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  1. Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of ce...

    Authors: Roberta Visconti, Rosa Della Monica and Domenico Grieco
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:153
    Content type: Review Published on:

  2. Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcin...

    Authors: Jian Gao, Camilla H. Ulekleiv and Trond S. Halstensen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:151
    Content type: Research Published on:

  3. Breast cancer is one of the leading cause of cancer-related deaths in women worldwide and increasing rapidly in developing countries. In the present study, we investigated the potential role and association of...

    Authors: Nirmala Jagadish, Sumit Agarwal, Namita Gupta, Rukhsar Fatima, Sonika Devi, Vikash Kumar, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya and Anil Suri
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:150
    Content type: Research Published on:

  4. Hsp90 proteins are important therapeutic targets for many anti-cancer drugs in clinical trials. Geldanamycin (GA) was identified as the first natural inhibitor of Hsp90, increasing evidence suggests that GA wa...

    Authors: Zhirui Zhang, Hong-Mei Li, Can Zhou, Qixiang Li, Linyan Ma, Zixuan Zhang, Yiming Sun, Lirong Wang, Xudong Zhang, Bing Zhu, Young-Soo Hong, Cheng-Zhu Wu and Hao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:149
    Content type: Research Published on:

  5. Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate its biological fun...

    Authors: Guohe Song, Shifeng Xu, Hong Zhang, Yupeng Wang, Chao Xiao, Tao Jiang, Leilei Wu, Tao Zhang, Xing Sun, Lin Zhong, Chongzhi Zhou, Zhaowen Wang, Zhihai Peng, Jian Chen and Xiaoliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:148
    Content type: Research Published on:

  6. Chemo-resistance is still a major obstacle in efforts to overcome acute myeloid leukemia (AML). An emerging concept has proposed that interactions between the bone marrow (BM) microenvironment and leukemia cel...

    Authors: Yuanmei Zhai, Jing Zhang, Hui Wang, Wei Lu, Sihong Liu, Yehua Yu, Wei Weng, Zhiyong Ding, Qi Zhu and Jun Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:147
    Content type: Research Published on:

  7. We have previously shown that the eukaryotic elongation factor subunit 1B gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit “C” (POLR2C), alone or complexed, in the pol II enzyme....

    Authors: Cinzia Pisani, Annalisa Onori, Francesca Gabanella, Francesca Delle Monache, Antonella Borreca, Martine Ammassari-Teule, Maurizio Fanciulli, Maria Grazia Di Certo, Claudio Passananti and Nicoletta Corbi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:146
    Content type: Research Published on:

  8. The recently identified phenomenon of double-stranded RNA (dsRNA)-mediated gene activation (RNAa) has been studied extensively, as it is present in humans, mice, and Caenorhabditis elegans, suggesting that dsRNA-...

    Authors: Huan-Lei Wu, Sen-Mao Li, Jia Hu, Xiao Yu, Hua Xu, Zhong Chen and Zhang-Qun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:145
    Content type: Research Published on:

  9. WNT5A (-/-) mammary tissue has been shown to exhibit increased ductal elongation, suggesting elevated mammary cell migration. Increased epithelial cell migration/invasion has often but not always been linked t...

    Authors: Chandra Prakash Prasad, Shivendra Kumar Chaurasiya, William Guilmain and Tommy Andersson
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:144
    Content type: Research Published on:

  10. Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) a...

    Authors: Yohei Takeda, Masahiro Azuma, Misako Matsumoto and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:143
    Content type: Research Published on:

  11. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the role and molecular mechanism of lncRNA XIST in gastric cancer is still unknown.

    Authors: Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu, Le-zong Chen, Zhao-lei Zeng, Dong-sheng Zhang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, De-shen Wang, Da-zhi Xu, Zhi-wei Zhou, Helene Pelicano, Peng Huang, Dan Xie, Feng-hua Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:142
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:208

  13. Interleukin-1 receptor associated kinase 1 (IRAK1), as a down-stream of toll-like receptor (TLR) signaling, plays important roles in series of malignancies. However, the role of IRAK1 in hepatocellular carcino...

    Authors: Ning Li, Jinhua Jiang, Jing Fu, Ting Yu, Bibo Wang, Wenhao Qin, An Xu, Mengchao Wu, Yao Chen and Hongyang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:140
    Content type: Research Published on:

  14. Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on its severity. Oxidative st...

    Authors: Udensi K. Udensi and Paul B. Tchounwou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:139
    Content type: Review Published on:

  15. Increased exposure to multitargeted kinase inhibitor sunitinib is associated with improved outcome, emphasizing the importance of maintaining adequate dosing and drug levels. The currently approved schedule (5...

    Authors: Maria Rovithi, Richard R. de Haas, Richard J. Honeywell, Dennis Poel, Godefridus J. Peters, Arjan W. Griffioen and Henk M. W. Verheul
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:138
    Content type: Research Published on:

  16. The antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death in cancer cells, including metastatic melanoma cells. However, the dose of Pyrimethamine t...

    Authors: Chiara Tommasino, Lucrezia Gambardella, Maria Buoncervello, Roger J. Griffin, Bernard T. Golding, Manuela Alberton, Daniele Macchia, Massimo Spada, Bruna Cerbelli, Giulia d’Amati, Walter Malorni, Lucia Gabriele and Anna Maria Giammarioli
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:137
    Content type: Research Published on:

  17. Mutations in the p53 oncosuppressor gene are highly frequent in human cancers. These alterations are mainly point mutations in the DNA binding domain of p53 and disable p53 from transactivating target genes de...

    Authors: Alessia Garufi, Giuseppa Pistritto, Mara Cirone and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:136
    Content type: Research Published on:

  18. Variant ATM heterozygotes have an increased risk of developing cancer, cardiovascular diseases, and diabetes. Costs and time of sequencing and ATM variant complexity make large-scale, general population screening...

    Authors: Andrea Prodosmo, Amelia Buffone, Manlio Mattioni, Agnese Barnabei, Agnese Persichetti, Aurora De Leo, Marialuisa Appetecchia, Arianna Nicolussi, Anna Coppa, Salvatore Sciacchitano, Carolina Giordano, Paola Pinnarò, Giuseppe Sanguineti, Lidia Strigari, Gabriele Alessandrini, Francesco Facciolo…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:135
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:185

  19. Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leuke...

    Authors: Hui Li, Zhenglan Huang, Miao Gao, Ningshu Huang, Zhenhong Luo, Huawei Shen, Xin Wang, Teng Wang, Jing Hu and Wenli Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:134
    Content type: Research Published on:

  20. The effects of PIM-1 on the progression of pancreatic cancer remain unclear, and the prognostic value of PIM-1 levels in tissues is controversial. Additionally, the expression levels and clinical value of PIM-...

    Authors: Jianwei Xu, Guangbing Xiong, Zhe Cao, Hua Huang, Tianxiao Wang, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Taiping Zhang and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:133
    Content type: Research Published on:

  21. In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expressi...

    Authors: Peixin Dong, Ying Xiong, Hidemichi Watari, Sharon J. B. Hanley, Yosuke Konno, Kei Ihira, Takahiro Yamada, Masataka Kudo, Junming Yue and Noriaki Sakuragi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:132
    Content type: Research Published on:

  22. Hepatocellular carcinoma (HCC) is associated with inflammation, and roughly 30 % of the global population shows serological evidence of current or past infection with hepatitis B or hepatitis C virus. Resident...

    Authors: Lingxiang Kong, Yongjie Zhou, Hong Bu, Tao Lv, Yujun Shi and Jiayin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:131
    Content type: Research Published on:

  23. Integrin-linked kinase (ILK) is a multifunctional adaptor protein which is involved with protein signalling within cells to modulate malignant (cancer) cell movement, cell cycle, metastasis and epithelial–mese...

    Authors: Xiang Zhuang, Mengxin Lv, Zhenyu Zhong, Luyu Zhang, Rong Jiang and Junxia Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:130
    Content type: Research Published on:

  24. In addition to treating acute promyelocytic leukemia, arsenic trioxide (ATO) suppresses other solid tumors, including chondrosarcoma. However, the effects of ATO on metastasis in chondrosarcoma cells, and the ...

    Authors: Xing Bao, Tingting Ren, Yi Huang, Shidong Wang, Fan Zhang, Kuisheng Liu, Bingxin Zheng and Wei Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:129
    Content type: Research Published on:

  25. Brain stereotactic biopsy (SB) followed by conventional histopathology and immunohistochemistry (IHC) is the gold standard approach for primary central nervous system lymphoma (PCNSL) diagnosis. Flow cytometry...

    Authors: Iole Cordone, Serena Masi, Mariantonia Carosi, Antonello Vidiri, Francesco Marchesi, Mirella Marino, Stefano Telera, Alessia Pasquale, Andrea Mengarelli, Laura Conti, Edoardo Pescarmona, Andrea Pace and Carmine M. Carapella
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:128
    Content type: Research Published on:

  26. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. The average survival and 5-year survival rates of HCC patients still remains poor. Thus, there is an urgent need to better un...

    Authors: Fuqiang Yin, Lipei Shu, Xia Liu, Ting Li, Tao Peng, Yueli Nan, Shu Li, Xiaoyun Zeng and Xiaoqiang Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:127
    Content type: Research Published on:

  27. The heregulin-1ß/HER3-driven pathway is implicated in several epithelial malignancies and its blockade is currently undergoing clinical investigation. Paradoxically, the status and the regulation of this pathw...

    Authors: Corina Buta, Eva Benabou, Marie Lequoy, Hélène Régnault, Dominique Wendum, Fatiha Merabtene, Hamza Chettouh, Lynda Aoudjehane, Filomena Conti, Yves Chrétien, Olivier Scatton, Olivier Rosmorduc, Françoise Praz, Laetitia Fartoux and Christèle Desbois-Mouthon
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:126
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:154

  28. Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression...

    Authors: Anbang He, Yuchen Liu, Zhicong Chen, Jianfa Li, Mingwei Chen, Li Liu, Xinhui Liao, Zhaojie Lv, Yonghao Zhan, Chengle Zhuang, Junhao Lin, Weiren Huang and Hongbing Mei
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:125
    Content type: Research Published on:

  29. Malignant gliomas are the most common primary brain tumors in adults and challenging cancers for diagnosis and treatment. They remain a disease for which non-invasive, diagnostic and/or prognostic novel biomar...

    Authors: Giulia Regazzo, Irene Terrenato, Manuela Spagnuolo, Mariantonia Carosi, Gaetana Cognetti, Lucia Cicchillitti, Francesca Sperati, Veronica Villani, Carmine Carapella, Giulia Piaggio, Andrea Pelosi and Maria Giulia Rizzo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:124
    Content type: Research Published on:

  30. Resistance to anticancer agents is a major obstacle for successful chemotherapy in tongue squamous cancer. Sam68 is an oncogenic-related protein in oral tongue squamous cell carcinoma functions as a signaling ...

    Authors: Shuwei Chen, Huan Li, Shimin Zhuang, Ji Zhang, Fan Gao, Xidi Wang, WenKuan Chen and Ming Song
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:123
    Content type: Research Published on:

  31. The most abundant cells in the extensive desmoplastic stroma of pancreatic adenocarcinomas are the pancreatic stellate cells, which interact with the carcinoma cells and strongly influence the progression of t...

    Authors: Vegard Tjomsland, Dagny Sandnes, Ewa Pomianowska, Smiljana Torbica Cizmovic, Monica Aasrum, Ingvild Johnsen Brusevold, Thoralf Christoffersen and Ivar P. Gladhaug
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:122
    Content type: Research Published on:

  32. The advent of targeted therapeutics in human cancer has begun to find novel druggable targets and, in this context, the endothelin-1 receptor (ET-1R), namely ETA receptor (ETAR) and ETB receptor, among the GPCR f...

    Authors: Laura Rosanò and Anna Bagnato
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:121
    Content type: Review Published on:

  33. Claudin-6 (CLDN6), a member of claudin transmembrane protein family, has recently been reported to be undetectable or at low levels in human breast cancer cell lines and tissues and plays a role in suppression...

    Authors: Yafang Liu, Xiangshu Jin, Yanru Li, Yang Ruan, Yan Lu, Minlan Yang, Dongjing Lin, Peiye Song, Yantong Guo, Shuai Zhao, Bing Dong, Yinping Xie, Qihua Dang and Chengshi Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:120
    Content type: Research Published on:

  35. Human T-cell leukemia virus (HTLV-1) is a lymphotropic retrovirus associated to adult T cell leukemia (ATL) and to non-neoplastic inflammatory conditions affecting the central nervous system, lung or skin. The...

    Authors: Maria Pia Fuggetta, Valentina Bordignon, Andrea Cottarelli, Beatrice Macchi, Caterina Frezza, Paola Cordiali-Fei, Fabrizio Ensoli, Stefania Ciafrè, Francesca Marino-Merlo, Antonio Mastino and Giampietro Ravagnan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:118
    Content type: Research Published on:

  36. Low nutrient environment is a major obstacle to solid tumor growth. However, many tumors have developed adaptive mechanisms to circumvent the requirement for exogenous growth factors.

    Authors: Xin Li, Guizhong Zhang, Qian Chen, Yingxue Lin, Junxin Li, Qingguo Ruan, Youhai Chen, Guang Yu and Xiaochun Wan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:117
    Content type: Research Published on:

  37. Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer...

    Authors: Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino and Alessandra Micera
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:116
    Content type: Review Published on:

  38. Synaptojanin 2 Binding Protein (SYNJ2BP) is essential to cell proliferation. Previous studies show that SYNJ2BP participates in sprouting angiogenesis, which plays an important part in several abnormal conditi...

    Authors: Xiao Liu, Jiangjiao Zhou, Ning Zhou, Jianwei Zhu, Yong Feng and Xiongying Miao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:115
    Content type: Research Published on:

  39. It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory cytokines to facilitate the development of radiation-induced liver disease. However, little is known on whether ...

    Authors: Yinying Dong, Xiaoyun Shen, Mingyan He, Zhifeng Wu, Qiongdan Zheng, Yaohui Wang, Yuhan Chen, Sifan Wu, Jiefeng Cui and Zhaochong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:114
    Content type: Research Published on:

  40. Osteosarcoma is the most common primary malignancy of bone. Its treatment relies on the administration of neoadjuvant and adjuvant chemotherapy combined with surgery. Alternative to common intravenous (i.v.) a...

    Authors: Bernhard Robl, Sander Martijn Botter, Giovanni Pellegrini, Olga Neklyudova and Bruno Fuchs
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:113
    Content type: Research Published on:

  41. Polyphyllin I (PPI), a bioactive phytochemical extracted from the Rhizoma of Paris polyphylla, has been reported to exhibit anti-cancer activity. However, the detailed mechanism underlying this remains to be eluc...

    Authors: Longmei Li, JingJing Wu, Fang Zheng, Qing Tang, WanYin Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:112
    Content type: Research Published on:

  42. Nestin expression has been reported to be associated with the prognosis of many solid tumors including human hepatocellular carcinoma (HCC). The present study aimed to identify the role, if any, of Nestin in t...

    Authors: Yan Zhang, Shan Zeng, Junli Ma, Ganlu Deng, Yanlin Qu, Cao Guo and Hong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:111
    Content type: Research Published on:

  43. 1-methylnicotinamide (1-MNA), an endogenous metabolite of nicotinamide, has recently gained interest due to its anti-inflammatory and anti-thrombotic activities linked to the COX-2/PGI2 pathway. Given the previou...

    Authors: Agnieszka Blazejczyk, Marta Switalska, Stefan Chlopicki, Andrzej Marcinek, Jerzy Gebicki, Marcin Nowak, Anna Nasulewicz-Goldeman and Joanna Wietrzyk
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:110
    Content type: Research Published on:

  44. Metastasis remains the major cause of death in nasopharyngeal carcinoma (NPC). Yippee-like 3 (YPEL3) plays an important role in tumorigenesis. However, its function and mechanism in NPC has not been systematic...

    Authors: Jian Zhang, Xin Wen, Xian-Yue Ren, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Na Liu and Jun Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:109
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:214

  45. Activating transcription factor 2 (ATF2) is a basic helix-loop-helix transcription factor, which has been shown to participate in the pathobiology of numerous cancers. However, the role of ATF2 in renal cell c...

    Authors: Deng-shuang Wu, Cheng Chen, Zhen-jie Wu, Bing Liu, Li Gao, Qing Yang, Wei Chen, Jun-ming Chen, Yi Bao, Le Qu and Lin-hui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:108
    Content type: Research Published on:

  46. HM-3 is a polypeptide inhibiting angiogenesis. Recent reports suggest that the antitumor effect of angiogenesis inhibitors administered alone might be limited. Cancer stem cells can survive the lack of oxygen ...

    Authors: Changhong Zhao, Junjin He, Haoran Cheng, Zhaohao Zhu and Hanmei Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:107
    Content type: Research Published on:

  47. Interleukin-9 (IL-9) was discovered as a helper T cell growth factor. It has long been recognized as an important regulator in allergic inflammation. Recent years it was discovered to induce cell growth and di...

    Authors: Xiao Lv, Lili Feng, Xueling Ge, Kang Lu and Xin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:106
    Content type: Research Published on:

  48. The prognosis of non-small-cell lung cancer (NSCLC) is poor yet mechanistic understanding and therapeutic options remain limited. We investigated the biological and clinical significance of microRNA-130b and i...

    Authors: Jianwei Tian, Liping Hu, Xiao Li, Jian Geng, Meng Dai and Xiaoyan Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:105
    Content type: Research Published on:

  49. The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outc...

    Authors: Alessandra Fabi, Paola Malaguti, Sabrina Vari and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:104
    Content type: Review Published on:

  50. The role of immune response is emerging as a key factor in the complex multistep process of cancer. Tumor microenvironment contains different types of immune cells, which contribute to regulate the fine balanc...

    Authors: Laura Paladini, Linda Fabris, Giulia Bottai, Carlotta Raschioni, George A. Calin and Libero Santarpia
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:103
    Content type: Review Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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