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  1. The introduction of functional in-silico models, in addition to in-vivo tumor models, opens up new and unlimited possibilities in cancer research and drug development. The world's first digital twin of the A54...

    Authors: Christian Baumgartner
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:298
  2. Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear.

    Authors: Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu and Xiaojun Zha
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:297
  3. Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer (GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC-LM) remains unknown. Exosomes have been id...

    Authors: Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:296
  4. Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients. Here, we aimed to uncover ...

    Authors: Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Hai-Kun Wang, Jia-Hao Jiang and Jian-Yong Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:295
  5. The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly found to be mutated in age-related clon...

    Authors: Kanak Joshi, Lei Zhang, Peter Breslin S.J., Ameet R. Kini and Jiwang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:294
  6. Protein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating arginine methylation in cancer and are increasingly recognized as potential drug targets. Inhibitors targeting PRM...

    Authors: Shuangjie Liu, Zhuonan Liu, Chiyuan Piao, Zhe Zhang, Chuize Kong, Lei Yin and Xi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:293
  7. The management of sub-totally resected sporadic vestibular schwannoma (VS) may include observation, re-resection or irradiation. Identifying the optimal choice can be difficult due to the disease’s variable pr...

    Authors: Moran Amit, Tongxin Xie, Frederico O. Gleber-Netto, Patrick J. Hunt, Gautam U. Mehta, Diana Bell, Deborah A. Silverman, Ismail Yaman, Yi Ye, Jared K. Burks, Gregory N. Fuller, Paul W. Gidley, Marc-Elie Nader, Shaan M. Raza and Franco DeMonte
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:292
  8. Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:291

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:21

  9. Authors: Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari and Rossella Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:290

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:24

  10. Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high specificity and low toxicity have emerged as a powerful technology of targeted protein degradation for biomedical applications. FOXM1,...

    Authors: Kun Wang, Xiaoyong Dai, Albert Yu, Chunyan Feng, Kewei Liu and Laiqiang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:289
  11. Pancreatic ductal adenocarcinoma is prone to metastasis, resulting in short survival and low quality of life. LncRNAs are pivotal orchestrators that participate in various tumor progress. The underlying role a...

    Authors: Min Zhou, Shutao Pan, Tingting Qin, Chunle Zhao, Taoyuan Yin, Yang Gao, Yuhui Liu, Zhenxiong Zhang, Yongkang Shi, Yu Bai, Jun Gong, Xingjun Guo, Min Wang and Renyi Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:288
  12. Lymph node metastasis is one of most common determinants of the stage and prognosis of gastric cancer (GC). However, the key molecular events and mechanisms mediating lymph node metastasis remain elusive.

    Authors: Yongxu Jia, Qian Yan, Yinli Zheng, Lei Li, Baifeng Zhang, Zhiwei Chang, Zehua Wang, Hong Tang, Yanru Qin and Xin-Yuan Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:287
  13. Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic acids and mediate intercellular communication among multiple cells in the tumour environment. Small extracell...

    Authors: Kewen Qian, Wenyan Fu, Tian Li, Jian Zhao, Changhai Lei and Shi Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:286
  14. Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance...

    Authors: Manuel Gámez-Chiachio, Ángela Molina-Crespo, Carmen Ramos-Nebot, Jeannette Martinez-Val, Lidia Martinez, Katja Gassner, Francisco J. Llobet, Mario Soriano, Alberto Hernandez, Marco Cordani, Cristina Bernadó-Morales, Eva Diaz, Alejandro Rojo-Sebastian, Juan Carlos Triviño, Laura Sanchez, Ruth Rodríguez-Barrueco…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:285
  15. Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cel...

    Authors: Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang and Jinhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:284

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:313

  16. Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic de...

    Authors: Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Alexander W. Loftus, Moeez Rathore, Ali Vaziri-Gohar, John M. Asara, Jordan M. Winter and Luke D. Rothermel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:283
  17. Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their s...

    Authors: Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger and Naris Nilubol
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:282
  18. Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development of many diseases, including tumors. This study aimed to investigate the potential roles of ci...

    Authors: Xiaopei Hao, Yao Zhang, Xiaoli Shi, Hanyuan Liu, Zhiying Zheng, Guoyong Han, Dawei Rong, Chuanyong Zhang, Weiwei Tang and Xuehao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:281
  19. Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- and second-line settings. However, only 15–20% of pati...

    Authors: Anna Tosi, Beatrice Parisatto, Anna Menegaldo, Giacomo Spinato, Maria Guido, Annarosa Del Mistro, Rossana Bussani, Fabrizio Zanconati, Margherita Tofanelli, Giancarlo Tirelli, Paolo Boscolo-Rizzo and Antonio Rosato
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:279
  20. Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant feat...

    Authors: Hashem Khanbabaei, Saeedeh Ebrahimi, Juan Luis García-Rodríguez, Zahra Ghasemi, Hossein Pourghadamyari, Milad Mohammadi and Lasse Sommer Kristensen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:278
  21. Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite accumulating understanding of OC in the post-genomic era, the preclinical knowledge stil...

    Authors: Tianyu Qin, Junpeng Fan, Funian Lu, Li Zhang, Chen Liu, Qiyue Xiong, Yang Zhao, Gang Chen and Chaoyang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:277
  22. The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important roles related to the hallmarks of cancer. In cancer, multiple components of the ECM have b...

    Authors: Ancuta Jurj, Calin Ionescu, Ioana Berindan-Neagoe and Cornelia Braicu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:276
  23. Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Her...

    Authors: Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Xiangyuan Luo, Xiaoping Chen, Bixiang Zhang, Danfei Liu, Yangyang Feng, Mengyu Sun, Wenjie Huang and Limin Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:275
  24. Severe hypoxia is a prominent character of pancreatic ductal adenocarcinoma (PDAC) microenvironment. In the process of gemcitabine based chemotherapy, PDAC cells are insulted from replication stresses co-induc...

    Authors: Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi and Bo Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:274
  25. Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being ...

    Authors: Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla and Isabella Saggio
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:273
  26. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0717-3

    Authors: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:272
  27. Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but now it has also been found to suppress cancer by inducing c...

    Authors: Peijie Zheng, Chuntao Zhou, Liuyi Lu, Bin Liu and Yuemin Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:271
  28. Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in various types of cancer. Current developments in transcriptome analyses unveiled the existence...

    Authors: Jiwei Zhang, Tao Pan, Weiwei Zhou, Ya Zhang, Gang Xu, Qi Xu, Si Li, Yueying Gao, Zhengtao Wang, Juan Xu and Yongsheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:270
  29. Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers resistant to conventional therapies. TCE are antibody-like proteins that simultaneously ...

    Authors: Margherita Passariello, Asami Yoshioka, Kota Takahashi, Shu-ichi Hashimoto, Toshikazu Inoue, Koji Nakamura and Claudia De Lorenzo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:269
  30. As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the...

    Authors: Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang and Peng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:268
  31. Circular RNA (circRNA) is crucial to the progression of hepatocellular cancer (HCC). In addition, Mitochondrial calcium uniporter regulatory factor 1 (MCUR1) is commonly overexpressed in HCC to increase cellul...

    Authors: Yi Li, Anqi Wu, Lin Chen, Aiting Cai, Yuhao Hu, Zhou Zhou, Qianyi Qi, Yixuan Wu, Donglin Xia, Peixin Dong, Shaoqing Ju and Feng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:267
  32. Colorectal cancer (CRC) remains largely incurable when diagnosed at the metastatic stage. Despite some advances in precision medicine for this disease in recent years, new molecular targets, as well as prognos...

    Authors: Margherita Pergolizzi, Laura Bizzozero, Federica Maione, Elena Maldi, Claudio Isella, Marco Macagno, Elisa Mariella, Alberto Bardelli, Enzo Medico, Caterina Marchiò, Guido Serini, Federica Di Nicolantonio, Federico Bussolino and Marco Arese
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:266
  33. As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically-applicable way. The int...

    Authors: Karama Asleh, Nazia Riaz and Torsten O. Nielsen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:265
  34. Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE),...

    Authors: Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng and Wael El-Rifai
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:264
  35. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1244-6..

    Authors: Xiaocheng Cao, Lihua Liu, Qing Yuan, Xiang Li, Yinghong Cui, Kaiqun Ren, Chang Zou, A. Chen, Chang Xu, Yebei Qiu, Meifang Quan, Jiansong Zhang, Jianguo Cao and Xiangding Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:263
  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wanxu Huang, Hua Li, Qingsong Yu, Wei Xiao and Dan Ohtan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:262

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:100

  37. Metastasis is the main cause of mortality in cervical cancer (CC). Circular RNAs (circRNAs) have been demonstrated to play a crucial role in carcinoma biology. However, the expression and function of circRNAs ...

    Authors: Leilei Liang, Yunshu Zhu, Jian Li, Jia Zeng and Lingying Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:261
  38. Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC metastasis remain to be fully understood. With the increas...

    Authors: Yanliang Wang, Yu Chen Feng, Yujin Gan, Liu Teng, Li Wang, Ting La, Peilin Wang, Yue Gu, Lei Yan, Na Li, Lina Zhang, Limeng Wang, Rick F. Thorne, Xu Dong Zhang, Huixia Cao and Feng-Min Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:260
  39. Radiation-induced bystander effect (RIBE) can promote tumor metastasis contributing to the failure of radiotherapy for esophageal squamous cell carcinoma (ESCC). Aberrant expression of DJ-1 has been identified...

    Authors: Junjie Gu, Yuanyuan Sun, Jiahang Song, Ruiling Zhao, Xiaoke Di, Yumeng Zhang, Xiaolin Ge, Shu Zhang, Yun Gu and Xinchen Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:259
  40. Pancreatic cancer is one of the most difficult cancers to detect early and most patients die from complications arising due to distant organ metastases. The lack of bona fide early biomarkers is one of the pri...

    Authors: Harrys Kishore Charles Jacob, Rossana Signorelli, John Lalith Charles Richard, Tyler Kashuv, Shweta Lavania, Ashley Middleton, Beatriz Aguilar Gomez, Anthony Ferrantella, Haleh Amirian, Junyi Tao, Ayse Burcu Ergonul, Melinda Minucci Boone, Marco Hadisurya, Weiguo Andy Tao, Anton Iliuk, Manoj Kumar Kashyap…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:258
  41. G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated...

    Authors: Yuan Li, Yibo Fan, Jinbang Xu, Longfei Huo, Ailing W. Scott, Jiankang Jin, Boxuan Yang, Shan Shao, Lang Ma, Ying Wang, Xiaodan Yao, Melissa Pool Pizzi, Matheus Sewastjanow Da Silva, Guoliang Zhang, Lijuan Zhuo, Eun Jeong Cho…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:257
  42. Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for TNBC. However, response to radiotherapy is ...

    Authors: Shayan Khozooei, Konstanze Lettau, Francesca Barletta, Tina Jost, Simone Rebholz, Soundaram Veerappan, Mirita Franz-Wachtel, Boris Macek, George Iliakis, Luitpold V. Distel, Daniel Zips and Mahmoud Toulany
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:256
  43. Malignant pleural mesothelioma is a highly aggressive tumor associated with asbestos exposure. There are few effective treatment options for mesothelioma, and patients have a very poor prognosis. Mesothelioma ...

    Authors: Paola Muti, Andrea Sacconi, Claudio Pulito, Giulia Orlandi, Sara Donzelli, Aldo Morrone, James Jiulian, Gerard P. Cox, Martin Kolb, Gregory Pond, Peter Kavsak, Mark Norman Levine, Giovanni Blandino and Sabrina Strano
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:255
  44. The progression of nasopharyngeal carcinoma (NPC) is profoundly affected by Epstein-Barr virus (EBV) infection. However, the role of EBV in the intercommunication between NPC and surrounding stromal cells has ...

    Authors: Po-Ju Lee, Yun-Hua Sui, Tzu-Tung Liu, Ngan-Ming Tsang, Chen-Han Huang, Ting-Yi Lin, Kai-Ping Chang and Shu-Chen Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:254
  45. Tumor-associated macrophages (TAMs), which form a large part of the tumor microenvironment, are normally regulated by metabolic reprogramming. However, the potential mechanisms of the immune-metabolism interac...

    Authors: Minghao Xu, Chenhao Zhou, Jialei Weng, Zhaoshuo Chen, Qiang Zhou, Jian Gao, Guoming Shi, Aiwu Ke, Ning Ren, Huichuan Sun and Yinghao Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:253
  46. The accumulating evidence confirms that long non-coding RNAs (lncRNAs) play a critical regulatory role in the progression of renal cell carcinoma (RCC). But, the application of lncRNAs in gene therapy remains ...

    Authors: Weipu Mao, Keyi Wang, Wentao Zhang, Shuqiu Chen, Jinbo Xie, Zongtai Zheng, Xue Li, Ning Zhang, Yuanyuan Zhang, Haimin Zhang, Bo Peng, Xudong Yao, Jianping Che, Junhua Zheng, Ming Chen and Wei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:252
  47. Gastric cancer (GC) is one of the most common malignant tumors in China. Circular RNAs (circRNAs) are novel non-coding RNAs with important regulatory roles in cancer progression. IGF2BP3 has been found to play...

    Authors: Qiang Ma, Feifei Yang, Bo Huang, Xiaojuan Pan, Wei Li, Ting Yu, Xiaolin Wang, Lingyu Ran, Kun Qian, Hui Li, Haiping Li, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:251
  48. Tyrosine kinase inhibitors (TKIs) such as sunitinib are multitarget antiangiogenic agents in clear cell renal cell carcinoma (ccRCC). They are widely used in the treatment of advanced/metastatic renal cancer. ...

    Authors: Wei Li, Kun Ye, Xurui Li, Xinlin Liu, Mou Peng, Fang Chen, Wei Xiong, Yinhuai Wang and Liang Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:250
  49. Authors: Gonçalo Outeiro-Pinho, Daniela Barros-Silva, Elena Aznar, Ana-Isabel Sousa, Márcia Vieira-Coimbra, Jorge Oliveira, Céline S. Gonçalves, Bruno M. Costa, Kerstin Junker, Rui Henrique and Carmen Jerónimo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:247

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:98

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