Articles

RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer

The RNA-binding protein Musashi-2 (MSI2) has been implicated in the tumorigenesis and tumor progression of some human cancers. MSI2 has also been reported to suppress tumor epithelial-to-mesenchymal transition...

Authors: Ming Li, An-qi Li, Shu-ling Zhou, Hong Lv, Ping Wei and Wen-tao Yang

The circular RNA 001971/miR-29c-3p axis modulates colorectal cancer growth, metastasis, and angiogenesis through VEGFA

Colorectal cancer (CRC) is one of the most common malignant tumors globally. Angiogenesis is a key event maintaining tumor cell survival and aggressiveness. The expression of vascular endothelial growth factor...

Authors: Chen Chen, Zhiguo Huang, Xiaoye Mo, Yanmin Song, Xiangmin Li, Xiaogang Li and Mu Zhang

ABCA8 is regulated by miR-374b-5p and inhibits proliferation and metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway

ATP binding cassette subfamily A member 8 (ABCA8) belongs to the ATP binding cassette (ABC) transporter superfamily. ABCA8 is a transmembrane transporter responsible for the transport of organics, such as chol...

Authors: Yifeng Cui, Shuhang Liang, Shugeng Zhang, Congyi Zhang, Yunzheng Zhao, Dehai Wu, Jiabei Wang, Ruipeng Song, Jizhou Wang, Dalong Yin, Yao Liu, Shangha Pan, Xirui Liu, Yan Wang, Jihua Han, Fanzheng Meng…

Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy

Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive ...

Authors: Filippo Galli, Jesus Vera Aguilera, Belinda Palermo, Svetomir N. Markovic, Paola Nisticò and Alberto Signore

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin has been proposed as an attractive target for new anti-tumor interventi...

Authors: Ming Li, Feng Gao, Xinfang Yu, Qing Zhao, Li Zhou, Wenbin Liu and Wei Li

A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer

Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown ...

Authors: Yuexian Zhou, Huifang Zong, Lei Han, Yueqing Xie, Hua Jiang, John Gilly, Baohong Zhang, Huili Lu, Jie Chen, Rui Sun, Zhidi Pan and Jianwei Zhu

Drug repurposing against COVID-19: focus on anticancer agents

The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III tri...

Authors: Gennaro Ciliberto, Rita Mancini and Marco G. Paggi

ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia

In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) are associated with a dismal outcome. Although uncoordinated 51-like kinase 1 (ULK1), whic...

Authors: Doh Yu Hwang, Ju-In Eom, Ji Eun Jang, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong and Yoo Hong Min

EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells

The Ecotropic viral integration site 5 (EVI5), an important protein in regulating cell cycle, cytokinesis and cellular membrane traffic, functions as a stabilizing factor maintaining anaphase-promoting complex...

Authors: Tingting Cai, Jieqi Zhou, Yuanyuan Zeng, Wenwen Du, Yang Zhang, Ting Liu, Yulong Fu, Jian-an Huang, Qian Qian, Jianjie Zhu, Chunhua Ling and Zeyi Liu

Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells

Our previous studies have confirmed that cobalt chloride (CoCl₂) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely ...

Authors: Kai Liu, Minying Zheng, Qi Zhao, Kexin Zhang, Zugui Li, Fangmei Fu, Hao Zhang, Jiaxing Du, Yuwei Li and Shiwu Zhang

Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex

Survivin and XIAP are two important members of the inhibitor of apoptosis protein family and have been considered as potential targets for cancer treatment due to their overexpression in large variety of cance...

Authors: Wanxia Fang, Xiaofang Che, Guohui Li, Anhui Wang, Yizhe Wang, Xiaonan Shi, Kezuo Hou, Xiaojie Zhang, Xiujuan Qu and Yunpeng Liu

SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane

HER2-positive breast cancer is usually associated to the more aggressive progression and the worse prognosis, but the mechanism underlying the innate resistance to HER2-targeted therapy remains elusive. The sc...

Authors: Hui Li, Mingming Zhang, Yanli Wei, Farhan Haider, Yitong Lin, Wen Guan, Yanbin Liu, Shaoyang Zhang, Ronghua Yuan, Xia Yang, Shulan Yang and Haihe Wang

Correction to: Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression

In the original publication of this manuscript [1], there are errors in Fig. 3. The authors declare that the identified errors do not change the results or conclusions of this paper.

Authors: Jiayan Yan, Yunxi Jia, Han Chen, Wei Chen and Xiaoying Zhou

SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway

The poor prognosis of patients with ovarian cancer is mainly due to cancer progression. γ-Synuclein (SNCG) has reported as a critical player in cancer metastasis. However, its biological roles and mechanism ar...

Authors: Jing Zhang, Xiao-han Liu, Cong Li, Xiao-xing Wu, Yan-lin Chen, Wen-wen Li, Xian Li, Fan Gong, Qin Tang and Dan Jiang

Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma

The majority of high-risk neuroblastomas can be divided into three distinct molecular subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements or alternative lengthening of telomeres ...

Authors: S. L. George, V. Parmar, F. Lorenzi, L. V. Marshall, Y. Jamin, E. Poon, P. Angelini and L. Chesler

Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers

Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target mo...

Authors: Liliana R. Loureiro, Anja Feldmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Domokos Máthé, Nikolett Hegedüs, Krisztián Szigeti, Paula A. Videira, Michael Bachmann and Claudia Arndt

Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied. In par...

Authors: Zhiyan Hu, Ting Long, Yidan Ma, Jiaxian Zhu, Lingfang Gao, Yan Zhong, Xia Wang, Xiaoyan Wang and Zuguo Li

Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models

The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which mod...

Authors: Somshuvra Bhattacharya, Kristin Calar and Pilar de la Puente

Cancer at the time of the COVID-19 hurricane

Authors: Giovanni Blandino

CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling

Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer t...

Authors: Lixia Gao, Zhigang Xu, Zheng Huang, Yan Tang, Donglin Yang, Jiuhong Huang, Leilei He, Manran Liu, Zhongzhu Chen and Yong Teng

Correction to: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway

In the original publication of this manuscript [1], Fig. 5a needs to be revised, and adjustments have also been made to the captions for Figs. 2, 4, 5 and S1 to improve clarity for the reader.

Authors: Deyao Shi, Fashuai Wu, Shidai Mu, Binwu Hu, Binlong Zhong, Feng Gao, Xiangcheng Qing, Jianxiang Liu, Zhicai Zhang and Zengwu Shao

miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis

Increasing evidence indicates that epithelial-mesenchymal transition (EMT) can be regulated by microRNAs (miRNAs). miR-615-3p was shown to be involved in tumor development. However, the role of miR-615-3p in t...

Authors: Bo Lei, Dandan Wang, Ming Zhang, Yuwei Deng, Huijie Jiang and Yiwen Li

A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma

Tumor metastasis is one of the main causes of the high mortality of hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong transcriptional repressor, associated with the development and...

Authors: Chunmei Guo, Chao Gao, Dongting Zhao, Jiahui Li, Jinxia Wang, Xujuan Sun, Qinlong Liu, Lihong Hao, Frederick T. Greenaway, Yuxiang Tian, Shuqing Liu and Ming-Zhong Sun

Cross-sectional analysis of circulating tumor DNA in primary colorectal cancer at surgery and during post-surgery follow-up by liquid biopsy

Liquid biopsy (LB) in early-stage, non-metastatic colorectal cancer (CRC) must be sensitive enough to detect extremely low circulating tumor DNA (ctDNA) levels. This challenge has been seldom and non-systemati...

Authors: Matteo Allegretti, Giuliano Cottone, Fabio Carboni, Ettore Cotroneo, Beatrice Casini, Elena Giordani, Carla Azzurra Amoreo, Simonetta Buglioni, Maria Diodoro, Edoardo Pescarmona, Settimio Zazza, Orietta Federici, Massimo Zeuli, Laura Conti, Giovanni Cigliana, Francesco Fiorentino…

Urinary expression of let-7c cluster as non-invasive tool to assess the risk of disease progression in patients with high grade non-muscle invasive bladder Cancer: a pilot study

High grade non-muscle-invasive bladder cancer (HG-NMIBC) is a heterogeneous disease with variable risk of progression. Urinary microRNAs are promising biomarkers for BC detection and surveillance. Let-7c-5p mi...

Authors: Manuela Spagnuolo, Manuela Costantini, Mariaconsiglia Ferriero, Marco Varmi, Isabella Sperduti, Giulia Regazzo, Lucia Cicchillitti, Ana Belén Díaz Méndez, Giovanni Cigliana, Vincenzo Pompeo, Andrea Russo, Valentina Laquintana, Riccardo Mastroianni, Giulia Piaggio, Umberto Anceschi, Aldo Brassetti…

Exosomal miRNAs in tumor microenvironment

Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as e...

Authors: Shiming Tan, Longzheng Xia, Pin Yi, Yaqian Han, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Linda Oyang, Jiaxin Liang, Jinguan Lin, Min Su, Yingrui Shi, Deliang Cao, Yujuan Zhou and Qianjin Liao

PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs),...

Authors: Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Yu Ri Kim, Jin Seok Kim, June-Won Cheong and Yoo Hong Min

Exosome-mediated transfer of miR-93-5p from cancer-associated fibroblasts confer radioresistance in colorectal cancer cells by downregulating FOXA1 and upregulating TGFB3

Cancer-associated fibroblasts (CAFs) have been intensively studied in recent studies with aims of finding more concrete evidence on their mechanism of involvement in tumor progression, which is currently unkno...

Authors: Xijuan Chen, Junqi Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Hong Ge and Yingqiang Liu

Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-catenin positive feedback loop

Sustained adrenergic signaling secondary to chronic stress promotes cancer progression; however, the underlying mechanisms for this phenomenon remain unclear. Hepatocellular carcinoma (HCC) frequently develops...

Authors: Xia-Hui Lin, Hua-Hua Liu, Shu-Jung Hsu, Rui Zhang, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren and Rong-Xin Chen

Long non-coding RNA NCK1-AS1 promotes the tumorigenesis of glioma through sponging microRNA-138-2-3p and activating the TRIM24/Wnt/β-catenin axis

Glioma is a common brain malignancy with high mortality. The competing endogenous RNA (ceRNA) networks may play key roles in cancer progression. This study was conducted to probe the role of long noncoding RNA...

Authors: Lifa Huang, Xu Li, Hui Ye, Yajun Liu, Xiaolong Liang, Chao Yang, Lin Hua, Zhaoxian Yan and Xin Zhang

Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer

Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid ce...

Authors: Xinyou Yu, Feng Gao, Wei Li, Li Zhou, Wenbin Liu and Ming Li

Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression

Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has n...

Authors: Zhonghou Rong, Zhiyi Wang, Xinxing Wang, Chengkun Qin and Wenmao Geng

Correction to: Down-regulated lncRNA SBF2-AS1 inhibits tumorigenesis and progression of breast cancer by sponging microRNA-143 and repressing RRS1

In the original publication of this manuscript [1], RRS1 stands for ‘Ribosome biogenesis regulatory protein homolog’ instead of ‘resistance to ralstonia solanacearum 1’. This mistake appears 4 times in the man...

Authors: Wenfei Xia, Yun Liu, Teng Cheng, Tao Xu, Menglu Dong and Xiaopeng Hu

Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-κB activation

Cullin-7 (CUL7) is a member of the DOC domain-containing cullin family and is involved in the regulation of cell transformation. However, the clinical significance, potential mechanism and upstream regulators ...

Authors: Jianye Xu, Zongpu Zhang, Mingyu Qian, Shaobo Wang, Wei Qiu, Zihang Chen, Zhongzheng Sun, Ye Xiong, Chaochao Wang, Xiaopeng Sun, Rongrong Zhao, Hao Xue and Gang Li

Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer

Human ovarian cancer specific transcript 2 (HOST2) is a long non-coding RNA (lncRNA) reported to be specifically high expressed in human ovarian cancer. However, the mechanism that how HOST2 regulates triple n...

Authors: Kaiyao Hua, Xiaochong Deng, Jiashu Hu, Changle Ji, Yunhe Yu, Jiayi Li, Xuehui Wang and Lin Fang

Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression

Circular RNAs (circRNAs) are a novel class of noncoding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. According to recent studies, circRNAs are involved in the pathoge...

Authors: Yuzhu Xu, Jun Yu, Zhenli Huang, Bohua Fu, Yu Tao, Xuefei Qi, Yong Mou, Yinan Hu, Yi Wang, Yong Cao, Dingsheng Jiang, Jungang Xie, Yongjian Xu, Jianping Zhao and Weining Xiong

Correction to: Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis

In the original publication of this manuscript [1], the Fig. 6a invasion si-hsa_circ_0058124_2# group (row 2 right and row 3 right) and Fig. 9c TPC-1 clone formation assay control group (row 1 left) were mispl...

Authors: Yao Yao, Xinyuan Chen, Hong Yang, Wei Chen, Yichun Qian, Zhongyi Yan, Tian Liao, Weiping Yao, Wenlan Wu, Tonghua Yu, Yun Chen and Yuan Zhang

circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D

Biological role and clinical significance of circular RNAs (circRNAs) remain largely unknown. Herein, we aimed to investigate biological function, molecular mechanism, and clinical significance of a circular R...

Authors: Chengtao Yu, Zhuoan Cheng, Shaohua Cui, Xiaowei Mao, Botai Li, Yujie Fu, Hui Wang, Haojie Jin, Qing Ye, Xiaojing Zhao, Liyan Jiang and Wenxin Qin

Exosomal MALAT1 sponges miR-26a/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K/Akt pathway

Exosomes are vesicles of endocytic origin released by various cell types and emerging as important mediators in tumor cells. Human metastases-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-...

Authors: Jingchao Xu, Yang Xiao, Bing Liu, Shimeng Pan, Qianqian Liu, Yujia Shan, Shuangda Li, Yu Qi, Yiran Huang and Li Jia

Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is a highly lethal malignancy. Improvement in genetic characterization of EOC patients is required to propose new potential targets, since surgical resection coupled to chemothe...

Authors: Luyao Guan, Zhang Li, Feifei Xie, Yuzhi Pang, Chenyun Zhang, Haosha Tang, Hao Zhang, Chun Chen, Yaying Zhan, Ting Zhao, Hongyuan Jiang, Xiaona Jia, Yuexiang Wang and Yuan Lu

Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo

Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the r...

Authors: Mei Hong, Jing He, Duo Li, Yuanyuan Chu, Jiarui Pu, Qiangsong Tong, Harish C. Joshi, Shaotao Tang and Shiwang Li

Dissecting the transcriptional regulatory networks of promoter-associated noncoding RNAs in development and cancer

In-depth analysis of global RNA sequencing has enabled a comprehensive overview of cellular transcriptomes and revealed the pervasive transcription of divergent RNAs from promoter regions across eukaryotic gen...

Authors: Lidia Chellini, Valentina Frezza and Maria Paola Paronetto

Reversal of ABCB1-related multidrug resistance by ERK5-IN-1

Inhibition of ABC transporters is considered the most effective way to circumvent multidrug resistance (MDR). In the present study, we evaluated the MDR modulatory potential of ERK5-IN-1, a potent extracelluar...

Authors: Fang Wang, Delan Li, ZongHeng Zheng, Kenneth Kin Wah To, Zhen Chen, Mengjun Zhong, Xiaodong Su, Likun Chen and Liwu Fu

Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigen...

Authors: Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh and Jamshid Hadjati

From single gene analysis to single cell profiling: a new era for precision medicine

Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate hu...

Authors: Maria Teresa Di Martino, Stefania Meschini, Katia Scotlandi, Chiara Riganti, Enrico De Smaele, Francesca Zazzeroni, Massimo Donadelli, Carlo Leonetti and Michele Caraglia

Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers

The promising expectations about personalized medicine have opened the path to routine large-scale sequencing and increased the importance of genetic counseling for hereditary cancers, among which hereditary b...

Authors: Giulia Federici and Silvia Soddu

Correction to: The interplay between HIF-1α and noncoding RNAs in cancer

In the original publication of this manuscript [1], Fig. 2 contains incorrect labels and feedback loops. The revised version of Fig. 2 is shown below.

Authors: Xiafeng Peng, Han Gao, Rui Xu, Huiyu Wang, Jie Mei and Chaoying Liu

FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers

FK506-binding protein 9 (FKBP9) is amplified in high-grade gliomas (HGGs). However, the roles and mechanism(s) of FKBP9 in glioma are unknown.

Authors: Huizhe Xu, Peng Liu, Yumei Yan, Kun Fang, Dapeng Liang, Xiukun Hou, Xiaohong Zhang, Songyan Wu, Jianmei Ma, Ruoyu Wang, Tao Li, Haozhe Piao and Songshu Meng

Correction to: Targeting hypoxia in tumor: a new promising therapeutic strategy

In the original publication of this manuscript [1], Fig. 1 contained a typographical error (‘Metabolic’ incorrectly written as ‘Metabolig’).

Authors: Maria Carla Bosco, Gabriella D’. Orazi and Donatella Del Bufalo

A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis

We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In ...

Authors: Yiyang Jia, Yantong Guo, Qiu Jin, Huinan Qu, Da Qi, Peiye Song, Xiaoli Zhang, Xinqi Wang, Wenhong Xu, Yuan Dong, Yingying Liang and Chengshi Quan