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  1. Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Chemotherapeutic insensitivity is one of major obstacle...

    Authors: Jinbo Chen, Long Wang, Yunhua Tang, Guanghui Gong, Longfei Liu, Minfeng Chen, Zhi Chen, Yu Cui, Chao Li, Xu Cheng, Lin Qi and Xiongbing Zu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:2
    Content type: Research Published on:

  2. Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system. Although surgical resection is the preferred treatment f...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:1
    Content type: Review Published on:

  4. Previously, we reported that polyploid giant cancer cells (PGCCs) induced by cobalt chloride (CoCl2) could have generated daughter cells with strong invasiveness and migration capabilities via asymmetric division...

    Authors: Fei Fei, Dan Zhang, Zhengduo Yang, Shujing Wang, Xian Wang, Zhengsheng Wu, Qiang Wu and Shiwu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:158
    Content type: Research Published on:

  5. Overexpression of Metastasis-associated protein 1 (MTA1) in various cancer cells promotes tumor invasion and migration and predicts cancer patients’ poor prognosis. The pilot RNA-Seq data from our laboratory i...

    Authors: Ning Zhou, Haijuan Wang, Hongxu Liu, Hongsheng Xue, Feng Lin, Xiting Meng, Ailing Liang, Zhilong Zhao, YongJun Liu and Haili Qian
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:157
    Content type: Research Published on:

  6. After progression to a standard first-line platinum and gemcitabine combination (GP), there is no established second-line therapy for patients with advanced biliary tract cancers (aBTC). Indeed, literature dat...

    Authors: Lorenzo Fornaro, Caterina Vivaldi, Stefano Cereda, Francesco Leone, Giuseppe Aprile, Sara Lonardi, Nicola Silvestris, Daniele Santini, Michele Milella, Chiara Caparello, Gianna Musettini, Giulia Pasquini, Alfredo Falcone, Giovanni Brandi, Isabella Sperduti and Enrico Vasile
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:156
    Content type: Research Published on:

  7. Nanocapsules, as a delivery system, are able to target drugs and other biologically sensitive molecules to specific cells or organs. This system has been intensively investigated as a way to protect bioactives...

    Authors: Jérôme Roy, Liliam Teixeira Oliveira, Camille Oger, Jean-Marie Galano, Valerie Bultel-Poncé, Sylvain Richard, Andrea Grabe Guimaraes, José Mário Carneiro Vilela, Margareth Spangler Andrade, Thierry Durand, Pierre Besson, Vanessa Carla Furtado Mosqueira and Jean-Yves Le Guennec
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:155
    Content type: Research Published on:

  8. Lung cancer is the most common cause of cancer-related deaths worldwide. Natural phytochemicals from traditional medicinal plants such as solamargine have been shown to have anticancer properties. The prostagl...

    Authors: YuQing Chen, Qing Tang, JingJing Wu, Fang Zheng, LiJun Yang and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:154
    Content type: Research Published on:

  9. Oncolytic virus which arms the therapeutic gene to enhance anti-tumor activity is a prevalent strategy to improve oncovirotherapy of cancer. Newcastle disease virus (NDV) is a naturally oncolytic virus used fo...

    Authors: Ding Wei, Qian Li, Xi-Long Wang, Yuan Wang, Jing Xu, Fei Feng, Gang Nan, Bin Wang, Can Li, Ting Guo, Zhi-Nan Chen and Huijie Bian
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:153
    Content type: Research Published on:

  10. Many promising anticancer molecules are abandoned during the course from bench to bedside due to lack of clear-cut efficiency and/or severe side effects. Vitamin K3 (vitK3) is a synthetic naphthoquinone exhibi...

    Authors: Tiantian He, Elie Hatem, Laurence Vernis, Ming Lei and Meng-Er Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:152
    Content type: Research Published on:

  11. Metastasis-associated gene 1(MTA1) has been identified as an oncogene in many tumors, and aberrant MTA1 expression has been linked to carcinogenesis and metastasis. We aim to investigate the mechanism of MTA1 ...

    Authors: Caihua Xu, Fei Hua, Yihuan Chen, Haoyue Huang, Wenxue Ye, Yunsheng Yu and Zhenya Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:151
    Content type: Research Published on:

  12. Patients diagnosed with melanoma brain metastases have few treatment options and poor prognosis, and improved treatment strategies for these patients require detailed understanding of the underlying pathobiolo...

    Authors: Trude G. Simonsen, Jon-Vidar Gaustad and Einar K. Rofstad
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:150
    Content type: Research Published on:

  14. Hematologic toxicity represents a major side effect of cytotoxic chemotherapy frequently preventing adequately dosed chemotherapy application and impeding therapeutic success. Transgenic (over)expression of ch...

    Authors: Sebastian Brennig, Nico Lachmann, Theresa Buchegger, Miriam Hetzel, Axel Schambach and Thomas Moritz
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:148
    Content type: Research Published on:

  15. Natural compounds have been demonstrated to lower breast cancer risk and sensitize tumor cells to anticancer therapies. Recently, we demonstrated that vernodalin (the active constituent of the medicinal herb Cent...

    Authors: Suresh Kumar Ananda Sadagopan, Nooshin Mohebali, Chung Yeng Looi, Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Aditya Arya, Hamed Karimian and Mohd Rais Mustafa
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:147
    Content type: Research Published on:

  16. The incidence of thyroid cancer has progressively increased over the past few decades, and the most frequent types of this cancer are papillary thyroid carcinoma (PTC) and small primary tumors. In PTC, oncogen...

    Authors: Shuiying Zhao, Qingzhu Wang, Zhizhen Li, Xiaojun Ma, Lina Wu, Hongfei Ji and Guijun Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:146
    Content type: Research Published on:

  17. Karyopherin alpha 2 (KPNA2), a member of the karyopherin family, plays a vital role in carcinogenesis. Yet its role in colon cancer is poorly characterized. We sought to clarify the clinical significance of it...

    Authors: Yu Zhang, Meng Zhang, Fudong Yu, Su Lu, Huimin Sun, Huamei Tang and Zhihai Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:145
    Content type: Research Published on:

  18. Tumour heterogeneity and resistance to systemic treatment in urothelial carcinoma (UC) may arise from cancer stem cells (CSC). A recent model describes cellular differentiation states within UC based on corres...

    Authors: Margaretha A. Skowron, Günter Niegisch, Gerhard Fritz, Tanja Arent, Joep G. H. van Roermund, Andrea Romano, Peter Albers, Wolfgang A. Schulz and Michèle J. Hoffmann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:144
    Content type: Research Published on:

  19. Protein kinase A (PKA) is a holoenzyme that consists of a dimer of regulatory subunits and two inactive catalytic subunits that bind to the regulatory subunit dimer. Four regulatory subunits (RIα, RIβ, RIIα, R...

    Authors: Emmanouil Saloustros, Paraskevi Salpea, Chen-Feng Qi, Lina A. Gugliotti, Kitman Tsang, Sisi Liu, Matthew F. Starost, Herbert C. Morse III and Constantine A. Stratakis
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:143
    Content type: Research Published on:

  20. Colorectal cancer (CRC) ranks third among the estimated cancer cases and cancer related mortalities in the Western world. Early detection and efficient therapy of CRC remains a major health challenge. Therefor...

    Authors: Nirmala Jagadish, Deepak Parashar, Namita Gupta, Sumit Agarwal, Sapna Purohit, Vikash Kumar, Aditi Sharma, Rukhsar Fatima, Amos Prashant Topno, Chandrima Shaha and Anil Suri
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:142
    Content type: Research Published on:

  21. PD-L1 expression on neutrophils contributes to the impaired immune response in infectious disease, but the detailed role of PD-L1 expression on neutrophils in HCC remains unclear.

    Authors: Gaixia He, Henghui Zhang, Jinxue Zhou, Beibei Wang, Yanhui Chen, Yaxian Kong, Xingwang Xie, Xueyan Wang, Ran Fei, Lai Wei, Hongsong Chen and Hui Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:141
    Content type: Research Published on:

  22. Hepatitis C Virus (HCV) infection is associated with chronically evolving disease and development of hepatocellular carcinoma (HCC), albeit the mechanism of HCC induction by HCV is still controversial. The nuc...

    Authors: Anna Maria Mileo, Stefano Mattarocci, Paola Matarrese, Simona Anticoli, Claudia Abbruzzese, Stefania Catone, Rodolfo Sacco, Marco G. Paggi and Anna Ruggieri
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:140
    Content type: Research Published on:

  23. The receptor tyrosine kinase-like orphan receptors (ROR) family contains the atypical member ROR1, which plays an oncogenic role in several malignant tumors. However, the clinical potentials and underlying mec...

    Authors: Jinqiu Tao, Xiaofei Zhi, Xiaoyu Zhang, Min Fu, Hao Huang, Yu Fan, Wenxian Guan and Chen Zou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:139
    Content type: Research Published on:

  24. Tumor progression locus 2 (TPL2), a serine-threonine kinase, functions as a critical regulator of inflammatory pathways and mediates oncogenic events. The potential role of Tpl2 in nonalcoholic fatty liver diseas...

    Authors: Xinli Li, Chun Liu, Blanche C. Ip, Kang-Quan Hu, Donald E. Smith, Andrew S. Greenberg and Xiang-Dong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:138
    Content type: Research Published on:

  25. Breast cancer is the most fatal malignant cancer among women, the conventional therapeutic modalities of it are limited. Morusin possesses cytotoxicity against some cancer cells in vitro. The purpose of this s...

    Authors: Haiyan Li, Qiaoping Wang, Lihua Dong, Chuanlan Liu, Zhen Sun, Ling Gao and Xiujie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:137
    Content type: Research Published on:

  26. Tumor-positive sentinel node(SLN) biopsy results in a risk of nonsentinel node metastases in case of micro and macro metastases ranging from 20 to 50 %, respectively. Therefore, most patients underwent unneces...

    Authors: F. Di Filippo, D. Giannarelli, C. Bouteille, L. Bernet, R. Cano, G. Cunnick and A. Sapino
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:136
    Content type: Research Published on:

  27. Linc00152 has been identified highly associated with the tumorigenesis and development of gastric cancer, however, the detailed mechanism of Linc00152 involved still remains unclear.

    Authors: Jianping Zhou, Xiaofei Zhi, Linjun Wang, Weizhi Wang, Zheng Li, Jie Tang, Jiwei Wang, Qun Zhang and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:135
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:30

  28. Enhanced signalling via the epidermal growth factor receptor (EGFR) is a hallmark of multiple human carcinomas. However, in recent years data have accumulated that EGFR might also be hyperactivated in human sa...

    Authors: Florian Sevelda, Lisa Mayr, Bernd Kubista, Daniela Lötsch, Sushilla van Schoonhoven, Reinhard Windhager, Christine Pirker, Michael Micksche and Walter Berger
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:134
    Content type: Research Published on:

  29. Hepatocellular carcinoma (HCC) is a common malignant tumor that severely threatens human health. The poor prognosis of HCC is mainly attributed to intrahepatic and extrahepatic metastases. HOXD9 proteins belon...

    Authors: Xiupeng Lv, Linlin Li, Li Lv, Xiaotong Qu, Shi Jin, Kejun Li, Xiaoqin Deng, Lei Cheng, Hui He and Lei Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:133
    Content type: Research Published on:

  30. Unresectable gastric cancer is associated with poor outcomes, with few treatment options available after failure of cytotoxic chemotherapy. Clinical trials of targeted therapies have generally shown no surviva...

    Authors: Hung Huynh, Richard Ong and Dieter Zopf
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:132
    Content type: Research Published on:

  31. Transcript dosage imbalance may influence the transcriptome. To gain insight into the role of altered gene expression in hereditary colorectal polyposis predisposition, in the present study we analyzed absolut...

    Authors: Gitana Maria Aceto, Fabiana Fantini, Sabrina De Iure, Marta Di Nicola, Giandomenico Palka, Rosa Valanzano, Patrizia Di Gregorio, Vittoria Stigliano, Maurizio Genuardi, Pasquale Battista, Alessandro Cama and Maria Cristina Curia
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:131
    Content type: Research Published on:

  32. Increasing evidence indicates that the dysregulation of miRNAs expression is involved in the tumorigenesis by acting as tumor suppressors or oncogenes. However, no study investigates the function and mechanism...

    Authors: Ying-Qing Li, Jian-Hua Lu, Xue-Ming Bao, Xi-Fu Wang, Jun-Hua Wu and Wei-Qiang Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:130
    Content type: Research Published on:

  33. Inflammation is a hallmark of cancer, yet the mechanisms that regulate immune cell infiltration into tumors remain poorly characterized. This study attempted to characterize the composition, distribution, and ...

    Authors: Li Li, Li Xu, Jing Yan, Zuo-Jun Zhen, Yong Ji, Chao-Qun Liu, Wan Yee Lau, Limin Zheng and Jing Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:129
    Content type: Research Published on:

  34. Although expression of MTA1 inversely correlates with the nuclear localization of ERα, the effect and molecular mechanism of ERα regulation of MTA1 remain unknown.

    Authors: Lei Deng, Hui Yang, Junwei Tang, Zhe Lin, Aihong Yin, Yun Gao, Xuehao Wang, Runqiu Jiang and Beicheng Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:128
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2024 43:172

  35. Glioma is the most common malignant primary brain tumor among adults, among which glioblastoma (GBM) exhibits the highest malignancy. Despite current standard chemoradiation, glioma is still invariably fatal. ...

    Authors: Zhi-Liang Wang, Chuan-Bao Zhang, Jin-Quan Cai, Qing-Bin Li, Zheng Wang and Tao Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:127
    Content type: Research Published on:

  36. Ribosomal protein S6 (rpS6), a component of the 40S ribosomal subunit, is involved in multiple cellular bioactivities. However, its clinicopathological significance in non-small cell lung cancer (NSCLC) is poo...

    Authors: Bojiang Chen, Zhi Tan, Jun Gao, Wei Wu, Lida Liu, Wei Jin, Yidan Cao, Shuang Zhao, Wen Zhang, Zhixin Qiu, Dan Liu, Xianming Mo and Weimin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:126
    Content type: Research Published on:

  37. Multi-drug resistance and predisposition to metastasize are major clinical problems in cancer treatment. Malignant primary brain tumor and pancreatic cancer are two well-known examples of malignant tumors resi...

    Authors: Barbara Guerra, Mette Fischer, Susanne Schaefer and Olaf-Georg Issinger
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:125
    Content type: Research Published on:

  38. While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased n...

    Authors: Ning Wang, Kimberley J. Reeves, Hannah K. Brown, Anne C M Fowles, Freyja E. Docherty, Penelope D. Ottewell, Peter I. Croucher, Ingunn Holen and Colby L. Eaton
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:124
    Content type: Research Published on:

  39. Uterine and ovarian carcinosarcomas (CS) are rare but highly aggressive gynecologic tumors which carry an extremely poor prognosis. We evaluated the expression levels of EpCAM and the in vitro activity of solitom...

    Authors: Francesca Ferrari, Stefania Bellone, Jonathan Black, Carlton L. Schwab, Salvatore Lopez, Emiliano Cocco, Elena Bonazzoli, Federica Predolini, Gulden Menderes, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz and Alessandro D. Santin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:123
    Content type: Research Published on:

  40. Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family involved in multiple malignancies. CMTM4 is a member of this family and is locat...

    Authors: Ting Li, Yingying Cheng, Pingzhang Wang, Wenyan Wang, Fengzhan Hu, Xiaoning Mo, Hongxia Lv, Tao Xu and Wenling Han
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:122
    Content type: Research Published on:

  41. Microspherule protein 1 (MCRS1) is a candidate oncogene and participates in various cellular processes, including growth, migration, senescence and transformation. MCRS1 is overexpressed in non-small cell lung...

    Authors: Minxia Liu, Kecheng Zhou, Yunchao Huang and Yi Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:121
    Content type: Research Published on:

  42. In women with macromastia, a type IV skin sparing mastectomy is often required to achieve an aesthetically pleasing reconstruction. The introduction of “skin-reducing mastectomy”, which inserts a permanent pro...

    Authors: Roy De Vita, Marcello Pozzi, Giovanni Zoccali, Maurizio Costantini, Pierpaolo Gullo, Ernesto Maria Buccheri and Antonio Varanese
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:120
    Content type: Research Published on:

  44. Tivantinib has been described as a highly selective inhibitor of MET and is currently in a phase III clinical trial for the treatment of hepatocellular carcinoma (HCC). However, the mechanism of tivantinib ant...

    Authors: Qingfeng Xiang, Zuojun Zhen, David YB Deng, Jingnan Wang, Yingjun Chen, Jieyuan Li, Yingfei Zhang, Fengjie Wang, Ningning Chen, Huanwei Chen and Yajin Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:118
    Content type: Research Published on:

  45. Neuron navigator 2 (NAV2) encodes a member of the neuron navigator gene family, which plays a role in tumorigenesis and cell migration. However, the prognostic value of NAV2 expression in colorectal cancer (CR...

    Authors: Fengbo Tan, Hong Zhu, Yiming Tao, Nanhui Yu, Qian Pei, Heli Liu, Yuan Zhou, Haifan Xu, Xiangping Song, Yuqiang Li, Zhongyi Zhou, Xiao He, Xingwen Zhang and Haiping Pei
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:117
    Content type: Research Published on:

  46. Accumulating evidence suggests the pro-inflammatory cytokine interleukin-6 (IL-6) in tumor microenvironment may promote the development of hepatocellular carcinoma (HCC). However, the underlying mechanism rema...

    Authors: Jun Wu, Jun Zhang, Bin Shen, Kai Yin, Jianwei Xu, Wencan Gao and Lihong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:116
    Content type: Research Published on:

  47. Osteosarcoma (OS) is a high-grade bone sarcoma with early metastasis potential, and the clinical chemotherapy drugs that are currently used for its treatment have some limitations. Recently, several studies ha...

    Authors: Yunlong Ma, Bin Zhu, Xiaoguang Liu, Huilei Yu, Lei Yong, Xiao Liu, Jia Shao and Zhongjun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:115
    Content type: Research Published on:

  48. Peptide based vaccines may suffer from limited stability and inefficient delivery to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). In order to overcome such limitations, several ...

    Authors: A. Petrizzo, C. Conte, M. Tagliamonte, M. Napolitano, K. Bifulco, V. Carriero, A. De Stradis, M. L. Tornesello, F. M. Buonaguro, F. Quaglia and L. Buonaguro
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:114
    Content type: Research Published on:

  49. The spread of mammographic screening programs has allowed an increasing amount of early breast cancer diagnosis. A modern approach to non-palpable breast lesions requires an accurate intraoperative localizatio...

    Authors: Giulia Anna Follacchio, Francesco Monteleone, Paolo Anibaldi, Giuseppe De Vincentis, Silvia Iacobelli, Raffaele Merola, Valerio D’Orazi, Massimo Monti and Vittorio Pasta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:113
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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