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  1. Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored.

    Authors: Xiang Li, Chen Zhang, Ting Zhao, Zhongping Su, Mengjing Li, Jiancheng Hu, Jianfei Wen, Jiajia Shen, Chao Wang, Jinshun Pan, Xianmin Mu, Tao Ling, Yingchang Li, Hao Wen, Xiaoren Zhang and Qiang You

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:172

    Content type: Research

    Published on:

  2. The Covid-19 pandemic has challenged hard the national health systems worldwide. According to the national policy issued in March 2020 in response to the evolving Covid-19 pandemic, several hospitals were re-c...

    Authors: Fabio Pelle, Sonia Cappelli, Franco Graziano, Loredana Piarulli, Flavia Cavicchi, Domenico Magagnano, Assunta De Luca, Roy De Vita, Marcello Pozzi, Maurizio Costantini, Antonio Varanese, Massimo Panimolle, Pietro Paolo Gullo, Maddalena Barba, Patrizia Vici, Enrico Vizza…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:171

    Content type: Commentary

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  3. The platinum-based chemotherapy is the first-line regimen for the treatment of Non-small cell lung cancer (NSCLC). However, the therapeutic efficiency is largely limited by tenacious chemo-insensitivity that r...

    Authors: Boshi Wang, Tiantian Jing, Weilin Jin, Jinnan Chen, Chengsi Wu, Mingrong Wang and Yizhen Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:170

    Content type: Research

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  5. cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found that CREB5 was involved in the occurrence and develo...

    Authors: Shuyang Wang, Junfeng Qiu, Lei Liu, Cailin Su, Lu Qi, Chengmei Huang, Xiaoning Chen, Yaxin Zhang, Yaping Ye, Yanqing Ding, Li Liang and Wenting Liao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:168

    Content type: Research

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  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Weiwei Sheng, Xiaoyang Shi, Yiheng Lin, Jingtong Tang, Chao Jia, Rongxian Cao, Jian Sun, Guosen Wang, Lei Zhou and Ming Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:167

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:16

  7. Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For the purpose of exploring roles of th...

    Authors: Xiang Qing, Guo-lin Tan, Huo-wang Liu, Wei Li, Jin-gang Ai, Shan-shan Xiong, Meng-qing Yang and Tian-sheng Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:166

    Content type: Research

    Published on:

  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li and Hua Tang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:165

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:14

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zichao Li, Luying Zhang, Mingquan Gao, Mei Han, Kaili Liu, Zhuang Zhang, Zhi Gong, Lifei Xing, Xianzhou Shi, Kui Lu and Hui Gao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:164

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:8

  10. As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies are needed to improve cancer therapy outcomes. Numerous pathways have been shown to contribute to migration and invasi...

    Authors: Madiha Kanwal, Michal Smahel, Mark Olsen, Jana Smahelova and Ruth Tachezy

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:163

    Content type: Review

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  11. Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metas...

    Authors: Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang yang, Hongjing Zang, Jiadi Luo, Qiuyuan Wen and Songqing Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:162

    Content type: Review

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  12. Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) ...

    Authors: Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André and Catarina Brito

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:161

    Content type: Research

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  13. Colorectal cancer (CRC) is one of the causes of cancer-related death worldwide. The aim of our study was to disclose the expression pattern and underlying molecular mechanism of circular RNA TADA2A (circTADA2A...

    Authors: Zhen Li, Hongyu Yao, Shihao Wang, Guobin Li and Xiaoming Gu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:160

    Content type: Research

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  14. Emerging evidence has shown that dysregulated expression of long noncoding RNAs (lncRNAs) is implicated in liver hepatocellular carcinoma (HCC). However, the role and molecular mechanism of differentially expr...

    Authors: Hui He, Yawei Wang, Peng Ye, Dehui Yi, Ying Cheng, Haibo Tang, Zhi Zhu, Xun Wang and Shi Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:159

    Content type: Research

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  15. Chemoresistance is emerging as a major barrier to successful treatment in acute myeloid leukemia (AML), and evasion of apoptosis is among the fundamental underlying mechanisms. Therefore, unraveling molecular ...

    Authors: Yihua Pang, Yanan Zhao, Yan Wang, Xinlu Wang, Ruiqing Wang, Na Liu, Peng Li, Min Ji, Jingjing Ye, Tao Sun, Jingxin Li, Daoxin Ma, Fei Lu and Chunyan Ji

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:158

    Content type: Research

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  16. Many cancer-associated single nucleotide polymorphisms (SNPs) are located in the genomic regions of long non-coding RNAs (lncRNAs). Mechanisms of these SNPs in connection to cancer risk are not fully understood.

    Authors: Tienan Feng, Nannan Feng, Tengteng Zhu, Qiang Li, Qi Zhang, Yu Wang, Ming Gao, Baosen Zhou, Herbert Yu, Min Zheng and Biyun Qian

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:157

    Content type: Research

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  17. Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the...

    Authors: Chongru Zhao, Min Wu, Ning Zeng, Mingchen Xiong, Weijie Hu, Wenchang Lv, Yi Yi, Qi Zhang and Yiping Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:156

    Content type: Review

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  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yanxia Huang, Jing Zhang, Lidan Hou, Ge Wang, Hui Liu, Rui Zhang, Xiaoyu Chen and Jinshui Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:155

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:194

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kun Qiao, Shipeng Ning, Lin Wan, Hao Wu, Qin Wang, Xingda Zhang, Shouping Xu and Da Pang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:154

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:418

  20. Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute...

    Authors: Rosamaria Lappano, Marianna Talia, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Domenica Scordamaglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Andrew H. Sims and Marcello Maggiolini

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:153

    Content type: Research

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  21. Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting g...

    Authors: Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Martina Vitale, Emanuela Pilozzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio and Giuseppe Pugliese

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:152

    Content type: Research

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  22. Pancreatic cancer (PC) is one of the most aggressive cancers and has an extremely poor prognosis worldwide. Long noncoding RNA (lncRNA) has been reported to be a potential prognostic biomarker in the initiatio...

    Authors: Qing Han, Junhe Li, Jianping Xiong and Zhiwang Song

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:151

    Content type: Research

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  23. Hepatocellular carcinoma (HCC) is one of the most prevalent common cancer worldwide with high mortality. Transforming growth factor-β (TGF-β) signaling pathway was reported dysregulated during liver cancer for...

    Authors: Zhao Huang, Jingyuan Wen, Jingjing Yu, Jingyu Liao, Sha Liu, Ning Cai, Huifang Liang, Xiaoping Chen, Zeyang Ding and Bixiang Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:150

    Content type: Research

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  24. Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed cell death ligand 1 (PD-L1) promoted cancer progression and drug resistance, and facilitated tumor immune evasion. Ho...

    Authors: Weijun Hong, Min Xue, Jun Jiang, Yajuan Zhang and Xiwen Gao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:149

    Content type: Research

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  25. Collagens are the most abundant proteins in extra cellular matrix and important components of tumor microenvironment. Recent studies have showed that aberrant expression of collagens can influence tumor cell b...

    Authors: Ting Wang, Haojie Jin, Jingying Hu, Xi Li, Haoyu Ruan, Huili Xu, Lin Wei, Weihua Dong, Fei Teng, Jianren Gu, Wenxin Qin, Xiaoying Luo and Yujun Hao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:148

    Content type: Research

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  26. Colorectal cancer (CRC) is one of the most common malignancies, and it’s expected that the CRC burden will substantially increase in the next two decades. New biomarkers for targeted treatment and associated m...

    Authors: Xiaojuan Wang, Fan Wu, Han Wang, Xiaoyuan Duan, Rong Huang, Amannisa Tuersuntuoheti, Luying Su, Shida Yan, Yuechao Zhao, Yan Lu, Kai Li, Jinjie Yao, Zhiwen Luo, Lei Guo, Jianmei Liu, Xiao Chen…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:147

    Content type: Research

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  27. The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. Abundant evidence has indicated that STAT-...

    Authors: Ming Hong, Selena Lee, Jacob Clayton, Wildman Yake and Jinke Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:146

    Content type: Research

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  28. Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear. This study aims to verify the role and the underlying mechanisms ...

    Authors: Shi-Jie Wang, Dong Chao, Wei Wei, Gang Nan, Jia-Yue Li, Fen-Ling Liu, Ling Li, Jian-Li Jiang, Hong-Yong Cui and Zhi-Nan Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:145

    Content type: Research

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  29. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal forms of adult cancer with poor prognosis. Substantial evidence indicates that reactive oxygen species (ROS) are important modulators of aggr...

    Authors: Zhenchuan Liu, Shaorui Gu, Tiancheng Lu, Kaiqing Wu, Lei Li, Chenglai Dong and Yongxin Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:144

    Content type: Research

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  30. Cervical cancer is one of the most common cancers among females worldwide and advanced patients have extremely poor prognosis. However, adverse reactions and accumulating resistance to radiation therapy requir...

    Authors: Shuzhen Tian, Lili Lou, Mengyuan Tian, Guangping Lu, Jianghua Tian and Xi Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:143

    Content type: Research

    Published on:

  31. Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles in carcinogenesis, as it has been document...

    Authors: Juan Yang, Ying Li, Ya Zhang, Xiaosheng Fang, Na Chen, Xiangxiang Zhou and Xin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:142

    Content type: Research

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  32. Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are stil...

    Authors: Yuhui Zhang, Weibin Huang, Yujie Yuan, Jin Li, Jing Wu, Jie Yu, Yulong He, Zhewei Wei and Changhua Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:141

    Content type: Research

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  33. Exosomal microRNAs (miRNAs or miRs) from bone marrow-derived mesenchymal stem cells (UCMSCs) have emerged as promising therapeutic strategies for cancer treatment. The current study aimed to elucidate the unde...

    Authors: Zhanfeng He, Weihao Li, Tianliang Zheng, Donglei Liu and Song Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:140

    Content type: Research

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  34. Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) re...

    Authors: Ting Yang, Wei-Cong Chen, Pei-Cong Shi, Man-Ru Liu, Tao Jiang, Hu Song, Jia-Qi Wang, Rui-Zhi Fan, Dong-Sheng Pei and Jun Song

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:139

    Content type: Research

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  35. The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant ph...

    Authors: Rui Chen, Mengxian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Ziyan Zhang, Yanpeng Ding and Yali Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:138

    Content type: Review

    Published on:

  36. Hypoxia, a fundamental characteristic of glioma, is considered to promote tumor malignancy by inducing process of epithelial mesenchymal transition (EMT). Ferritin Light Chain (FTL) is one of the iron metaboli...

    Authors: Junhui Liu, Lun Gao, Na Zhan, Pengfei Xu, Ji’an Yang, Fan’en Yuan, Yang Xu, Qiang Cai, Rongxin Geng and Qianxue Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:137

    Content type: Research

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  37. Accumulating evidence have highlighted the importance of long noncoding RNAs (lncRNAs) in multiple cancers development and progression. Cancer susceptibility candidate 9 (CASC9) is a novel long non-coding RNA ...

    Authors: Yonghao Zhan, Lianghao Zhang, Shuanbao Yu, Jianguo Wen, Yuchen Liu and Xuepei Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:136

    Content type: Research

    Published on:

  38. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with poor prognosis and high incidence. The clinical data analysis of liver hepatocellular carcinoma samples downloaded from The Cance...

    Authors: Shijiao Cai, Yunpeng Bai, Huan Wang, Zihan Zhao, Xiujuan Ding, Heng Zhang, Xiaoyun Zhang, Yantao Liu, Yan Jia, Yinan Li, Shuang Chen, Honggang Zhou, Huijuan Liu, Cheng Yang and Tao Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:135

    Content type: Research

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  39. Transfer of noncoding microRNAs (miRNAs) by extracellular vesicles (EVs) promotes the development of chemoresistance in many tumor types. Additionally, restoration or depletion of several miRNAs has been obser...

    Authors: Yu Zhang, Wenbo Meng, Ping Yue and Xun Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:134

    Content type: Research

    Published on:

  40. Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality. Circular RNAs (CircRNAs) have become a research hotspot in recent years for their vital...

    Authors: Xiaoqi Chen, Jing Jiang, Yunxia Zhao, Xinting Wang, Chuanlei Zhang, Lv Zhuan, Danyang Zhang and Yuling Zheng

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:133

    Content type: Research

    Published on:

  41. Crosstalk between cancer cells and tumor-associated macrophages (TAMs) mediates tumor progression in colorectal cancer (CRC). Cytoplasmic polyadenylation element binding protein 3 (CPEB3) has been shown to exh...

    Authors: Qian Zhong, Yuxin Fang, Qiuhua Lai, Shanci Wang, Chengcheng He, Aimin Li, Side Liu and Qun Yan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:132

    Content type: Research

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  42. Esophageal cancer (EC) represents one of the most aggressive digestive neoplasms globally, with marked geographical variations in morbidity and mortality. Chemoprevention is a promising approach for cancer the...

    Authors: Shuyao Zhang, Fuchun Zheng, Liqun Zhang, Zuojun Huang, Xiaoshan Huang, Zhen Pan, Shuang Chen, Chenchen Xu, Yi Jiang, Shuyi Gu, Chengkuan Zhao, Qiuzhen Zhang and Ganggang Shi

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:131

    Content type: Research

    Published on:

  43. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yujun Tang, Yishi Lu, Yuan Cheng, Lei Luo, Lei Cai, Bangjian Peng, Wenbin Huang, Hangyu Liao, Liang Zhao and Mingxin Pan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:130

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:473

  44. Radiotherapy is the cornerstone of treatment of high-grade gliomas (HGGs). It eradicates tumor cells by inducing oxidative stress and subsequent DNA damage. Unfortunately, almost all HGGs recur locally within ...

    Authors: Han Shen, Kristina Cook, Harriet E. Gee and Eric Hau

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:129

    Content type: Review

    Published on:

  45. Hepatocellular carcinoma is the third top cause of cancer-related mortalities worldwide. The prognosis of HCC patients remains poor due to rapid progression and high incidence of tumor recurrence. Nicastrin (N...

    Authors: Hui Li, Tian Lan, Lin Xu, Hailing Liu, Jinju Wang, Jiaxin Li, Xiangzheng Chen, Jiwei Huang, Xuefeng Li, Kefei Yuan, Yong Zeng and Hong Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:128

    Content type: Research

    Published on:

  46. Recent studies have shown that the classic hypoglycemic drug metformin inhibits tumor growth; however, the underlying mechanism remains unclear. We previously showed that metformin disrupts the sponge effect o...

    Authors: Chenglai Xia, Chang Liu, Zhihong He, Yantao Cai and Jinman Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:127

    Content type: Research

    Published on:

  47. Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sora...

    Authors: Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai and Chuanyong Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:126

    Content type: Review

    Published on:

  48. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhiyan Hu, Ting Long, Yidan Ma, Jiaxian Zhu, Lingfang Gao, Yan Zhong, Xia Wang, Xiaoyan Wang and Zuguo Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:125

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:76

  49. Malformation of blood vessels represents a hallmark of cancers, but the role and regulation of vascular mural cells (vMCs), including vascular smooth muscle cells (vSMCs) and pericytes, in tumors has not been ...

    Authors: Xinxin Zhang, Xianchun Yan, Jing Cao, Ziyan Yang, Xiuli Cao, Yufei Zhang, Liang Liang, Minhua Zheng, Xiaowei Liu, Jian Zhang and Hua Han

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:124

    Content type: Research

    Published on:

  50. 3-Hydroxy butyrate dehydrogenase 2 (BDH2) is a short-chain dehydrogenase/reductase family member that plays a key role in the development and pathogenesis of human cancers. However, the role of BDH2 in gastric...

    Authors: Jia-Zhou Liu, Yi-Lin Hu, Ying Feng, Yun Jiang, Yi-Bing Guo, Yi-Fei Liu, Xi Chen, Jun-Ling Yang, Yu-yan Chen, Qin-Sheng Mao and Wan-Jiang Xue

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:123

    Content type: Research

    Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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