Jiangbo Zhang, Lan Zhou and Liang Duan
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:236
  36. Malignant ascites commonly occurs in advanced or recurrent stages of epithelial ovarian cancer during peritoneal carcinomatosis and is correlated with poor prognosis. Due to its complex composition of cellular...

    Authors: Antonio Hrvat, Mathias Schmidt, Bernd Wagner, Denise Zwanziger, Rainer Kimmig, Lothar Volbracht, Sven Brandau and Nina Mallmann-Gottschalk
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:235
  37. Neoadjuvant radiotherapy has been used as the standard treatment of colorectal cancer (CRC). However, radiotherapy resistance often results in treatment failure. To identify radioresistant genes will provide n...

    Authors: Tingting Liu, Hang Wang, Yuanyuan Chen, Zhijie Wan, Zhipeng Du, Hui Shen, Yue Yu, Shengzhe Ma, Ying Xu, Zhuqing Li, Nanxi Yu, Fangxiao Zhang, Kun Cao, Jianming Cai, Wei Zhang, Fu Gao…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:234
  38. Sec23 homolog A (SEC23A), a core component of coat protein complex II (COPII), has been reported to be involved in several cancers. However, the role of SEC23A in gastric cancer remains unclear.

    Authors: Quan Cheng, Kanghui Liu, Jian Xiao, Kuan Shen, Yuanhang Wang, Xinyi Zhou, Jiawei Wang, Zekuan Xu and Li Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:232
  39. Acute lymphoblastic leukemia (ALL) is the most common pediatric hematological malignancy, with ETV6::RUNX1 being the most prevalent translocation whose exact pathogenesis remains unclear. IGF2BP1 (Insulin-like Gr...

    Authors: Gunjan Sharma, Tiffany M. Tran, Ishu Bansal, Mohammad Sabique Beg, Ruchi Bhardwaj, Jaspal Bassi, Yuande Tan, Amit Kumar Jaiswal, Christine Tso, Ayushi Jain, Jay Singh, Parthaprasad Chattopadhyay, Archna Singh, Anita Chopra, Sameer Bakhshi, David Casero…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:231
  40. Most of the endometrial cancer (EC) patients are diagnosis in early stage with a good prognosis while the patients with locally advanced recurrent or metastatic result in a poor prognosis. Adjuvant therapy cou...

    Authors: Xi Chen, Xin Liu, Qian-hui Li, Bing-feng Lu, Bu-min Xie, Yu-meng Ji and Yang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:230
  41. As a subclass of endogenous stable noncoding RNAs, circular RNAs are beginning to be appreciated for their potential as tumor therapeutics. However, the functions and mechanisms by which circRNAs exert protect...

    Authors: Deze Zhao, Yeping Dong, Minghao Duan, Dan He, Qun Xie, Wei Peng, Weifang Cui, Junjie Jiang, Yuanda Cheng, Heng Zhang, Faqing Tang, Chunfang Zhang, Yang Gao and Chaojun Duan
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:229
  42. Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression of Triple-negative breast cancer (TNBC). The publicly available TCG...

    Authors: Zhitao Han, Qi Jia, Jing Zhang, Miaomiao Chen, Lining Wang, Kai Tong, Weiwei He, Yajie Zhang, Weina Zhu, Ju Qin, Tao Wang, Tielong Liu, Yong Ma, Yuanming Chen, Siluo Zha and Chunlei Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:228
  43. Breast cancer (BC) is the leading cause of morbidity and the second leading cause of death among female malignant tumors. Although available drugs have been approved for the corresponding breast cancer subtype...

    Authors: Hong Yang, Xiangjin Zhen, Yihui Yang, Yizhi Zhang, Sen Zhang, Yue Hao, Guanhua Du, Hongquan Wang, Bailin Zhang, Wan Li and Jinhua Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:227
  44. Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic repressor. Serving as a substrat...

    Authors: Siyu Chen, Ping Leng, Jinlin Guo and Hao Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:226
  45. Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specifi...

    Authors: Hongli Gao, Jianqiao Yin, Ce Ji, Xiaopeng Yu, Jinqi Xue, Xin Guan, Shuang Zhang, Xun Liu and Fei Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:225
  46. FAT4 (FAT Atypical Cadherin 4) is a member of the cadherin-associated protein family, which has been shown to function as a tumor suppressor by inhibiting proliferation and metastasis. The Wnt/β-catenin pathwa...

    Authors: Dongying Wang, Shuying Wu, Jiaxing He, Luguo Sun, Hongming Zhu, Yuxuan Zhang, Shanshan Liu, Xuefeng Duan, Yanhong Wang and Tianmin Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:222
  47. Acute myeloid leukemia (AML) patients bearing the ITD mutation in the tyrosine kinase receptor FLT3 (FLT3-ITD) present a poor prognosis and a high risk of relapse. FLT3-ITD is retained in the endoplasmic retic...

    Authors: Francesca Liccardo, Martyna Śniegocka, Claudia Tito, Alessia Iaiza, Tiziana Ottone, Mariadomenica Divona, Serena Travaglini, Maurizio Mattei, Rosella Cicconi, Selenia Miglietta, Giuseppe Familiari, Stefania Annarita Nottola, Vincenzo Petrozza, Luca Tamagnone, Maria Teresa Voso, Silvia Masciarelli…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:223
  48. Lung cancer remains the leading cause of cancer-related deaths globally, and the survival rate remains low despite advances in diagnosis and treatment. The progression of lung cancer is a multifaceted and dyna...

    Authors: Naushad Ahmad Khan, Mohammad Asim, Kabir H. Biswas, Amani N Alansari, Harman Saman, Mohammad Zahid Sarwar, Kudaibergen Osmonaliev and Shahab Uddin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:221

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