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  1. Breast cancer is the most fatal malignant cancer among women, the conventional therapeutic modalities of it are limited. Morusin possesses cytotoxicity against some cancer cells in vitro. The purpose of this s...

    Authors: Haiyan Li, Qiaoping Wang, Lihua Dong, Chuanlan Liu, Zhen Sun, Ling Gao and Xiujie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:137
    Content type: Research Published on:

  2. Tumor-positive sentinel node(SLN) biopsy results in a risk of nonsentinel node metastases in case of micro and macro metastases ranging from 20 to 50 %, respectively. Therefore, most patients underwent unneces...

    Authors: F. Di Filippo, D. Giannarelli, C. Bouteille, L. Bernet, R. Cano, G. Cunnick and A. Sapino
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:136
    Content type: Research Published on:

  3. Linc00152 has been identified highly associated with the tumorigenesis and development of gastric cancer, however, the detailed mechanism of Linc00152 involved still remains unclear.

    Authors: Jianping Zhou, Xiaofei Zhi, Linjun Wang, Weizhi Wang, Zheng Li, Jie Tang, Jiwei Wang, Qun Zhang and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:135
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:30

  4. Enhanced signalling via the epidermal growth factor receptor (EGFR) is a hallmark of multiple human carcinomas. However, in recent years data have accumulated that EGFR might also be hyperactivated in human sa...

    Authors: Florian Sevelda, Lisa Mayr, Bernd Kubista, Daniela Lötsch, Sushilla van Schoonhoven, Reinhard Windhager, Christine Pirker, Michael Micksche and Walter Berger
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:134
    Content type: Research Published on:

  5. Hepatocellular carcinoma (HCC) is a common malignant tumor that severely threatens human health. The poor prognosis of HCC is mainly attributed to intrahepatic and extrahepatic metastases. HOXD9 proteins belon...

    Authors: Xiupeng Lv, Linlin Li, Li Lv, Xiaotong Qu, Shi Jin, Kejun Li, Xiaoqin Deng, Lei Cheng, Hui He and Lei Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:133
    Content type: Research Published on:

  6. Unresectable gastric cancer is associated with poor outcomes, with few treatment options available after failure of cytotoxic chemotherapy. Clinical trials of targeted therapies have generally shown no surviva...

    Authors: Hung Huynh, Richard Ong and Dieter Zopf
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:132
    Content type: Research Published on:

  7. Transcript dosage imbalance may influence the transcriptome. To gain insight into the role of altered gene expression in hereditary colorectal polyposis predisposition, in the present study we analyzed absolut...

    Authors: Gitana Maria Aceto, Fabiana Fantini, Sabrina De Iure, Marta Di Nicola, Giandomenico Palka, Rosa Valanzano, Patrizia Di Gregorio, Vittoria Stigliano, Maurizio Genuardi, Pasquale Battista, Alessandro Cama and Maria Cristina Curia
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:131
    Content type: Research Published on:

  8. Increasing evidence indicates that the dysregulation of miRNAs expression is involved in the tumorigenesis by acting as tumor suppressors or oncogenes. However, no study investigates the function and mechanism...

    Authors: Ying-Qing Li, Jian-Hua Lu, Xue-Ming Bao, Xi-Fu Wang, Jun-Hua Wu and Wei-Qiang Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:130
    Content type: Research Published on:

  9. Inflammation is a hallmark of cancer, yet the mechanisms that regulate immune cell infiltration into tumors remain poorly characterized. This study attempted to characterize the composition, distribution, and ...

    Authors: Li Li, Li Xu, Jing Yan, Zuo-Jun Zhen, Yong Ji, Chao-Qun Liu, Wan Yee Lau, Limin Zheng and Jing Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:129
    Content type: Research Published on:

  10. Although expression of MTA1 inversely correlates with the nuclear localization of ERα, the effect and molecular mechanism of ERα regulation of MTA1 remain unknown.

    Authors: Lei Deng, Hui Yang, Junwei Tang, Zhe Lin, Aihong Yin, Yun Gao, Xuehao Wang, Runqiu Jiang and Beicheng Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:128
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2024 43:172

  11. Glioma is the most common malignant primary brain tumor among adults, among which glioblastoma (GBM) exhibits the highest malignancy. Despite current standard chemoradiation, glioma is still invariably fatal. ...

    Authors: Zhi-Liang Wang, Chuan-Bao Zhang, Jin-Quan Cai, Qing-Bin Li, Zheng Wang and Tao Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:127
    Content type: Research Published on:

  12. Ribosomal protein S6 (rpS6), a component of the 40S ribosomal subunit, is involved in multiple cellular bioactivities. However, its clinicopathological significance in non-small cell lung cancer (NSCLC) is poo...

    Authors: Bojiang Chen, Zhi Tan, Jun Gao, Wei Wu, Lida Liu, Wei Jin, Yidan Cao, Shuang Zhao, Wen Zhang, Zhixin Qiu, Dan Liu, Xianming Mo and Weimin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:126
    Content type: Research Published on:

  13. Multi-drug resistance and predisposition to metastasize are major clinical problems in cancer treatment. Malignant primary brain tumor and pancreatic cancer are two well-known examples of malignant tumors resi...

    Authors: Barbara Guerra, Mette Fischer, Susanne Schaefer and Olaf-Georg Issinger
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:125
    Content type: Research Published on:

  14. While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased n...

    Authors: Ning Wang, Kimberley J. Reeves, Hannah K. Brown, Anne C M Fowles, Freyja E. Docherty, Penelope D. Ottewell, Peter I. Croucher, Ingunn Holen and Colby L. Eaton
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:124
    Content type: Research Published on:

  15. Uterine and ovarian carcinosarcomas (CS) are rare but highly aggressive gynecologic tumors which carry an extremely poor prognosis. We evaluated the expression levels of EpCAM and the in vitro activity of solitom...

    Authors: Francesca Ferrari, Stefania Bellone, Jonathan Black, Carlton L. Schwab, Salvatore Lopez, Emiliano Cocco, Elena Bonazzoli, Federica Predolini, Gulden Menderes, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz and Alessandro D. Santin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:123
    Content type: Research Published on:

  16. Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family involved in multiple malignancies. CMTM4 is a member of this family and is locat...

    Authors: Ting Li, Yingying Cheng, Pingzhang Wang, Wenyan Wang, Fengzhan Hu, Xiaoning Mo, Hongxia Lv, Tao Xu and Wenling Han
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:122
    Content type: Research Published on:

  17. Microspherule protein 1 (MCRS1) is a candidate oncogene and participates in various cellular processes, including growth, migration, senescence and transformation. MCRS1 is overexpressed in non-small cell lung...

    Authors: Minxia Liu, Kecheng Zhou, Yunchao Huang and Yi Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:121
    Content type: Research Published on:

  18. In women with macromastia, a type IV skin sparing mastectomy is often required to achieve an aesthetically pleasing reconstruction. The introduction of “skin-reducing mastectomy”, which inserts a permanent pro...

    Authors: Roy De Vita, Marcello Pozzi, Giovanni Zoccali, Maurizio Costantini, Pierpaolo Gullo, Ernesto Maria Buccheri and Antonio Varanese
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:120
    Content type: Research Published on:

  20. Tivantinib has been described as a highly selective inhibitor of MET and is currently in a phase III clinical trial for the treatment of hepatocellular carcinoma (HCC). However, the mechanism of tivantinib ant...

    Authors: Qingfeng Xiang, Zuojun Zhen, David YB Deng, Jingnan Wang, Yingjun Chen, Jieyuan Li, Yingfei Zhang, Fengjie Wang, Ningning Chen, Huanwei Chen and Yajin Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:118
    Content type: Research Published on:

  21. Neuron navigator 2 (NAV2) encodes a member of the neuron navigator gene family, which plays a role in tumorigenesis and cell migration. However, the prognostic value of NAV2 expression in colorectal cancer (CR...

    Authors: Fengbo Tan, Hong Zhu, Yiming Tao, Nanhui Yu, Qian Pei, Heli Liu, Yuan Zhou, Haifan Xu, Xiangping Song, Yuqiang Li, Zhongyi Zhou, Xiao He, Xingwen Zhang and Haiping Pei
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:117
    Content type: Research Published on:

  22. Accumulating evidence suggests the pro-inflammatory cytokine interleukin-6 (IL-6) in tumor microenvironment may promote the development of hepatocellular carcinoma (HCC). However, the underlying mechanism rema...

    Authors: Jun Wu, Jun Zhang, Bin Shen, Kai Yin, Jianwei Xu, Wencan Gao and Lihong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:116
    Content type: Research Published on:

  23. Osteosarcoma (OS) is a high-grade bone sarcoma with early metastasis potential, and the clinical chemotherapy drugs that are currently used for its treatment have some limitations. Recently, several studies ha...

    Authors: Yunlong Ma, Bin Zhu, Xiaoguang Liu, Huilei Yu, Lei Yong, Xiao Liu, Jia Shao and Zhongjun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:115
    Content type: Research Published on:

  24. Peptide based vaccines may suffer from limited stability and inefficient delivery to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). In order to overcome such limitations, several ...

    Authors: A. Petrizzo, C. Conte, M. Tagliamonte, M. Napolitano, K. Bifulco, V. Carriero, A. De Stradis, M. L. Tornesello, F. M. Buonaguro, F. Quaglia and L. Buonaguro
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:114
    Content type: Research Published on:

  25. The spread of mammographic screening programs has allowed an increasing amount of early breast cancer diagnosis. A modern approach to non-palpable breast lesions requires an accurate intraoperative localizatio...

    Authors: Giulia Anna Follacchio, Francesco Monteleone, Paolo Anibaldi, Giuseppe De Vincentis, Silvia Iacobelli, Raffaele Merola, Valerio D’Orazi, Massimo Monti and Vittorio Pasta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:113
    Content type: Research Published on:

  26. Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma Kinase (ALK) and MET gene has been implicated in the m...

    Authors: Francesca Megiorni, Heather P. McDowell, Simona Camero, Olga Mannarino, Simona Ceccarelli, Milena Paiano, Paul D. Losty, Barry Pizer, Rajeev Shukla, Antonio Pizzuti, Anna Clerico and Carlo Dominici
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:112
    Content type: Research Published on:

  28. Dysregulated endocytosis of membrane proteins contributes significantly to several hallmarks of cancer. Basigin can enhance cancer progression, but its precise mechanism remains unclear. CD98 promotes cell spr...

    Authors: Bo Wu, Yi Wang, Xiang-Min Yang, Bao-Qing Xu, Fei Feng, Bin Wang, Qiang Liang, Yu Li, Yang Zhou, Jian-Li Jiang and Zhi-Nan Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:110
    Content type: Research Published on:

  30. Cancer-related immune antigens in the tumor microenvironment could represent an obstacle to agents targeting EGFR “cetuximab” or VEGF “bevacizumab” in metastatic colorectal cancer (mCRC) patients.

    Authors: Guido Giordano, Antonio Febbraro, Eugenio Tomaselli, Maria Lucia Sarnicola, Pietro Parcesepe, Domenico Parente, Nicola Forte, Alessio Fabozzi, Andrea Remo, Andrea Bonetti, Erminia Manfrin, Somayehsadat Ghasemi, Michele Ceccarelli, Luigi Cerulo, Flavia Bazzoni and Massimo Pancione
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:108
    Content type: Research Published on:

  32. Dual loading drug delivery system with tumor targeting efficacy and sequential release function provides a promising platform for anticancer drug delivery. Herein, we establ...

    Authors: Li Fan, Qian Yang, Jiali Tan, Youbei Qiao, Qiaofeng Wang, Jingya He, Hong Wu and Yongsheng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:106
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:252

  33. Arrest of metastasising lung cancer cells to the brain microvasculature maybe mediated by interactions between ligands on circulating tumour cells and endothelial E-selectin adhesion molecules; a process likel...

    Authors: Srijana Rai, Zaynab Nejadhamzeeigilani, Nicholas J. Gutowski and Jacqueline L. Whatmore
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:105
    Content type: Research Published on:

  34. Neuroblastoma (NB) is one of the most common childhood malignancies. Currently, high risk NB carries a poor outcome and significant treatment related toxicities and, thus has been a focus for new therapeutics ...

    Authors: Anjali Singh, Yibing Ruan, Tanya Tippett and Aru Narendran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:104
    Content type: Research Published on:

  35. Herein, we demonstrated the use of a newly generated anti FAT1 antibody (clone mAB198.3) for intracellular delivery of anionic gold NPs, to form active targeting Au nanoparticles with high payload characterist...

    Authors: Li Fan, Susanna Campagnoli, Hong Wu, Alberto Grandi, Matteo Parri, Elisa De Camilli, Guido Grandi, Giuseppe Viale, Piero Pileri, Renata Grifantini, Chaojun Song and Boquan Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:103
    Content type: Research Published on:

  36. Dysregulated long non-coding RNAs (lncRNAs) have been found to have oncogenic and/or tumor suppressive roles in the development and progression of cancer, implying their potentials as novel independent biomark...

    Authors: Meng Zhou, Hengqiang Zhao, Zhenzhen Wang, Liang Cheng, Lei Yang, Hongbo Shi, Haixiu Yang and Jie Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:102
    Content type: Research Published on:

  37. Several studies have found that DDR2 is up-regulated in many tumor types and facilitates tumor progression. However, the role of DDR2 in hepatocellular carcinoma (HCC) progression and its downstream signaling ...

    Authors: Binhui Xie, Weihao Lin, Junming Ye, Xiaonong Wang, Bing Zhang, Shiqiu Xiong, Heping Li and Guosheng Tan
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:101
    Content type: Research Published on:

  38. Aberrant expression of long noncoding RNAs (lncRNAs) has frequently been reported in cancer studies, including those of colorectal cancer (CRC). Increasing evidence suggests that lncRNAs are significantly corr...

    Authors: Jie Ding, Binbin Lu, Jianping Wang, Juan Wang, Yongguo Shi, Yifan Lian, Ya Zhu, Jirong Wang, Yingrui Fan, Zhaoxia Wang, Wei De and Keming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:100
    Content type: Research Published on:

  39. Ursolic acid (UA), a pentacyclic triterpenoid, is known to have anti-tumor activity in various cancers including human non small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the actio...

    Authors: Jingjing Wu, Shunyu Zhao, Qing Tang, Fang Zheng, YuQin Chen, LiJun Yang, Xiaobing Yang, Liuning Li, WanYin Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:99
    Content type: Research Published on:

  40. Hematopoietic Stem Cell Transplantation (HSCT) is known to induce the inhibitory immune receptor NKG2A on NK cells of donor origin. This occurs in allogeneic recipients, in both the haploidentical and HLA-matc...

    Authors: Alessandra Picardi, Andrea Mengarelli, Mirella Marino, Enzo Gallo, Maria Benevolo, Edoardo Pescarmona, Roberta Cocco, Rocco Fraioli, Elisa Tremante, Maria Concetta Petti, Paolo De Fabritiis and Patrizio Giacomini
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:98
    Content type: Research Published on:

  41. Interleukin-24(IL-24), also referred to as melanoma differentiation-associated gene-7(mda-7), is a unique member of the IL-10 gene family, which displays nearly ubiquitous cancer-specific toxicity. The most no...

    Authors: Jichen Li, Dezhao Yang, Wei Wang, Songlin Piao, Jianyu Zhou, Wuliji Saiyin, Changyu Zheng, Hongchen Sun and Yu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:97
    Content type: Research Published on:

  42. It is well-known that the treatment and monitoring methods are limited for advanced stage of endometrial carcinoma. Biological molecules with expression changes during tumor progression become potential therap...

    Authors: Lu Deng, Yiping Gao, Xiao Li, Mingbo Cai, Huimin Wang, Huiyu Zhuang, Mingzi Tan, Shuice Liu, Yingying Hao and Bei Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:96
    Content type: Research Published on:

  43. The epidermal growth factor receptor (EGFR) signaling pathway is important in regulating biological behaviors in many malignancies. We explored whether expression and activation of EGFR and several components ...

    Authors: Zhengfei Zhu, Weiwei Yu, Xiaolong Fu, Menghong Sun, Qiao Wei, Dali Li, Haiquan Chen, Jiaqing Xiang, Hecheng Li, Yawei Zhang, Weixin Zhao and Kuaile Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:95
    Content type: Research Published on:

  44. Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficient anti-C...

    Authors: Cai Xun, Min-Bin Chen, Li Qi, Zhang Tie-Ning, Xue Peng, Li Ning, Chen Zhi-Xiao and Wang Li-Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:94
    Content type: Research Published on:

  45. The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancer...

    Authors: Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch and Ziad Omran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:93
    Content type: Review Published on:

  46. Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer (aNSCLC) has facilitated personalised therapies that target specific molecular aberrations associated with the disease. B...

    Authors: James Sherwood, Simon Dearden, Marianne Ratcliffe and Jill Walker
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:92
    Content type: Review Published on:

  47. Elucidation of the downstream targets regulated by the metastasis-suppressive miRNAs can shed light on the metastatic processes in prostate cancer (PCa). We conducted microarray analyses and found that miR-195...

    Authors: Jia Guo, Min Wang and Xiuheng Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:91
    Content type: Research Published on:

  48. Blood platelet numbers are correlated with growth and aggressiveness of several tumor types, including hepatocellular carcinoma (HCC). We previously found that platelet lysates (hPLs) both stimulated HCC cell ...

    Authors: Catia Lippolis, Maria Grazia Refolo, Rosalba D’Alessandro, Nicola Carella, Caterina Messa, Aldo Cavallini and Brian Irving Carr
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:90
    Content type: Research Published on:

  49. When a patient concomitantly uses two or more drugs, a drug-drug interaction (DDI) can possibly occur, potentially leading to an increased or decreased clinical effect of a given treatment. Cancer patients are...

    Authors: Silvia Ussai, Riccardo Petelin, Antonio Giordano, Mario Malinconico, Donatella Cirillo and Francesca Pentimalli
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:89
    Content type: Research Published on:

  50. Discoidin domain receptors 1 (DDR1), a subtype of DDRs, has been reported as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.

    Authors: Yanmiao Huo, Minwei Yang, Wei Liu, Jianyu Yang, Xueliang Fu, Dejun Liu, Jiao Li, Junfeng Zhang, Rong Hua and Yongwei Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:88
    Content type: Research Published on:

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  • Citation Impact 2023
    Journal Impact Factor: 11.4
    5-year Journal Impact Factor: 11.4
    Source Normalized Impact per Paper (SNIP): 1.770
    SCImago Journal Rank (SJR): 2.806

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    Submission to first editorial decision (median days): 5
    Submission to acceptance (median days): 100

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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