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  1. Deregulation of protein translation control is a hallmark of cancers. Eukaryotic initiation factor 4A2 (EIF4A2) is required for mRNA binding to ribosome and plays an important role in translation initiation. H...

    Authors: Zhan-Hong Chen, Jing-Jing Qi, Qi-Nian Wu, Jia-Huan Lu, Ze-Xian Liu, Yun Wang, Pei-Shan Hu, Ting Li, Jin-Fei Lin, Xiang-Yuan Wu, Lei Miao, Zhao-Lei Zeng, Dan Xie, Huai-Qiang Ju, Rui-Hua Xu and Feng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:196
  2. Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), represents the most aggre...

    Authors: Jiang-Jiang Qin, Li Yan, Jia Zhang and Wei-Dong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:195
  3. Several targeted immunotherapies have recently showed significant advances in treatment of non-small cell lung cancer (NSCLC), including antibodies and inhibitors targeting programmed death-1 (PD-1) and its li...

    Authors: Yanhui Chen, Quanxing Liu, Zhiming Chen, Yating Wang, Wanning Yang, Ying Hu, Wenbo Han, Hui Zeng, Haitao Ma, Jigang Dai and Henghui Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:193
  4. Modulation of cell surface expression of MHC class I chain-related protein A/B (MICA/B) has been proven to be one of the mechanisms by which tumor cells escape from NK cell-mediated killing. Abnormal metabolic...

    Authors: Qingke Duan, Hehe Li, Chenggang Gao, Hengqiang Zhao, Shihong Wu, Heshui Wu, Chunyou Wang, Qiang Shen and Tao Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:192
  5. The very aggressive nature and low survival rate of pancreatic ductal adenocarcinoma (PDAC) dictates the necessity to find novel efficacious therapies. Recent evidence suggests that phosphoinositide 3-kinase (...

    Authors: Aikaterini Emmanouilidi, Chanse A. Fyffe, Riccardo Ferro, Charlotte E. Edling, Emily Capone, Simona Sestito, Simona Rapposelli, Rossano Lattanzio, Stefano Iacobelli, Gianluca Sala, Tania Maffucci and Marco Falasca
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:191
  6. One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal ca...

    Authors: Chiara Marchiori, Melania Scarpa, Andromachi Kotsafti, Susan Morgan, Matteo Fassan, Vincenza Guzzardo, Andrea Porzionato, Imerio Angriman, Cesare Ruffolo, Stefania Sut, Stefano Dall’Acqua, Romeo Bardini, Raffaele De Caro, Carlo Castoro, Marco Scarpa and Ignazio Castagliuolo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:190
  7. Hepatocellular carcinoma (HCC) is still the most common cause of tumor-related death worldwide and accumulating studies report that long non-coding RNAs (LncRNAs) are closely related with HCC development, meta...

    Authors: Hongda Ding, Junpeng Liu, Ruoyao Zou, Pengrui Cheng and Yang Su
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:189
  8. Forkhead box M1 (FOXM1) is a proliferation-associated transcription factor of the forkhead box proteins superfamily, which includes four isoforms FOXM1a, b, c, and d. FOXM1 has been implicated in hepatocellula...

    Authors: Guohui Hu, Zhengwei Yan, Cheng Zhang, Minzhang Cheng, Yehong Yan, Yiting Wang, Libin Deng, Quqin Lu and Shiwen Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:188
  9. Current prognostic tools and targeted therapeutic approaches have limited value for metastatic triple negative breast cancer (TNBC). Building upon current knowledge, we hypothesized that epoxyeicosatrienoic ac...

    Authors: Maria Karmella Apaya, Jeng-Yuan Shiau, Guo-Shiou Liao, Yu-Jen Liang, Chia-Wei Chen, Hsin-Chou Yang, Chi-Hong Chu, Jyh-Cherng Yu and Lie-Fen Shyur
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:187
  10. Breast cancer is the most prevalent cancer among women. In triple-negative breast cancer (TNBC) cells, a novel quinone derivative, coenzyme Q0 (CoQ0), promotes apoptosis and cell-cycle arrest. This study explored...

    Authors: Hsin-Ling Yang, Varadharajan Thiyagarajan, Pei-Chun Shen, Dony Chacko Mathew, Kai-Yuan Lin, Jiunn-Wang Liao and You-Cheng Hseu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:186
  11. Malignant peripheral nerve sheath tumours (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome, neurofibromatosis type 1 (NF1). This study ...

    Authors: Kang Yang, Wei Guo, Tingting Ren, Yi Huang, Yu Han, Hongliang Zhang and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:185
  12. Celastrol, a triterpene compound derived from the traditional Chinese medicine Tripterygium wilfordii, has been reported to possess potential antitumor activity towards various malignancies. However, the effect o...

    Authors: Xihong Liu, Peiyuan Zhao, Xiujuan Wang, Lei Wang, Yingjun Zhu, Yadi Song and Wei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:184

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:284

  13. Acquired resistance to sorafenib greatly limits its therapeutic efficiency in the treatment of hepatocellular carcinoma (HCC). Increasing evidence indicates that long noncoding RNAs (lncRNAs) play important ro...

    Authors: Weidong Li, Xuesong Dong, Changjun He, Gang Tan, Ziyi Li, Bo Zhai, Jing Feng, Xian Jiang, Chang Liu, Hongchi Jiang and Xueying Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:183
  14. MicroRNA-139-5p (miR-139) has been shown to play important roles in hepatocellular carcinoma (HCC) development. However, the exact mechanism of miR-139 in HCC remains largely unknown.

    Authors: Ying Zan, Baofeng Wang, Liang Liang, Yujiao Deng, Tian Tian, Zhijun Dai and Lei Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:182
  15. GMEB1 was originally identified via its interaction with GMEB2, which binds to the promoter region of the tyrosine aminotransferase (TAT) gene and modulates transactivation of the glucocorticoid receptor gene. In...

    Authors: Wentao An, Shun Yao, Xiaoyang Sun, Zhaoyuan Hou, Yidan Lin, Ling Su and Xiangguo Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:181
  16. Lung cancer often ranks one of the most prevalent malignancies in the world. One of the most challenging aspects of treating late-stage lung cancer patients is the development of drug resistance, from both con...

    Authors: Wen-Chien Huang, Kuang-Tai Kuo, Chun-Hua Wang, Chi-Tai Yeh and Yongjie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:180
  17. Recent studies have revealed that numerous oncogenic long non-coding RNAs (lncRNAs) play pivotal roles in pancreatic ductal adenocarcinoma (PDAC) progression, but little is known about tumor-suppressive lncRNA...

    Authors: Jing Ling, Fan Wang, Chuan Liu, Xiao Dong, Ying Xue, Xuebing Jia, Weifeng Song and Qi Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:179
  18. Pioglitazone, a synthetic peroxisome proliferator activated receptor (PPAR-γ) ligand, is known as an antidiabetic drug included in the thiazolidinediones (TZDs) class. It regulates the lipid and glucose cell m...

    Authors: Vincenza Ciaramella, Ferdinando Carlo Sasso, Raimondo Di Liello, Carminia Maria Della Corte, Giusi Barra, Giuseppe Viscardi, Giovanna Esposito, Francesca Sparano, Teresa Troiani, Erika Martinelli, Michele Orditura, Ferdinando De Vita, Fortunato Ciardiello and Floriana Morgillo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:178
  19. .

    Authors: Sen Li, Xiliang Cong, Hongyu Gao, Xiuwen Lan, Zhiguo Li, Wenpeng Wang, Shubin Song, Yimin Wang, Chunfeng Li, Hongfeng Zhang, Yuzhou Zhao and Yingwei Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:177

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:6

  20. High-grade serous ovarian cancer (HGSOC) is the most lethal of all gynecological malignancies. Patients often suffer from chemoresistance. Several studies have reported that Fn14 could regulate migration, inva...

    Authors: An-Yue Wu, Li-Ying Gu, Wei Cang, Meng-Xing Cheng, Wen-Jing Wang, Wen Di, Lei Huang and Li-Hua Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:176
  21. Head and neck squamous-cell carcinoma (HNSCC) ranks sixth among cancers worldwide. Though several molecular mechanisms of tumor initiation and progression of HNSCC are known, others remain unclear. Significanc...

    Authors: Sourabh Soni, Munish Kumar Saroch, Bal Chander, Narendra Vijay Tirpude and Yogendra S. Padwad
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:175
  22. Non-small cell lung cancer (NSCLC) is a devastating disease with a heterogeneous prognosis, and the molecular mechanisms underlying tumor progression remain elusive. Mammalian Eps15 homology domain 1 (EHD1) pl...

    Authors: Ting Wang, Ying Xing, Qingwei Meng, Hailing Lu, Wei Liu, Shi Yan, Yang Song, Xinyuan Xu, Jian Huang, Yue Cui, Dexin Jia and Li Cai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:174
  23. Breast cancer angiogenesis is key for metastasis and predicts a poor prognosis. Angiotensin-converting enzyme 2 (ACE2), as a member of the renin-angiotensin system (RAS), was reported to restrain the progressi...

    Authors: Qi Zhang, Sihong Lu, Tianfu Li, Liang Yu, Yunjian Zhang, Huijuan Zeng, Xueke Qian, Jiong Bi and Ying Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:173
  24. Thousands of long noncoding RNAs (lncRNAs) are aberrantly expressed in various types of cancers, however our understanding of their role in the disease is still very limited.

    Authors: Morvarid Saeinasab, Ahmad Reza Bahrami, Jovanna González, Francesco P. Marchese, Dannys Martinez, Seyed Javad Mowla, Maryam M. Matin and Maite Huarte
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:172

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:441

  25. Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and re...

    Authors: Yuanliang Yan, Xi Chen, Xiang Wang, Zijin Zhao, Wenfeng Hu, Shuangshuang Zeng, Jie Wei, Xue Yang, Long Qian, Shuyi Zhou, Lunquan Sun, Zhicheng Gong and Zhijie Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:171
  26. Cancer stem cells (CSCs) require stromal signals for maintaining pluripotency and self-renewal capacities to confer tumor metastasis. Resolvin D1 (RvD1), an endogenous anti-inflammatory lipid mediator, has rec...

    Authors: Liankang Sun, Yufeng Wang, Liang Wang, Bowen Yao, Tianxiang Chen, Qing Li, Zhikui Liu, Runkun Liu, Yongshen Niu, Tao Song, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:170
  27. FGFR3 plays an important role in the development of bladder cancer (BCa). Hsa_circ_0068871 is a circRNA generated from several exons of FGFR3. However, the potential functional role of hsa_circ_0068871 in BCa ...

    Authors: Weipu Mao, Xin Huang, Longsheng Wang, Ziwei Zhang, Mengnan Liu, Yan Li, Ming Luo, Xudong Yao, Jie Fan and Jiang Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:169
  28. Chimeric antigen receptor (CAR)-engineered T cells have displayed outstanding performance in the treatment of patients with hematological malignancies. However, their efficacy against solid tumors has been lar...

    Authors: Yitian Wang, Wei Yu, Jian Zhu, Junjie Wang, Kaishun Xia, Chengzhen Liang and Huimin Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:168
  29. Xenotropic and polytropic retrovirus receptor 1 (XPR1), a previously identified cellular receptor for several murine leukemia viruses, plays a role in many pathophysiological processes. However, the role of XP...

    Authors: Wei-chao Chen, Qiu-li Li, Qimei Pan, Hua-yong Zhang, Xiao-yan Fu, Fan Yao, Jian-ning Wang and An-kui Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:167
  30. Acquired drug resistance is a constraining factor in clinical treatment of glioblastoma (GBM). However, the mechanisms of chemoresponsive tumors acquire therapeutic resistance remain poorly understood. Here, w...

    Authors: Zhuoran Zhang, Jianxing Yin, Chenfei Lu, Yutian Wei, Ailiang Zeng and Yongping You
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:166
  31. miRNAs play crucial role in the progression of K-Ras-mutated nonsmall cell lung cancer (NSCLC). However, most studies have focused on miRNAs that target K-Ras. Here, we investigated miRNAs regulated by mutant ...

    Authors: Hua Jin, Yoonjeong Jang, Nian Cheng, Qing Li, Peng-Fei Cui, Zhi-Wei Zhou, Hu-Lin Jiang, Myung-Haing Cho, Kenneth D. Westover, Qun-You Tan and Cheng-Xiong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:165
  32. Metastasis remains the main cause of cancer-related death for gastric cancer (GC) patients, but the mechanisms are poorly understood. Using The Cancer Genome Atlas (TCGA) data base and bioinformatics analyses,...

    Authors: Jia-Xing Zhang, Wei-Ling He, Zi-Hao Feng, Dong-Liang Chen, Ying Gao, Ying He, Kai Qin, Zhou-San Zheng, Cui Chen, Hui-Wen Weng, Miao Yun, Sheng Ye, Rui-Hua Xu and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:164
  33. ALKBH5 regulated the malignant behavior of breast cancer and glioblastoma. However, the expression and function of ALKBH5 in epithelial ovarian cancer have not yet been determined. In the present study, we inv...

    Authors: Hongtao Zhu, Xiaoling Gan, Xingwei Jiang, Shuai Diao, Huan Wu and Jianguo Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:163
  34. Pancreatic cancer is one of the most lethal type of cancers, with an overall five-year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited therapeutic options. To date, no ...

    Authors: Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli and Chun-Wai Mai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:162
  35. Long non-coding RNAs (lncRNAs) have been identified to play an important role in the development and progression of various tumors, including colorectal cancer (CRC). However, the regulatory molecular mechanis...

    Authors: Jing Li, Meirong He, Wen Xu and Silin Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:161
  36. Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to En...

    Authors: Luigi Mele, Marcella la Noce, Francesca Paino, Tarik Regad, Sarah Wagner, Davide Liccardo, Gianpaolo Papaccio, Angela Lombardi, Michele Caraglia, Virginia Tirino, Vincenzo Desiderio and Federica Papaccio
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:160
  37. Tripartite motif 47 (TRIM47), a member of the TRIM family proteins, plays a key role in many types of cancers including colorectal cancer (CRC). We found that levels of TRIM47 mRNA and protein were increased s...

    Authors: Qian Liang, Chaotao Tang, Mingyu Tang, Qingwei Zhang, Yunjie Gao and Zhizheng Ge
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:159
  38. RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migrat...

    Authors: Maureen Keller, Fatéméh Dubois, Sylvain Teulier, Alexandre P. J. Martin, Jérôme Levallet, Elodie Maille, Solenn Brosseau, Nicolas Elie, Alexander Hergovich, Emmanuel Bergot, Jacques Camonis, Gérard Zalcman and Guénaëlle Levallet
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:158
  39. Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness. Epidermal growth factor rec...

    Authors: Yuning Liao, Zhiqiang Guo, Xiaohong Xia, Yuan Liu, Chuyi Huang, Lili Jiang, Xuejun Wang, Jinbao Liu and Hongbiao Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:157
  40. Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that...

    Authors: N. A. Seebacher, A. E. Stacy, G. M. Porter and A. M. Merlot
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:156
  41. As most lung cancer patients present with invasive, metastatic disease, it is vital to investigate anti-metastatic treatments for non-small cell lung cancer (NSCLC). Houttuynia cordata is commonly used as a Chine...

    Authors: Rilei Jiang, Cheng Hu, Qian Li, Ziyu Cheng, Ling Gu, Hongxiao Li, Yuanyuan Guo, Qirui Li, Yueyang Lu, Ke Li, Meijuan Chen and Xu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:155
  42. Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose phosphate pathway (PPP), a branch of glycolysis, is an important metabolic pathway for the survival and biosynthesis of cancer cells...

    Authors: Zhaoyu Qin, Chan Xiang, Fan Zhong, Yang Liu, Qiongzhu Dong, Kai Li, Wenhao Shi, Chen Ding, Lunxiu Qin and Fuchu He
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:154
  43. Hepatocellular carcinoma (HCC) is the major histological type of liver cancer with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNA) has been proved to be associated with various cancer type...

    Authors: Yu-Gang Wang, Tao Wang, Min Shi and Bo Zhai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:153
  44. With the rapid development of the high throughput detection techniques, tumor-related Omics data has become an important source for studying the mechanism of tumor progression including breast cancer, one of t...

    Authors: Fen Lin, Yu-Jie Xie, Xin-Ke Zhang, Tie-Jun Huang, Hong-Fa Xu, Yan Mei, Hu Liang, Hao Hu, Si-Ting Lin, Fei-Fei Luo, Yan-Hong Lang, Li-Xia Peng, Chao-Nan Qian and Bi-Jun Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:152
  45. Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. An increasing number of studies have recently focused on the malignant functions of cancer-associated fibroblasts (CAFs) in numer...

    Authors: Xiaoning Wang, Xing Qin, Ming Yan, Jianbo Shi, Qin Xu, Zhihui Li, Wenjun Yang, Jianjun Zhang and Wantao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:151
  46. Deregulated ErbB signaling plays an important role in tumorigenesis of pancreatic cancer. However, patients with pancreatic cancer benefit little from current existed therapies targeting the ErbB signaling. He...

    Authors: Tingting Lin, Qun Ren, Weimin Zuo, Ruxue Jia, Linhui Xie, Rong Lin, Hu Zhao, Jin Chen, Yan Lei, Ping Wang, Huiyue Dong, Lianghu Huang, Jinquan Cai, Yonghai Peng, Zongyang Yu, Jianming Tan…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:150
  47. The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mech...

    Authors: Mingjing Shen, Zhonghua Xu, Weihua Xu, Kanqiu Jiang, Fuquan Zhang, Qifeng Ding, Zhonghen Xu and Yongbing Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:149
  48. Recent Clinical trials of administration of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in combination with standard first-line chemotherapy have failed to improve survival in patie...

    Authors: Tianze Liu, Lizi Jin, Wenjing Lu, Hairun Gan, Zhidong Lin, Miao Chen, Jiani Liu, Fan Zhang, Siyang Wang, Hongyu Zhang, Wuguo Deng and Hongtao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:148
  49. Ionizing radiation (IR) therapy is the standard first-line treatment for newly diagnosed patients with glioblastoma (GBM), the most common and malignant primary brain tumor. However, the effects of IR are limi...

    Authors: Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang, Yanxin Li and Haizhong Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:147

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:331

  50. The recent developments in immuno-oncology have opened an unprecedented avenue for the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered a very promising strategy to activate ...

    Authors: Alessandra Lopes, Gaëlle Vandermeulen and Véronique Préat
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:146

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