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  1. Human T-cell leukemia virus (HTLV-1) is a lymphotropic retrovirus associated to adult T cell leukemia (ATL) and to non-neoplastic inflammatory conditions affecting the central nervous system, lung or skin. The...

    Authors: Maria Pia Fuggetta, Valentina Bordignon, Andrea Cottarelli, Beatrice Macchi, Caterina Frezza, Paola Cordiali-Fei, Fabrizio Ensoli, Stefania Ciafrè, Francesca Marino-Merlo, Antonio Mastino and Giampietro Ravagnan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:118
  2. Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer...

    Authors: Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino and Alessandra Micera
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:116
  3. Synaptojanin 2 Binding Protein (SYNJ2BP) is essential to cell proliferation. Previous studies show that SYNJ2BP participates in sprouting angiogenesis, which plays an important part in several abnormal conditi...

    Authors: Xiao Liu, Jiangjiao Zhou, Ning Zhou, Jianwei Zhu, Yong Feng and Xiongying Miao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:115
  4. It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory cytokines to facilitate the development of radiation-induced liver disease. However, little is known on whether ...

    Authors: Yinying Dong, Xiaoyun Shen, Mingyan He, Zhifeng Wu, Qiongdan Zheng, Yaohui Wang, Yuhan Chen, Sifan Wu, Jiefeng Cui and Zhaochong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:114
  5. Osteosarcoma is the most common primary malignancy of bone. Its treatment relies on the administration of neoadjuvant and adjuvant chemotherapy combined with surgery. Alternative to common intravenous (i.v.) a...

    Authors: Bernhard Robl, Sander Martijn Botter, Giovanni Pellegrini, Olga Neklyudova and Bruno Fuchs
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:113
  6. Polyphyllin I (PPI), a bioactive phytochemical extracted from the Rhizoma of Paris polyphylla, has been reported to exhibit anti-cancer activity. However, the detailed mechanism underlying this remains to be eluc...

    Authors: Longmei Li, JingJing Wu, Fang Zheng, Qing Tang, WanYin Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:112
  7. Nestin expression has been reported to be associated with the prognosis of many solid tumors including human hepatocellular carcinoma (HCC). The present study aimed to identify the role, if any, of Nestin in t...

    Authors: Yan Zhang, Shan Zeng, Junli Ma, Ganlu Deng, Yanlin Qu, Cao Guo and Hong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:111
  8. 1-methylnicotinamide (1-MNA), an endogenous metabolite of nicotinamide, has recently gained interest due to its anti-inflammatory and anti-thrombotic activities linked to the COX-2/PGI2 pathway. Given the previou...

    Authors: Agnieszka Blazejczyk, Marta Switalska, Stefan Chlopicki, Andrzej Marcinek, Jerzy Gebicki, Marcin Nowak, Anna Nasulewicz-Goldeman and Joanna Wietrzyk
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:110
  9. Metastasis remains the major cause of death in nasopharyngeal carcinoma (NPC). Yippee-like 3 (YPEL3) plays an important role in tumorigenesis. However, its function and mechanism in NPC has not been systematic...

    Authors: Jian Zhang, Xin Wen, Xian-Yue Ren, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Na Liu and Jun Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:109

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:214

  10. Activating transcription factor 2 (ATF2) is a basic helix-loop-helix transcription factor, which has been shown to participate in the pathobiology of numerous cancers. However, the role of ATF2 in renal cell c...

    Authors: Deng-shuang Wu, Cheng Chen, Zhen-jie Wu, Bing Liu, Li Gao, Qing Yang, Wei Chen, Jun-ming Chen, Yi Bao, Le Qu and Lin-hui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:108
  11. HM-3 is a polypeptide inhibiting angiogenesis. Recent reports suggest that the antitumor effect of angiogenesis inhibitors administered alone might be limited. Cancer stem cells can survive the lack of oxygen ...

    Authors: Changhong Zhao, Junjin He, Haoran Cheng, Zhaohao Zhu and Hanmei Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:107
  12. Interleukin-9 (IL-9) was discovered as a helper T cell growth factor. It has long been recognized as an important regulator in allergic inflammation. Recent years it was discovered to induce cell growth and di...

    Authors: Xiao Lv, Lili Feng, Xueling Ge, Kang Lu and Xin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:106
  13. The prognosis of non-small-cell lung cancer (NSCLC) is poor yet mechanistic understanding and therapeutic options remain limited. We investigated the biological and clinical significance of microRNA-130b and i...

    Authors: Jianwei Tian, Liping Hu, Xiao Li, Jian Geng, Meng Dai and Xiaoyan Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:105
  14. The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outc...

    Authors: Alessandra Fabi, Paola Malaguti, Sabrina Vari and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:104
  15. The role of immune response is emerging as a key factor in the complex multistep process of cancer. Tumor microenvironment contains different types of immune cells, which contribute to regulate the fine balanc...

    Authors: Laura Paladini, Linda Fabris, Giulia Bottai, Carlotta Raschioni, George A. Calin and Libero Santarpia
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:103
  16. Authors: Xiu-Yan Huang, Zi-Li Huang, Bin Xu, Zi Chen, Thomas Joseph Re, Qi Zheng, Zhao-You Tang and Xin-Yu Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:102

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:85

  17. Serum miRNAs profiles between papillary thyroid carcinoma (PTC) patients with non-131I and 131I-avid lung metastases are differentially expressed. These miRNAs have to be further validated and the role of these m...

    Authors: Chen-Tian Shen, Zhong-Ling Qiu, Hong-Jun Song, Wei-Jun Wei and Quan-Yong Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:101
  18. Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins, is overexpressed in high-grade gliomas and plays an oncogenic function in glioma biology. However, little is known about the role of TRIM11 i...

    Authors: Xiaolin Wang, Weiping Shi, Hongcan Shi, Shichun Lu, Kang Wang, Chao Sun, Jiansheng He, Weiguo Jin, Xiaoxia Lv, Hui Zou and Yusheng Shu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:100
  19. Long non-coding RNAs (lncRNAs) have been proved to act as key molecules in cancer development and progression. Dysregulation of lncRNAs is discovered in various tumor tissues and cancer cells where they can se...

    Authors: Jianfa Li, Chengle Zhuang, Yuchen Liu, Mingwei Chen, Yincong Chen, Zhicong Chen, Anbang He, Junhao Lin, Yonghao Zhan, Li Liu, Wen Xu, Guoping Zhao, Yinglu Guo, Hanwei Wu, Zhiming Cai and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:99

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:321

  20. Growing evidence suggests that SALL4 plays a vital role in tumor progression and metastasis. However, the molecular mechanism of SALL4 promoting esophageal squamous cell carcinoma (ESCC) remains to be elucidated.

    Authors: Jing He, Mingxia Zhou, Xinfeng Chen, Dongli Yue, Li Yang, Guohui Qin, Zhen Zhang, Qun Gao, Dan Wang, Chaoqi Zhang, Lan Huang, Liping Wang, Bin Zhang, Jane Yu and Yi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:98
  21. Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is freq...

    Authors: Shuai Zhao, Yang Cao, Shi-bo Liu, Xu-an Wang, Run-fa Bao, Yi-jun Shu, Yun-ping Hu, Yi-jian Zhang, Lin Jiang, Fei Zhang, Hai-bin Liang, Huai-feng Li, Qiang Ma, Yi Xu, Zheng Wang, Yi-chi Zhang…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:97
  22. Authors: Adel Galal El-Shemi, Ahmad Mohammed Ashshi, Youjin Na, Yan Li, Mohammed Basalamah, Faisal Ahmad Al-Allaf, Eonju Oh, Bo-Kyeong Jung and Chae-Ok YUN
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:96

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:74

  23. Authors: Liang Feng, Hang-Ping Yao, Sharad Sharma, Yong-Qing Zhou, Jianwei Zhou, Ruiwen Zhang and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:95

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:70

  24. Medulloblastoma (MB) is the most common pediatric brain tumor. Current treatment regimes consisting of primary surgery followed by radio- and chemotherapy, achieve 5-year overall survival rates of only about 6...

    Authors: Ina Patties, Rolf-Dieter Kortmann, Franziska Menzel and Annegret Glasow
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:94
  25. MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human malignant tumors. In the present study, we analyzed the role miR-155-3p plays in Hepatocellular carcinoma (HCC), which has been rep...

    Authors: Bo Tang, Biao Lei, Guangying Qi, Xingsi Liang, Fang Tang, Shengguang Yuan, Zhenran Wang, Shuiping Yu and Songqing He
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:93
  26. MUC4 is a high molecular weight membrane protein that is overexpressed in pancreatic cancer (PC) and is associated with the development and progression of this disease. However, the exact mechanisms through wh...

    Authors: Jie Tang, Yi Zhu, Kunling Xie, Xiaoyu Zhang, Xiaofei Zhi, Weizhi Wang, Zheng Li, Qun Zhang, Linjun Wang, Jiwei Wang and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:91

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:34

  27. Glioma is one of the most common and aggressive primary malignant tumor in the brain. Accumulating evidences indicated that aberrantly expressed non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNA...

    Authors: Chun-Chun Ma, Zhang Xiong, Guan-Nan Zhu, Chao Wang, Gang Zong, Hong-Liang Wang, Er-Bao Bian and Bing Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:90
  28. Increasing evidence suggests that microRNAs (miRNAs) play critical roles in malignant transformation, tumor progression and metastasis. Aberrant miR-655-3p expression has been associated with several cancers. ...

    Authors: Gang Wu, Kunming Zheng, Shuguan Xia, Yawei Wang, Xiangyu Meng, Xiaoming Qin and Ying Cheng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:89
  29. Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor progression and plays an important role in cancer invasion and metastasis. RNF8 is an ubiquitin E3 ligase with RING domain, and plays e...

    Authors: Jingyu Kuang, Li Li, Limei Guo, Yanrong Su, Yuxuan Wang, Yongjie Xu, Xiaozhen Wang, Shucong Meng, Liandi Lei, Luzheng Xu and Genze Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:88
  30. The role of HBV X protein (HBx) in the development of hepatocellular carcinoma (HCC) has been well studied. However, little is known about the molecular functions of HBV whole-X protein (HBwx), a protein fused...

    Authors: Yu Zhang, Hongli Liu, Ruitian Yi, Taotao Yan, Yingli He, Yingren Zhao and Jinfeng Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:87
  31. Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in low-grade gliomas and secondary glioblastomas (sGBM). Because they yield the same oncometabolite, D-2-hydroxygl...

    Authors: Hao-Yuan Wang, Kai Tang, Ting-Yu Liang, Wei-Zhong Zhang, Ji-Ye Li, Wen Wang, Hui-Min Hu, Ming-Yang Li, Hui-Qing Wang, Xiao-Zheng He, Zhi-Yuan Zhu, Yan-Wei Liu and Shi-Zhong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:86
  32. Hepatectomy generally offers the best chance of long-term survival for patients with hepatocellular carcinoma (HCC). Many studies have shown that hepatectomy accelerates tumor metastasis, but the mechanism rem...

    Authors: Xiu-Yan Huang, Zi-Li Huang, Bin Xu, Zi Chen, Thomas Joseph Re, Qi Zheng, Zhao-You Tang and Xin-Yu Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:85

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:102

  33. The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal tran...

    Authors: Samantha Kaufhold, Hermes Garbán and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:84
  34. Long non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development and progression. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a novel long non-codin...

    Authors: Yonghao Zhan, Junhao Lin, Yuchen Liu, Mingwei Chen, Xiaoying Chen, Chengle Zhuang, Li Liu, Wen Xu, Zhicong Chen, Anbang He, Qiaoxia Zhang, Xiaojuan Sun, Guoping Zhao and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:83

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:185

  35. Increasing evidence supports the association of CTNND1 with tumor development and progression. However, the mechanism and clinical significance of CTNND1 deregulation in hepatocellular carcinoma (HCC) remains ...

    Authors: Bo Tang, Fang Tang, Zhenran Wang, Guangying Qi, Xingsi Liang, Bo Li, Shengguang Yuan, Jie Liu, Shuiping Yu and Songqing He
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:82
  36. It was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells. We showed in an ...

    Authors: Dana Hamam, Mohamed Abdouh, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:80
  37. Tumor cells use aerobic glycolysis to rapidly generate ATP and growth substrate which expenses a large amount of glucose. However, how tumor cells take in enough glucose from the tumor microenvironment of insu...

    Authors: Shixiong Lei, Jiandong Yang, Chong Chen, Jiachen Sun, Liu Yang, Haili Tang, Tao Yang, An Chen, Huadong Zhao, Yan Li and Xilin Du
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:79
  38. Glioblastoma multiforme is the most aggressive malignant primary brain tumor, characterized by rapid growth and extensive infiltration to neighboring normal brain parenchyma. Both PI3K/Akt and JNK pathways are...

    Authors: Hua-Fu Zhao, Jing Wang, Hao-Ran Jiang, Zhong-Ping Chen and Shing-Shun Tony To
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:78
  39. Lung cancer is the most common malignancies worldwide. However, the detailed molecular mechanisms underlying lung cancer progression are still not completely clear. MicroRNAs are small noncoding RNAs which occ...

    Authors: Wei Chen, Jun Wang, Sulai Liu, Shaoqiang Wang, Yuanda Cheng, Wolong Zhou, Chaojun Duan and Chunfang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:76
  40. Recent evidence has proven that long noncoding RNAs (lncRNAs) play important roles in cancer biology, while few lncRNAs have been characterized in NSCLC. Here, we characterized a novel lncRNA, SBF2 antisense R...

    Authors: Junjie Lv, Mantang Qiu, Wenjia Xia, Chao Liu, Youtao Xu, Jie Wang, Xuechun Leng, Su Huang, Rong Zhu, Ming Zhao, Fengqing Ji, Lin Xu, Keping Xu and Rong Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:75
  41. Gene-based virotherapy mediated by oncolytic viruses is currently experiencing a renaissance in cancer therapy. However, relatively little attention has been given to the potentiality of dual gene virotherapy ...

    Authors: Adel Galal El-Shemi, Ahmad Mohammed Ashshi, Youjin Na, Yan Li, Mohammed Basalamah, Faisal Ahmad Al-Allaf, Eonju Oh, Bo-Kyeong Jung and Chae-Ok YUN
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:74

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:96

  42. Chemotherapy with docetaxel (Doc) remains the standard treatment for metastatic and castration-resistance prostate cancer (CRPC). However, the clinical success of Doc is limited by its chemoresistance and side...

    Authors: Piwen Wang, Susanne M. Henning, Clara E. Magyar, Yahya Elshimali, David Heber and Jaydutt V. Vadgama
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:73
  43. Abnormal DNA methylation/demethylation is recognized as a hallmark of cancer. TET (ten-eleven translocation) family members are novel DNA demethylation related proteins that dysregulate in multiple malignances...

    Authors: Zhongxue Ye, Jie Li, Xi Han, Huilian Hou, He Chen, Xia Zheng, Jiaojiao Lu, Lijie Wang, Wei Chen, Xu Li and Le Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:72
  44. Hepatocellular carcinoma (HCC) accounts for 75 % of liver cancers and is the second most lethal cancer, associated with its multiple etiologies, poor prognosis and resistance to chemotherapy drugs. Chemotherap...

    Authors: Zheng Hu, Guixiang Lv, Yongning Li, Enze Li, Haixia Li, Qi Zhou, Bin Yang and Wenwu Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:71
  45. Aberrant expression of the RON receptor tyrosine kinase, a member of the MET proto-oncogene family, in breast cancer and non-small cell lung cancer (NSCLC) has therapeutic implication. Here we evaluated the ef...

    Authors: Liang Feng, Hang-Ping Yao, Sharad Sharma, Yong-Qing Zhou, Jianwei Zhou, Ruiwen Zhang and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:70

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:95

  46. MicroRNA-138 (miR-138) has been proven to be a tumor suppressor gene in various types of tumors. However, the expression and the role of miR-138 in human osteosarcoma are still poorly understood. We investigat...

    Authors: Baoen Jiang, Weidong Mu, Jiangquan Wang, Jianshu Lu, Shanyong Jiang, Liang Li, Haining Xu and Hongyan Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:69
  47. Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated in the regulation of cell proliferation, invasive migration and survival. However, PHB expression and its biolo...

    Authors: Yang Cao, Haibin Liang, Fei Zhang, Zhou Luan, Shuai Zhao, Xu-an Wang, Shibo Liu, Runfa Bao, Yijun Shu, Qiang Ma, Jian Zhu and Yingbin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:68

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  • Citation Impact 2023
    Journal Impact Factor: 11.4
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    Source Normalized Impact per Paper (SNIP): 1.770
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