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  1. Apoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. 99mTc-HYNIC-annexinV has been reported as a promising agent fo...

    Authors: Ming-fang Guo, Yaqing Zhao, Rong Tian, Lin Li, Leiming Guo, Feng Xu, Yong-mei Liu, Yong-bo He, Sen Bai and Jin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:136
    Content type: Research Published on:

  2. To investigate prostate cancer (Pca) risk in relation to estrogen metabolism, expressed as urinary 2-hydroxyestrone (2-OHE1), 16α-hydroxyestrone (16α-OHE1) and 2-OHE1 to 16α-OHE1 ratio.

    Authors: Maddalena Barba, Li Yang, Holger J Schünemann, Francesca Sperati, Sara Grioni, Saverio Stranges, Kim C Westerlind, Giovanni Blandino, Michele Gallucci, Rossella Lauria, Luca Malorni and Paola Muti
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:135
    Content type: Review Published on:

  3. Chromophobe renal cell carcinoma (ChRCC) is a subtype of renal cell carcinoma (RCC). ChRCC is diagnosed mainly in 6th decade of life. An incidence of ChRCC is similar in both men and woman. Eighty six percent ...

    Authors: Rafał Stec, Bartłomiej Grala, Michał Mączewski, Lubomir Bodnar and Cezary Szczylik
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:134
    Content type: Review Published on:

  4. The epidermal growth factor receptor variant III (EGFRvIII) is the most common variation of EGFR. Because it shows a high frequency in several different types of tumor and has not been detected in normal tissu...

    Authors: Xiao-yi Duan, Dong-gang Han, Ming-xin Zhang and Jian-sheng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:133
    Content type: Research Published on:

  5. Many studies have shown that colon cancer is an estrogen-dependent carcinoma. This study explored the efficacy of endocrine therapy in colon cancer cells with high metastatic potential (HT29). We investigated ...

    Authors: Yu-Jing Fang, Zhi-Zhong Pan, Li-Ren Li, Zhen-Hai Lu, Li-Yi Zhang and De-Sen Wan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:132
    Content type: Research Published on:

  6. This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine3(5-HT3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in ...

    Authors: Lijun Tan, Jiangtao Liu, Xiuli Liu, Jie Chen, Zhijun Yan, Huifen Yang and Daxin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:131
    Content type: Research Published on:

  7. Polo-like kinase-1 (PLK-1) is reported to be upregulated in a variety of human tumors and is implicated in cell proliferation and survival. However, its importance in cervical carcinoma has not yet been fully ...

    Authors: Yuan Zhang, Yu Liu, Yuan-Xian Yang, Jia-Hong Xia, Hong-Xiu Zhang, Hua-Bin Li and Chun-Zhao Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:130
    Content type: Research Published on:

  8. Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we in...

    Authors: Alexandra Szalad, Mark Katakowski, Xuguang Zheng, Feng Jiang and Michael Chopp
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:129
    Content type: Research Published on:

  9. Sexual dysfunction following surgery for rectal cancer may be frequent and often severe. The aim of the present study is to evaluate the occurrence of this complication from both a clinical point of view and b...

    Authors: Alberto Pietrangeli, Patrizia Pugliese, Maria Perrone, Isabella Sperduti, Maurizio Cosimelli and Bruno Jandolo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:128
    Content type: Case study Published on:

  11. Although gastric caner (GC) remains the second cause of cancer-related death, useful biomarkers for prognosis are still unavailable. We present here the attempt of mining novel biomarkers for GC prognosis by u...

    Authors: Fu-Ming Qiu, Jie-Kai Yu, Yi-Ding Chen, Qi-Feng Jin, Mei-Hua Sui and Jian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:126
    Content type: Research Published on:

  12. The aim of this study was to determine the clinicopathological features of gastric cancers with loss of imprinting (LOI) of LIT1. Insulin-like growth factor 2 (IGF2) and H19 in Chinese patients.

    Authors: Yang Lu, Ping Lu, Zhi Zhu, Huimian Xu and Xike Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:125
    Content type: Research Published on:

  13. Vasculogenic mimicry (VM) was increasingly recognized as a form of aggressive melanoma acquiring blood supply. Genistein had attracted much attention as a potential anticancer agent. Therefore, we examined the...

    Authors: Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng and Bin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:124
    Content type: Research Published on:

  14. Despite of the recent success of EGFR inhibitory agents, the primary drug-resistant becomes a major challenge for EGFR inhibitor therapies. PTEN gene is an important positive regulatory factor for response to ...

    Authors: Hong-Qing Zhuang, Jun Wang, Zhi-Yong Yuan, Lu-Jun Zhao, Ping Wang and Chang-Li Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:123
    Content type: Research Published on:

  15. Hepatocellular carcinoma (HCC), a major cause of cancer death in China, is preceded by chronic hepatitis and liver cirrhosis (LC). Although hepatitis B virus (HBV) has been regarded as a clear etiology of huma...

    Authors: Ning Li, Yunzhu Long, Xuegong Fan, Hongbo Liu, Cui Li, Lizhang Chen and Zhiming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:122
    Content type: Research Published on:

  16. In cancer patients, MUC1 glycoprotein may carry Lewis y which could be involved in immune response. Purposes: 1- to evaluate the presence of Lewis y and MUC1 in circulating immune complexes (Lewis y/CIC and MU...

    Authors: Marina Isla Larrain, Sandra Demichelis, Marina Crespo, Ezequiel Lacunza, Alberto Barbera, Aldo Cretón, Francisco Terrier, Amada Segal-Eiras and María Virginia Croce
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:121
    Content type: Research Published on:

  17. Germ cell testicular tumors have survival rate that diminishes with high tumor marker levels, such as human chorionic gonadotropin (hCG). hCG may regulate vascular neoformation through vascular endothelial gro...

    Authors: Oscar Arrieta, Rosa Mayela Michel Ortega, Julián Ángeles-Sánchez, Cynthia Villarreal-Garza, Alejandro Avilés-Salas, José G Chanona-Vilchis, Elena Aréchaga-Ocampo, Arturo Luévano-González, Miguel Ángel Jiménez and José Luis Aguilar
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:120
    Content type: Research Published on:

  18. This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb.

    Authors: Xiang-Yun Zong, Yang Yu and Hong-Jian Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:119
    Content type: Research Published on:

  19. Vimentin is one of the cytoplasmic intermediate filament proteins which are the major component of the cytoskeleton. In our study we checked the usefulness of vimentin expression in identifying cases of breast...

    Authors: Renata U Kusinska, Radzislaw Kordek, Elzbieta Pluciennik, Andrzej K Bednarek, Janusz H Piekarski and Piotr Potemski
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:118
    Content type: Research Published on:

  20. Recently, the use of hypo-fractionated treatment schemes for the prostate cancer has been encouraged due to the fact that α/β ratio for prostate cancer should be low. However a major concern on the use of hypo...

    Authors: Simona Marzi, Biancamaria Saracino, Maria G Petrongari, Stefano Arcangeli, Sara Gomellini, Giorgio Arcangeli, Marcello Benassi and Valeria Landoni
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:117
    Content type: Research Published on:

  21. Recently, maintaining higher relative dose intensity (RDI) of chemotherapeutic drugs has become a widespread practice in an attempt to achieve better outcomes in the treatment of aggressive lymphoma. The addit...

    Authors: Yoshiki Terada, Hirohisa Nakamae, Ran Aimoto, Hiroshi Kanashima, Erina Sakamoto, Mizuki Aimoto, Eri Inoue, Hideo Koh, Takahiko Nakane, Yasunobu Takeoka, Masahiko Ohsawa, Ki-Ryang Koh, Takahisa Yamane, Yoshitaka Nakao, Kensuke Ohta, Atsuko Mugitani…
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:116
    Content type: Research Published on:

  22. Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. A number of studies have conducted on the association of TP53 codon 72 polymorphisms with susceptibility to bre...

    Authors: Wenlei Zhuo, Yunsong Zhang, Zhaolan Xiang, Lei Cai and Zhengtang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:115
    Content type: Research Published on:

  23. The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperativ...

    Authors: Enrico P Spugnini, Gennaro Citro and Alfonso Baldi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:114
    Content type: Review Published on:

  24. Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utiliz...

    Authors: Jeffrey B Hoag, Aimel Azizi, Timothy J Doherty, Jason Lu, Rudolph E Willis and Mark E Lund
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:113
    Content type: Research Published on:

  25. Liver cancer is a common malignancy with a high mortality rate. Given the poor prognosis associated with this cancer, many patients seek additional therapies that may improve quality of life or survival. Sever...

    Authors: Ping Wu, Jean Jacques Dugoua, Oghenowede Eyawo and Edward J Mills
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:112
    Content type: Research Published on:

  26. APMCF1 is a novel human gene first cloned from apoptotic MCF-7 cells. Our previous study found ectogenic APMCF1 could induce G1 arrest in hepatocarcinoma cell line HHCC. In order to search its broad expression...

    Authors: Yaqing Zhang, Qinlong Li, Feng Zhu, Jihong Cui, Kainan Li, Qing Li, Ruian Wang, Wenyong Wang, Weihua Wang and Wei Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:111
    Content type: Research Published on:

  27. Despite multidisciplinary treatment, lung cancer remains a highly lethal disease due to poor response to chemotherapy. The identification of therapeutic agents with synergistic effects with traditional drugs i...

    Authors: Hecheng Li, XiaoLi Zhu, Yawei Zhang, Jiaqing Xiang and Haiquan Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:110
    Content type: Research Published on:

  28. Combination chemotherapy with oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) has become a standard regimen for colorectal cancer. An increase of adverse events with combination chemotherapy is predicted i...

    Authors: Shinichi Sugimoto, Kuniyuki Katano, Akiyoshi Kanazawa, Hiroshi Yoshimura, Akihiko Kidani, Hiroshi Takeda, Masato Makino, Nobuhiro Ozaki, Tsuneo Tanaka and Masahide Ikeguchi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:109
    Content type: Research Published on:

  29. Barrett's mucosa is the precursor of esophageal adenocarcinoma. The molecular mechanisms behind Barrett's carcinogenesis are largely unknown. Experimental models of longstanding esophageal reflux of duodenal-g...

    Authors: Giuseppe Ingravallo, Luigi Dall'Olmo, Daniela Segat, Matteo Fassan, Claudia Mescoli, Emanuela Dazzo, Carlo Castoro, Lorenzo Polimeno, Christian Rizzetto, Maurizio David Baroni, Giovanni Zaninotto, Ermanno Ancona and Massimo Rugge
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:108
    Content type: Research Published on:

  30. Liver cancr is a heterogeneous disease in terms of etiology, biologic and clinical behavior. Very little is known about how many genes concur at the molecular level of tumor development, progression and aggres...

    Authors: Yue-Fang Liu, Bin-Shan Zha, Hui-Lin Zhang, Xiao-Jing Zhu, Yu-Hua Li, Jin Zhu, Xiao-Hong Guan, Zhen-Qing Feng and Jian-Ping Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:107
    Content type: Research Published on:

  31. Genetic instability is known as a cause of oncogenesis. Though Rad18 is reported to function in a post replication mismatch repair system, the relation between the status of Rad18 and human tumorigenesis has n...

    Authors: Tadahiko Nakamura, Shinji Ishikawa, Yoshikatsu Koga, Youhei Nagai, Yu Imamura, Kouei Ikeda, Takeshi Mori, Hiroaki Nomori and Hideo Baba
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:106
    Content type: Review Published on:

  32. Osteosarcoma is a highly malignant bone tumor and is the most commonly encountered malignant bone tumor in children and adolescents. Furthermore, significant numbers of patients eventually develop pulmonary me...

    Authors: Zeng Feng Xin, Yang Kyung Kim and Sung Taek Jung
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:105
    Content type: Research Published on:

  33. Non-synonymous single nucleotide polymorphisms (SNPs) within vital DNA repair genes may cause reduction of activity leaving the genome unrepaired resulting in genomic instability and cancer.

    Authors: Amit Kumar Mitra, Neetu Singh, Vivek Kumar Garg, Rashmi Chaturvedi, Mandira Sharma and Srikanta Kumar Rath
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:104
    Content type: Research Published on:

  34. A reliable and precise classification is essential for successful diagnosis and treatment of cancer. Gene expression microarrays have provided the high-throughput platform to discover genomic biomarkers for ca...

    Authors: Peng Guan, Desheng Huang, Miao He and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:103
    Content type: Research Published on:

  35. Opioid analgesics are generally used to combat the pain associated with cancerous conditions. These agents not only inhibit respiratory function and cause constipation, but also induce other significant side e...

    Authors: Hyo-Jeong Lee, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Kwan-Hyun Kim, Sun-Hyung Kim, Keun-Sung Lee, Hee-Jae Jung and Sung-Hoon Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:102
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2009 28:137

  36. Authors: Huang Hao, Yu Nancai, Fu Lei, Wei Xiong, Su Wen, Huang Guofu, Wu yanxia, Huang Hanju, Liu Qian and Xiao Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:101
    Content type: Retraction Note Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2008 27:27

  37. Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in ...

    Authors: Huaifu Li, Guofeng Ruan, Zhijun Li, Ziwei Liu, Xiaoqing Zheng, Hao zheng, Guangming Cheng, Benyi Li and Ming Zhan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:100
    Content type: Research Published on:

  38. Imatinib, a tyrosine kinase inhibitor currently approved for treatment of several malignancies, has been shown to be a substrate for multiple efflux-transporter proteins, including ABCB1 (P-glycoprotein) and A...

    Authors: Erin R Gardner, Nicola F Smith, William D Figg and Alex Sparreboom
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:99
    Content type: Research Published on:

  40. The prognostic value of HER2 expression in patients with advanced non-small cell lung cancer remains controversial. The relationship between HER2 expression, and platinum resistance and patient survival, was i...

    Authors: Zuleyha Calikusu, Yesim Yildirim, Zafer Akcali, Hakan Sakalli, Nebil Bal, Ilker Unal and Ozgur Ozyilkan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:97
    Content type: Research Published on:

  41. Resveratrol is a non flavonoid polyphenol compound present in many plants and fruits and, at especially high concentrations, in the grape berries of Vitis vinifera. This compound has a strong bioactivity and its ...

    Authors: Valerio Berardi, Francesca Ricci, Mauro Castelli, Gaspare Galati and Gianfranco Risuleo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:96
    Content type: Research Published on:

  42. To compare intracavitary brachytherapy (ICBT) planning methods for cervical cancer, based on either orthogonal radiographs (conventional plan) or CT sections (CT plan); the comparison focused on target volume ...

    Authors: Cem Onal, Gungor Arslan, Erkan Topkan, Berrin Pehlivan, Melek Yavuz, Ezgi Oymak and Aydin Yavuz
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:95
    Content type: Research Published on:

  43. Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that t...

    Authors: Xiaoxiang Guan, Hui Zhao, Jiangong Niu, Dongfeng Tan, Jaffer A Ajani and Qingyi Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:94
    Content type: Research Published on:

  45. Selenite is a promising anticancer agent which has been shown to induce apoptosis in malignant mesothelioma cells in a phenotype-dependent manner, where cells of the chemoresistant sarcomatoid phenotype are mo...

    Authors: Gustav Nilsonne, Eric Olm, Adam Szulkin, Filip Mundt, Agnes Stein, Branka Kocic, Anna-Klara Rundlöf, Aristi P Fernandes, Mikael Björnstedt and Katalin Dobra
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:92
    Content type: Research Published on:

  46. Platinum-based neoadjuvant chemotherapy (NAC) is new therapeutic strategy for locally advanced cervical carcinoma, but the variables used to predict NAC response are still infrequently reported. The aim of our...

    Authors: Xiao-Dong Cheng, Wei-Guo Lu, Feng Ye, Xiao-Yun Wan and Xing Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:91
    Content type: Research Published on:

  47. Type 2 diabetes (T2D) is associated with obesity and has been shown recently to be associated with tumors/cancer. HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. We have previously shown th...

    Authors: Ramachandran Meenakshisundaram, Nunzia Piumelli, Laura Pierpaoli and Claudia Gragnoli
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:90
    Content type: Research Published on:

  48. Lung cancer is the leading cause of death from cancer worldwide. Conventional studies mainly think that insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) may promote and inhibit tumor gr...

    Authors: Bo Chen, Shan Liu, Wei Xu, Xueli Wang, Weihong Zhao and Jianqing Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:89
    Content type: Research Published on:

  50. To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis.

    Authors: Lara CV Harrison, Tiina Luukkaala, Hannu Pertovaara, Tuomas O Saarinen, Tomi T Heinonen, Ritva Järvenpää, Seppo Soimakallio, Pirkko-Liisa I Kellokumpu-Lehtinen, Hannu J Eskola and Prasun Dastidar
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:87
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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