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  1. Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apo...

    Authors: Monika Kosacka, Paweł Piesiak, Aneta Kowal, Marcin Gołecki and Renata Jankowska
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:101
    Content type: Research Published on:

  2. A broad population-based assay to detect individuals with Lynch Syndrome (LS) before they develop cancer would save lives and healthcare dollars via cancer prevention. LS is caused by a germline mutation in a ...

    Authors: Samar Hassen, Bruce M Boman, Nawab Ali, Marcie Parker, Chandra Somerman, Zohra J Ali-Khan Catts, Akhtar A Ali and Jeremy Z Fields
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:100
    Content type: Research Published on:

  4. DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer. DNMT methyltransferase 1 (DNMT1), which plays a significa...

    Authors: Yi Zhang, Fu-qiang Chen, Ye-hong Sun, Shu-yan Zhou, Ti-yuan Li and Rui Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:98
    Content type: Research Published on:

  5. Brain-derived neurotrophic factor (BDNF) and its receptor Tropomysin-related kinase B (TrkB) are commonly up-regulated in a variety of human tumors. However, the roles of BDNF/TrkB in hepatocellular carcinoma ...

    Authors: Dawei Guo, Xuezhong Hou, Hongbin Zhang, Wenyu Sun, Lei Zhu, Jian Liang and Xiaofeng Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:97
    Content type: Research Published on:

  6. Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or del...

    Authors: Rachel Purcell, Margaret Childs, Rudolf Maibach, Carina Miles, Clinton Turner, Arthur Zimmermann and Michael Sullivan
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:96
    Content type: Research Published on:

  7. Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for poly...

    Authors: Kuniyasu Soda
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:95
    Content type: Review Published on:

  8. A substantial body of literature has accumulated during the past 20 years showing the plasma concentrations of 5-fluorouracil (5-FU) to correlate with clinical response and/or toxicity in colorectal cancer, an...

    Authors: Akiko Kuwahara, Motohiro Yamamori, Kaori Kadoyama, Kohshi Nishiguchi, Tsutomu Nakamura, Ikuya Miki, Takao Tamura, Tatsuya Okuno, Hideaki Omatsu and Toshiyuki Sakaeda
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:94
    Content type: Research Published on:

  9. Previously, adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) database were reviewed to confirm platinum agent-associated hypersensitivity reactions. The present study was per...

    Authors: Kaori Kadoyama, Akiko Kuwahara, Motohiro Yamamori, JB Brown, Toshiyuki Sakaeda and Yasushi Okuno
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:93
    Content type: Research Published on:

  10. Cancer gene therapy by retroviral vectors is mainly limited by the level of transduction. Retroviral gene transfer requires target cell division. Cell synchronization, obtained by drugs inducing a reversible i...

    Authors: Laetitia Finzi, Aurore Kraemer, Claude Capron, Severine Noullet, Diane Goere, Christophe Penna, Bernard Nordlinger, Josette Legagneux, Jean-Fançois Emile and Robert Malafosse
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:92
    Content type: Research Published on:

  11. Breast and ovarian cancers are among the 10 leading cancer types in females with mortalities of 15% and 6%, respectively. Despite tremendous efforts to conquer malignant diseases, the war on cancer declared by Ri...

    Authors: Niels Eckstein
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:91
    Content type: Review Published on:

  12. Previous data demonstrate that JMJD2A is a cancer-associated gene and may be involved in human breast cancer by demethylation of H3K9me3. The aim of this study was to investigate depressive effects on JMJD2A b...

    Authors: Bei-Xu Li, Ming-Chang Zhang, Cheng-Liang Luo, Peng Yang, Hui Li, Hong-Mei Xu, Hong-Fei Xu, Yi-Wen Shen, Ai-Min Xue and Zi-Qin Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:90
    Content type: Research Published on:

  13. Clear cell renal cell carcinoma, a solid growing tumor, is the most common tumor in human kidney. Evaluating the usefulness of β-galactoside binding galectin-3 as a diagnostic marker for this type of cancer co...

    Authors: Tamara Straube, Alexandra F Elli, Christoph Greb, Axel Hegele, Hans-Peter Elsässer, Delphine Delacour and Ralf Jacob
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:89
    Content type: Research Published on:

  14. Protein kinase C epsilon (PKCε), an oncogene overexpressed in several human cancers, is involved in cell proliferation, migration, invasion, and survival. However, its roles in clear cell renal cell carcinoma ...

    Authors: Bin Huang, Kaiyuan Cao, Xiubo Li, Shengjie Guo, Xiaopeng Mao, Zhu Wang, Jintao Zhuang, Jincheng Pan, Chengqiang Mo, Junxing Chen and Shaopeng Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:88
    Content type: Research Published on:

  15. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the unde...

    Authors: Rebecca SY Wong
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:87
    Content type: Review Published on:

  16. matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis. Aquaporin-3 (AQP3) also plays a critic...

    Authors: Hao Xu, Yong Xu, Wenjie Zhang, Lizong Shen, Li Yang and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:86
    Content type: Research Published on:

  17. Lymph node involvement and tumor-induced lymphangiogenesis appear as the earliest features of esophageal squamous cell carcinoma (ESCC), although the molecular regulatory mechanisms involved have remained uncl...

    Authors: Chunhua Su, Zhenguang Chen, Honghe Luo, Yihua Su, Wangkai Liu, Lie Cai, Tao Wang, Yiyan Lei and Beilong Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:85
    Content type: Research Published on:

  18. Toll-like receptor 9 (TLR9) is a cellular DNA-receptor whose activation with cognate ligands triggers an immune reaction, with increased production of inflammatory cytokines. The aim of this study was to exami...

    Authors: Hanna Ronkainen, Pasi Hirvikoski, Saila Kauppila, Katri S Vuopala, Timo K Paavonen, Katri S Selander and Markku H Vaarala
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:84
    Content type: Research Published on:

  19. Metastasis-associated in colon cancer 1 (MACC1) is demonstrated to be up-regulated in several types of cancer, and can serve as biomarker for cancer invasion and metastasis. To investigate the relations betwee...

    Authors: Ruitao Zhang, Huirong Shi, Zhimin Chen, Qinghua Wu, Fang Ren and Haoliang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:83
    Content type: Research Published on:

  20. The inflammatory enzyme indoleamine 2, 3-dioxygenase (IDO) participates in immune tolerance and promotes immune escape of IDO+ tumors. A recent hypothesis suggested that IDO may contribute to the differentiati...

    Authors: Jingyan Sun, Jinpu Yu, Hui Li, Lili Yang, Feng Wei, Wenwen Yu, Juntian Liu and Xiubao Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:82
    Content type: Research Published on:

  21. Hyperglycemia is among the major side effects of dexamethasone (DEX). Glucose or glucocorticoid (GC) regulates the expression of thioredoxin-interacting protein (TXNIP) that controls the production of reactive...

    Authors: Ellen Friday, Johnathan Ledet and Francesco Turturro
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:81
    Content type: Research Published on:

  22. Glioblastoma multiforme (GBM) carries a dismal prognosis primarily due to its aggressive proliferation in the brain regulated by complex molecular mechanisms. One promising molecular target in GBM is over-expr...

    Authors: Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang and Jinhuan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:80
    Content type: Research Published on:

  23. Ubiquitin Carboxyl-Terminal Hydrolase-L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed throughout the central and peripheral nervous system and in cells of the diffuse neuroendocrine system. A...

    Authors: Katy S Orr, Zhanzhong Shi, W Mark Brown, Kathleen A O'Hagan, Terence R Lappin, Perry Maxwell and Melanie J Percy
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:79
    Content type: Research Published on:

  24. The immune response has been proposed to be an important factor in determining patient outcome in colorectal cancer (CRC). Previous studies have concentrated on characterizing T cell populations in the primary...

    Authors: Roslyn A Kemp, Michael A Black, John McCall, Han-Seung Yoon, Vicky Phillips, Ahmad Anjomshoaa and Anthony E Reeve
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:78
    Content type: Research Published on:

  25. Hypoxia-inducible factor-1 alpha (HIF-1α) maybe an important regulatory factor for angiogenesis of small cell lung cancer (SCLC). Our study aimed to investigate the effect of HIF-1α on angiogenic potential of ...

    Authors: Jun Wan, Huiping Chai, Zaicheng Yu, Wei Ge, Ningning Kang, Wanli Xia and Yun Che
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:77
    Content type: Research Published on:

  26. Malignant gliomas are the most common in central nervous system cancer. Genome-wide association study identifies that CDKN2A was a susceptibility loci for glioma. The CDKN2A/cyclin-dependent kinase 4, 6/Retino...

    Authors: Weidong Liu, Guohua Lv, Yawei Li, Lei li and Bing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:76
    Content type: Research Published on:

  27. Alcohol consumption is an established risk factor for breast cancer metastasis. Yet, the mechanism by which alcohol promotes breast cancer metastases is unknown. The ability of cancer cells to invade through t...

    Authors: Amy W Wong, Qiwei X Paulson, Jina Hong, Renee E Stubbins, Karen Poh, Emily Schrader and Nomeli P Nunez
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:75
    Content type: Research Published on:

  28. Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of...

    Authors: Masashi Yanae, Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, Motohiro Imano, Yuzuru Yamazoe and Shozo Nishida
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:74
    Content type: Research Published on:

  30. Zoledronic acid (ZOL) is widely used for preventing bone loss in early breast cancer patients. However, the adverse effects caused by ZOL itself should not be neglected. Musculoskeletal disorders were common a...

    Authors: Wen-Bin Zhou, Peng-Ling Zhang, Xiao-An Liu, Tao Yang and Wei He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:72
    Content type: Research Published on:

  31. To investigate the effects of ulinastatin and docetaxel on invasion of breast cancer cells and expression of uPA, uPAR and ERK, breast cancer MDA-MB-231 and MCF-7 cells.

    Authors: Jie Luo, Xin Sun, Feng Gao, Xiaoliang Zhao, Biao Zhong, Hong Wang and Zhijun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:71
    Content type: Research Published on:

  33. MRI plays a key role in the preclinical development of new drugs, diagnostics and their delivery systems. However, very high installation and running costs of existing superconducting MRI machines limit the sp...

    Authors: Henrike Caysa, Hendrik Metz, Karsten Mäder and Thomas Mueller
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:69
    Content type: Research Published on:

  34. The human multi-drug resistance gene (MDR1), which encodes the major trans-membrane transporter P-glycoprotein (P-gp), was found to be associated with susceptibility to cancer and response to chemotherapy. The C3...

    Authors: Nizar M Mhaidat, Osama Y Alshogran, Omar F Khabour, Karem H Alzoubi, Ismail I Matalka, William J Haddadin, Ibraheem O Mahasneh and Ahmad N Aldaher
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:68
    Content type: Research Published on:

  35. Our study aims to evaluate the anti-growth effects of recombinant immunotoxin (IT) anti-c-Met/PE38KDEL on gastric cancer cells, and its mechnisms.

    Authors: Xu Wei, Zhu Xiao Juan, Feng Xiao Min, Cai Nan, Zhang Xiu Hua, Feng Zheng Qing and Liu Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:67
    Content type: Research Published on:

  36. Oxymatrine, an isolated extract from traditional Chinese herb Sophora Flavescens Ait, has been traditionally used for therapy of anti-hepatitis B virus, anti-inflammation and anti-anaphylaxis. The present study w...

    Authors: Qi Ling, Xiao Xu, Xuyong Wei, Weibing Wang, Bin Zhou, Bei Wang and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:66
    Content type: Research Published on:

  37. Overall therapeutic outcomes of advanced non-small-cell lung cancer (NSCLC) are poor. The dendritic cell (DC) immunotherapy has been developed as a new strategy for the treatment of lung cancer. The purpose of...

    Authors: Maurício W Perroud Jr, Helen N Honma, Aristóteles S Barbeiro, Simone CO Gilli, Maria T Almeida, José Vassallo, Sara TO Saad and Lair Zambon
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:65
    Content type: Research Published on:

  38. Approximately 20% of children and adolescents in Europe are overweight. Survivors of pediatric acute lymphoblastic leukemia (ALL) are at increased risk of overweight and obesity. The purpose of this study was ...

    Authors: Szymon Skoczen, Przemyslaw J Tomasik, Miroslaw Bik-Multanowski, Marcin Surmiak, Walentyna Balwierz, Jacek J Pietrzyk, Krystyna Sztefko, Jolanta Gozdzik, Danuta Galicka-Latała and Wojciech Strojny
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:64
    Content type: Research Published on:

  39. The human coagulation trigger tissue factor (TF) is overexpressed in several types of cancer and involved in tumor growth, vascularization, and metastasis. To explore the role of TF in biological processes of ...

    Authors: Chengcheng Xu, Qi Gui, Wenshu Chen, Leiming Wu, Wei Sun, Ni Zhang, Qinzi Xu, Jianing Wang and Xiangning Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:63
    Content type: Research Published on:

  40. Monocyte recruited into the tumor and maturation to tumor-associated macrophage (TAM). Interleukin-10(IL-10) is a potent immunosuppressive cytokine, which can be secreted from both primary tumor and stromal cells...

    Authors: Rui Wang, Meng Lu, Haiquan Chen, Sufeng Chen, Xiaoyang Luo, Ying Qin and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:62
    Content type: Research Published on:

  41. Hypoxia inducible factor-1 (HIF-1) has been considered as a critical transcriptional factor in response to hypoxia. It can increase P-glycoprotein (P-Gp) thus generating the resistant effect to chemotherapy. A...

    Authors: Wen-sen Jin, Zhao-lu Kong, Zhi-fen Shen, Yi-zun Jin, Wu-kui Zhang and Guang-fu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:61
    Content type: Research Published on:

  42. MTA1(metastasis associated-1) is a tumor metastasis associated candidate gene and overexpression in many human tumors, including breast cancer. In this study, we investigated depressive effect on MTA1 by MTA1-...

    Authors: Qingming Jiang, Hui Zhang and Ping Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:60
    Content type: Research Published on:

  43. Circulating levels of novel long-chain hydroxy fatty acids (called GTAs) were recently discovered in the serum of healthy subjects which were shown to be reduced in subjects with colorectal cancer (CRC), indep...

    Authors: Shawn A Ritchie, Dushmanthi Jayasinghe, Gerald F Davies, Pearson Ahiahonu, Hong Ma and Dayan B Goodenowe
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:59
    Content type: Research Published on:

  45. Epidermal Growth Factor Receptor (EGFR) mutations, especially in-frame deletions in exon 19 (ΔLRE) and a point mutation in exon 21 (L858R) predict gefitinib sensitivity in patients with non-small cell lung can...

    Authors: Sandrine Dufort, Marie-Jeanne Richard, Sylvie Lantuejoul and Florence de Fraipont
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:57
    Content type: Research Published on:

  46. Signal transducer and activator of transcription 3 (STAT3) is a key signaling molecule and a central cytoplasmic transcription factor, implicated in the regulation of growth. Its aberrant activation has been d...

    Authors: Diana David, Lakshmy M Rajappan, Krishna Balachandran, Jissa V Thulaseedharan, Asha S Nair and Radhakrishna M Pillai
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:56
    Content type: Research Published on:

  48. Although the addition of bevacizumab significantly improves the efficacy of chemotherapy for advanced breast cancer, regulatory concerns still exist with regard to the magnitude of the benefits and the overall...

    Authors: Federica Cuppone, Emilio Bria, Vanja Vaccaro, Fabio Puglisi, Alessandra Fabi, Isabella Sperduti, Paolo Carlini, Michele Milella, Cecilia Nisticò, Michelangelo Russillo, Paola Papaldo, Gianluigi Ferretti, Matti Aapro, Diana Giannarelli and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:54
    Content type: Research Published on:

  50. An advantage of the Intensity Modulated Radiotherapy (IMRT) technique is the feasibility to deliver different therapeutic dose levels to PTVs in a single treatment session using the Simultaneous Integrated Boo...

    Authors: Vicente Bruzzaniti, Armando Abate, Massimo Pedrini, Marcello Benassi and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:52
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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