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  1. This study investigates the expression of Lewis y antigen, integrin αv, β3 in epithelial ovarian cancer tissues. We further evaluate the relationship between their expression and chemotherapy resistance of ova...

    Authors: Jian Gao, Zhenhua Hu, Dawo Liu, Juanjuan Liu, Chuan Liu, Rui Hou, Song Gao, Danye Zhang, Shulan Zhang and Bei Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:36
    Content type: Research Published on:

  2. Ankyrin repeat domain 12 (ANKRD12), is encoding a 224 kDa nuclear protein and most conserved at its N-terminal ankyrin repeats region and the C-terminal co-activator interacting domain. The aim of this study w...

    Authors: Rui Bai, Dan Li, Zhong Shi, Xuefeng Fang, Weiting Ge and Shu Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:35
    Content type: Research Published on:

  3. The use of [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for detection of gastric cancer is often debated because FDG uptake varies for each patient. The purpose of this study was to ...

    Authors: Ryusuke Takebayashi, Kunihiko Izuishi, Yuka Yamamoto, Reiko Kameyama, Hirohito Mori, Tsutomu Masaki and Yasuyuki Suzuki
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:34
    Content type: Research Published on:

  4. The metastasis-associated gene 1 (MTA1) has been identified as one critical regulator of tumor metastasis. Previously, we identified miR-125b as a downregualted miRNA in non-small cell lung cancer (NSCLC) cell...

    Authors: Yiyi Li, Yilan Chao, Yuan Fang, Jian Wang, Min Wang, Hong Zhang, Min Ying, Xiaoxia Zhu and Haofei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:33
    Content type: Research Published on:

  5. To observe the influence of combination treatment with glibenclamide and CoCl2 on the growth and invasiveness of TA2 breast cancer, and to detect the protein and mRNA expression of MMP9.

    Authors: Zhe Rong, Li Li, Fei Fei, Lailong Luo and Yang Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:32
    Content type: Research Published on:

  6. Anticancer activities of cinnamic acid derivatives include induction of apoptosis by irreversible DNA damage leading to cell death. The present work aimed to compare the cytotoxic and genotoxic potential of ci...

    Authors: Evandro Luís de Oliveira Niero and Gláucia Maria Machado-Santelli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:31
    Content type: Research Published on:

  7. Several reports have described the potential effects of natural compounds as anti-cancer agents in vitro as well as in vivo. The aim of this study was to evaluate the anti-cancer effect of Limoniastrum guyonianum

    Authors: Mounira Krifa, Mahmoud Alhosin, Christian D Muller, Jean-Pierre Gies, Leila Chekir-Ghedira, Kamel Ghedira, Yves Mély, Christian Bronner and Marc Mousli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:30
    Content type: Research Published on:

  8. E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC).

    Authors: Min-Li Mo, Zhao Chen, Hai-Meng Zhou, Hui Li, Tomomi Hirata, David M Jablons and Biao He
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:29
    Content type: Research Published on:

  9. Previous reports have suggested that malignant transformations originate from adult stem cells, and may thus express the stem-cell-associated markers. The purpose of this study is to investigate the differenti...

    Authors: Laodong Li, Huina Yu, Xiaoyang Wang, Jinrong Zeng, Dangyu Li, Jingyan Lu, Changming Wang, Jiying Wang, Jianghong Wei, Ming Jiang and Biwen Mo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:28
    Content type: Research Published on:

  10. Medulloblastoma (MB) is the most common malignant brain tumor in childhood with a 5-year survival of approximately 60%. We have recently shown that treatment of human MB cells with 5-aza-2’-deoxycytidine (5-az...

    Authors: Ina Patties, Rolf-Dieter Kortmann and Annegret Glasow
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:27
    Content type: Research Published on:

  12. The aim of the study was to evaluate predictive and prognostic significance of microtubule-associated protein Tau in epithelial ovarian cancer (EOC) patients treated with paclitaxel and platinum-based chemothe...

    Authors: Marta Smoter, Lubomir Bodnar, Bartlomiej Grala, Rafal Stec, Krystyna Zieniuk, Wojciech Kozlowski and Cezary Szczylik
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:25
    Content type: Research Published on:

  13. Tumors are diseases characterized by uncontrolled cell growth and, in spite of the progress of medicine over the years, continue to represent a major threat to the health, requiring new therapies. Several synt...

    Authors: Carmen Petronzi, Michela Festa, Antonella Peduto, Maria Castellano, Jessica Marinello, Antonio Massa, Anna Capasso, Giovanni Capranico, Annalisa La Gatta, Mario De Rosa, Michele Caraglia and Rosanna Filosa
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:24
    Content type: Research Published on:

  14. Diagnostic imaging plays a relevant role in the care of patients with breast cancer (BC). Positron Emission Tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (FDG) has been widely proven to be a clinical tool...

    Authors: Valentina Bravatà, Alessandro Stefano, Francesco P Cammarata, Luigi Minafra, Giorgio Russo, Stefania Nicolosi, Sabina Pulizzi, Cecilia Gelfi, Maria C Gilardi and Cristina Messa
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:23
    Content type: Research Published on:

  16. Peritumoral activated hepatic stellate cells (HSCs) are versatile myofibroblast-like cells closely related with hepatocellular carcinoma (HCC) progression. So far, comprehensive comparison of gene expression o...

    Authors: Rui Liao, Han Wu, Yong Yi, Jia-Xing Wang, Xiao-Yan Cai, Hong-Wei He, Yun-Feng Cheng, Jian Zhou, Jia Fan, Jian Sun and Shuang-Jian Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:22
    Content type: Research Published on:

  17. Growing evidences indicate microRNAs play important roles in cancer development, progression, metastasis and may constitute robust biomarkers for cancer prognosis. The aim of this study was to identify the cli...

    Authors: Ming-Qi Fan, Chi-Bing Huang, Yan Gu, Ya Xiao, Jin-Xin Sheng and Lin Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:21
    Content type: Research Published on:

  18. Depletion of calcium (Ca2+) from the endoplasmic reticulum (ER) activates the ubiquitous store-operated Ca2+ entry (SOCE) pathway which sustains long-term Ca2+ signals and is critical for cellular functions. Stro...

    Authors: Guilin Li, Zhenxing Zhang, Renzhi Wang, Wenbin Ma, Ying Yang, Junji Wei and Yanping Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:20
    Content type: Research Published on:

  19. Toll-like receptor (TLR) agonists have important properties that can be exploited for immunotherapy against tumors. Locally injected immunostimulatory oligodeoxynucleotides containing CpG motifs (CpG-ODNs), wh...

    Authors: Rym Ben Abdelwahed, Jérémie Cosette, Sabrina Donnou, Lucile Crozet, Hanane Ouakrim, Wolf Herman Fridman, Catherine Sautès-Fridman, Aouni Mahjoub and Sylvain Fisson
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:18
    Content type: Research Published on:

  20. SOX7 is a transcription factor belonging to the SOX family. Its role in lung cancer is unknown.

    Authors: Takahide Hayano, Manoj Garg, Dong Yin, Makoto Sudo, Norihiko Kawamata, Shuo Shi, Wenwen Chien, Ling-wen Ding, Geraldine Leong, Seiichi Mori, Dong Xie, Patrick Tan and H Phillip Koeffler
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:17
    Content type: Research Published on:

  21. We explore the clinical and prognostic significance of expression of vascular endothelial growth factor receptor (VEGFR)-2, platelet-derived growth factor receptor (PDGFR)-β, and c-Met in patients with hepatoc...

    Authors: Jie Sheng Chu, Fei Jiao Ge, Bo Zhang, Yan Wang, Nicola Silvestris, Lie Jun Liu, Chuan Hua Zhao, Li Lin, Anna Elisabetta Brunetti, Ya Li Fu, Jun Wang, Angelo Paradiso and Jian Ming Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:16
    Content type: Research Published on:

  22. The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results wer...

    Authors: Yanlong Yang, Yuanliang Xie and Lei Xian
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:15
    Content type: Review Published on:

  23. Metabolic Syndrome (MS) has been correlated to breast carcinogenesis. MS is common in the general population (34%) and increases with age and body mass index. Although the link between obesity, MS and hormone ...

    Authors: Immacolata Capasso, Emanuela Esposito, Francesca Pentimalli, Maurizio Montella, Anna Crispo, Nicola Maurea, Massimiliano D’Aiuto, Alfredo Fucito, Maria Grimaldi, Ernesta Cavalcanti, Giuseppe Esposito, Giuseppe Brillante, Sergio Lodato, Tonino Pedicini, Giuseppe D’Aiuto, Gennaro Ciliberto…
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:14
    Content type: Research Published on:

  24. In a prospective multicenter phase II trial of radioembolization with yttrium-90 (90Y-RE) in chemorefractory liver-dominant metastatic colorectal cancer (mCRC), we showed that median survival was 12.6 months (95%...

    Authors: Elisa Melucci, Maurizio Cosimelli, Livio Carpanese, Giuseppe Pizzi, Francesco Izzo, Francesco Fiore, Rita Golfieri, Emanuela Giampalma, Isabella Sperduti, Cristiana Ercolani, Rosa Sciuto, Raffaello Mancini, Carlo Garufi, Maria Grazia Diodoro and Marcella Mottolese
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:13
    Content type: Research Published on:

  25. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies and tends to be relatively resistant to conventional therapies. Activated Ras oncogene mutations are found in up to 90% ...

    Authors: Niranjan Awasthi, Changhua Zhang, Stefan Hinz, Margaret A Schwarz and Roderich E Schwarz
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:12
    Content type: Research Published on:

  26. To investigate the role of HER-2/neu-mediated COX-2/P450arom signal in estrogen-dependent endometrial carcinoma.

    Authors: Shu Li, XiaoXin Ma, Li Ma, Cuicui Wang, YuanQi He and ZhiJuan Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:11
    Content type: Research Published on:

  27. Bladder transitional cell carcinoma greatly threatens human health all over the world. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows a strong apoptosis-inducing effect on a variety of c...

    Authors: Youguang Zhao, Ying Li, Liang Wang, Hang Yang, Qingtang Wang, Haiyan Qi, Shadan Li, Peng Zhou, Ping Liang, Qiwu Wang and Xiaowei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:10
    Content type: Research Published on:

  28. Although a previous meta-analysis reported no association between metabolic syndrome (MetS) and prostate cancer risk, a number of studies suggest that MetS may be associated with the aggressiveness and progres...

    Authors: Yu-zhu Xiang, Hui Xiong, Zi-lian Cui, Shao-bo Jiang, Qing-hua Xia, Yong Zhao, Guan-bin Li and Xun-bo Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:9
    Content type: Research Published on:

  29. MYST1 (also known as hMOF), a member of the MYST family of histone acetyltransferases (HATs) as an epigenetic mark of active genes, is mainly responsible for histone H4K16 acetylation in the cells. Recent stud...

    Authors: Yong Wang, Rui Zhang, Donglu Wu, Zhihua Lu, Wentao Sun, Yong Cai, Chunxi Wang and Jingji Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:8
    Content type: Research Published on:

  30. Malignant mesothelioma is an aggressive, treatment-resistant tumor arising from mesothelium of pleura, peritoneum and pericardium. Despite current combined regimen, its prognosis remains dismal, calling for mo...

    Authors: Yi Zhang, Jianxing He, Fang Zhang, Hui Li, Dongsheng Yue, Changli Wang, David M Jablons, Biao He and Natalie Lui
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:7
    Content type: Research Published on:

  31. Although surgery and anesthesia induce immunesuppression, remains largely unknown whether various anesthetic techniques have different immunosuppressive effects on cancer patients. Therefore, the aim of this s...

    Authors: Maria Sofra, Paola Cordiali Fei, Luana Fabrizi, Maria Elena Marcelli, Claudia Claroni, Michele Gallucci, Fabrizio Ensoli and Ester Forastiere
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:6
    Content type: Research Published on:

  32. An adenovirus that expresses both interleukin (IL)-12 and granulocyte-macrophage colony-stimulating-factor (GM-CSF) has been proven to be very effective in treating several tumors, but causes serious normal ti...

    Authors: Fang Wei, Huiping Wang, Jufeng Zhang, Xiafang Chen, Chuanyuan Li and Qian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:5
    Content type: Research Published on:

  33. The paper intends to help scientific authors to make the best choice of journals in which to publish, by describing and comparing journal features in the area of oncology. For this purpose, the authors identif...

    Authors: Elisabetta Poltronieri, Elena Bravo, Tiziana Camerini, Maurizio Ferri, Roberto Rizzo, Renata Solimini and Gaetana Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:4
    Content type: Research Published on:

  34. Hepatocellular carcinoma (HCC) is a typical malignancy in a background of chronic inflammation. Th17 cells (a major source of IL-17) constitute crucial components of infiltrating inflammatory/immune cells in H...

    Authors: Rui Liao, Jian Sun, Han Wu, Yong Yi, Jia-Xing Wang, Hong-Wei He, Xiao-Yan Cai, Jian Zhou, Yun-Feng Cheng, Jia Fan and Shuang-Jian Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:3
    Content type: Research Published on:

  35. Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controvers...

    Authors: Hiroaki Ito, Haruhiro Inoue, Noriko Odaka, Hitoshi Satodate, Michitaka Suzuki, Shumpei Mukai, Yusuke Takehara, Hiroyuki Kida and Shin-ei Kudo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:2
    Content type: Research Published on:

  37. Lobular breast carcinoma usually shows poor responsiveness to chemotherapies and often lacks targeted therapies. Since FGFR1 expression has been shown to play pivotal roles in primary breast cancer tumorigenes...

    Authors: Eleonora Brunello, Matteo Brunelli, Giuseppe Bogina, Anna Caliò, Erminia Manfrin, Alessia Nottegar, Marco Vergine, Annamaria Molino, Emilio Bria, Francesco Massari, Giampaolo Tortora, Sara Cingarlini, Serena Pedron, Marco Chilosi, Giuseppe Zamboni, Keith Miller…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:103
    Content type: Research Published on:

  38. Acquired radioresistance of cancer cells remains a fundamental barrier to attaining the maximal efficacy of radiotherapy for the treatment of breast cancer. Anti-apoptotic proteins, such as Bcl-2 and Bcl-xL, p...

    Authors: Ji-Yu Li, Yu-Yang Li, Wei Jin, Qing Yang, Zhi-Ming Shao and Xing-Song Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:102
    Content type: Research Published on:

  39. Alpha B-crystallin (αB-crystallin) has been suggested to play an important role in the development of solid tumors. However, the association between αB-crystallin expression and clinicopathological characteris...

    Authors: Yuan Mao, Da-Wei Zhang, Hong Lin, Lin Xiong, Ying Liu, Qing-Dong Li, Jun Ma, Qing Cao, Ren-Jie Chen, Jin Zhu and Zhen-Qing Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:101
    Content type: Research Published on:

  40. The genetic pathways of aggressive changes of bone tumors are still poorly understood. It is very important to analyze DNA copy number alterations (DCNAs), to identify the molecular events in the step of progr...

    Authors: Masahiko Kanamori, Akimi Sano, Taketoshi Yasuda, Takeshi Hori and Kayo Suzuki
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:100
    Content type: Research Published on:

  41. Ku80 is crucially implicated in DNA repair, apoptosis, and chemoresistance. In this study, we aimed to assess the expression of Ku80 in clinical lung adenocarcinoma specimens, and investigate its role in the r...

    Authors: Qingshan Ma, Ping Li, Minyu Xu, Jinzhi Yin, Zhenzhong Su, Wei Li and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:99
    Content type: Research Published on:

  42. Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early int...

    Authors: Xiao-Tong Wang, Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao and Yu-Bo Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:98
    Content type: Review Published on:

  43. Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis. MicroRNAs (miRNAs) are a class of small non-coding RNAs, approximately 21–25 nucleotides in length. Recently, some researc...

    Authors: Qiong Wang, Pengcun Li, Ailin Li, Wei Jiang, Hong Wang, Jinhuan Wang and Keliang Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:97
    Content type: Research Published on:

  44. Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs) to c...

    Authors: Prisco Piscitelli, Maddalena Barba, Massimo Crespi, Massimo Di Maio, Antonio Santoriello, Massiliamo D’Aiuto, Alfredo Fucito, Arturo Losco, Francesca Pentimalli, Pasquale Maranta, Giovanna Chitano, Alberto Argentiero, Cosimo Neglia, Alessandro Distante, Gian luca Di Tanna, Maria Luisa Brandi…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:96
    Content type: Research Published on:

  45. Epidemiological studies revealed significantly lower mortality rates in cancer patients receiving cardiac glycosides, which turned on interest in the anticancer properties of these drugs. However, cardiac glyc...

    Authors: Francesca Cuozzo, Marisa Raciti, Laura Bertelli, Rosanna Parente and Livia Di Renzo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:95
    Content type: Research Published on:

  46. DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance...

    Authors: Xiao-Lin Zhu, Zhang-Feng Wang, Wen-Bin Lei, Hui-Wen Zhuang, Wei-Jian Hou, Yi-Hui Wen and Wei-Ping Wen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:94
    Content type: Research Published on:

  47. Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma...

    Authors: Guo-Cai Li, Qing-Hai Ye, Qiong-Zhu Dong, Ning Ren, Hu-Liang Jia and Lun-Xiu Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:93
    Content type: Research Published on:

  48. Leukemia, a heterogeneous clonal disorder of hematopoietic progenitor cells, presents a world-wide health problem, especially in childhood. F1F0 ATPase, an inner mitochondrial enzyme, is expressed on the plasm...

    Authors: Zhao Wen-Li, Wang Jian, Tao Yan-Fang, Feng Xing, Li Yan-Hong, Zhu Xue-Ming, Zhang Min, Ni Jian and Pan Jian
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:92
    Content type: Research Published on:

  49. In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation in t...

    Authors: Michele Maio, Paolo Ascierto, Alessandro Testori, Ruggero Ridolfi, Emilio Bajetta, Paola Queirolo, Michele Guida, Antonella Romanini, Vanna Chiarion-Sileni, Jacopo Pigozzo, Anna Maria Di Giacomo, Mario Calandriello, Guido Didoni, Marck van Baardewijk, Cyril Konto and Carlo Lucioni
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:91
    Content type: Research Published on:

  50. Type IV collagen (ColIV) is the most important scaffold for the basement membrane (BM) proteins, and plays an important role in regulating and limiting tumour invasion and metastasis.

    Authors: Hai-Xia Fan, Hai-Xia Li, Dong Chen, Zhong-Xiuzi Gao and Jin-Hua Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:90
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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