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  1. Content type: Research

    DEPTOR is an endogenous inhibitor of mTORC1 and mTORC2 that plays a vital role in the progression of human malignances. However, the biological function of DEPTOR in HCC metastasis and the underlying molecular...

    Authors: Jin Chen, Haidan Zhu, Qiumeng Liu, Deng Ning, Zhaoqi Zhang, Long Zhang, Jie Mo, Pengcheng Du, Xu Liu, Shasha Song, Yawei Fan, Huifang Liang, Jikui Liu, Bixiang Zhang and Xiaoping Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:273

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  2. Content type: Research

    Development of resistance to inhibitors of BRAF (BRAFi) and MEK (MEKi) remains a great challenge for targeted therapy in patients with BRAF-mutant melanoma. Here, we explored the role of miRNAs in melanoma acq...

    Authors: Simona Caporali, Adriana Amaro, Lauretta Levati, Ester Alvino, Pedro Miguel Lacal, Simona Mastroeni, Federica Ruffini, Laura Bonmassar, Gian Carlo Antonini Cappellini, Nadia Felli, Alessandra Carè, Ulrich Pfeffer and Stefania D’Atri

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:272

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  3. Content type: Research

    Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and mitochondria. Sequence corresponding to CHTM1 is a...

    Authors: Mansi Babbar, Ying Huang, Christopher M. Curtiss and M. Saeed Sheikh

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:271

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  4. Content type: Review

    Gliomas represent the most common type of malignant brain tumor, among which, glioblastoma remains a clinical challenge with limited treatment options and dismal prognosis. It has been shown that the dysregula...

    Authors: Fangling Cheng and Dongsheng Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:270

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  6. Content type: Review

    Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this succes...

    Authors: Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner and Michael von Bergwelt-Baildon

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:268

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  7. Content type: Research

    FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associat...

    Authors: Kyoung Min Kim, Usama Khamis Hussein, See-Hyoung Park, Mi Ae Kang, Young Jae Moon, Zhongkai Zhang, Yiping Song, Ho Sung Park, Jun Sang Bae, Byung-Hyun Park, Sang Hoon Ha, Woo Sung Moon, Jung Ryul Kim and Kyu Yun Jang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:267

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  8. Content type: Research

    Glioblastoma (GBM) is an aggressive brain tumor with universal recurrence and poor prognosis. The recurrence is largely driven by chemoradiation resistant cancer stem cells (CSCs). Epidermal growth factor rece...

    Authors: Raghupathy Vengoji, Muzafar A. Macha, Rama Krishna Nimmakayala, Satyanarayana Rachagani, Jawed A. Siddiqui, Kavita Mallya, Santhi Gorantla, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra and Nicole Shonka

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:266

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  9. Content type: Research

    Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clinically. In this study, we sought to explore whether ivermectin (IVM), a macrolide ...

    Authors: Lu Jiang, Pan Wang, Ying-Jian Sun and Yi-Jun Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:265

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  10. Content type: Research

    Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to asse...

    Authors: Xiaocheng Cao, Lihua Liu, Qing Yuan, Xiang Li, Yinghong Cui, Kaiqun Ren, Chang Zou, A. Chen, Chang Xu, Yebei Qiu, Meifang Quan, Jiansong Zhang, Jianguo Cao and Xiangding Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:264

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  11. Content type: Research

    Hepatocellular carcinoma (HCC) is the most common tumors in the worldwide, it develops resistance to radiotherapy during treatment, understanding the regulatory mechanisms of radioresistance generation is the ...

    Authors: Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li and Binsheng Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:263

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:336

  12. Content type: Review

    Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considere...

    Authors: Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni and Gabriella D’Orazi

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:262

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  13. Content type: Research

    Although the prognosis of patients with occult hepatitis B virus (HBV) infection (OBI) is usually benign, a small portion may undergo cirrhosis and subsequently hepatocellular carcinoma (HCC). We studied the m...

    Authors: Xiao-Ping Chen, Xin Long, Wen-long Jia, Han-Jie Wu, Jing Zhao, Hui-Fang Liang, Arian Laurence, Jun Zhu, Dong Dong, Yan Chen, Long Lin, Yu-Dong Xia, Wei-Yang Li, Gui-Bo Li, Zhi-Kun Zhao, Kui Wu…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:261

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  14. Content type: Research

    Lung cancer is still the main cause of cancer death worldwide despite the availability of targeted therapies and immune-checkpoint inhibitors combined with chemotherapy. Cancer cell heterogeneity and primary o...

    Authors: Federica Giordano, Valentina Vaira, Diego Cortinovis, Sara Bonomo, Joyce Goedmakers, Federica Brena, Annamaria Cialdella, Leonarda Ianzano, Irene Forno, Maria Grazia Cerrito, Roberto Giovannoni, Gian Luca Ferri, Ennio Tasciotti, Silve Vicent, Francesco Damarco, Silvano Bosari…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:260

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  15. Content type: Research

    USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear.

    Authors: Xiaojun Man, Chiyuan Piao, Xuyong Lin, Chuize Kong, Xiaolu Cui and Yuanjun Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:259

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  16. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play significant roles in metastatic progression and ch...

    Authors: Hyun Ju Hwang, Min-Suk Oh, Dong Woo Lee and Hyo-Jeong Kuh

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:258

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  17. Content type: Research

    We reported that horizontal transfer of malignant traits to target cells is a potential pathway to explain cancer dissemination. Although these results were encouraging, they were never corroborated by data sh...

    Authors: Mohamed Abdouh, Matteo Floris, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:257

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  18. Content type: Research

    Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies, including breast cancer (B...

    Authors: Xue Gao, Tao Qin, Jun Mao, Jun Zhang, Shujun Fan, Ying Lu, Zhigang Sun, Qingqing Zhang, Bo Song and Lianhong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:256

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  20. Content type: Research

    Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mut...

    Authors: Ping Chen, Han-Peng Huang, Yi Wang, Jun Jin, Wei-Guo Long, Kan Chen, Xiao-Hui Zhao, Chen-Guo Chen and Jian Li

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:254

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  21. Content type: Research

    Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is a strong rationale for combining them with targeted therapy. Inhibition of MAPK pathway may have pleiotropic ef...

    Authors: Carminia Maria Della Corte, Giusi Barra, Vincenza Ciaramella, Raimondo Di Liello, Giovanni Vicidomini, Silvia Zappavigna, Amalia Luce, Marianna Abate, Alfonso Fiorelli, Michele Caraglia, Mario Santini, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello and Floriana Morgillo

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:253

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  22. Content type: Research

    Optimal therapeutic strategies for hepatocellular carcinoma (HCC) patients are still challenging due to the high recurrence rate after surgical resection and chemotherapy resistance. Growing evidence shows tha...

    Authors: Jie Zhao, Ann Wozniak, Abby Adams, Josiah Cox, Anusha Vittal, Jordan Voss, Brian Bridges, Steven A. Weinman and Zhuan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:252

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  23. Content type: Research

    Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identificati...

    Authors: Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:251

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  25. Content type: Research

    Colorectal cancer (CRC) is the third most frequent cancer and the second leading cause of cancer-related death worldwide. Increasing evidence indicates that the deregulation of long noncoding RNAs (lncRNAs) co...

    Authors: Kaili Luo, Jingwen Geng, Qinkai Zhang, Yesha Xu, Xunzhu Zhou, Zheng Huang, Ke-Qing Shi, Chenwei Pan and Jianmin Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:249

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  26. Content type: Research

    Glioma is the most common and lethal type of malignant brain tumor. Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processe...

    Authors: Yichen Song, Lianqi Shao, Yixue Xue, Xuelei Ruan, Xiaobai Liu, Chunqing Yang, Jian Zheng, Shuyuan Shen, Jiajia Chen, Zhen Li and Yunhui Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:248

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  27. Content type: Research

    Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. Little is known about its invasion and metastasis mechanism so far.

    Authors: Hui Shen, Min He, Ruirong Lin, Ming Zhan, Sunwang Xu, Xince Huang, Chu Xu, Wei Chen, Yanhua Yao, Man Mohan and Jian Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:247

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  28. Content type: Research

    Prostate cancer (PCa) is considered one of the most prevalent malignancy globally, and metastasis is a major cause of death. Apigenin (API) is a dietary flavonoid which exerts an antimetastatic effect in vario...

    Authors: Ming-Hsien Chien, Yung-Wei Lin, Yu-Ching Wen, Yi-Chieh Yang, Michael Hsiao, Junn-Liang Chang, Hsiang-Ching Huang and Wei-Jiunn Lee

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:246

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  29. Content type: Research

    Cisplatin is the first-line chemotherapy used against most upper aerodigestive tract carcinomas. In head and neck cancer, sensitivity to cisplatin remains the key issue in treatment response and outcome. Genet...

    Authors: Wei-Min Chang, Yu-Chan Chang, Yi-Chieh Yang, Sze-Kwan Lin, Peter Mu-Hsin Chang and Michael Hsiao

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:245

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  30. Content type: Research

    Gallbladder cancer (GBC) is the most malignant cancer occurring in the biliary tract cancer featured with undesirable prognosis, in which most patients die within a year of cholecystectomy. Long noncoding RNAs...

    Authors: Nan Lin, Zhicheng Yao, Mingxing Xu, Jingyao Chen, Yi Lu, Lin Yuan, Shuqin Zhou, Xiaoguang Zou and Ruiyun Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:244

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  31. Content type: Research

    The chemotherapy-resistance of triple-negative breast cancer (TNBC) remains a major challenge. The Nek2B kinase and β-catenin serve as crucial regulators of mitotic processes. The aim of this study was to test...

    Authors: Honghong Shen, Wenpeng Yan, Jinyang Yuan, Ziyue Wang and Chen Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:243

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  32. Content type: Research

    Lung cancer remains the most common cause of cancer-related deaths, with a high incidence and mortality in both sexes worldwide. Chemoprevention has been the most effective strategy for lung cancer prevention....

    Authors: Yanmei Lou, Zhenzhen Guo, Yuanfeng Zhu, Muyan Kong, Rongrong Zhang, Linlin Lu, Feichi Wu, Zhongqiu Liu and Jinjun Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:242

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  33. Content type: Research

    Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic stress that triggers paracrine, adaptive responses...

    Authors: Svenja Offer, Julien A. Menard, Julio Enríquez Pérez, Kelin G. de Oliveira, Vineesh Indira Chandran, Maria C. Johansson, Anna Bång-Rudenstam, Peter Siesjö, Anna Ebbesson, Ingrid Hedenfalk, Pia C. Sundgren, Anna Darabi and Mattias Belting

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:241

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  34. Content type: Research

    To determine whether the upregulation of basic leucine zipper ATF-like transcription factor 2 (BATF2) by calycosin suppresses the growth and epithelial-to-mesenchymal transition (EMT) in human colorectal cance...

    Authors: Qun Wang, Weijun Lu, Tao Yin and Li Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:240

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:288

  35. Content type: Research

    Temozolomide-perillyl alcohol conjugate (NEO212), a novel temozolomide (TMZ) analog, was previously reported to exert its anti-cancer effect in non-small cell lung cancer (NSCLC), and human nasopharyngeal carc...

    Authors: Xingguo Song, Lisheng Liu, Minghui Chang, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie and Xianrang Song

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:239

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  36. Content type: Research

    Adherent junction associated protein 1 (AJAP1), a typical molecule of adherent junctions, has been found to be a tumor suppressor in many cancer types. Aberrant activation of β-catenin has been demonstrated to...

    Authors: Cong Xu, Fang Liu, Guomin Xiang, Lu Cao, Shuling Wang, Jing Liu, Qingxiang Meng, Danni Xu, Shuhua Lv, Jiao Jiao and Yun Niu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:238

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  37. Content type: Research

    Liver cancer stem cells (LCSCs) are a small subset of cells characterized by unlimited self-renewal, cell differentiation, and uncontrollable cellular growth. LCSCs are also resistant to conventional therapies...

    Authors: Dong-Mei Wu, Zi-Hui Zheng, Ying-Bo Zhang, Shao-Hua Fan, Zi-Feng Zhang, Yong-Jian Wang, Yuan-Lin Zheng and Jun Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:237

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  38. Content type: Research

    Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with chemotherapy is an effective treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC). However, only ...

    Authors: Valentina Belli, Nunzia Matrone, Stefania Napolitano, Giorgia Migliardi, Francesca Cottino, Andrea Bertotti, Livio Trusolino, Erika Martinelli, Floriana Morgillo, Davide Ciardiello, Vincenzo De Falco, Emilio Francesco Giunta, Umberto Bracale, Fortunato Ciardiello and Teresa Troiani

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:236

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  39. Content type: Research

    Vascular maturity and functionality are closely associated with tumor progression and chemosensitivity. The antidiabetic agent metformin has shown its ability to inhibit tumor angiogenesis in metastatic breast...

    Authors: Ji-Chang Wang, Guang-Yue Li, Bo Wang, Su-Xia Han, Xin Sun, Yi-Na Jiang, Yan-Wei Shen, Can Zhou, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Mao-De Wang and Pei-Jun Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:235

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  40. Content type: Research

    Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response pro...

    Authors: Sandra Muñoz-Galván, Blanca Felipe-Abrio, Miguel García-Carrasco, Julia Domínguez-Piñol, Elisa Suarez-Martinez, Eva M. Verdugo-Sivianes, Asunción Espinosa-Sánchez, Lola E. Navas, Daniel Otero-Albiol, Juan J. Marin, Manuel P. Jiménez-García, Jose M. García-Heredia, Adoración G. Quiroga, Purificacion Estevez-Garcia and Amancio Carnero

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:234

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  41. Content type: Research

    Previous study demonstrated that extracellular ATP could promote cell migration and invasion in multiple human cancers. Till now, the pro-invasive mechanisms of ATP and P2RX6, a preferred receptor for ATP, are...

    Authors: Dongkui Gong, Jin Zhang, Yonghui Chen, Yunfei Xu, Junjie Ma, Guanghui Hu, Yiran Huang, Junhua Zheng, Wei Zhai and Wei Xue

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:233

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  42. Content type: Research

    Sorafenib is approved as a standard therapy for advanced hepatocellular carcinoma (HCC), but its clinical application is limited due to moderate therapeutic efficacy and high incidence of acquired resistance r...

    Authors: Ning Zheng, Weiqun Liu, Bifei Li, Huifang Nie, Jian Liu, Yunlong Cheng, Jichuang Wang, Haiyan Dong and Lee Jia

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:232

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  43. Content type: Review

    Because of the complexity of the blood-brain barrier (BBB), brain tumors, especially the most common and aggressive primary malignant tumor type arising from the central nervous system (CNS), glioblastoma, rem...

    Authors: George E. D. Petrescu, Alexandru A. Sabo, Ligia I. Torsin, George A. Calin and Mihnea P. Dragomir

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:231

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  44. Content type: Review

    Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine the...

    Authors: Dominika Piasecka, Marcin Braun, Kamila Kitowska, Kamil Mieczkowski, Radzislaw Kordek, Rafal Sadej and Hanna Romanska

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:230

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  45. Content type: Research

    The study examines the expression and function of hypoxia-inducible gene 2 (HIG2) in hepatocellular carcinoma (HCC) tissues and cells.

    Authors: Chuanbao Cui, Kaiwen Fu, Lu Yang, Shuzhi Wu, Zuojie Cen, Xingxing Meng, Qiongguang Huang and Zhichun Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:229

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  46. Content type: Research

    Tumor microenvironment (TME) plays a very important role in cancer progression. The mesenchymal stem cells (MSC), a major compartment of TME, have been shown to promote hepatocellular carcinoma (HCC) progressi...

    Authors: Yang Liu, Haozhen Ren, Yuan Zhou, Longcheng Shang, Yuheng Zhang, Faji Yang and Xiaolei Shi

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:228

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  47. Content type: Research

    Cancer stem-like traits contribute to prostate cancer (PCa) progression and metastasis. Deciphering the novel molecular mechanisms underlying stem-like traits may provide important insight for developing novel...

    Authors: Jing Hu, Feifei Sun, Weiwen Chen, Jing Zhang, Tao Zhang, Mei Qi, Tingting Feng, Hui Liu, Xinjun Li, Yuanxin Xing, Xueting Xiong, Benkang Shi, Gengyin Zhou and Bo Han

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:227

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  48. Content type: Research

    A novel paradigm in tumor biology suggests that osteosarcoma (OS) chemo-resistance is driven by osteosarcoma stem cell-like cells (OSCs). As the sensitivity of only a few tumors to epidermal growth factor rece...

    Authors: Tian Wang, Dexing Wang, Lian Zhang, Ping Yang, Jing Wang, Qi Liu, Fei Yan and Feng Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:226

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  49. Content type: Research

    Triple-negative breast cancer (TNBC) is often aggressive and associated with a poor prognosis. Due to the lack of available targeted therapies and to problems of resistance with conventional chemotherapeutic a...

    Authors: Jinjiao Hu, Yanhao Zhang, Xiuxing Jiang, Hongwei Zhang, Ziyi Gao, Yunong Li, Ruoqiu Fu, Lirong Li, Jie Li, Hongjuan Cui and Ning Gao

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:225

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  50. Content type: Research

    Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer. ...

    Authors: Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun and Changhua Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:223

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Journal of Experimental & Clinical Cancer Research

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