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  1. Over-expression and over-activation of immunosuppressive enzyme indoleamine 2, 3 -dioxygenase 1 (IDO1) is a key mechanism of cancer immune escape. However, the regulation of IDO1 has not been fully studied. Th...

    Authors: Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:88
  2. The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels an...

    Authors: Yalei Yin, Mingju Sun, Xi Zhan, Changqing Wu, Pengyu Geng, Xiaoyan Sun, Yunsong Wu, Shuijun Zhang, Jianhua Qin, Zhengping Zhuang and Yang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:83
  3. Aberrant EVI1 expression is frequently reported in cancer studies; however, its role in nasopharyngeal carcinoma (NPC) has not been examined in detail. The aim of the present study is to investigate the involv...

    Authors: Yaoyong Lu, Yingying Liang, Xin Zheng, Xubin Deng, Wendong Huang and Gong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:82
  4. How exosomal microRNAs (miRNAs) derived from macrophages contribute to the development of drug resistance in the context of the hypoxic tumor microenvironment in epithelial ovarian cancer (EOC) remains poorly ...

    Authors: Xiaolan Zhu, Huiling Shen, Xinming Yin, Meiling Yang, Hong Wei, Qi Chen, Fan Feng, Yueqin Liu, Wenlin Xu and Yuefeng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:81
  5. The differentiation-based therapy for acute promyelocytic leukemia (APL) is an inspiring example for the search of novel strategies aimed at treatment of other subtypes of acute myeloid leukemia (AML). Thus, t...

    Authors: Alejandro Pérez-Fernández, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Carla Ijurko, María Díez-Campelo, Fermín Sánchez-Guijo and Ángel Hernández-Hernández
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:80
  6. Personalized cancer vaccines based on neoantigens have reached the clinical trial stage in melanoma. Different vaccination protocols showed efficacy in preclinical models without a clear indication of the qual...

    Authors: Luigi Aurisicchio, Erika Salvatori, Lucia Lione, Silvio Bandini, Matteo Pallocca, Roberta Maggio, Maurizio Fanciulli, Francesca De Nicola, Frauke Goeman, Gennaro Ciliberto, Antonella Conforti, Laura Luberto and Fabio Palombo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:78
  7. Metformin, a first-line drug for type 2 diabetes, could induce apoptosis in cancer cells. However, the concentration of glucose affects the effect of metformin, especially low glucose in the culture medium can...

    Authors: Liwei Ma, Jianwei Wei, Junhu Wan, Weiwei Wang, Li Wang, Yongjie Yuan, Zijun Yang, Xianzhi Liu and Liang Ming
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:77
  8. S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that specifically recognizes phosphorylated cell cycle regulator proteins and mediates their ubiquitination. Programmed cell d...

    Authors: Ce Li, Lutao Du, Yidan Ren, Xiaoyan Liu, Qinlian Jiao, Donghai Cui, Mingxin Wen, Chuanxin Wang, Guangwei Wei, Yunshan Wang, Aiguo Ji and Qin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:76
  9. The abnormal expression of leucine-rich-alpha-2-glycoprotein 1 (LRG-1) is reported to be associated with multiple malignancies, but its role in the progression of pancreatic ductal adenocarcinoma (PDAC) remain...

    Authors: Zhi-Bo Xie, Yi-Fan Zhang, Chen Jin, Yi-Shen Mao and De-Liang Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:75
  10. MicroRNAs have an important role in diverse biological processes including tumorigenesis. MiR-223 has been reported to be deregulated in several human cancer types. However, its biological role has not been fu...

    Authors: Peng Luo, Qi Wang, Yuanyuan Ye, Ju Zhang, Dapeng Lu, Longqiang Cheng, Hangcheng Zhou, Mingran Xie and Baolong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:74
  11. The drug-resistance and relapse of diffuse large B-cell lymphoma (DLBCL), which are related to mesenchymal stem cells (MSCs), have become increasingly common. However, the underlying mechanisms remain elusive.

    Authors: Weijie Zhong, Zhigang Zhu, Xin Xu, Hui Zhang, Huabao Xiong, Qingshan Li and Yaming Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:73
  12. Damage-regulated autophagy modulator 2(DRAM2) is associated with autophagy processes. However, the role of DRAM2 in the progression of human neoplasms is still unknown. Here, we show that DRAM2 may act as an onco...

    Authors: Muli Wudu, Hongjiu Ren, Linping Hui, Jun Jiang, Siyang Zhang, Yitong Xu, Qiongzi Wang, Hongbo Su, Xizi Jiang, Runa Dao and Xueshan Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:72
  13. The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality medi...

    Authors: Lijun Liang, Kaiyuan Hui, Chenxi Hu, Yixuan Wen, Shikun Yang, Panrong Zhu, Lei Wang, Youyou Xia, Yun Qiao, Wen Sun, Jiayan Fei, Ting Chen, Fenghua Zhao, Baocheng Yang and Xiaodong Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:71
  14. Hepatocellular carcinoma (HCC) is the most major type of primary hepatic cancer. Serine hydroxymethyltransferase 1 (SHMT1) is recently found to play critical roles in human cancers including lung cancer, ovari...

    Authors: Changwei Dou, Qiuran Xu, Jie Liu, Yufeng Wang, Zhenyu Zhou, Weifeng Yao, Kai Jiang, Jian Cheng, Chengwu Zhang and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:70
  15. Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 a...

    Authors: Vid Mlakar, Simona Jurkovic Mlakar, Laurence Lesne, Denis Marino, Komal S. Rathi, John M. Maris, Marc Ansari and Fabienne Gumy-Pause
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:69
  16. Glioma is the most common intracranial neoplasm with vasculogenic mimicry formation as one form of blood supply. Many RNA-binding proteins and long non-coding RNAs are involved in tumorigenesis of glioma.

    Authors: Xiaozhi Li, Yixue Xue, Xiaobai Liu, Jian Zheng, Shuyuan Shen, Chunqing Yang, Jiajia Chen, Zhen Li, Libo Liu, Jun Ma, Teng Ma and Yunhui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:68
  17. Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components. The specific degradation of nuclear componen...

    Authors: Yunong Li, Xiuxing Jiang, Yanhao Zhang, Ziyi Gao, Yanxia Liu, Jinjiao Hu, Xiaoye Hu, Lirong Li, Jingshan Shi and Ning Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:67
  18. Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types. It is very urgent to study the development mechanisms of thi...

    Authors: Xuhui Ma, Boya Li, Jie Liu, Yan Fu and Yongzhang Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:66
  19. Angiogenesis plays a critical role in the progression of glioma. Previous studies have indicated that RNA-binding proteins (RBPs) interact with RNAs and participate in the regulation of the malignant behaviors...

    Authors: Zhenwei He, Xuelei Ruan, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Lianqi Shao, Di Wang, Shuyuan Shen, Chunqing Yang and Yixue Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:65
  20. CFLARL, also known as c-FLIPL, is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown that arginine 122 of CFLARL can be mono-methylated. Howeve...

    Authors: Mingyue Li, Wentao An, Linyan Xu, Yidan Lin, Ling Su and Xiangguo Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:64
  21. Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in tumorigenesis, tumor progression and differentiation in colon cancer cells. IL-11 signaling has been recently identified as a potential t...

    Authors: Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li and Jiayuh Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:63

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:374

  22. To investigate the lung cancer-promoting mechanism of mesenchymal stem cell-secreted extracellular vesicles (MSC-EV).

    Authors: Weihua Ren, Jianfeng Hou, Chenguang Yang, Hanjun Wang, Shuangting Wu, Yabin Wu, Xingpeng Zhao and Chao Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:62
  23. Ionizing radiation (IR) is one of the major clinical therapies of cancer, although it increases the epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC), unexpectedly. The cellular and...

    Authors: Wenjuan Wang, Yajie Xiong, Xinyuan Ding, Long Wang, Yifan Zhao, Yao Fei, Ying Zhu, Xiao Shen, Caihong Tan and Zhongqin Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:61
  24. Long non-coding RNA LINC00346 has been recently suggested as a prognostic marker in pancreatic cancer. However, its biological function in pancreatic cancer has not yet been determined. In this study, we attem...

    Authors: Weidong Shi, Chenyue Zhang, Zhouyu Ning, Yongqiang Hua, Ye Li, Lianyu Chen, Luming Liu, Zhen Chen and Zhiqiang Meng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:60
  25. Long non-coding RNAs has been reported in tumorigenesis and play important roles in regulating malignant behavior of cancers, including glioma.

    Authors: Han Li, Yixue Xue, Jun Ma, Lianqi Shao, Di Wang, Jian Zheng, Xiaobai Liu, Chunqing Yang, Qianru He, Xuelei Ruan, Zhen Li and Yunhui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:59
  26. Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that associates with both integrins and growth factor receptors toward the adhesion, migration and invasion of cancer cells. The G-protein...

    Authors: Damiano Cosimo Rigiracciolo, Maria Francesca Santolla, Rosamaria Lappano, Adele Vivacqua, Francesca Cirillo, Giulia Raffaella Galli, Marianna Talia, Lucia Muglia, Michele Pellegrino, Nijiro Nohata, Maria Teresa Di Martino and Marcello Maggiolini
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:58
  27. Several members of the tripartite motif-containing (TRIM) protein family have been reported to serve as vital regulators of tumorigenesis. Recent studies have demonstrated an oncogenic role of TRIM 14 in multi...

    Authors: Shuang Feng, Xiaomin Cai, Yangyang Li, Xiaoguang Jian, Linxin Zhang and Bin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:57
  28. Melanoma is the most aggressive and deadly form of skin cancer with increasing case numbers worldwide. The development of inhibitors targeting mutated BRAF (found in around 60% of melanoma patients) has marked...

    Authors: Christiane Margue, Demetra Philippidou, Ines Kozar, Giulia Cesi, Paul Felten, Dagmar Kulms, Elisabeth Letellier, Claude Haan and Stephanie Kreis
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:56
  29. Dysregulated miR-7 and aberrant NF-κB activation were reported in various human cancers. However, the expression profile, clinical relevance and dysregulated mechanism of miR-7 and NF-κB RelA/p65 in human gast...

    Authors: Tingbo Ye, Meihua Yang, Daochao Huang, Xin Wang, Bingqian Xue, Na Tian, Xiaohui Xu, Liming Bao, Huajian Hu, Tiewei Lv and Yi Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:55
  30. Multiple myeloma (MM) accounts for 10% of all hematological malignancies. Dysregulation of microRNAs (miRNAs) or long non-coding RNAs (lncRNAs) has important impacts on progression of MM. Circular RNAs (circRN...

    Authors: Yashu Feng, Ling Zhang, Jieying Wu, Bijay Khadka, Zhigang Fang, Jiaming Gu, Baoqiang Tang, Ruozhi Xiao, Guangjin Pan and Jiajun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:54
  31. Gastric cancer (GC) has a clear predilection for metastasis toward the omentum which is primarily composed of adipose tissue, indicating that fatty acids may contribute to this phenomenon. However their functi...

    Authors: Jiaomeng Pan, Zhiyuan Fan, Zhenqiang Wang, Qingqiang Dai, Zhen Xiang, Fei Yuan, Min Yan, Zhenggang Zhu, Bingya Liu and Chen Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:52
  32. Radiotherapy is one of the main treatment options for non-metastatic prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a considerable fraction of patien...

    Authors: Rihan El Bezawy, Stella Tinelli, Monica Tortoreto, Valentina Doldi, Valentina Zuco, Marco Folini, Claudio Stucchi, Tiziana Rancati, Riccardo Valdagni, Paolo Gandellini and Nadia Zaffaroni
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:51
  33. Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated...

    Authors: Lin Tuo, Jin Xiang, Xuanming Pan, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang, Kai Wang and Ni Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:50
  34. The JAK2-STAT signaling pathway plays a critical role in myeloproliferative neoplasms (MPN). An activating mutation in JAK2 (V617F) is present in ~ 95% of polycythemia vera, essential thrombocythemia, and prim...

    Authors: Min Hu, Chengbo Xu, Chao Yang, Hongli Zuo, Chengjuan Chen, Dan Zhang, Gaona Shi, Wenjie Wang, Jiangong Shi and Tiantai Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:49
  35. As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 BRAF mutant melanomas. However, acquired drug resistance invariably develops after its initi...

    Authors: Jiaojiao Hao, Wenhua Fan, Yizhuo Li, Ranran Tang, Chunfang Tian, Qian Yang, Tianhua Zhu, Chaoliang Diao, Sheng Hu, Manyu Chen, Ping Guo, Qian Long, Changlin Zhang, Ge Qin, Wendan Yu, Miao Chen…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:48
  36. Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer...

    Authors: Ping Fan, Jingyuan Zhao, Zibo Meng, Heyu Wu, Bo Wang, Heshui Wu and Xin Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:47
  37. Chemotherapy used for patients with unresectable lung tumors remains largely palliative due to chemoresistance, which may be due to tumor heterogeneity. Recently, multiple studies on the crosstalk between lung...

    Authors: Se-Hyuk Kim, Yeonhwa Song and Haeng Ran Seo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:46
  38. Authors: Valerio Ciccone, Erika Terzuoli, Sandra Donnini, Antonio Giachetti, Lucia Morbidelli and Marina Ziche
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:45

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:311

  39. Osteosarcoma (OS) is a common malignant cancer in children and adolescents and has a cure rate that has not improved in the last two decades. CYT997 (lexibulin) is a novel potent microtubule-targeting agent wi...

    Authors: Zongyi Wang, Fei Yin, Jing Xu, Tao Zhang, Gangyang Wang, Ming Mao, Zhuoying Wang, Wei Sun, Jing Han, Mengkai Yang, Yafei Jiang, Yingqi Hua and Zhengdong Cai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:44
  40. Some membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a memb...

    Authors: Yingqiu Xie, Ayan A. Nurkesh, Nazgul Ibragimova, Zhuldyz Zhanzak, Aizhan Meyerbekova, Zhanna Alexeyeva, Aiya Yesbolatova, Madina Satayeva, Aidana Mustafa, Limara Manarbek, Aisulu Maipas, Akerke Altaikyzy, Zhibek Keneskhanova, Burkitkan Akbay and Zhenbang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:43
  41. Discovering how to regulate mitochondrial function to reduce cancer growth holds great potential for future cancer therapy development. Here we explore the effects of cryptotanshinone (CPT), a natural product ...

    Authors: Jia-Hau Yen, Hung Sen Huang, Chia Ju Chuang and Sheng-Teng Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:42
  42. Previous studies showed that the combination of an anti-Epidermal growth factor (EGFR) and a MEK-inhibitor is able to prevent the onset of resistance to anti-EGFR monoclonal antibodies in KRAS-wild type colore...

    Authors: Pietro Paolo Vitiello, Claudia Cardone, Giulia Martini, Davide Ciardiello, Valentina Belli, Nunzia Matrone, Giusi Barra, Stefania Napolitano, Carmina Della Corte, Mimmo Turano, Maria Furia, Teresa Troiani, Floriana Morgillo, Ferdinando De Vita, Fortunato Ciardiello and Erika Martinelli
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:41
  43. Zinc-finger protein-326 (ZNF326) was initially found in the NIH3T3 cell line to regulate cell growth, however, the expression and underlying role of ZNF326 in human tumours, especially in glioma, is not fully ...

    Authors: Xinmiao Yu, Minghao Wang, Jingjing Wu, Qiang Han and Xiupeng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:40

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:14

  44. Tobacco smoke (TS) critically contributes to the development of hepatocellular carcinoma. Cancer stem cells (CSCs) induced by TS is an early event in the initiation of carcinogenesis. Tumor specific microenvir...

    Authors: Chunfeng Xie, Jianyun Zhu, Xueqi Wang, Jiaqi Chen, Shanshan Geng, Jieshu Wu, Caiyun Zhong and Xiaoting Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:39

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:141

  45. Early invasion and metastasis are responsible for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC), and epithelial-to-mesenchymal transition (EMT) is recognized as a crucial biological progress ...

    Authors: Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang and Guoping Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:38

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:249

  46. Accumulating evidence has highlighted the potential role of RNA binding proteins (RBPs) in the biological behaviors of glioblastoma cells. Herein, the expression and function of RNA binding proteins FXR1 were ...

    Authors: Shuo Cao, Jian Zheng, Xiaobai Liu, Yunhui Liu, Xuelei Ruan, Jun Ma, Libo Liu, Di Wang, Chunqing Yang, Heng Cai, Zhen Li, Ziyi Feng and Yixue Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:37
  47. Glioblastoma is a malignant brain tumor characterized by rapid growth, diffuse invasion and therapeutic resistance. We recently used microRNA expression profiles to subclassify glioblastoma into five genetical...

    Authors: Yun Zhao, Wei Huang, Tae-Min Kim, Yuchae Jung, Lata G. Menon, Hongyan Xing, Hongwei Li, Rona S. Carroll, Peter J. Park, Hong Wei Yang and Mark D. Johnson
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:36
  48. The transcription factor PR domain containing 16 (PRDM16) is known to play a significant role in the determination and function of brown and beige fat. However, the role of PRDM16 in tumor biology has not been...

    Authors: Liang-Ru Fei, Wen-Jing Huang, Yuan Wang, Lei Lei, Zhi-Han Li, Yi-Wen Zheng, Zhao Wang, Mai-Qing Yang, Chen-Chen Liu and Hong-Tao Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:35

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