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  1. Leucine-rich-alpha-2-glycoprotein 1 (LRG1) has been reported to be involved in several tumors, whether it participates in colorectal cancer (CRC) progression remains unclear. Here, we investigated the biologic...

    Authors: Jingjing Zhang, Lingyin Zhu, Jingyuan Fang, Zhizheng Ge and Xiaobo Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:29
  2. Previous studies have investigated the sustained aberrantly activated Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is crucial for pancreatic cancer growth a...

    Authors: Li Huang, Bin Hu, Jianbo Ni, Jianghong Wu, Weiliang Jiang, Congying Chen, Lijuan Yang, Yue Zeng, Rong Wan, Guoyong Hu and Xingpeng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:27
  3. Epithelial-mesenchymal transition (EMT) is a dedifferentiation process that mainly involves in mesenchymal marker upregulation, epithelial maker downregulation and cell polarity loss. Related hypoxia factors p...

    Authors: Jian Yang, Xu Zhang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Ye Li, Yanbo Zhu, Dechun Li and Jian Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:26
  4. The importance of individual microRNAs (miRNAs) in tumor has been established in different cancers. However, their association with tumor chemoresistance has not been fully understood. Previously, we found two...

    Authors: Lin Zhao, Yan Wang, Longyang Jiang, Miao He, Xuefeng Bai, Lifeng Yu and Minjie Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:25

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:94

  5. Granzyme B (GrB) is a serine protease, traditionally known as expressed by cytotoxic lymphocytes to induce target cell apoptosis. However, it is emerging that GrB, being also produced by a variety of normal an...

    Authors: Donatella D’Eliseo, Giuliana Di Rocco, Rossella Loria, Silvia Soddu, Angela Santoni and Francesca Velotti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:24
  6. Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies ...

    Authors: Yuanliang Yan, Zhijie Xu, Shuang Dai, Long Qian, Lunquan Sun and Zhicheng Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:23
  7. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays key role in the progression of some human cancers. However, the role of NEAT1 in human laryngeal squamous cell cancer (LSCC) is still ...

    Authors: Peng Wang, Tianyi Wu, Han Zhou, Qianqian Jin, Guoqing He, Haoyang Yu, Lijia Xuan, Xin Wang, Linli Tian, Yanan Sun, Ming Liu and Lingmei Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:22
  8. Growing evidence suggests that Wnt/β-catenin pathway plays an important role in CRC development, progression and metastasis. Aberrant miR-224 expression has been reported in CRC. However, the mechanism of miR-...

    Authors: Tingting Li, Qiuhua Lai, Shuyang Wang, Juanjuan Cai, Zhiyuan Xiao, Danling Deng, Liuqing He, Hongli Jiao, Yaping Ye, Li Liang, Yanqing Ding and Wenting Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:21

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:143

  9. Authors: Yiting Tang, Yayun Cui, Zengpeng Li, Zhuqing Jiao, Yong Zhang, Yan He, Guangxia Chen, Qunyan Zhou, Wenjie Wang, Xifa Zhou, Judong Luo and Shuyu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:20

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:7

  10. Emerging evidence demonstrates that microRNAs (miRNAs) play an important role in regulation of cell growth, invasion and metastasis through inhibiting the expression of their targets. It has been reported that...

    Authors: Yang Liu, Yumei Li, Rui Wang, Shukui Qin, Jing Liu, Fang Su, Yan Yang, Fuyou Zhao, Zishu Wang and Qiong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:19
  11. Dendritic cells (DCs) have been used successfully in clinical pilot studies. However, tumor-specific immunity and clinical responses were only induced in certain cancer patients. It has been well documented th...

    Authors: Fan-Qin Wei, Wei Sun, Thian-Sze Wong, Wei Gao, Yi-Hui Wen, Jia-Wei Wei, Yi Wei and Wei-Ping Wen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:18
  12. MicroRNAs (miRNAs) have been shown to play a critical role in the development and progression of nasopharyngeal carcinoma (NPC). Although accumulating studies have been performed on the molecular mechanisms of...

    Authors: Fan Wang, Juan Lu, Xiaohong Peng, Jie Wang, Xiong Liu, Xiaomei Chen, Yiqi Jiang, Xiangping Li and Bao Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:17

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:84

  13. Neuropilin-1 (NRP-1) is a transmembrane glycoprotein participating in the growth and metastasis of cancer cells as multifunctional co-receptors by interacting with the signaling pathways. However, its role in ...

    Authors: Linhao Li, Xian Jiang, Qian Zhang, Xuesong Dong, Yuqiang Gao, Yuanlong He, Haiquan Qiao, Fangyu Xie, Xiangjun Xie and Xueying Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:16
  14. HOXA1 is a member of the Homeobox gene family, which encodes a group of highly conserved transcription factors that are important in embryonic development. However, it has been reported that HOXA1 exhibits onc...

    Authors: Chenwei Yuan, Xingwu Zhu, Yang Han, Chenlong Song, Chenchen Liu, Su Lu, Meng Zhang, Fudong Yu, Zhihai Peng and Chongzhi Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:15
  15. The aberrant expression of sperm-associated antigen 9 (SPAG9) is associated with numerous cancers, including hepatocellular carcinoma (HCC). The exploration of molecules and mechanisms regulating SPAG9 express...

    Authors: Guohua Lou, Xuejun Dong, Caixia Xia, Bingjue Ye, Qiuyue Yan, Shanshan Wu, Ye Yu, Feifei Liu, Min Zheng, Zhi Chen and Yanning Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:14
  16. Interleukin-37 (IL-37), a newly identified member of the IL-1 family, has been known to play an immunosuppressive role in a variety of inflammatory disorders, but whether it participates in the regulation of p...

    Authors: Guanqun Ge, Aiqin Wang, Jingyue Yang, Yan Chen, Jin Yang, Yize Li and Yan Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:13
  17. Both tumor-associated macrophages (TAMs) and the epithelial to mesenchymal transition (EMT) of cancer cells play key roles in promoting tumor progression. However, whether TAMs could induce EMT in the progress...

    Authors: Yong Hu, Meng-Ying He, Li-Fang Zhu, Cong-Chong Yang, Mei-Ling Zhou, Qiong Wang, Wei Zhang, Yang-Yu Zheng, Dong-Miao Wang, Zeng-Qi Xu, Yu-Nong Wu and Lai-Kui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:12
  18. MicroRNA-106b (miR-106b) was recently identified as an oncogene participating in cancer progression. Transforming growth factor β1(TGF-β1) is an indispensable cytokine regulating the local microenvironment, th...

    Authors: Yuan Cheng, Yanli Guo, Youyi Zhang, Ke You, Zijian Li and Li Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:11
  19. MicroRNAs (miRNAs) are a class of small non-coding RNAs, which post-transcriptionally repress the expression of genes involved in cancer initiation and progression. Although some miRNAs that target many signal...

    Authors: Xiaochun Sun, Manhua Cui, Aichen Zhang, Lingling Tong, Kun Wang, Kai Li, Xue Wang, Ziqian Sun and Hongye Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:10
  20. In this study we explored the role of microRNAs (miRNAs) as mediators of leukemogenic effects of the fusion gene MLL-AF9, which results from a frequent chromosomal translocation in infant and monoblastic acute my...

    Authors: Katrin K. Fleischmann, Philipp Pagel, Julia von Frowein, Thomas Magg, Adelbert A. Roscher and Irene Schmid
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:9
  21. In spite of progress in diagnostics and treatment of Hepatocellular Carcinoma (HCC), its prognosis remains poor, and improved treatment strategies for HCC require detailed understanding of the underlying mecha...

    Authors: Lei Chang, Cuicui Li, Tao Guo, Haitao Wang, Weijie Ma, Yufeng Yuan, Quanyan Liu, Qifa Ye and Zhisu Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:8
  22. Lung cancer has long been the most dangerous malignant tumor among males in both well developed and poorly developed countries. Radiotherapy plays a critical role in the curative management of inoperable non-s...

    Authors: Yiting Tang, Yayun Cui, Zengpeng Li, Zhuqing Jiao, Yong Zhang, Yan He, Guangxia Chen, Qunyan Zhou, Wenjie Wang, Xifa Zhou, Judong Luo and Shuyu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:7

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:20

  23. While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis...

    Authors: Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers and Nobuhiko Oridate
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:6
  24. Grb2-associated binder 2 (Gab2), a scaffolding adaptor protein, has recently been implicated in cancer progression. However, the role of Gab2 in the progression and metastasis of colorectal cancer (CRC) remain...

    Authors: Chenbo Ding, Junmin Luo, Longmei Li, Shanshan Li, Liwen Yang, Hongfei Pan, Qianyi Liu, Huan Qin, Chao Chen and Jihong Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:5
  25. Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal and adult tissues but its...

    Authors: Louiza Belkacemi and Shaun Xiaoliu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:4
  26. The synthetic biology technology which enhances the specificity and efficacy of treatment is a novel try in biomedical therapy during recent years. A high frequency of somatic mutations was shown in the human ...

    Authors: Li Liu, Yuchen Liu, Tianbiao Zhang, Hanwei Wu, Muqi Lin, Chaoliang Wang, Yonghao Zhan, Qing Zhou, Baoping Qiao, Xiaojuan Sun, Qiaoxia Zhang, Xiaoqiang Guo, Guoping Zhao, Weixing Zhang and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:3
  27. Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Chemotherapeutic insensitivity is one of major obstacle...

    Authors: Jinbo Chen, Long Wang, Yunhua Tang, Guanghui Gong, Longfei Liu, Minfeng Chen, Zhi Chen, Yu Cui, Chao Li, Xu Cheng, Lin Qi and Xiongbing Zu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:2
  28. Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system. Although surgical resection is the preferred treatment f...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:1
  29. Previously, we reported that polyploid giant cancer cells (PGCCs) induced by cobalt chloride (CoCl2) could have generated daughter cells with strong invasiveness and migration capabilities via asymmetric division...

    Authors: Fei Fei, Dan Zhang, Zhengduo Yang, Shujing Wang, Xian Wang, Zhengsheng Wu, Qiang Wu and Shiwu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:158
  30. Overexpression of Metastasis-associated protein 1 (MTA1) in various cancer cells promotes tumor invasion and migration and predicts cancer patients’ poor prognosis. The pilot RNA-Seq data from our laboratory i...

    Authors: Ning Zhou, Haijuan Wang, Hongxu Liu, Hongsheng Xue, Feng Lin, Xiting Meng, Ailing Liang, Zhilong Zhao, YongJun Liu and Haili Qian
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:157
  31. After progression to a standard first-line platinum and gemcitabine combination (GP), there is no established second-line therapy for patients with advanced biliary tract cancers (aBTC). Indeed, literature dat...

    Authors: Lorenzo Fornaro, Caterina Vivaldi, Stefano Cereda, Francesco Leone, Giuseppe Aprile, Sara Lonardi, Nicola Silvestris, Daniele Santini, Michele Milella, Chiara Caparello, Gianna Musettini, Giulia Pasquini, Alfredo Falcone, Giovanni Brandi, Isabella Sperduti and Enrico Vasile
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:156
  32. Nanocapsules, as a delivery system, are able to target drugs and other biologically sensitive molecules to specific cells or organs. This system has been intensively investigated as a way to protect bioactives...

    Authors: Jérôme Roy, Liliam Teixeira Oliveira, Camille Oger, Jean-Marie Galano, Valerie Bultel-Poncé, Sylvain Richard, Andrea Grabe Guimaraes, José Mário Carneiro Vilela, Margareth Spangler Andrade, Thierry Durand, Pierre Besson, Vanessa Carla Furtado Mosqueira and Jean-Yves Le Guennec
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:155
  33. Lung cancer is the most common cause of cancer-related deaths worldwide. Natural phytochemicals from traditional medicinal plants such as solamargine have been shown to have anticancer properties. The prostagl...

    Authors: YuQing Chen, Qing Tang, JingJing Wu, Fang Zheng, LiJun Yang and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:154
  34. Oncolytic virus which arms the therapeutic gene to enhance anti-tumor activity is a prevalent strategy to improve oncovirotherapy of cancer. Newcastle disease virus (NDV) is a naturally oncolytic virus used fo...

    Authors: Ding Wei, Qian Li, Xi-Long Wang, Yuan Wang, Jing Xu, Fei Feng, Gang Nan, Bin Wang, Can Li, Ting Guo, Zhi-Nan Chen and Huijie Bian
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:153
  35. Many promising anticancer molecules are abandoned during the course from bench to bedside due to lack of clear-cut efficiency and/or severe side effects. Vitamin K3 (vitK3) is a synthetic naphthoquinone exhibi...

    Authors: Tiantian He, Elie Hatem, Laurence Vernis, Ming Lei and Meng-Er Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:152
  36. Metastasis-associated gene 1(MTA1) has been identified as an oncogene in many tumors, and aberrant MTA1 expression has been linked to carcinogenesis and metastasis. We aim to investigate the mechanism of MTA1 ...

    Authors: Caihua Xu, Fei Hua, Yihuan Chen, Haoyue Huang, Wenxue Ye, Yunsheng Yu and Zhenya Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:151
  37. Patients diagnosed with melanoma brain metastases have few treatment options and poor prognosis, and improved treatment strategies for these patients require detailed understanding of the underlying pathobiolo...

    Authors: Trude G. Simonsen, Jon-Vidar Gaustad and Einar K. Rofstad
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:150
  38. Hematologic toxicity represents a major side effect of cytotoxic chemotherapy frequently preventing adequately dosed chemotherapy application and impeding therapeutic success. Transgenic (over)expression of ch...

    Authors: Sebastian Brennig, Nico Lachmann, Theresa Buchegger, Miriam Hetzel, Axel Schambach and Thomas Moritz
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:148
  39. Natural compounds have been demonstrated to lower breast cancer risk and sensitize tumor cells to anticancer therapies. Recently, we demonstrated that vernodalin (the active constituent of the medicinal herb Cent...

    Authors: Suresh Kumar Ananda Sadagopan, Nooshin Mohebali, Chung Yeng Looi, Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Aditya Arya, Hamed Karimian and Mohd Rais Mustafa
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:147
  40. The incidence of thyroid cancer has progressively increased over the past few decades, and the most frequent types of this cancer are papillary thyroid carcinoma (PTC) and small primary tumors. In PTC, oncogen...

    Authors: Shuiying Zhao, Qingzhu Wang, Zhizhen Li, Xiaojun Ma, Lina Wu, Hongfei Ji and Guijun Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:146
  41. Karyopherin alpha 2 (KPNA2), a member of the karyopherin family, plays a vital role in carcinogenesis. Yet its role in colon cancer is poorly characterized. We sought to clarify the clinical significance of it...

    Authors: Yu Zhang, Meng Zhang, Fudong Yu, Su Lu, Huimin Sun, Huamei Tang and Zhihai Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:145
  42. Tumour heterogeneity and resistance to systemic treatment in urothelial carcinoma (UC) may arise from cancer stem cells (CSC). A recent model describes cellular differentiation states within UC based on corres...

    Authors: Margaretha A. Skowron, Günter Niegisch, Gerhard Fritz, Tanja Arent, Joep G. H. van Roermund, Andrea Romano, Peter Albers, Wolfgang A. Schulz and Michèle J. Hoffmann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:144
  43. Protein kinase A (PKA) is a holoenzyme that consists of a dimer of regulatory subunits and two inactive catalytic subunits that bind to the regulatory subunit dimer. Four regulatory subunits (RIα, RIβ, RIIα, R...

    Authors: Emmanouil Saloustros, Paraskevi Salpea, Chen-Feng Qi, Lina A. Gugliotti, Kitman Tsang, Sisi Liu, Matthew F. Starost, Herbert C. Morse III and Constantine A. Stratakis
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:143
  44. Colorectal cancer (CRC) ranks third among the estimated cancer cases and cancer related mortalities in the Western world. Early detection and efficient therapy of CRC remains a major health challenge. Therefor...

    Authors: Nirmala Jagadish, Deepak Parashar, Namita Gupta, Sumit Agarwal, Sapna Purohit, Vikash Kumar, Aditi Sharma, Rukhsar Fatima, Amos Prashant Topno, Chandrima Shaha and Anil Suri
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:142
  45. PD-L1 expression on neutrophils contributes to the impaired immune response in infectious disease, but the detailed role of PD-L1 expression on neutrophils in HCC remains unclear.

    Authors: Gaixia He, Henghui Zhang, Jinxue Zhou, Beibei Wang, Yanhui Chen, Yaxian Kong, Xingwang Xie, Xueyan Wang, Ran Fei, Lai Wei, Hongsong Chen and Hui Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:141
  46. Hepatitis C Virus (HCV) infection is associated with chronically evolving disease and development of hepatocellular carcinoma (HCC), albeit the mechanism of HCC induction by HCV is still controversial. The nuc...

    Authors: Anna Maria Mileo, Stefano Mattarocci, Paola Matarrese, Simona Anticoli, Claudia Abbruzzese, Stefania Catone, Rodolfo Sacco, Marco G. Paggi and Anna Ruggieri
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:140

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