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  1. Acute myeloid leukemia (AML) is a heterogeneous neoplasm of the bone marrow with poor prognosis. In clinical practice new prognostic factors are still needed. MicroRNAs (miRs), small endogenous noncoding RNAs,...

    Authors: Aleksandra Butrym, Justyna Rybka, Dagmara Baczyńska, Andrzej Tukiendorf, Kazimierz Kuliczkowski and Grzegorz Mazur
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:68
    Content type: Research article Published on:

  2. Hypoxia is a common feature of solid tumors, including HCC. And hypoxia has been reported to play an important role in HCC progression. However, the potential mechanism of miRNAs in hypoxia mediating HCC progr...

    Authors: Chengli Du, Xiaoyu Weng, Wendi Hu, Zhen Lv, Heng Xiao, Chaofeng Ding, Owusu-anash K. Gyabaah, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:67
    Content type: Research article Published on:

  3. The Yin Yang 1 (YY1) transcription factor has been identified to target a plethora of potential target genes, which are important for cell proliferation and differentiation. Although the role that YY1 plays in...

    Authors: Guowei Zhao, Qiang Li, Aiqin Wang and Jian Jiao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:66
    Content type: Research article Published on:

  4. Halofuginone (HF) is a low-molecular-weight alkaloid that has been demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β (TGF-β) function and, to present antiangiogenic, antiprol...

    Authors: Patricia A. Assis, Lorena L. De Figueiredo-Pontes, Ana Silvia G. Lima, Vitor Leão, Larissa A. Cândido, Carolina T. Pintão, Aglair B. Garcia, Fabiano P. Saggioro, Rodrigo A Panepucci, Fernando Chahud, Arnon Nagler, Roberto P. Falcão and Eduardo M. Rego
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:65
    Content type: Research article Published on:

  5. The role of insulin in the pathogenesis of cancer has been increasingly emphasized because of the high incidence of obesity and metabolic syndrome and their correlated complication including cancer. This study...

    Authors: Zhao Wei, Li Liang, Liu Junsong, Chen Rui, Chang Shuai, Qiu Guanglin, He Shicai, Wang Zexing, Wang Jin, Che Xiangming and Wang Shufeng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:64
    Content type: Research article Published on:

  6. The purpose of this study was to develop a cost-effective approach for the determination of EGFR and KRAS mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal ...

    Authors: Guohua Xie, Fang Xie, Ping Wu, Xiangliang Yuan, Yanhui Ma, Yunchuan Xu, Li Li, Ling Xu, Ming Yang and Lisong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:63
    Content type: Research article Published on:

  7. There is growing evidence that emerging malignancies in solid tissues might be kept under control by physical intercellular contacts with normal fibroblasts.

    Authors: Andrey Alexeyenko, Twana Alkasalias, Tatiana Pavlova, Laszlo Szekely, Vladimir Kashuba, Helene Rundqvist, Peter Wiklund, Lars Egevad, Peter Csermely, Tamas Korcsmaros, Hayrettin Guven and George Klein
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:62
    Content type: Research article Published on:

  8. Piwi-interacting RNAs (piRNAs) are small RNAs of 27–30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is...

    Authors: Jonas Busch, Bernhard Ralla, Monika Jung, Zofia Wotschofsky, Elena Trujillo-Arribas, Philipp Schwabe, Ergin Kilic, Annika Fendler and Klaus Jung
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:61
    Content type: Research article Published on:

  9. Developmental pluripotency-associated 4 (Dppa4) gene plays an important role in self-renewal and pluripotency sustainability in embryonic stem cells. It is re-expressed in several malignant tumors and is ident...

    Authors: Meng Zhang, Feifei Cui, Su Lu, Huijun Lu, Yingming Xue, Jingtao Wang, Jian Chen, Senlin Zhao, Shaofei Ma, Yu Zhang, Yang Yu, Zhihai Peng and Huamei Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:60
    Content type: Research article Published on:

  10. Our pilot study using miRNA PCR array found that miRNA-29b (miR-29b) is differentially expressed in primary cultured CD133-positive A549 cells compared with CD133-negative A549 cells.

    Authors: Hongyan Wang, Xiaoying Guan, Yongsheng Tu, Shaoqiu Zheng, Jie Long, Shuhua Li, Cuiling Qi, Xiaobin Xie, Huiqiu Zhang and Yajie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:59
    Content type: Research article Published on:

  11. Three-dimensional (3D) culture models are considered to recapitulate the cell microenvironment in solid tumors, including the extracellular matrix (ECM), cell-cell interactions, and signal transduction. These ...

    Authors: Chujie Bai, Min Yang, Zhengfu Fan, Shu Li, Tian Gao and Zhiwei Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:58
    Content type: Research article Published on:

  12. The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12–14 months. The search for novel and more efficient chemo-agents against thi...

    Authors: Li-sen Qin, Pi-feng Jia, Zhi-qing Zhang and Shi-ming Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:57
    Content type: Research article Published on:

  13. Treatment of blast phase chronic myeloid leukemia (BP-CML) remains a challenge, and the median survival is less than 6 months. Because effective treatments are lacking, we studied tight targeting of blast cris...

    Authors: Bailing Zu, Yi Shi, Min Xu, Guoling You, Zhenglan Huang, Miao Gao and Wenli Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:56
    Content type: Research article Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:57

  14. DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia (AML) with normal karyotype. Although various recurrent somatic mutations of DNMT3A hav...

    Authors: Rimma Berenstein, Igor Wolfgang Blau, Nikola Suckert, Claudia Baldus, Antonio Pezzutto, Bernd Dörken and Olga Blau
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:55
    Content type: Research article Published on:

  15. T-type Ca2+ channels are often aberrantly expressed in different human cancers and participate in the regulation of cell cycle progression, proliferation and death. Methods: RT-PCR, Q-PCR, western blotting and wh...

    Authors: Weifeng Huang, Chunjing Lu, Yong Wu, Shou Ouyang and Yuanzhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:54
    Content type: Research article Published on:

  16. There is increasing evidence to suggest that miRNAs play an important role in predicting cancer survival. To identify a panel of miRNA signature that can divided tumor from normal bladder using miRNA expressio...

    Authors: Hui Zhou, Kun Tang, Haibing Xiao, Jin Zeng, Wei Guan, Xiaolin Guo, Hua Xu and Zhangqun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:53
    Content type: Research article Published on:

  17. Bone marrow mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with tumor growth and progression. However, the roles of tumor-resident MSCs in cancer have not been thoroughly clarif...

    Authors: Wei Li, Ying Zhou, Jin Yang, Xu Zhang, Huanhuan Zhang, Ting Zhang, Shaolin Zhao, Ping Zheng, Juan Huo and Huiyi Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:52
    Content type: Research article Published on:

  18. Dying tumor cells after irradiation could promote the proliferation of living tumor cells might cause tumor relapse and treatment failure. Our previous study showed that activated caspase-3 after irradiation p...

    Authors: Zhengxiang Zhang, Min Wang, Ling Zhou, Xiao Feng, Jin Cheng, Yang Yu, Yanping Gong, Ying Zhu, Chuanyuan Li, Ling Tian and Qian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:51
    Content type: Research article Published on:

  19. Mucin-1 (MUC1, CD227), more widely known as CA15-3, is an abundantly expressed epithelial cell surface antigen and has evolved to be the most predictive serum tumour marker in breast cancer. PankoMab-GEXâ„¢, whi...

    Authors: Sabine Heublein, Doris Mayr, Markus Egger, Uwe Karsten, Steffen Goletz, Martin Angele, Julia Gallwas, Udo Jeschke and Nina Ditsch
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:50
    Content type: Research article Published on:

  20. Accumulating evidence suggests that dysregulated snoRNA may play a role in the development of malignancy. In the present study, we investigated the role of SNORD78 in the tumorigenesis of non-small cell lung c...

    Authors: Di Zheng, Jie Zhang, Jian Ni, Jie Luo, Jiying Wang, Liang Tang, Ling Zhang, Li Wang, Jianfang Xu, Bo Su and Gang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:49
    Content type: Research article Published on:

  21. P21-activated kinase 4 (PAK4), an effector of the Rho family protein Cdc42, is an important oncogene whose expression is increased in many human cancers and is generally positively correlated with advanced dis...

    Authors: Songwang Cai, Zhiqiang Ye, Xiaohong Wang, Yuhang Pan, Yimin Weng, Sen Lao, Hongbo Wei and Lian Li
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:48
    Content type: Research article Published on:

  22. Hepatocellular carcinoma (HCC) is a common malignancy worldwide, which is especially prevalent in Asia. Elucidating the molecular basis of HCC is crucial to develop targeted diagnostic tools and novel therapie...

    Authors: Fei He, Jie Li, JianFeng Xu, Sheng Zhang, YaPing Xu, WenXiu Zhao, ZhenYu Yin and XiaoMin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:47
    Content type: Research article Published on:

  23. Prostate cancer is one of the most common malignancies in men. The mucin 1 (MUC1) heterodimeric oncoprotein is overexpressed in human prostate cancers with aggressive pathologic and clinical features, resultin...

    Authors: Jing Li, SongTao Xiang, QiouHong Zhang, JingJing Wu, Qing Tang, JianFu Zhou, LiJun Yang, ZhiQiang Chen and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:46
    Content type: Research article Published on:

  24. One-third of estrogen (ER+) and/or progesterone receptor-positive (PGR+) breast tumors treated with Tamoxifen (TAM) do not respond to initial treatment, and the remaining 70% are at risk to relapse in the futu...

    Authors: Subha Madhavan, Yuriy Gusev, Salendra Singh and Rebecca B Riggins
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:45
    Content type: Research article Published on:

  25. CD133 and Nestin, as the markers of cancer stem cells, have recently been reported frequently in the pathogenesis and development of human gliomas. However, the prognostic role of CD133 and Nestin in gliomas s...

    Authors: Bin Wu, Caixing Sun, Fang Feng, Minghua Ge and Liang Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:44
    Content type: Research article Published on:

  26. Measurement of prostate-specific antigen (PSA) advanced the diagnostic and prognostic potential for prostate cancer (PCa). However, due to PSA’s lack of specificity, novel biomarkers are needed to improve risk...

    Authors: Igor Tsaur, Kristina Thurn, Eva Juengel, Kilian M. Gust, Hendrik Borgmann, Rene Mager, Georg Bartsch, Elsie Oppermann, Hanns Ackermann, Karen Nelson, Axel Haferkamp and Roman A. Blaheta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:43
    Content type: Research article Published on:

  27. For the successful therapeutic use of inhibitors of the vascular endothelial growth factor receptor (VEGFR) pathway detailed knowledge of the mechanisms leading to tumor progression is indispensable. The main ...

    Authors: Caren Jayasinghe, Nektaria Simiantonaki, Sylvia Habedank and Charles James Kirkpatrick
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:42
    Content type: Research article Published on:

  28. Baicalein, a natural flavonoid obtained from the Scutellaria baicalensis root, has been reported to inhibit growth of human lung cancer. However, the detailed mechanism underlying this has not been well elucid...

    Authors: Fang Zheng, Jingjing Wu, Shunyu Zhao, Qingmei Luo, Qing Tang, LiJun Yang, Liuning Li, WanYing Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:41
    Content type: Research article Published on:

  29. The Forkhead box M1 (FOXM1) is an oncogenic transcription factor and plays a significant role in cell EMT, proliferation, metastasis in a multitude of human solid tumors including colorectal cancer (CRC). Howe...

    Authors: KanKan Yang, LinHua Jiang, You Hu, Jing Yu, HenFeng Chen, YiZhou Yao and XinGuo Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:40
    Content type: Research article Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:130

  30. Innervation interacts with enteric immune responses. Chronic intestinal inflammation is associated with increased risk of colorectal cancer. We aimed to study potential extrinsic neuronal modulation of intesti...

    Authors: Verena Liu, Alexandra Dietrich, Michael S Kasparek, Petra Benhaqi, Marlon R Schneider, Michael Schemann, Hendrik Seeliger and Martin E Kreis
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:39
    Content type: Research article Published on:

  31. Ovarian cancer remains still the leading cause of death of gynecological malignancy, in spite of first-line chemotherapy with cisplatin and paclitaxel. Although initial response is favorably, relapses are comm...

    Authors: Caroline van Haaften, Arnoud Boot, Willem E Corver, Jaap DH van Eendenburg, Baptist JMZ Trimbos and Tom van Wezel
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:38
    Content type: Research article Published on:

  32. Monoclonal gammopathies encompass a wide range of diseases characterized by the monoclonal expansion of a B-cell clone. Despite emerging therapeutic strategies, chances of survival of patients who are affected...

    Authors: Giovanni Cigliana, Eleonora Torti, Francesca Gulli, Elena De Santis, Maria Teresa Dell’Abate, Luigi Colacicco, Francesco Pisani, Laura Conti and Umberto Basile
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:37
    Content type: Research article Published on:

  33. Malignant melanoma’s (MM) incidence is rising faster than that of any other cancer in the US and the overall survival at 5 years is less than 10%. B cell associated protein 31 (BAP31) is overexpressed in most ...

    Authors: Shaojuan Yu, Fuli Wang, Li Fan, Yuying Wei, Haitao Li, Yuanjie Sun, Angang Yang, Boquan Jin, Chaojun Song and Kun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:36
    Content type: Research article Published on:

  34. Gastric cancer (GC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its metastasis is still largely unclear. MicroRNAs have emerged as important regulators of m...

    Authors: Jun Liu, Hui Xue, Jianjun Zhang, Tao Suo, Yijin Xiang, Wen Zhang, Jun Ma, Dingfang Cai and Xixi Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:35
    Content type: Research article Published on:

  35. Our previous studies have demonstrated that autophagosome-enriched vaccine (named DRibbles: DRiPs-containing blebs) induce a potent anti-tumor efficacy in different murine tumor models, in which DRibble-contai...

    Authors: Mohanad Aldarouish, Huzhan Wang, Meng Zhou, Hong-Ming Hu and Li-xin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:34
    Content type: Research article Published on:

  36. Metastatic spread of tumor cells remains a serious problem in cancer treatment. Gene-directed enzyme/prodrug therapy mediated by tumor-homing genetically engineered mesenchymal stromal cells (MSC) represents a...

    Authors: Miroslava Matuskova, Zuzana Kozovska, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Zuzana Cierna, Roman Bohovic and Lucia Kucerova
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:33
    Content type: Research article Published on:

  37. A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer research since they play a central role in regulation of gene-expression and miRNA aberrant expressio...

    Authors: Germana Falcone, Armando Felsani and Igea D’Agnano
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:32
    Content type: Review Published on:

  38. The anti-tumor activity of glucose analogs 2-deoxy-glucose (2-DG) and D-allose was investigated alone or in combination with p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190 or platinum analogs a...

    Authors: Scott W Malm, Neale T Hanke, Alexander Gill, Liliana Carbajal and Amanda F Baker
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:31
    Content type: Research article Published on:

  39. Nectin-4 belongs to the nectin family that has diverse physiological and pathological functions in humans. Recent studies have also suggested some roles for Nectin-4 in several human cancers. However, the prec...

    Authors: Satoshi Nishiwada, Masayuki Sho, Satoshi Yasuda, Keiji Shimada, Ichiro Yamato, Takahiro Akahori, Shoichi Kinoshita, Minako Nagai, Noboru Konishi and Yoshiyuki Nakajima
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:30
    Content type: Research article Published on:

  40. In 2009, treatment guidelines were updated to recommend KRAS testing at diagnosis for patients with metastatic colorectal cancer (mCRC). We investigated KRAS testing rates over time and compared characteristics o...

    Authors: Gebra Cuyun Carter, Pamela B Landsman-Blumberg, Barbara H Johnson, Paul Juneau, Steven J Nicol, Li Li and Veena Shankaran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:29
    Content type: Research article Published on:

  41. Increasing evidence showed that miRNAs serve as modulators of human cancer, either as oncogene or tumor suppressors. Cisplatin resistance is the most common cause of chemotherapy failure in gastric cancer (GC)...

    Authors: Xiaoying Zhou, Wujuan Jin, Hongyan Jia, Jin Yan and Guoxin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:28
    Content type: Research article Published on:

  42. miRNA-184 is an oncogene in human hepatocellular carcinoma but acts as a tumor suppressor in tongue squamous cell carcinoma. Studies have shown that miR-184 was down-regulated in glioma and TNFα-induced protei...

    Authors: Zhe Cheng, Hang Zhou Wang, Xuetao Li, Zhiwu Wu, Yong Han, Yanyan Li, Guilin Chen, Xueshun Xie, Yulun Huang, Ziwei Du and Youxin Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:27
    Content type: Research Published on:

  43. The role of chemotherapy in the treatment of metastatic male breast cancer patients remains unknown, and the only available evidence stem from small, retrospective series evaluating outdated drugs and/or regim...

    Authors: Luigi Di Lauro, Laura Pizzuti, Maddalena Barba, Domenico Sergi, Isabella Sperduti, Marcella Mottolese, Pietro Del Medico, Franca Belli, Patrizia Vici, Ruggero De Maria and Marcello Maugeri-Saccà
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:26
    Content type: Research article Published on:

  44. SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteogly...

    Authors: Carolina M Vicente, Marcelo A Lima, Helena B Nader and Leny Toma
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:25
    Content type: Research article Published on:

  45. Traditional subjective method for the analysis of time-intensity curves (TICs) from breast dynamic contrast enhanced MRI (DCE-MRI) presented a low specificity. Hence, a semi-automatic quantitative method was p...

    Authors: Jiandong Yin, Jiawen Yang, Lu Han, Qiyong Guo and Wei Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:24
    Content type: Research article Published on:

  46. Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that pred...

    Authors: Kai-Ming Gao, Xin-cheng Chen, Jun-xia Zhang, Yingyi Wang, Wei Yan and Yong-Ping You
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:23
    Content type: Research article Published on:

  47. Osteosarcoma is the most common malignancy of bone. HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic...

    Authors: Tu Hu, Nengbin He, Yunsong Yang, Chengqian Yin, Nianli Sang and Qingcheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:22
    Content type: Research article Published on:

  48. Huachansu (HCS), a class of toxic steroids extracted from toad venom, which has been shown to be a valuable anticancer drug in many kinds of cancers. However, the effect of HCS on bladder cancer has not been e...

    Authors: Tao Yang, Runlin Shi, Lei Chang, Kun Tang, Ke Chen, Gan Yu, Yuanfeng Tian, Yonglian Guo, Wei He, Xiaodong Song, Hua Xu and Zhangqun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:21
    Content type: Research article Published on:

  49. Aberrant insulin-like growth factor-binding protein 7 (IGFBP-7) expression has been found in various cancers such as prostate, breast, and colon. IGFBP-7 induced the apoptosis of tumor and potentially predicte...

    Authors: Li-Hsuen Chen, Dai-Wei Liu, Junn-Liang Chang, Peir-Rong Chen, Lee-Ping Hsu, Hon-Yi Lin, Yu-Fu Chou, Chia-Fong Lee, Miao-Chun Yang, Yu-Hsuan Wen, Wen-Lin Hsu and Ching-Feng Weng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:20
    Content type: Research article Published on:

  50. Long noncoding RNAs (lncRNAs) have been identified as having functional roles in cancer biology and are deregulated in many cancers. The present study aimed to determine the expression, roles and functional me...

    Authors: Liang Deng, Shi-Bin Yang, Feng-Feng Xu and Ji-Hong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:18
    Content type: Research article Published on:

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Journal of Experimental & Clinical Cancer Research

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