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  1. Content type: Research

    With the development of novel therapeutic agents, the survival of multiple myeloma (MM) patients has much improved. However, the disease is incurable due to drug resistance. Previous studies have found that hi...

    Authors: Xing Guo, Donghua He, Enfan Zhang, Jing Chen, Qingxiao Chen, Yi Li, Li Yang, Yang Yang, Yi Zhao, Gang Wang, Jingsong He and Zhen Cai

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:205

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  2. Content type: Research

    Accumulating evidence suggests that M2-polarized tumor-associated macrophages (TAMs) play an important role in cancer progression and metastasis, making M2 polarization of TAMs an ever more appealing target fo...

    Authors: Fei Xu, Wen-Qiang Cui, Ying Wei, Jie Cui, Jian Qiu, Ling-Li Hu, Wei-Yi Gong, Jing-Cheng Dong and Bao-Jun Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:207

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  3. Content type: Review

    Circular RNAs (circRNAs) are a type of noncoding RNAs with a closed loop structure. With the development of high-throughput sequencing, massive circRNAs have been discovered in tumorous tissues. Emerging evide...

    Authors: Xuehui Wang and Lin Fang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:206

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  4. Content type: Review

    Epithelial-to-mesenchymal transition (EMT) is a complex process involving multiple genes, steps and stages. It refers to the disruption of tight intercellular junctions among epithelial cells under specific co...

    Authors: Long Yan, Feng Xu and Chao-liu Dai

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:203

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  5. Content type: Research

    Considerable efforts have been devoted toward the uncovering of the molecular mechanisms underlying the maintenance of hematopoietic stem cells (HSCs) by the normal bone marrow (BM) niche. Previously, we demon...

    Authors: Chao Tang, Ming-Hao Li, Ya-Li Chen, Hui-Ying Sun, Sheng-Li Liu, Wei-Wei Zheng, Meng-Yi Zhang, Hui Li, Wei Fu, Wen-Jun Zhang, Ai-Bin Liang, Zhong-Hua Tang, Deng-Li Hong, Bin-Bing S. Zhou and Cai-Wen Duan

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:204

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  6. Content type: Research

    Resistance to trastuzumab has become a leading cause of mortality in breast cancer patients and is one of the major obstacles for improving the clinical outcome. Cell behavior can be modulated by long non-codi...

    Authors: Huaying Dong, Wei Wang, Shaowei Mo, Ru Chen, Kejian Zou, Jing Han, Fan Zhang and Jianguo Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:202

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  7. Content type: Research

    Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of chemoresistance, of which the underlying molecular me...

    Authors: Xin Xiao, Wei Wang, Yuqian Li, Di Yang, Xiaokang Li, Chao Shen, Yan Liu, Xianzhu Ke, Shuo Guo and Zheng Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:201

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  8. Content type: Research

    The function of preadipocytes in the progression of early stage breast cancer has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in breast cancer progression, we inves...

    Authors: Hoe Suk Kim, Minji Jung, Sul Ki Choi, Jisu Woo, Yin Ji Piao, Eun Hye Hwang, Hyelim Kim, Seung Ja Kim and Woo Kyung Moon

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:200

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  9. Content type: Research

    Metastasis rather than the primary cancer determines the survival of cancer patients. Activation of Akt plays a critical role in the epithelial-to-mesenchymal transition (EMT), the initial step in lung cancer ...

    Authors: Jer-Hwa Chang, Chao-Wen Cheng, Yi-Chieh Yang, Wan-Shen Chen, Wen-Yueh Hung, Jyh-Ming Chow, Pai-Sheng Chen, Michael Hsiao, Wei-Jiunn Lee and Ming-Hsien Chien

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:199

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  10. Content type: Research

    Phosphatase and tensin homolog (PTEN) is an important tumor suppressor gene, and its encoded protein has activities of both a protein phosphatase and a lipid phosphatase. However, the substitution effect of pr...

    Authors: Wenting Xu, Zhen Yang, Chuan Xie, Yin Zhu, Xu Shu, Zhe Zhang, Nianshuang Li, Na Chai, Song Zhang, Kaichun Wu, Yongzhan Nie and Nonghua Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:198

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  11. Content type: Research

    Bone tissue is one of the main sites for breast metastasis; patients diagnosed with advanced breast cancer mostly develop bone metastasis characterized by severe osteolytic lesions, which heavily influence the...

    Authors: Valeria Carina, Viviana Costa, Stefania Pagani, Angela De Luca, Lavinia Raimondi, Daniele Bellavia, Stefania Setti, Milena Fini and Gianluca Giavaresi

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:197

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  12. Content type: Research

    Interleukin-33 (IL-33) participates in various types of diseases including cancers. Previous studies of this cytokine in cancers mainly focused on its regulation on immune responses by which IL-33 modulated ca...

    Authors: Yongkui Li, Jie Shi, Shanshan Qi, Jian Zhang, Dong Peng, Zhenzhen Chen, Guobin Wang, Zheng Wang and Lin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:196

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  13. Content type: Research

    The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both of biomarkers predicting efficacy for therapies in use and of novel efficacious therapeutic agents...

    Authors: Irene Ferrer, Álvaro Quintanal-Villalonga, Sonia Molina-Pinelo, Jose Manuel Garcia-Heredia, Marco Perez, Rocío Suárez, Santiago Ponce-Aix, Luis Paz-Ares and Amancio Carnero

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:195

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  14. Content type: Research

    Cancer cells maintain energy metabolism mainly by glycolysis, even under sufficient oxygen conditions. It gives cancer cells better growth advantages under complicated internal environment. KPNA2 is a novel on...

    Authors: Jie Li, Qian Liu, Zihao Liu, Qian Xia, Zihao Zhang, Rui Zhang, Taihong Gao, Guangyan Gu, Yanan Wang, Dan Wang, Xiuyang Chen, Yihang Yang, Dong He and Tao Xin

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:194

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  15. Content type: Research

    Murine breast cancer models relying on intraductal tumor cell inoculations are attractive because they allow the study of breast cancer from early ductal carcinoma in situ to metastasis. Using a fully immunoco...

    Authors: Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere and Evelyne Meyer

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:191

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  16. Content type: Research

    Holliday junction recognition protein (HJURP) has been implicated in many cancers including hepatocellular carcinoma (HCC). However, the underlying mechanism by which HJURP promotes HCC cell proliferation rema...

    Authors: Tianchi Chen, Hechen Huang, Yuan Zhou, Lei Geng, Tian Shen, Shengyong Yin, Lin Zhou and Shusen Zheng

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:193

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  17. Content type: Research

    Epstein-Barr virus (EBV) is widely found in nasopharyngeal carcinoma (NPC) tissue and associated with poor prognosis of patients. EBV nuclear antigen 1 (EBNA1) is expressed in all NPC tumors and plays multiple...

    Authors: Heng Zhou, Yu Liu, Chao Wang, Limei Liu, Huan Wang, Yaqian Zhang, Cong Long and Xiaoping Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:192

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  18. Content type: Research

    Exosomes derived from tumor cells (TEXs) are involved in both immune suppression, angiogenesis, metastasis and anticancer stimulatory, but the biological characteristics and role of diffuse large B cell lympho...

    Authors: Zhenzhen Chen, Liangshun You, Lei Wang, Xianbo Huang, Hui Liu, Ju ying Wei, Li Zhu and Wenbin Qian

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:190

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  19. Content type: Research

    Makorin RING zinc finger-2 (MKRN2) belongs to the makorin RING zinc finger family and is a novel ubiquitin E3 ligase targeting the p65 subunit of NF-κB to negatively regulate inflammatory responses; however, the ...

    Authors: Jun Jiang, Yitong Xu, Hongjiu Ren, Muli Wudu, Qiongzi Wang, Xin Song, Hongbo Su, Xizi Jiang, Lihong Jiang and Xueshan Qiu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:189

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  20. Content type: Research

    Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-...

    Authors: Guo-sheng Zhao, Zi-ran Gao, Qiao Zhang, Xue-feng Tang, Yang-fan Lv, Zhao-si Zhang, Yuan Zhang, Qiu-lin Tan, Dong-bin Peng, Dian-ming Jiang and Qiao-Nan Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:188

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  21. Content type: Research

    Gallbladder cancer (GBC) is a highly malignant cancer with poor prognosis. Several long noncoding RNAs (lncRNAs) have been reported to be involved in the tumorigenesis and progression of GBC. However, the expr...

    Authors: Liang Yang, Qingxiang Gao, Xiaoxiong Wu, Feiling Feng and Kaiyun Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:186

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  22. Content type: Research

    Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlyi...

    Authors: Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang and Haihe Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:187

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  23. Content type: Research

    ANXA2 (Annexin A2) is a pleiotropic calcium-dependent phospholipid binding protein that is abnormally expressed in various cancers. We previously found that ANXA2 is upregulated in esophageal squamous cell car...

    Authors: Sai Ma, Chen-Chen Lu, Li-Yan Yang, Juan-Juan Wang, Bo-Shi Wang, Hong-Qing Cai, Jia-Jie Hao, Xin Xu, Yan Cai, Yu Zhang and Ming-Rong Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:183

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  24. Content type: Research

    Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of licorice (Glycyrrhiza uralensis), has shown various pharmacological properties including anti-oxidant, anti-inflammatory and anti-cancer acti...

    Authors: Shijian Xiang, Huoji Chen, Xiaojun Luo, Baichao An, Wenfeng Wu, Siwei Cao, Shifa Ruan, Zhuxian Wang, Lidong Weng, Hongxia Zhu and Qiang Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:184

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  25. Content type: Research

    Tumor cells transfer into endothelial cells by epithelial–endothelial transition (EET), which is characterized by vasculagenic mimicry (VM) in morphology. VM can change tumor microcirculation, progression, and...

    Authors: Ting Xiao, Qiang Zhang, Shumin Zong, Wei-long Zhong, Yuan Qin, Zhun Bi, Shuang Chen, Hui-juan Liu, Jun-jie Wei, Bi-jiao Zhou, Lu-meng Wang, Hong-gang Zhou, Yan-rong Liu, Tao Sun and Cheng Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:185

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  26. Content type: Research

    Human telomerase reverse transcriptase (hTERT) is highly expressed in over 80% of tumors, including human epithelial ovarian cancer (EOC). However, the mechanisms through which hTERT is up-regulated in EOC and...

    Authors: Yong-Bin Liu, Ying Mei, Jing Long, Yu Zhang, Dong-Li Hu and Hong-Hao Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:182

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  27. Content type: Research

    Glioma is the most common primary central nervous system tumor derived from glial cells. Kininogen-1 (KNG1) can exert antiangiogenic properties and inhibit proliferation of endothelial cells. The effect of KNG...

    Authors: Jinfang Xu, Jun Fang, Zhonghao Cheng, Longlong Fan, Weiwei Hu, Feng Zhou and Hong Shen

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:180

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  28. Content type: Research

    Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Gliobla...

    Authors: Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You and Qin Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:181

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  29. Content type: Research

    In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse and resistance to treatment. Our previous studies have demonstrated that osteopo...

    Authors: Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:179

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  30. Content type: Research

    Colorectal cancer (CRC) is a commonly diagnosed digestive malignancy worldwide. Ras-related protein 1A (RAP1A) is a member of the Ras superfamily of small GTPases and has been recently identified as a novel on...

    Authors: Liguo Liu, Xuebing Yan, Dapeng Wu, Yi Yang, Mengcheng Li, Yang Su, Wenchao Yang, Zezhi Shan, Yuping Gao and Zhiming Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:178

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  31. Content type: Research

    Recent studies show that exosomes are involved in intercellular communication and that abundant circular RNAs (circRNAs) are present within exosomes. However, whether these exosomal circRNAs contribute to tumo...

    Authors: Jie Li, Zhonghu Li, Peng Jiang, Minjie Peng, Xi Zhang, Kai Chen, Hui Liu, Huaqiang Bi, Xiangde Liu and Xiaowu Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:177

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  32. Content type: Research

    Adaptation to ER stress has been indicated to play an important role in resistance to therapy in human melanoma. However, the relationship between adaptation to ER stress and cell metastasis in human melanoma ...

    Authors: Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao and Chuanchun Han

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:176

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  33. Content type: Research

    Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology. However, its role in focal adhesion ...

    Authors: Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong and Daxing Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:175

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  34. Content type: Review

    The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in this article. The physiological functions and molecular machineries in stem cells, including embryonic stem (ES) cells ...

    Authors: Go J. Yoshida

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:173

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:285

  35. Content type: Research

    Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become a major obstacle in improving the clinical outcome of patients with metastatic and advanced-stage esophageal squamous cell car...

    Authors: Min Kang, Meiping Ren, Yan Li, Yuqiong Fu, Minmin Deng and Changping Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:171

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  36. Content type: Research

    The development of radioresistance is one of main causes for therapeutic failure of prostate cancer (PCa). The present study aims to investigate the function and the related mechanism by which HZ08 sensitizes ...

    Authors: Yanyan Zhang, Zhi Xu, Jiaji Ding, Chunli Tan, Weizi Hu, Yunman Li, Wenlong Huang and Yong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:174

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  37. Content type: Research

    Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in hepatocellular cancer (HCC) is largely unk...

    Authors: Ning Bai, Eming Peng, Xingsheng Qiu, Ning Lyu, Zhejia Zhang, Yiming Tao, Xinying Li and Zhiming Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:172

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  38. Content type: Research

    Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleeve...

    Authors: Francesca Monteleone, Simona Taverna, Riccardo Alessandro and Simona Fontana

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:170

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  39. Content type: Research

    Glioblastoma (GBM) is a primary brain tumor with a 5-year survival rate of ≤5%. We have shown earlier that GBM-antibody-linked curcumin (CC) and also phytosomal curcumin (CCP) rescue 50–60% of GBM-bearing mice...

    Authors: Sumit Mukherjee, Angela Fried, Rahman Hussaini, Richard White, Juliet Baidoo, Sri Yalamanchi and Probal Banerjee

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:168

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  40. Content type: Research

    Increasing studies confirmed that abnormal lncRNAs expression play a critical role in cervical cancer (CC) development and progression. LncRNA TPT1-AS1, a novel lncRNA, its role and underlying mechanisms invol...

    Authors: Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou and Xianhan Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:169

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  41. Content type: Research

    Aberrant expression of Wiskott–Aldrich syndrome protein interacting protein family member 1 (WIPF1) contributes to the invasion and metastasis of several malignancies. However, the role of WIPF1 in human pancr...

    Authors: Yu Pan, Fengchun Lu, Ping Xiong, Maoen Pan, Zheyang Zhang, Xianchao Lin, Minggui Pan and Heguang Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:167

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  42. Content type: Research

    The KRAS mutation is the driving force of pancreatic ductal adenocarcinoma (PDAC). Downstream effectors of KRAS signal pathways are crucial to the development of PDAC. The purpose of this study was to investig...

    Authors: Yan Sun, Wenfang Peng, Weiwei He, Man Luo, Guilin Chang, Jiping Shen, Xiaoping Zhao and Yu Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:166

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  43. Content type: Research

    Tongue squamous cell carcinoma (TSCC) is the most common oral cancer. Neoadjuvant systemic treatment before or after surgery for advanced TSCC is considered one of the most crucial factors in reducing mortalit...

    Authors: Yixue Gu, Hao Liu, Fangren Kong, Jiahui Ye, Xiaoting Jia, Zhijie Zhang, Nan Li, Jiang Yin, Guopei Zheng and Zhimin He

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:164

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  44. Content type: Research

    Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain protein Ajuba regulates β-catenin and YA...

    Authors: Min Liu, Ke Jiang, Guibin Lin, Peng Liu, Yumei Yan, Tian Ye, Gang Yao, Martin P. Barr, Dapeng Liang, Yang Wang, Peng Gong, Songshu Meng and Haozhe Piao

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:165

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  45. Content type: Research

    Exosomes are critically involved in cancer development and progression. The exosomal contents have been suggested as ideal cancer biomarkers. In this study, we investigated the expression of exosomal proteins ...

    Authors: Hailong Fu, Huan Yang, Xu Zhang, Bo Wang, Jiahui Mao, Xia Li, Mei Wang, Bin Zhang, Zixuan Sun, Hui Qian and Wenrong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:162

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  46. Content type: Review

    Biomarkers are an integral part of cancer management due to their use in risk assessment, screening, differential diagnosis, prognosis, prediction of response to treatment, and monitoring progress of disease. ...

    Authors: Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison and Kim L. O’Neill

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:163

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  47. Content type: Research

    Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward o...

    Authors: Huei-Yu Chen, Atikul Islam, Tien-Ming Yuan, Shi-Wen Chen, Pei-Fen Liu and Pin Ju Chueh

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:161

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  48. Content type: Research

    Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis...

    Authors: Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He and Qingde Wa

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:160

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  49. Content type: Research

    Paired box 8 (PAX8) has been documented to be downregulated in gastric cancer. However, its biological function in this malignancy is poorly understood.

    Authors: Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu and Bin Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:159

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  50. Content type: Research

    Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine’s inhibition on cancers thr...

    Authors: Jia Shen, Tao Zhang, Zheng Cheng, Ni Zhu, Hua Wang, Li Lin, Zexia Wang, Haotian Yi and Meichun Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:157

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