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  1. An increasing body of evidence now implicates acetaldehyde as a major underlying factor for the carcinogenicity of alcoholic beverages and especially for oesophageal and oral cancer. Acetaldehyde associated wi...

    Authors: Dirk W Lachenmeier and Yulia B Monakhova
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:3
    Content type: Research Published on:

  2. Anticancer activities of several substituted naphthalimides (1H-benz[de]isoquinoline-1,3-diones) are well documented. Some of them have undergone Phase I-II clinical trials. Presently a series of ten N-(hydrox...

    Authors: Asama Mukherjee, Sushanta Dutta, Muthiah Shanmugavel, Dilip M Mondhe, Parduman R Sharma, Shashank K Singh, Ajit K Saxena and Utpal Sanyal
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:175
    Content type: Research Published on:

  3. This study aimed to determine the miRNA profile in breast cancer stem cells (BCSCs) and to explore the functions of characteristic BCSC miRNAs.

    Authors: Jian-guo Sun, Rong-xia Liao, Jun Qiu, Jun-yu Jin, Xin-xin Wang, Yu-zhong Duan, Fang-lin Chen, Ping Hao, Qi-chao Xie, Zhi-xin Wang, De-zhi Li, Zheng-tang Chen and Shao-xiang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:174
    Content type: Research Published on:

  4. Primary and secondary drug resistance to imatinib and sunitinib in patients with gastrointestinal stromal tumors (GISTs) has led to a pressing need for new therapeutic strategies such as drug combinations. Mos...

    Authors: Maria Abbondanza Pantaleo, Giordano Nicoletti, Cristina Nanni, Chiara Gnocchi, Lorena Landuzzi, Carmelo Quarta, Stefano Boschi, Margherita Nannini, Monica Di Battista, Paolo Castellucci, Stefano Fanti, Pier Luigi Lollini, Elena Bellan, Mauro Castelli, Domenico Rubello and Guido Biasco
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:173
    Content type: Research Published on:

  5. Specific gene expression is tightly regulated by various transcription factors. Osteopontin (OPN) is a phosphoprotein that mediates hepatocellular carcinoma (HCC) progression and metastasis. However, the mecha...

    Authors: Rong-Xin Chen, Yun-Hong Xia, Tong-Chun Xue and Sheng-Long Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:172
    Content type: Research Published on:

  6. The present study was undertaken to relate the co-expression of prostate-associated antigens, PSMA and PSA, with the degree of vascularization in normal and pathologic (hyperplasia and cancer) prostate tissues...

    Authors: Awatef Ben Jemaa, Yosra Bouraoui, Sataa Sallami, Ahmed Banasr, Nawfel Ben Rais, Latifa Ouertani, Yassin Nouira, Ali Horchani and Ridha Oueslati
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:171
    Content type: Research Published on:

  7. The purpose of the study was to explore the anti-tumor effect of ultrasound -targeted microbubble destruction mediated herpes simplex virus thymidine kinase (HSV-TK) suicide gene system on mice hepatoma.

    Authors: Shiji Zhou, Shengwei Li, Zuojin Liu, Yong Tang, Zhigang Wang, Jianping Gong and Changan Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:170
    Content type: Research Published on:

  8. The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in micr...

    Authors: Ren Li, Niansong Qian, Kaishan Tao, Nan You, Xinchuan Wang and Kefeng Dou
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:169
    Content type: Research Published on:

  9. The Open Archive Initiative (OAI) refers to a movement started around the '90s to guarantee free access to scientific information by removing the barriers to research results, especially those related to the e...

    Authors: Elisabetta Poltronieri, Ivana Truccolo, Corrado Di Benedetto, Mauro Castelli, Mauro Mazzocut and Gaetana Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:168
    Content type: Research Published on:

  11. ChromograninA in prostate carcinoma (PC) indicate NE differentiation. This tumour is more aggressive and resistant to hormone therapy.

    Authors: Marialuisa Appetecchia, Aurela Meçule, Giuseppe Pasimeni, Concetta V Iannucci, Piero De Carli, Roberto Baldelli, Agnese Barnabei, Giovanni Cigliana, Isabella Sperduti and Michele Gallucci
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:166
    Content type: Research Published on:

  12. Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. Unfortunately, most patients re...

    Authors: Hoang Thanh Chi, Bui Thi Kim Ly, Takahiro Taguchi, Toshiki Watanabe and Yuko Sato
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:165
    Content type: Research Published on:

  13. More data about TACE and pTACE seem necessary to better define the global treatment strategy for HCC. Aim of our analysis was to evaluate the role of TACE, either with lipiodol (traditional) or drug-eluting mi...

    Authors: Mario Scartozzi, Gianluca Svegliati Baroni, Luca Faloppi, Marzia Di Pietro Paolo, Chiara Pierantoni, Roberto Candelari, Rossana Berardi, Stefania Antognoli, Cinzia Mincarelli, Andrea Risaliti, Cristina Marmorale, Ettore Antico, Antonio Benedetti and Stefano Cascinu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:164
    Content type: Research Published on:

  14. In spite of its establishment from the peripheral blood of a case with acute myeloid leukemia (AML)-M1, HPB-AML-I shows plastic adherence with spindle-like morphology. In addition, lipid droplets can be induce...

    Authors: Bambang Ardianto, Takeshi Sugimoto, Seiji Kawano, Shimpei Kasagi, Siti NA Jauharoh, Chiyo Kurimoto, Eiji Tatsumi, Keiko Morikawa, Shunichi Kumagai and Yoshitake Hayashi
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:163
    Content type: Research Published on:

  15. Somatostatin prevents cell proliferation by inducing apoptosis. Downregulation of the XAF1 transcript may occur during the development of prostate cancer. It is interesting to evaluate the potential regulatory ef...

    Authors: Zhaoquan Xing, Zunlin Zhou, Rong Yu, Shuling Li, Chunde Li, Sten Nilsson and Zhaoxu Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:162
    Content type: Research Published on:

  16. Pim-1 is a serine-threonine kinase which promotes early transformation, cell proliferation and cell survival during tumorigenesis. Several studies have demonstrated that Pim-1 kinase play a role in different c...

    Authors: Shengjie Guo, Xiaopeng Mao, Junxing Chen, Bin Huang, Chu Jin, Zhenbo Xu and Shaopeng Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:161
    Content type: Research Published on:

  17. Urinary bladder cancer is a common malignancy worldwide, and outcomes for patients with advanced bladder cancer remain poor. Antiproliferative factor (APF) is a potent glycopeptide inhibitor of epithelial cell...

    Authors: Hanief M Shahjee, Kristopher R Koch, Li Guo, Chen-Ou Zhang and Susan K Keay
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:160
    Content type: Research Published on:

  18. Saikosaponin-a and -d, two naturally occurring compounds derived from Bupleurum radix, have been shown to exert anti-cancer activity in several cancer cell lines. However, the effect of combination of saikosap...

    Authors: Qiong Wang, Xue-lian Zheng, Lan Yang, Fang Shi, Lin-bo Gao, Ying-jia Zhong, Hong Sun, Fan He, Yong Lin and Xia Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:159
    Content type: Research Published on:

  19. Chordoma was a typically slow-growing tumor. The therapeutic approach to chordoma had traditionally relied mainly on surgical therapy. And the main reason for therapeutic failure was resistance to chemotherapy...

    Authors: Zhengang Ji, Hua Long, Yunsheng Hu, Xiuchun Qiu, Xiang Chen, Zhao Li, Degang Fan, Baoan Ma and Qingyu Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:158
    Content type: Research Published on:

  20. The present report was designed to investigate the origins of elevated oxidative stress measured in cancer patients in our previous work related to a case-control study (17 cases, 43 controls) on oesophageal c...

    Authors: Stéphanie Lagadu, Mathilde Lechevrel, François Sichel, Jean Breton, Didier Pottier, Rémy Couderc, Fathi Moussa and Virginie Prevost
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:157
    Content type: Research Published on:

  21. This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells.

    Authors: Nan Li, Weixing Guo, Jie Shi, Jie Xue, Huasheng Hu, Dong Xie, Mengchao Wu and Shuqun Cheng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:156
    Content type: Research Published on:

  22. Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers and might be associated with cancer risk ...

    Authors: Ruixing Zhang, Rui Wang, Fengbin Zhang, Chensi Wu, Haiyan Fan, Yan Li, Cuiju Wang and Zhanjun Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:155
    Content type: Research Published on:

  23. Molecular therapies that target genetic abnormalities in leukemic cells and their affected signaling pathways have been emerging in pediatric acute lymphoblastic leukemia (ALL). Glycogen synthase kinase-3β (GS...

    Authors: Yanni Hu, Xiaoyan Gu, Ruiyan Li, Qing Luo and Youhua Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:154
    Content type: Research Published on:

  24. Pleomorphic malignant fibrous histiocytoma (MFH) is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a m...

    Authors: Jun Nishio, Hiroshi Iwasaki, Kazuki Nabeshima, Masako Ishiguro, Teruto Isayama and Masatoshi Naito
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:153
    Content type: Research Published on:

  25. Noninvasive and tissue-specific technologies of gene transfection would be valuable in clinical gene therapy. This present study was designed to determine whether it could enhance gene transfection in vivo by the...

    Authors: Zhi-Yi Chen, Kun Liang and Ri-Xiang Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:152
    Content type: Research Published on:

  26. MicroRNAs are important gene regulators that potentially play a profound role in tumorigenesis. Increasing evidence indicates that miR-145 is a tumor suppressor capable of inhibiting breast and colon cancer ce...

    Authors: Zhe Chen, Huazong Zeng, Yong Guo, Pei Liu, Hui Pan, Anmei Deng and Jian Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:151
    Content type: Research Published on:

  27. Glucocorticoid (GC) resistance is frequently seen in acute lymphoblastic leukemia of T-cell lineage (T-ALL). In this study we investigate the potential and mechanism of using rapamycin to restore the sensitivi...

    Authors: Ling Gu, Chenyan Zhou, Huajun Liu, Ju Gao, Qiang Li, Dezhi Mu and Zhigui Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:150
    Content type: Research Published on:

  28. Management of peritoneal dissemination is the most critical problem in gastric cancer. This study was performed to investigate the inhibitory effects of valproic acid (VPA) on a highly peritoneal-seeding cell ...

    Authors: Yasumichi Yagi, Sachio Fushida, Shinichi Harada, Jun Kinoshita, Isamu Makino, Katsunobu Oyama, Hidehiro Tajima, Hideto Fujita, Hiroyuki Takamura, Itasu Ninomiya, Takashi Fujimura, Tetsuo Ohta, Masakazu Yashiro and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:149
    Content type: Research Published on:

  29. Colloidal silver has been used as an antimicrobial and disinfectant agent. However, there is scarce information on its antitumor potential. The aim of this study was to determine if colloidal silver had cytoto...

    Authors: Moisés A Franco-Molina, Edgar Mendoza-Gamboa, Crystel A Sierra-Rivera, Ricardo A Gómez-Flores, Pablo Zapata-Benavides, Paloma Castillo-Tello, Juan Manuel Alcocer-González, Diana F Miranda-Hernández, Reyes S Tamez-Guerra and Cristina Rodríguez-Padilla
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:148
    Content type: Research Published on:

  30. Deletions within the short arm of chromosome 7 are observed in approximately 25% of adult and 10% of Wilms pediatric renal tumors. Within Wilms tumors, the region of interest has been delineated to a 2-Mb mini...

    Authors: Kimberly R Blish, Kathryn A Clausen, Gregory A Hawkins, A Julian Garvin, Mark C Willingham, Julie C Turner, Frank M Torti and Suzy V Torti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:147
    Content type: Research Published on:

  31. Epidemiological studies have clearly validated the association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with chronic HBV infection are at increased risk of HCC, in...

    Authors: Zhong-Jun Wu, Yu Zhu, De-Rong Huang and Zhi-Qiang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:146
    Content type: Research Published on:

  32. Norcantharidin, the demethylated analog of cantharidin derived from a traditional Chinese medicine, Mylabris, has been used in the treatment of anti-cancer effects. However, the detailed mechanisms underlying ...

    Authors: Cheng Chang, You-Qing Zhu, Juan-juan Mei, Shi-quan Liu and Jun Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:145
    Content type: Research Published on:

  33. Real-time reverse transcription PCR (qRT-PCR) is frequently used for gene expression quantification due to its methodological reproducibility and sensitivity. The gene expression is quantified by normalization...

    Authors: Lise Aa Sørby, Solveig N Andersen, Ida RK Bukholm and Morten B Jacobsen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:144
    Content type: Research Published on:

  34. The Polycomb group (PcG) genes are a class of regulators responsible for maintaining homeotic gene expression throughout cell division. PcG expression is deregulated in some types of human cancer. Both Bmi-1 and ...

    Authors: You-Wei Lu, Jin Li and Wei-Jian Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:143
    Content type: Research Published on:

  35. Radiotherapy has been shown to be an effective for the treatment human glioma and consists of 30 fractions of 2 Gy each for 6-7 weeks in the tumor volume with margins. However. in preclinical studies, many dif...

    Authors: Sandrine Vinchon-Petit, Delphine Jarnet, Eric Jadaud, Loïc Feuvret, Emmanuel Garcion and Philippe Menei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:142
    Content type: Research Published on:

  36. To study on expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocarcinoma (GC).

    Authors: Ji-wei Yu, Peng Zhang, Ju-gang Wu, Sheng-hua Wu, Xiao-qiang Li, Shi-ting Wang, Rui-qi Lu, Xiao-chun Ni and Bo-jian Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:141
    Content type: Research Published on:

  37. HBO1 (histone acetyltransferase binding to ORC1) is a histone acetyltransferase (HAT) which could exert oncogenic function in breast cancer. However, the biological role and underlying mechanism of HBO1 in bre...

    Authors: Wen-zhong Wang, Hai-ou Liu, Yi-hong Wu, Yi Hong, Jun-wu Yang, Ye-heng Liu, Wei-bin Wu, Lei Zhou, Lin-lin Sun, Jie-jie Xu, Xiao-jing Yun and Jian-xin Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:140
    Content type: Research Published on:

  38. Peritoneal dissemination is one of the main causes of death in gastric cancer patients. Transforming growth factor-beta1 (TGF-β1), one of the most potent fibrotic stimuli for mesothelial cells, may play a key ...

    Authors: Zhi-Dong Lv, Di Na, Fu-Nan Liu, Zong-Min Du, Zhe Sun, Zhen Li, Xiao-Yang Ma, Zhen-Ning Wang and Hui-Mian Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:139
    Content type: Research Published on:

  39. Gliomas represent the most common primary malignant brain tumors, yet little is known about the molecular pathogenesis of these tumors. The highly-regulated Wnt signal transduction pathway is essential for nor...

    Authors: Youxin Zhou, Fang Liu, Qinian Xu and Xiuyun Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:138
    Content type: Research Published on:

  40. Platinum-based chemotherapy has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it has high toxicity. In China, Shenqi Fuzheng, a newly developed injection concocted from Chinese m...

    Authors: Ju Dong, Shi-Yue Su, Min-Yan Wang and Zhen Zhan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:137
    Content type: Research Published on:

  41. The CIP2A protein is a recently characterized oncoprotein which inhibits protein phosphatase 2A activity. Expression of CIP2A has been detected in several carcinomas, but its expression and significance in pro...

    Authors: Markku H Vaarala, Marja-Riitta Väisänen and Ari Ristimäki
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:136
    Content type: Research Published on:

  42. Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are ass...

    Authors: Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:135
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:22

  43. The possibility that autologous NK cells could serve as an effective treatment modality for solid tumors has long been considered. However, implementation is hampered by (i) the small number of NK cells in per...

    Authors: Caroline J Voskens, Ryuko Watanabe, Sandra Rollins, Dario Campana, Kenichiro Hasumi and Dean L Mann
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:134
    Content type: Research Published on:

  44. The esophageal cancer related gene 4 (ECRG4) was initially identified and cloned in our laboratory from human normal esophageal epithelium (GenBank accession no.AF325503). ECRG4 was a new tumor suppressor gene...

    Authors: Linwei Li, Chunpeng Zhang, Xiaoyan Li, ShihHsin Lu and Yun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:133
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:19

  45. We have compared mutation analysis by DNA sequencing and Amplification Refractory Mutation Systemâ„¢ (ARMSâ„¢) for their ability to detect mutations in clinical biopsy specimens.

    Authors: Gillian Ellison, Emma Donald, Gael McWalter, Lucy Knight, Lynn Fletcher, James Sherwood, Mireille Cantarini, Maria Orr and Georgina Speake
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:132
    Content type: Research Published on:

  46. Studies have shown that Dickkopf-1 (DKK-1) is involved in tumorigenesis. Recently, we found that 9 out of 12 human glioma cell lines had high level of DKK-1 protein while the other 3 had very low or non-detect...

    Authors: Youxin Zhou, Wenshuai Li, Qinian Xu and Yulun Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:131
    Content type: Research Published on:

  47. Hepatocellular carcinoma (HCC) is frequently preceded by hepatitis virus infection or alcohol abuse. Genetic backgrounds may increase susceptibility to HCC from these exposures.

    Authors: Ruixing Zhang, Fengbin Zhang, Cuiju Wang, Shunxiang Wang, Yih-Horng Shiao and Zhanjun Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:130
    Content type: Research Published on:

  48. Human 8-oguanine glycosylase 1(hOGG1), voltage-dependent anion channel 1(VDAC1), hexokinase 2(HK-2), represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aim...

    Authors: Peng Guo-Qing, Yang Yuan, Zhong Cai-Gao, Yin Hongling, Hu Gonghua and Tian Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:129
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:53

  49. Colorectal cancer (CRC) screening is key to CRC prevention and mortality reduction, but patient compliance with CRC screening is low. We previously reported a blood-based test for CRC that utilizes a seven-gen...

    Authors: Kok-Thye Yip, Prashanta K Das, David Suria, Chun-Ren Lim, Guey-Hooi Ng and Choong-Chin Liew
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:128
    Content type: Research Published on:

  50. Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibi...

    Authors: Yasuhiro Kidera, Masanobu Tsubaki, Yuzuru Yamazoe, Kaori Shoji, Haruyuki Nakamura, Mitsuhiko Ogaki, Takao Satou, Tatsuki Itoh, Misako Isozaki, Junichi Kaneko, Yoshihiro Tanimori, Masashi Yanae and Shozo Nishida
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:127
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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