Skip to main content

Articles

Page 71 of 77

  1. Ovarian cancer is the most fatal gynecologic malignancies in the world. Although, platinum based treatments are widely used, the disease becomes treatment refractory within two years, and novel treatment optio...

    Authors: Bulent Karabulut, Burcak Karaca, Umut Varol, Ugur Muslu, Burcu Cakar, Harika Atmaca, Aslı Kısım, Selim Uzunoglu and Ruchan Uslu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:102
    Content type: Research Published on:

  2. Sulfotransferase (SULT) plays an important role in the formation of estrogen which is usually conferred as a risk factor for breast cancer. Polymorphism of the SULT1A1 may be closely associated with breast can...

    Authors: Yiwei Jiang, Liheng Zhou, Tingting Yan, Zhenzhou Shen, Zhimin Shao and Jinsong Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:101
    Content type: Research Published on:

  3. Currently definitive 5-fluorouracil (5-FU)/cisplatin (CDDP) -based chemotherapy is recognized as one of the most promising treatments for esophageal cancer. A series of studies performed found genetic polymorp...

    Authors: Akiko Kuwahara, Motohiro Yamamori, Megumi Fujita, Tatsuya Okuno, Takao Tamura, Kaori Kadoyama, Noboru Okamura, Tsutomu Nakamura and Toshiyuki Sakaeda
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:100
    Content type: Research Published on:

  4. Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also ...

    Authors: Bo Chen, Xueli Wang, Weihong Zhao and Jianqing Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:99
    Content type: Research Published on:

  5. The novel gene HA117 is a multidrug resistance (MDR) gene expressed by all-trans retinoic acid-resistant HL-60 cells. In the present study, we compared the multidrug resistance of the HA117 with that of the cl...

    Authors: Lihua Zhao, Xianqing Jin, Youhua Xu, Yuxia Guo, Rui Liang, Zhenhua Guo, Tingfu Chen, Yanhui Sun and Xionghui Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:98
    Content type: Research Published on:

  7. Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis of gastrointestinal stromal tumors (GIST).

    Authors: Sean Caenepeel, Lisa Renshaw-Gegg, Angelo Baher, Tammy L Bush, Will Baron, Todd Juan, Raffi Manoukian, Andrew S Tasker, Anthony Polverino and Paul E Hughes
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:96
    Content type: Research Published on:

  8. Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the activity of bevacizumab and sorafenib. We hypothesized that these toxicities would correspond to favorable outcome in these drugs, th...

    Authors: Lokesh Jain, Tristan M Sissung, Romano Danesi, Elise C Kohn, William L Dahut, Shivaani Kummar, David Venzon, David Liewehr, Bevin C English, Caitlin E Baum, Robert Yarchoan, Giuseppe Giaccone, Jürgen Venitz, Douglas K Price and William D Figg
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:95
    Content type: Research Published on:

  9. To explore the therapeutic effects of thymidine kinase (TK) expressed by enhanced vector pGL3-basic- hTERTp-TK-EGFP-CMV driven by human telomerase reverse transcriptase promoter (hTERTp) as well as cytomegalov...

    Authors: Cong-Xiang Shen, Zhong Wen, Yu-Hong Qian, Shao-Feng Mu and Xiao-Fang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:94
    Content type: Research Published on:

  10. Nm23 gene was isolated as a metastatic suppressor gene. The antimetastatic effect of Nm23 has been an enigma for more than 10 years. Little is known about its molecular mechanisms. In this study we overexpress...

    Authors: Shangyang She, Boying Xu, Min He, Xiuwan Lan and Qiuyan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:93
    Content type: Research Published on:

  11. Tumor cell expression of Toll-like receptors (TLRs) can promote inflammation and cell survival in the tumor microenvironment. Toll-like receptor 4 (TLR4) signaling in tumor cells can mediate tumor cell immune ...

    Authors: Huan Yang, Huiqin Zhou, Ping Feng, Xiaoni Zhou, Huiyan Wen, Xiaofang Xie, Haiying Shen and Xueming Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:92
    Content type: Research Published on:

  12. Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant r...

    Authors: Nicole D Fer, Robert H Shoemaker and Anne Monks
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:91
    Content type: Research Published on:

  13. MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma.

    Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:90
    Content type: Research Published on:

  14. ECRG4 has been shown to be a candidate tumor suppressor in several tumors, but its role in glioma remains poorly understood. In this study, we examined the mRNA expression of ECRG4 and investigated its biologi...

    Authors: Wei Li, Xinrui Liu, Bo Zhang, Dongxue Qi, Lihong Zhang, Yuhong Jin and Hongfa Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:89
    Content type: Research Published on:

  15. This study explored the expression and function of Slug in human extrahepatic hilar cholangiocarcinoma (EHC) to identify its role in tumor progression.

    Authors: Ke-jun Zhang, Dong-sheng Wang, Shao-yan Zhang, Xue-long Jiao, Chun-wei Li, Xin-sheng Wang, Qin-chao Yu and Hai-ning Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:88
    Content type: Research Published on:

  16. Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most active chemotherapeutic agent in Lung Cancer. Here we repor...

    Authors: Syed H Jafri, Jonathan Glass, Runhua Shi, Songlin Zhang, Misty Prince and Heather Kleiner-Hancock
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:87
    Content type: Research Published on:

  17. Various strains of Bacillus thuringiensis (Bt) have been found to produce parasporal proteins that are cytotoxic to human cancer cells. This study aims to establish the binding affinity of purified Bt 18 toxin fo...

    Authors: Rebecca SY Wong, Shar M Mohamed, Vishna D Nadarajah and Ibrahim Azmi T Tengku
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:86
    Content type: Research Published on:

  18. To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian ca...

    Authors: Ying Ma, Lin Ma, Quan Guo and Shulan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:85
    Content type: Research Published on:

  19. Orthotopic models are important in cancer research. Here we developed orthotopic xenograft mouse model of metastatic lung cancer and glioblastoma with a specially designed system.

    Authors: Xi Feng Fei, Quan Bin Zhang, Jun Dong, Yi Diao, Zhi Min Wang, Ru Jun Li, Zi Cheng Wu, Ai Dong Wang, Qing Lan, Shi Ming Zhang and Qiang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:84
    Content type: Research Published on:

  20. The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy...

    Authors: Tatsuya Tanaka, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Takeyasu Katada, Midori Shiozaki, Yasuhiro Naganawa, Yoshitaka Fujii and Hiromitsu Takeyama
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:83
    Content type: Research Published on:

  21. Breast cancer is one of the most common diseases affecting women. Inherited susceptibility genes, BRCA1 and BRCA2, are considered in breast, ovarian and other common cancers etiology. BRCA1 and BRCA2 genes have b...

    Authors: Safinaz S Ibrahim, Elsayed E Hafez and Mervat M Hashishe
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:82
    Content type: Research Published on:

  22. We have previously reported that Myeov (MYEloma OVerexpressed gene) expression is enhanced in colorectal cancer (CRC) and that it promotes CRC cell proliferation and invasion. The role of Myeov in CRC migratio...

    Authors: Garrett Lawlor, Peter P Doran, Padraic MacMathuna and David W Murray
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:81
    Content type: Research Published on:

  23. Breast cancer stem cells (BCSCs) have been recently identified in breast carcinoma as CD44+CD24- cells, which exclusively retain tumorigenic activity and display stem cell-like properties. Using a mammosphere cul...

    Authors: Mingzhu Huang, Yuqing Li, Huanle Zhang and Feifei Nan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:80
    Content type: Research Published on:

  24. Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene. However, recent studies revealed that over expression of Cx26 ...

    Authors: Shinya Nomura, Kiyoshi Maeda, Eiji Noda, Toru Inoue, Shinya Fukunaga, Hisashi Nagahara and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:79
    Content type: Research Published on:

  25. Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (D...

    Authors: Feng Ye, Yan Yu, Yuting Hu, Weiguo Lu and Xing Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:78
    Content type: Research Published on:

  26. Total thyroidectomy is the treatment of choice in the majority of thyroid malignancies, preventing the risk of reoperative surgery due to recurrences. In order to assess the usefulness of such an approach, exp...

    Authors: Guglielmo Ardito, Luca Revelli, Alma Boninsegna, Alessandro Sgambato, Francesca Moschella, Maria Cristina Marzola, Erica Giustozzi, Nicola Avenia, Mauro Castelli and Domenico Rubello
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:77
    Content type: Research Published on:

  27. Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and un...

    Authors: Xian-ping Liu, Sheng-tao Zhou, Xing-yi Li, Xian-cheng Chen, Xia Zhao, Zhi-yong Qian, Li-na Zhou, Zhi-yong Li, Yu-mei Wang, Qian Zhong, Tao Yi, Zheng-yu Li, Xiang He and Yu-quan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:76
    Content type: Research Published on:

  28. Recent studies have shown that microRNAs (miRNAs) play roles in tumorigenesis and are reliable classifiers of certain cancer types and subtypes. However, the role of miRNAs in the pathogenesis and diagnosis of...

    Authors: Liqin Du, Jeoffrey J Schageman, Irnov, Luc Girard, Scott M Hammond, John D Minna, Adi F Gazdar and Alexander Pertsemlidis
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:75
    Content type: Research Published on:

  29. The tumor suppressor gene CDKN2A generates at least three different transcriptional variants, each of which is thought to encode a tumor suppressor. However, the inhibitory activities of these variants have not y...

    Authors: Wei Zhang, Jing Zhu, Jing Bai, Hui Jiang, Fangli Liu, An Liu, Peng Liu, Guohua Ji, Rongwei Guan, Donglin Sun, Wei Ji, Yang Yu, Yan Jin, Xiangning Meng and Songbin Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:74
    Content type: Research Published on:

  30. To retrospectively compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multidetector-row computed tomography (MDCT) in the assessment of the mandibular invasion by squamous cell carcinoma (...

    Authors: Antonello Vidiri, Antonino Guerrisi, Raul Pellini, Valentina Manciocco, Renato Covello, Oreste Mattioni, Isabella Guerrisi, Salvatore Di Giovanni, Giuseppe Spriano and Marcello Crecco
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:73
    Content type: Research Published on:

  31. Interleukin-10(IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Polymorphisms in the IL-10 gene promoter genetically determine interindividual differences in IL-10...

    Authors: Fanjun Kong, Jie Liu, Yongheng Liu, Bao Song, Hualing Wang and Wenchao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:72
    Content type: Research Published on:

  32. SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis.

    Authors: Jian-fang Liang, Hong-kun Wang, Hong Xiao, Ning Li, Cai-xia Cheng, Yu-ze Zhao, Yan-bo Ma, Jian-zhong Gao, Rui-bing Bai and Hui-xia Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:71
    Content type: Research Published on:

  33. Intra-arterial radioembolization with yttrium-90 microspheres ( 90Y-RE) is an increasingly used therapy for patients with unresectable liver malignancies. Over the last decade, radioactive holmium-166 poly(L-lact...

    Authors: Maarten LJ Smits, Johannes FW Nijsen, Maurice AAJ van den Bosch, Marnix GEH Lam, Maarten AD Vente, Julia E Huijbregts, Alfred D van het Schip, Mattijs Elschot, Wouter Bult, Hugo WAM de Jong, Pieter CW Meulenhoff and Bernard A Zonnenberg
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:70
    Content type: Research Published on:

  34. Positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism. We have analyzed the effect ...

    Authors: Seong-Jang Kim, Sang-Hyun Hwang, In Joo Kim, Min Ki Lee, Chang Hun Lee, Sang-Yull Lee and Eun Yup Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:69
    Content type: Research Published on:

  35. This study aimed to investigate the efficacy of prophylactic amifostine in reducing the risk of severe radiation colitis in cancer patients receiving radical radiotherapy to the pelvis.

    Authors: Konstantinos H Katsanos, Evangelos Briasoulis, Pericles Tsekeris, Anna Batistatou, Maria Bai, Christos Tolis, Antonio Capizzello, Ioannis Panelos, Vasileios Karavasilis, Dimitrios Christodoulou and Epameinondas V Tsianos
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:68
    Content type: Research Published on:

  36. Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and pe...

    Authors: Qiong Yang, De-Rong Xie, Zhi-Min Jiang, Wen Ma, Yuan-Dong Zhang, Zhuo-Fei Bi and Deng-Lin Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:67
    Content type: Research Published on:

  37. The prognosis of gastric cancer patients is difficult to predict because of defects in establishing the surgical-pathological features. Cancer-associated fibroblasts (CAFs) have been found to play prominent ro...

    Authors: Kangkang Zhi, Xiaojun Shen, Hao Zhang and Jianwei Bi
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:66
    Content type: Research Published on:

  38. In the province of Cadiz (Spain), the adjusted mortality rate for gastric cancer in the coastal town of Barbate is 10/100.000 inhabitants, whereas in the inland town of Ubrique, the rate is twice as high. The ...

    Authors: Juan-Bosco Lopez-Saez, Victoria Gómez-Biondi, Germán Santamaría-Rodriguez, Margarita Dominguez-Villar, Antonio Amaya-Vidal, Antonio Lorenzo-Peñuelas and Avelino Senra-Varela
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:65
    Content type: Research Published on:

  39. This study aimed to examine whether EBV seropositive patients with lung cancer have an altered virus-specific CTL response, as compared to age-matched healthy controls and whether any variation in this respons...

    Authors: Vaios Karanikas, Maria Zamanakou, Faye Soukou, Theodora Kerenidi, Ioannis Tsougos, Kiki Theodorou, Panagiotis Georgoulias, Konstantinos I Gourgoulianis and Anastasios E Germenis
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:64
    Content type: Research Published on:

  40. in recent years, Livin, a new member of IAPs family, is found to be a key molecule in cancers. Researchers consider Livin may become a new target for tumor therapy; however, the role of it in bladder cancer is...

    Authors: Liu Chuan, Wu Xiaohou, Luo Chunli, Hu Zili, Yin Zhikang, He Yunfeng, Du Hu, Zhang Weili, Jiang Qing and Lin Yanjun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:63
    Content type: Research Published on:

  41. The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare t...

    Authors: Gregory E Rice, Tracey A Edgell and Dominic J Autelitano
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:62
    Content type: Research Published on:

  42. CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. CD147 has been implicated in numerous physiological and pathological activities. Enriched on the surface of many tumo...

    Authors: Bo Wang, Yong-Fei Xu, Bang-Shun He, Yu-Qin Pan, Li-Rong Zhang, Chan Zhu, Li-Li Qu and Shu-Kui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:61
    Content type: Research Published on:

  43. Survival of laryngeal squamous cell carcinoma (LSCC) patients has remained unchanged over recent years due to its uncontrolled recurrence and local lymph node metastasis. Vasculogenic mimicry (VM) is an altern...

    Authors: Wei Wang, Peng Lin, Chunrong Han, Wenjuan Cai, Xiulan Zhao and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:60
    Content type: Research Published on:

  44. Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to ...

    Authors: Jie Yin, Guowei Chen, Yucun Liu, Si Liu, Pengyuan Wang, Yuanlian Wan, Xin Wang, Jing Zhu and Hongqiao Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:59
    Content type: Research Published on:

  45. Although the addition of bevacizumab to 1st line chemotherapy provides a significant survival benefit for advanced colorectal cancer, the magnitudes of both advantages and toxicities have not been extensively inv...

    Authors: Fotios Loupakis, Emilio Bria, Vanja Vaccaro, Federica Cuppone, Michele Milella, Paolo Carlini, Chiara Cremolini, Lisa Salvatore, Alfredo Falcone, Paola Muti, Isabella Sperduti, Diana Giannarelli and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:58
    Content type: Research Published on:

  46. Constitutively decreased TGFBR1 allelic expression is emerging as a potent modifier of colorectal cancer risk in mice and humans. This phenotype was first observed in mice, then in lymphoblastoid cell lines from ...

    Authors: Boris Pasche, Kari B Wisinski, Maureen Sadim, Virginia Kaklamani, Michael J Pennison, Qinghua Zeng, Naresh Bellam, Jacquelyn Zimmerman, Nengjun Yi, Kui Zhang, John Baron, Daniel O Stram and M Geoffrey Hayes
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:57
    Content type: Research Published on:

  47. VEGF is a well-validated target for antiangiogenic intervention in cancer. To date, RNAi technology has been proven to be a promising approach for targeted therapy. DDP is frequently used as a first-line drug ...

    Authors: Yong P Ma, Yang Yang, Shuang Zhang, Xiang Chen, Na Zhang, Wei Wang, Zhi X Cao, Yu Jiang, Xia Zhao, Yu Q Wei and Hong X Deng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:56
    Content type: Research Published on:

  48. It has been demonstrated that certain NK-1 antagonists could reduce proliferation of several cancer cell lines, however, it is unknown whether SR140333 exerts proliferation inhibition in breast cancer cell line.

    Authors: Wei-Qing Huang, Ji-Gang Wang, Lei Chen, Hong-Jun Wei and Hua Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:55
    Content type: Research Published on:

  49. DNA-damage-inducible transcript 3 (DDIT3), a candidate tumor suppressor gene (TSG), has been found involved in the regulation of cellular growth and differentiation. The epigenetic changes of TSGs are recently re...

    Authors: Ya-li Wang, Jun Qian, Jiang Lin, Dong-ming Yao, Zhen Qian, Zhao-hui Zhu and Jian-yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:54
    Content type: Research Published on:

  50. MUC5AC is a secretory mucin normally expressed in the surface muconous cells of stomach and bronchial tract. It has been known that MUC5AC de novo expression occurred in the invasive ductal carcinoma and pancreat...

    Authors: Sadaaki Yamazoe, Hiroaki Tanaka, Tetsuji Sawada, Ryosuke Amano, Nobuya Yamada, Masaichi Ohira and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:53
    Content type: Research Published on:

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 11.4
    5-year Journal Impact Factor: 11.4
    Source Normalized Impact per Paper (SNIP): 1.770
    SCImago Journal Rank (SJR): 2.806

    Speed 2023
    Submission to first editorial decision (median days): 5
    Submission to acceptance (median days): 100

    Usage 2023
    Downloads: 3,003,080
    Altmetric mentions: 3,022

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us