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  1. Numerous studies have shown that long non-coding RNAs (lncRNAs) play key roles during multiple cancer processes, such as cell proliferation, apoptosis, migration and invasion. The previous studies found that N...

    Authors: Zhiliang Lu, Yuan Li, Jingnan Wang, Yun Che, Shouguo Sun, Jianbing Huang, Zhaoli Chen and Jie He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:54
  2. Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates ...

    Authors: Peiming Zheng, Lei Chen, Xiangliang Yuan, Qin Luo, Yi Liu, Guohua Xie, Yanhui Ma and Lisong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:53
  3. Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to che...

    Authors: Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K. Keppler and Walter Berger
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:52
  4. P73 antisense RNA 1 T (non-protein coding), also known as TP73-AS1, is a long non-coding RNA (lncRNA) which is involved in cell proliferation and the development of tumors. However, the exact effects and molec...

    Authors: Shaling Li, Yan Huang, Yun Huang, Yongming Fu, Daolin Tang, Rui Kang, Rongrong Zhou and Xue-gong Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:51
  5. Itraconazole has been proved therapeutically effective against a variety of human cancers. This study assessed the effect of itraconazole on the Hedgehog (Hh) pathway and proliferation of human gastric cancer ...

    Authors: Qiang Hu, Yi-Chao Hou, Jiao Huang, Jing-Yuan Fang and Hua Xiong
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:50
  6. RNA-binding protein 38 (RBM38) is a member of the RNA recognition motif (RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming regulatory loops with relevant genes. c-Myc is an...

    Authors: Xiao-Xia Li, Liang Shi, Xu-Jie Zhou, Jing Wu, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Lei Zhu, Ji-Fu Wei and Qiang Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:49
  7. Epithelial–mesenchymal transition (EMT) and dysregulated microRNAs (miRNAs) have important roles in driving chemoresistance. We previously reported that iASPP is a key EMT inducer and could increase cisplatin ...

    Authors: Ying Xiong, Fei Sun, Peixin Dong, Hidemichi Watari, Junming Yue, Min-fei Yu, Chun-yan Lan, Yin Wang and Ze-biao Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:48
  8. Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various tumor types. Previous work has demonstrated that curcumin inhibits cancer cell growth by targeting multiple si...

    Authors: Lihua Wang, Xiwen Chen, Zhuanyun Du, Gefei Li, Mayun Chen, Xi Chen, Guang Liang and Tongke Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:47
  9. The transcription factor sex-determining region Y-box protein 3 (SOX3) plays important roles in various types of cancer. However, its expression and function have not yet been elucidated in osteosarcoma (OS).

    Authors: Manle Qiu, Daoyun Chen, Chaoyong Shen, Ji Shen, Huakun Zhao and Yaohua He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:46
  10. Accumulating evidence indicates that microRNA-27a (miR-27a) is involved in carcinogenesis and tumor progression. However, the exact function and molecular mechanism of miR-27a in gastric cancer remain unclear.

    Authors: Lei Ding, Shanyong Zhang, Mu Xu, Renwen Zhang, Pengcheng Sui and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:45
  11. Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found in plant extracts which are wide...

    Authors: Dong Xu, Junzhe Jin, Hao Yu, Zheming Zhao, Dongyan Ma, Chundong Zhang and Honglei Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:44
  12. Drug resistance and disease progression are still the major obstacles in the treatment of chronic myeloid leukemia (CML). Increasing researches have demonstrated that autophagy becomes activated when cancer ce...

    Authors: Ziyuan Lu, Na Xu, Bolin He, Chengyun Pan, Yangqing Lan, Hongsheng Zhou and Xiaoli Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:43
  13. Growing evidence suggests that hepatitis C virus (HCV) contributes to hepatocellular carcinoma (HCC) by directly modulating oncogenic signaling pathways. Protein phosphatase magnesium-dependent 1A (PPM1A) has ...

    Authors: Yali Zhou, Yan Zhao, Yaoying Gao, Wenjun Hu, Yan Qu, Ning Lou, Ying Zhu, Xiaoping Zhang and Hongmei Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:42
  14. Cancer stem cells (CSCs) are correlated with the initiation, chemoresistance and relapse of tumors. Notch pathway has been reported to function in CSCs maintenance, but whether it is involved in renal cell car...

    Authors: Wei Xiao, Zhiyong Gao, Yixing Duan, Wuxiong Yuan and Yang Ke
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:41
  15. Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F family member, was reported to associate with progr...

    Authors: Jing Sun, Run Shi, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma and Chuan Su
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:40
  16. Non-small cell lung cancer (NSCLC) is the most commonly diagnosed type of lung cancer that is associated with poor prognosis. In this study we explored the potential role of p53-induced gene 3 (PIG3) in the pr...

    Authors: Ming Li, Shanhu Li, Biao Liu, Meng-Meng Gu, Shitao Zou, Bei-Bei Xiao, Lan Yu, Wei-Qun Ding, Ping-Kun Zhou, Jundong Zhou and Zeng-Fu Shang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:39
  17. CD133-positive cells in hepatocellular carcinoma (HCC) exhibit cancer stem cell (CSC)-like properties as well as resistance to chemotherapeutic agents and ionizing radiation; however, their function remains un...

    Authors: Yeonhwa Song, Jaewoo Jang, Tae-Hoon Shin, Sang Mun Bae, Jin-sun Kim, Kang Mo Kim, Seung-Jae Myung, Eun Kyung Choi and Haeng Ran Seo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:38
  18. Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic var...

    Authors: Nataly Cruz-Rodriguez, Alba L. Combita, Leonardo J. Enciso, Lauren F. Raney, Paula L. Pinzon, Olga C. Lozano, Alba M. Campos, Niyireth Peñaloza, Julio Solano, Maria V. Herrera, Jovanny Zabaleta and Sandra Quijano
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:37
  19. The purpose of the present study was to explore novel biomarkers that can predict the clinical outcome of patients before treatment or during vaccination. These would be useful for the selection of appropriate...

    Authors: Yoshitaro Shindo, Shoichi Hazama, Nobuaki Suzuki, Haruo Iguchi, Kazuhiro Uesugi, Hiroaki Tanaka, Atsushi Aruga, Takashi Hatori, Hidenobu Ishizaki, Yuzo Umeda, Toshiyoshi Fujiwara, Tetsuya Ikemoto, Mitsuo Shimada, Kazuhiko Yoshimatsu, Hiroko Takenouchi, Hiroto Matsui…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:36
  20. Cancer cells are known to over-express TRAF6 that is critical for both AKT and TAK1 activations. The Really Interesting New Gene (RING) domain of TRAF6 is believed to be responsible for the E3 ligase activity,...

    Authors: Yonghao Qi, Ambara R. Pradipta, Miao Li, Xuan Zhao, Lulu Lu, Xuegang Fu, Jing Wei, Richard P. Hsung, Katsunori Tanaka and Lijun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:35
  21. Authors: Jie Tang, Yi Zhu, Kunling Xie, Xiaoyu Zhang, Xiaofei Zhi, Weizhi Wang, Zheng Li, Qun Zhang, Linjun Wang, Jiwei Wang and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:34

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:91

  22. Authors: Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:33

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:21

  23. Solid tumours are less oxygenated than normal tissues. Consequently, cancer cells acquire to be adapted to a hypoxic environment. The poor oxygenation of solid tumours is also a major indicator of an adverse c...

    Authors: Tiziana Bruno, Mariacristina Valerio, Luca Casadei, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Valeria Catena, Simona Iezzi, Cristina Sorino, Agata Desantis, Cesare Manetti, Giovanni Blandino, Aristide Floridi and Maurizio Fanciulli
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:32
  24. Authors: Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu and Chengshui Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:31

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:173

  25. Overexpression of paternally expressed gene-10 (PEG10) is known to promote the progression of several carcinomas, however, its role in pancreatic cancer (PC) is unknown. We investigated the expression and func...

    Authors: Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Jing-Jing Zhang, Ji-Shu Wei, Xian Liu, Xin-Chun Liu, Wen-Tao Gao, Kui-Rong Jiang and Yi Miao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:30
  26. MicroRNA-381 (miR-381) has been reported to play suppressive or promoting roles in different malignancies. However, the expression level, biological function, and underlying mechanisms of miR-381 in gastric ca...

    Authors: Qinghua Cao, Fang Liu, Kaiyuan Ji, Ni Liu, Yuan He, Wenhui Zhang and Liantang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:29
  27. Metformin, an FDA-approved drug for the treatment of Type II diabetes, has emerged as a promising anti-cancer agent. Other biguanide analogs, including buformin and phenformin, are suggested to have similar pr...

    Authors: Amanda B. Parris, Qingxia Zhao, Erin W. Howard, Ming Zhao, Zhikun Ma and Xiaohe Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:28
  28. Angiogenesis is a hallmark of cancer and plays a critical role in lung cancer progression, which involves interactions between cancer cells, endothelial cells and the surrounding microenvironment. However, the...

    Authors: Hao-Wei Cheng, Yi-Fang Chen, Jau-Min Wong, Chia-Wei Weng, Hsuan-Yu Chen, Sung-Liang Yu, Huei-Wen Chen, Ang Yuan and Jeremy J.W. Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:27
  29. Adipose microenvironment is involved in signaling pathways that influence breast cancer. We aim to characterize factors that are modified: 1) in tumor and non tumor human breast epithelial cell lines when incu...

    Authors: Sabrina Johanna Fletcher, Paula Alejandra Sacca, Mercedes Pistone-Creydt, Federico Andrés Coló, María Florencia Serra, Flavia Eliana Santino, Corina Verónica Sasso, Constanza Matilde Lopez-Fontana, Rubén Walter Carón, Juan Carlos Calvo and Virginia Pistone-Creydt
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:26
  30. Molecular mechanisms of intrinsic or acquired radioresistance serve as critical barrier for curative therapy of head and neck squamous cell carcinoma (HNSCC) and remain a major obstacle for progression-free an...

    Authors: Jennifer Grünow, Chao Rong, Jan Hischmann, Karim Zaoui, Christa Flechtenmacher, Klaus-Josef Weber, Peter Plinkert and Jochen Hess
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:25
  31. One of the main problems in B cell lymphoma treatment is severe adverse effects and low therapeutic efficacy resulting from systemic chemotherapy. A pH-sensitive controlled drug release system based on mesopor...

    Authors: Shoubing Zhou, Dan Wu, Xiaodong Yin, Xiaoxiao Jin, Xiu Zhang, Shiya Zheng, Cailian Wang and Yanwen Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:24
  32. Recent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas, including colorectal cancer (CRC). F...

    Authors: DeJie Wang, Guohui Hu, Ying Du, Cheng Zhang, Quqin Lu, Nonghua Lv and Shiwen Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:23
  33. Children with Down syndrome (DS) have increased risk for developing AML (DS-AMKL), and they usually experience severe therapy-related toxicities compared to non DS-AMKL. Refractory/relapsed disease has very po...

    Authors: Ranjan Bista, David W. Lee, Oliver B. Pepper, David O. Azorsa, Robert J. Arceci and Eiman Aleem
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:22
  34. Nasopharyngeal carcinoma (NPC) is a common malignancy in Southern China and Southeast Asia. In this study, we investigated the functional and molecular mechanisms by which CDC42-interacting protein 4 (CIP4) in...

    Authors: Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:21

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:33

  35. Melanoma is a heterogeneous tumor in which phenotype-switching and CD133 marker have been associated with metastasis promotion and chemotherapy resistance. CD133 positive (CD133+) subpopulation has also been s...

    Authors: Ayele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Chiara Cipriani, Ilaria Bucci, Roberta Sorrentino, Ilaria Sciamanna, Alessandra Gambacurta, Paola Sinibaldi-Vallebona and Claudia Matteucci
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:20
  36. Gastric cancer is one of the major causes of cancer-related mortality worldwide. Most of patients presenting with inoperable gastric cancers rely on systemic chemotherapy for prolongation of survival. Doxorubi...

    Authors: Jiahui Xu, Deying Liu, Huilin Niu, Guifang Zhu, Yangwei Xu, Danli Ye, Jian Li and Qingling Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:19

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:23

  37. Authors: Qing-Xuan Wang, En-Dong Chen, Ye-Feng Cai, Quan Li, Yi-Xiang Jin, Wen-Xu Jin, Ying-Hao Wang, Zhou-Ci Zheng, Lu Xue, Ou-Chen Wang and Xiao-Hua Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:18

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:169

  38. Increasing evidence highlights the important roles of tripartite motif containing 24 (TRIM24) in tumor initiation and malignant progression in many tumors, including gastric cancer (GC). Although TRIM24 expres...

    Authors: Ziling Fang, Ling Zhang, Quan Liao, Yi Wang, Feng Yu, Miao Feng, Xiaojun Xiang and Jianping Xiong
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:17
  39. Strategies aimed at obtaining a complete cytoreduction are needed to improve long-term survival for patients with colorectal cancer peritoneal carcinomatosis (CRC-pc).

    Authors: Fabio Bozzi, Angela Mogavero, Luca Varinelli, Antonino Belfiore, Giacomo Manenti, Claudio Caccia, Chiara C. Volpi, Galina V. Beznoussenko, Massimo Milione, Valerio Leoni, Annunziata Gloghini, Alexandre A. Mironov, Ermanno Leo, Silvana Pilotti, Marco A. Pierotti, Italia Bongarzone…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:16
  40. Hepatocellular carcinoma (HCC) develops in a complex microenvironment characterized by chronic inflammation. In recent years, cholesterol metabolic abnormalities have been implicated the importance in cancer c...

    Authors: Mingyan He, Wenhui Zhang, Yinying Dong, Lishun Wang, Tingting Fang, Wenqing Tang, Bei Lv, Guanglang Chen, Biwei Yang, Peixin Huang and Jinglin Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:15
  41. Pancreatic cancer is a lethal malignancy that frequently acquires resistance to conventional chemotherapies often associated with overexpression of inhibitors of apoptosis proteins (IAPs). We have recently des...

    Authors: Yassar M. Hashim, Suwanna Vangveravong, Narendra V. Sankpal, Pratibha S. Binder, Jingxia Liu, S. Peter Goedegebuure, Robert H. Mach, Dirk Spitzer and William G. Hawkins
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:14
  42. Epithelial-mesenchymal transition (EMT) elicits dramatic changes, including cytoskeleton remodelling as well as changes in gene expression and cellular phenotypes. During this process, actin filament assembly ...

    Authors: Deng Huang, Li Cao and Shuguo Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:13
  43. Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecul...

    Authors: Valeria Catena and Maurizio Fanciulli
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:12
  44. Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HC...

    Authors: Tian Lan, Weijie Ma, Zhenfei Hong, Long Wu, Xi Chen and Yufeng Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:11
  45. The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear.

    Authors: Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu and Yanhui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:10
  46. Glioblastoma is an untreatable brain cancer. The tumors contain a population of stem-like cells which are highly invasive and resistant to therapies. These cells are the main reason for the lethality of gliobl...

    Authors: Irene Ylivinkka, Harri Sihto, Olli Tynninen, Yizhou Hu, Aki Laakso, Riku Kivisaari, Pirjo Laakkonen, Jorma Keski-Oja and Marko Hyytiäinen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:9
  47. Sorafenib, a multi-kinase inhibitor, is used as a standard therapy for advanced hepatocellular carcinoma (HCC). However, complete remission has not been achieved and the molecular basis of HCC resistance to so...

    Authors: Lixia Gao, Xuli Wang, Yaoliang Tang, Shuang Huang, Chien-An Andy Hu and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:8
  48. Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aero...

    Authors: Hui-Min Li, Jie-Gang Yang, Zhuo-Jue Liu, Wei-Ming Wang, Zi-Li Yu, Jian-Gang Ren, Gang Chen, Wei Zhang and Jun Jia
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:7
  49. Although chemopreventative agents targeting the estrogen/estrogen receptor (ER) pathway have been effective for ER+ breast cancers, prevention of hormone receptor-negative breast cancers, such as Her2/erbB-2+ bre...

    Authors: Zhikun Ma, Amanda B. Parris, Zhengzheng Xiao, Erin W. Howard, Stanley D. Kosanke, Xiaoshan Feng and Xiaohe Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:6
  50. Oleuropein (OL) is a well-known anti-oxidative agent and is shown to reduce the hypoxia-inducible factor 1 α (HIF1α) protein expression after radiation. The current study investigated the effects of OL on radi...

    Authors: Ting Xu and Dajiang Xiao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:3

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