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  1. Activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) presents aggressive clinical courses and poor prognosis. Targeting key pathways may raise the possibility of improving clinical outcomes.

    Authors: Zhen Jin, Kai Qing, Yuan Ouyang, Zhao Liu, Wenfang Wang, Xiaoyang Li, Zizhen Xu and Junmin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:52
    Content type: Research Published on:

  2. CC-chemokine receptor 7 (CCR7), which plays an important role in cell directional movement, is highly expressed in various cancers and positively related to lymph node metastasis. The inflammatory cytokine tum...

    Authors: HaiJie Hong, CaiLong He, SiYuan Zhu, YanHui Zhang, XiaoQian Wang, FeiFei She and YanLing Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:51
    Content type: Research Published on:

  3. The aim of this analysis was to investigate the potential impact of Ki67 assay in a series of patients affected by early stage invasive lobular carcinoma (ILC) undergone surgery.

    Authors: Luisa Carbognin, Isabella Sperduti, Matteo Brunelli, Lisa Marcolini, Rolando Nortilli, Sara Pilotto, Ilaria Zampiva, Sara Merler, Elena Fiorio, Elisa Filippi, Erminia Manfrin, Francesca Pellini, Franco Bonetti, Giovanni Paolo Pollini, Giampaolo Tortora and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:50
    Content type: Research Published on:

  4. The achievement of complete response (CR) significantly correlates with a better clinical outcome in multiple myeloma (MM) patients treated with autologous stem cell transplant (ASCT). The depth of response is...

    Authors: Iole Cordone, Francesco Marchesi, Serena Masi, Valentina Summa, Francesco Pisani, Roberta Merola, Giovanni Cigliana, Giulia Orlandi, Svitlana Gumenyuk, Francesca Palombi, Atelda Romano, Antonio Spadea, Daniela Renzi, Elena Papa, Marco Canfora, Laura Conti…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:49
    Content type: Research Published on:

  5. Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. An isoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed t...

    Authors: Koichi Fujisawa, Shuji Terai, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki, Toshihiko Matsumoto, Kazuhito Yamaguchi, Yuji Owada, Hiroshi Nishina, Takafumi Noma and Isao Sakaida
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:48
    Content type: Research Published on:

  6. MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive.

    Authors: Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang and Jin-Shui Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:47
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:61

  7. Progressive loss of skeletal muscle, termed muscle wasting, is a hallmark of cancer cachexia and contributes to weakness, reduced quality of life, as well as poor response to therapy. Previous studies have ind...

    Authors: Xiu-yan Huang, Zi-li Huang, Ju-hong Yang, Yong-hua Xu, Jiu-Song Sun, Qi Zheng, Chunyao Wei, Wei Song and Zhou Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:46
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:77

  8. A widespread decrease of mature microRNAs is often observed in human malignancies giving them potential to act as tumor suppressors. Thus, microRNAs may be potential targets for cancer therapy. The global miRN...

    Authors: Aymone Gurtner, Emmanuela Falcone, Francesca Garibaldi and Giulia Piaggio
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:45
    Content type: Review Published on:

  9. Ewing’s sarcoma is an aggressive bone and soft tissue tumor with a high incidence in children and adolescents. Due to its high malignancy and poor prognosis, identification of novel biomarkers for intervention...

    Authors: Chongmin Ren, Tingting Ren, Kang Yang, Shidong Wang, Xing Bao, Fan Zhang and Wei Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:44
    Content type: Research Published on:

  10. Acting as inflammatory mediators, tumor oncogenes or suppressors, microRNAs are involved in cell survival, death, epithelial–mesenchymal transition and metastasis, etc. Investigating the communication between ...

    Authors: Yudan Chi and Dongming Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:43
    Content type: Review Published on:

  11. Mortalin/GRP75 is a ubiquitous mitochondrial chaperone which related to the cytosolic heat shock protein 70 (HSP70), and plays a role in carcinogenesis. This study aims to investigate the Mortalin expression i...

    Authors: Haidan Jin, Meiying Ji, Liyan Chen, Qixiang Liu, Shuanlong Che, Ming Xu and Zhenhua Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:42
    Content type: Research Published on:

  12. N-Hydroxyphthalimide (NHPI), an important chemical raw material, was found to have potent and selective anti-proliferative effect on human breast carcinoma BT-20 cells, human colon ade...

    Authors: Min Wang, Ankun Zhou, Tao An, Lingmei Kong, Chunlei Yu, Jianmei Liu, Chengfeng Xia, Hongyu Zhou and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:41
    Content type: Research Published on:

  13. Atractylenolide I (ATR-1), an active component of Rhizoma Atractylodis Macrocephalae, possesses cytotoxicity against various carcinomas. However, little is known about the effects of ATR-1on bladder cancer. In th...

    Authors: Rui Yu, Bi-xia Yu, Jun-feng Chen, Xiu-yi Lv, Ze-jun Yan, Yue Cheng and Qi Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:40
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:249

  14. Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote tumor development and to be a good target for cancer treatment. Most studies to date have used human mesothel...

    Authors: Emmanuel Zervos, Steven Agle, Andrew G. Freistaedter, Gwendolyn J. B. Jones and Rachel L. Roper
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:39
    Content type: Research Published on:

  15. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Recurrence and metastasis after curative resection remain critical obstacles in HCC treatment. CD146 predicted p...

    Authors: Guoqing Jiang, Long Zhang, Qin Zhu, Dousheng Bai, Chuanyong Zhang and Xuehao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:38
    Content type: Research Published on:

  16. KDM5B is a jmjc domain-containing histone demethylase which remove tri-, di-, and monomethyl groups from histone H3 lysine 4 (H3K4). KDM5B has been determined as an oncogene in many malignancies. However, its ...

    Authors: Dong Wang, Sheng Han, Rui Peng, Chenyu Jiao, Xing Wang, Xinxiang Yang, Renjie Yang and Xiangcheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:37
    Content type: Research Published on:

  17. Aquaporins (AQP) are water channel proteins that enable fluid fluxes across cell membranes, important for homeostasis of the tissue environment and for cell migration. AQP1 knockout mouse models of human cance...

    Authors: Hilary S. Dorward, Alice Du, Maressa A. Bruhn, Joseph Wrin, Jinxin V. Pei, Andreas Evdokiou, Timothy J. Price, Andrea J. Yool and Jennifer E. Hardingham
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:36
    Content type: Research Published on:

  18. Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common and is strongly associated with mortality. It is therefore critical to identify new targe...

    Authors: Xiaodong Feng, Yuchen Jiang, Liang Xie, Lu Jiang, Jing Li, Chongkui Sun, Hao Xu, Ruinan Wang, Min Zhou, Yu Zhou, Hongxia Dan, Zhiyong Wang, Ning Ji, Peng Deng, Ga Liao, Ning Geng…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:35
    Content type: Research Published on:

  19. Biochemical recurrence (BCR) is widely used to define the treatment success and to make decisions on if or how to initiate a secondary therapy, but uniform criteria to define BCR after radical prostatectomy (R...

    Authors: Xuechao Wan, Shu Yang, Wenhua Huang, Denglong Wu, Hongbing Chen, Ming Wu, Junliang Li, Tao Li and Yao Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:34
    Content type: Research Published on:

  20. Interactions of inflammatory cells with pancreatic cancer cells play crucial roles in pancreatic cancer, however the dynamic changes of inflammatory cell populations in pancreatic cancerogensis and after chemo...

    Authors: Qiaofei Liu, Yuan Li, Zheyu Niu, Yi Zong, Mengyi Wang, Lutian Yao, Zhaohui Lu, Quan Liao and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:33
    Content type: Research Published on:

  21. Glioblastoma is the most common and deadly primary brain tumor in adults. Low-dose,metronomic (LDM) temozolomide (TMZ) displays improved efficacy in the treatment of glioblastoma by targeting angiogenesis, but...

    Authors: Caixing Sun, Yang Yu, Lizhen Wang, Bin Wu, Liang Xia, Fang Feng, Zhiqiang Ling and Shihua Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:32
    Content type: Research Published on:

  22. It has been proposed that cyclin G1 (CCNG1) participates in p53-dependent G1–S and G2 checkpoints and might function as an oncogenic protein in the initiation and metastasis of ovarian carcinoma. MicroRNA 23b (mi...

    Authors: Jing Yan, Jing-yi Jiang, Xiao-Na Meng, Yin-Ling Xiu and Zhi-Hong Zong
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:31
    Content type: Research Published on:

  24. Leucine-rich-alpha-2-glycoprotein 1 (LRG1) has been reported to be involved in several tumors, whether it participates in colorectal cancer (CRC) progression remains unclear. Here, we investigated the biologic...

    Authors: Jingjing Zhang, Lingyin Zhu, Jingyuan Fang, Zhizheng Ge and Xiaobo Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:29
    Content type: Research Published on:

  26. Previous studies have investigated the sustained aberrantly activated Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is crucial for pancreatic cancer growth a...

    Authors: Li Huang, Bin Hu, Jianbo Ni, Jianghong Wu, Weiliang Jiang, Congying Chen, Lijuan Yang, Yue Zeng, Rong Wan, Guoyong Hu and Xingpeng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:27
    Content type: Research Published on:

  27. Epithelial-mesenchymal transition (EMT) is a dedifferentiation process that mainly involves in mesenchymal marker upregulation, epithelial maker downregulation and cell polarity loss. Related hypoxia factors p...

    Authors: Jian Yang, Xu Zhang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Ye Li, Yanbo Zhu, Dechun Li and Jian Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:26
    Content type: Research Published on:

  28. The importance of individual microRNAs (miRNAs) in tumor has been established in different cancers. However, their association with tumor chemoresistance has not been fully understood. Previously, we found two...

    Authors: Lin Zhao, Yan Wang, Longyang Jiang, Miao He, Xuefeng Bai, Lifeng Yu and Minjie Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:25
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:94

  29. Granzyme B (GrB) is a serine protease, traditionally known as expressed by cytotoxic lymphocytes to induce target cell apoptosis. However, it is emerging that GrB, being also produced by a variety of normal an...

    Authors: Donatella D’Eliseo, Giuliana Di Rocco, Rossella Loria, Silvia Soddu, Angela Santoni and Francesca Velotti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:24
    Content type: Research Published on:

  30. Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies ...

    Authors: Yuanliang Yan, Zhijie Xu, Shuang Dai, Long Qian, Lunquan Sun and Zhicheng Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:23
    Content type: Review Published on:

  31. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays key role in the progression of some human cancers. However, the role of NEAT1 in human laryngeal squamous cell cancer (LSCC) is still ...

    Authors: Peng Wang, Tianyi Wu, Han Zhou, Qianqian Jin, Guoqing He, Haoyang Yu, Lijia Xuan, Xin Wang, Linli Tian, Yanan Sun, Ming Liu and Lingmei Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:22
    Content type: Research Published on:

  32. Growing evidence suggests that Wnt/β-catenin pathway plays an important role in CRC development, progression and metastasis. Aberrant miR-224 expression has been reported in CRC. However, the mechanism of miR-...

    Authors: Tingting Li, Qiuhua Lai, Shuyang Wang, Juanjuan Cai, Zhiyuan Xiao, Danling Deng, Liuqing He, Hongli Jiao, Yaping Ye, Li Liang, Yanqing Ding and Wenting Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:21
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:143

  33. Authors: Yiting Tang, Yayun Cui, Zengpeng Li, Zhuqing Jiao, Yong Zhang, Yan He, Guangxia Chen, Qunyan Zhou, Wenjie Wang, Xifa Zhou, Judong Luo and Shuyu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:20
    Content type: Erratum Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:7

  34. Emerging evidence demonstrates that microRNAs (miRNAs) play an important role in regulation of cell growth, invasion and metastasis through inhibiting the expression of their targets. It has been reported that...

    Authors: Yang Liu, Yumei Li, Rui Wang, Shukui Qin, Jing Liu, Fang Su, Yan Yang, Fuyou Zhao, Zishu Wang and Qiong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:19
    Content type: Research Published on:

  35. Dendritic cells (DCs) have been used successfully in clinical pilot studies. However, tumor-specific immunity and clinical responses were only induced in certain cancer patients. It has been well documented th...

    Authors: Fan-Qin Wei, Wei Sun, Thian-Sze Wong, Wei Gao, Yi-Hui Wen, Jia-Wei Wei, Yi Wei and Wei-Ping Wen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:18
    Content type: Research Published on:

  36. MicroRNAs (miRNAs) have been shown to play a critical role in the development and progression of nasopharyngeal carcinoma (NPC). Although accumulating studies have been performed on the molecular mechanisms of...

    Authors: Fan Wang, Juan Lu, Xiaohong Peng, Jie Wang, Xiong Liu, Xiaomei Chen, Yiqi Jiang, Xiangping Li and Bao Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:17
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:84

  37. Neuropilin-1 (NRP-1) is a transmembrane glycoprotein participating in the growth and metastasis of cancer cells as multifunctional co-receptors by interacting with the signaling pathways. However, its role in ...

    Authors: Linhao Li, Xian Jiang, Qian Zhang, Xuesong Dong, Yuqiang Gao, Yuanlong He, Haiquan Qiao, Fangyu Xie, Xiangjun Xie and Xueying Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:16
    Content type: Research Published on:

  38. HOXA1 is a member of the Homeobox gene family, which encodes a group of highly conserved transcription factors that are important in embryonic development. However, it has been reported that HOXA1 exhibits onc...

    Authors: Chenwei Yuan, Xingwu Zhu, Yang Han, Chenlong Song, Chenchen Liu, Su Lu, Meng Zhang, Fudong Yu, Zhihai Peng and Chongzhi Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:15
    Content type: Research Published on:

  39. The aberrant expression of sperm-associated antigen 9 (SPAG9) is associated with numerous cancers, including hepatocellular carcinoma (HCC). The exploration of molecules and mechanisms regulating SPAG9 express...

    Authors: Guohua Lou, Xuejun Dong, Caixia Xia, Bingjue Ye, Qiuyue Yan, Shanshan Wu, Ye Yu, Feifei Liu, Min Zheng, Zhi Chen and Yanning Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:14
    Content type: Research Published on:

  40. Interleukin-37 (IL-37), a newly identified member of the IL-1 family, has been known to play an immunosuppressive role in a variety of inflammatory disorders, but whether it participates in the regulation of p...

    Authors: Guanqun Ge, Aiqin Wang, Jingyue Yang, Yan Chen, Jin Yang, Yize Li and Yan Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:13
    Content type: Research Published on:

  41. Both tumor-associated macrophages (TAMs) and the epithelial to mesenchymal transition (EMT) of cancer cells play key roles in promoting tumor progression. However, whether TAMs could induce EMT in the progress...

    Authors: Yong Hu, Meng-Ying He, Li-Fang Zhu, Cong-Chong Yang, Mei-Ling Zhou, Qiong Wang, Wei Zhang, Yang-Yu Zheng, Dong-Miao Wang, Zeng-Qi Xu, Yu-Nong Wu and Lai-Kui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:12
    Content type: Research Published on:

  42. MicroRNA-106b (miR-106b) was recently identified as an oncogene participating in cancer progression. Transforming growth factor β1(TGF-β1) is an indispensable cytokine regulating the local microenvironment, th...

    Authors: Yuan Cheng, Yanli Guo, Youyi Zhang, Ke You, Zijian Li and Li Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:11
    Content type: Research Published on:

  43. MicroRNAs (miRNAs) are a class of small non-coding RNAs, which post-transcriptionally repress the expression of genes involved in cancer initiation and progression. Although some miRNAs that target many signal...

    Authors: Xiaochun Sun, Manhua Cui, Aichen Zhang, Lingling Tong, Kun Wang, Kai Li, Xue Wang, Ziqian Sun and Hongye Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:10
    Content type: Research Published on:

  44. In this study we explored the role of microRNAs (miRNAs) as mediators of leukemogenic effects of the fusion gene MLL-AF9, which results from a frequent chromosomal translocation in infant and monoblastic acute my...

    Authors: Katrin K. Fleischmann, Philipp Pagel, Julia von Frowein, Thomas Magg, Adelbert A. Roscher and Irene Schmid
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:9
    Content type: Research Published on:

  45. In spite of progress in diagnostics and treatment of Hepatocellular Carcinoma (HCC), its prognosis remains poor, and improved treatment strategies for HCC require detailed understanding of the underlying mecha...

    Authors: Lei Chang, Cuicui Li, Tao Guo, Haitao Wang, Weijie Ma, Yufeng Yuan, Quanyan Liu, Qifa Ye and Zhisu Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:8
    Content type: Research Published on:

  46. Lung cancer has long been the most dangerous malignant tumor among males in both well developed and poorly developed countries. Radiotherapy plays a critical role in the curative management of inoperable non-s...

    Authors: Yiting Tang, Yayun Cui, Zengpeng Li, Zhuqing Jiao, Yong Zhang, Yan He, Guangxia Chen, Qunyan Zhou, Wenjie Wang, Xifa Zhou, Judong Luo and Shuyu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:7
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:20

  47. While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis...

    Authors: Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers and Nobuhiko Oridate
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:6
    Content type: Research Published on:

  48. Grb2-associated binder 2 (Gab2), a scaffolding adaptor protein, has recently been implicated in cancer progression. However, the role of Gab2 in the progression and metastasis of colorectal cancer (CRC) remain...

    Authors: Chenbo Ding, Junmin Luo, Longmei Li, Shanshan Li, Liwen Yang, Hongfei Pan, Qianyi Liu, Huan Qin, Chao Chen and Jihong Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:5
    Content type: Research Published on:

  49. Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal and adult tissues but its...

    Authors: Louiza Belkacemi and Shaun Xiaoliu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:4
    Content type: Review Published on:

  50. The synthetic biology technology which enhances the specificity and efficacy of treatment is a novel try in biomedical therapy during recent years. A high frequency of somatic mutations was shown in the human ...

    Authors: Li Liu, Yuchen Liu, Tianbiao Zhang, Hanwei Wu, Muqi Lin, Chaoliang Wang, Yonghao Zhan, Qing Zhou, Baoping Qiao, Xiaojuan Sun, Qiaoxia Zhang, Xiaoqiang Guo, Guoping Zhao, Weixing Zhang and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:3
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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