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  1. The majority of women with epithelial ovarian cancer (OvCa) are diagnosed with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized non-infectious pandemic that increases OvC...

    Authors: Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Jeff Johnson, Wanrui Wang, Elizabeth I. Harper, Connor Ott, Caitlin O’Brien, Leigh Campbell, Brian Crowley, Stephen Grisoli, Nicholas M. Stavrou, Anna Juncker-Jensen and M. Sharon Stack
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:165
  2. Autologous tumor cell-based vaccines (ATVs) aim to prevent and treat tumor metastasis by activating patient-specific tumor antigens to induce immune memory. However, their clinical efficacy is limited. Mannan-...

    Authors: Juan Ye, Herui Wang, Rogelio Medina, Samik Chakraborty, Mitchell Sun, Alex Valenzuela, Xueyu Sang, Yaping Zhang, Ondrej Uher, Jan Zenka, Karel Pacak and Zhengping Zhuang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:163
  3. A growing body of research has revealed the connection of metabolism reprogramming and tumor progression, yet how metabolism reprogramming affects inter-patient heterogeneity and prognosis in head and neck squ...

    Authors: Jiezhong Guan, Xi Xu, Guo Qiu, Chong He, Xiaoyue Lu, Kang Wang, Xinyu Liu, Yuanyuan Li, Zihang Ling, Xuan Tang, Yujie Liang, Xiaoan Tao, Bin Cheng and Bo Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:162
  4. After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression. However, systematic study about the relationshi...

    Authors: Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu and Xiuping Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:161
  5. Endothelial-mesenchymal transition (EndoMT) is an emerging adaptive process that modulates lymphatic endothelial function to drive aberrant lymphatic vascularization in the tumour microenvironment (TME); howev...

    Authors: Wen-Fei Wei, Hui-Ling Zhou, Pei-Yu Chen, Xiao-Lan Huang, Long Huang, Luo-Jiao Liang, Chu-Hong Guo, Chen-Fei Zhou, Lan Yu, Liang-Sheng Fan and Wei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:160
  6. The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation...

    Authors: Yawei Xu, Lei Li, Wuping Yang, Kenan Zhang, Zedan Zhang, Chaojian Yu, Jianhui Qiu, Lin Cai, Yanqing Gong, Zheng Zhang, Jingcheng Zhou and Kan Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:159
  7. Authors: Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li and Shiyang Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:158

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:138

  8. Pancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis. Metabolic remodelling and epigenetic reprogramming are two important hallm...

    Authors: Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:155
  9. Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery and multidrug chemotherapy are the standard of treatment achieving 60–70% of event-free survival for localized diseas...

    Authors: Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P. Colombo and Claudia Chiodoni
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:154
  10. Authors: Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:153

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:125

  11. Immune checkpoint blockade (ICB) treatment of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) infection may activate viral-specific T cells to attack HBV infected hepatocytes and thus indu...

    Authors: Lulu Liu, Junwei Liu, Pan Li, Jijun Luo, Rui Qin, Qiao Peng, Bin Li, Xuyong Wei, Tian Wang, Hongyu Shi, Ming-Da Wang, Chao Li, Weijia Fang, Wei Chen, Xiao Xu, Tian Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:152
  12. Glycolysis is the key hallmark of cancer and maintains malignant tumor initiation and progression. The role of N6-methyladenosine (m6A) modification in glycolysis is largely unknown. This study explored the bi...

    Authors: Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang and Hao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:151

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2024 43:26

  13. The incidence of colorectal cancer and cancer death rate are increasing every year, and the affected population is becoming younger. Traditional Chinese medicine therapy has a unique effect in prolonging survi...

    Authors: Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye and Shenglan Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:150
  14. Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are ...

    Authors: Jing Yuan, Li Xu, Hai-Juan Bao, Jie-lin Wang, Yang Zhao and Shuo Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:149
  15. AXL is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases family (RTKs), and its abnormal expression has been linked to clinicopathological features and poor prognosis of cancer patients. Th...

    Authors: Yaoxiang Tang, Hongjing Zang, Qiuyuan Wen and Songqing Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:148
  16. The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that endows epithelial cells with mesenchymal properties, including motility and invasion capacity; therefore, its aberrant rea...

    Authors: Laura Amicone, Alessandra Marchetti and Carla Cicchini
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:147
  17. Invasive adenocarcinoma (IAC), which is typically preceded by minimally invasive adenocarcinoma (MIA), is the dominant pathological subtype of early-stage lung adenocarcinoma (LUAD). Identifying the molecular ...

    Authors: Yanan Cui, Jun Li, Pengpeng Zhang, Dandan Yin, Ziyu Wang, Jiali Dai, Wei Wang, Erbao Zhang and Renhua Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:146
  18. Metabolic reprogramming is a well-known marker of cancer, and it represents an early event during hepatocellular carcinoma (HCC) development. The recent approval of several molecular targeted agents has revolu...

    Authors: Christian Bergamini, Ilaria Leoni, Nicola Rizzardi, Mattia Melli, Giuseppe Galvani, Camelia Alexandra Coada, Catia Giovannini, Elisa Monti, Irene Liparulo, Francesca Valenti, Manuela Ferracin, Matteo Ravaioli, Matteo Cescon, Francesco Vasuri, Fabio Piscaglia, Massimo Negrini…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:145
  19. Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to ther...

    Authors: E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schröder, S. de Jong, A. L. Harris and M. Jalving
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:143

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:220

  20. Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.

    Authors: Weikai Wang, Kaizhong Lu, Xin Jiang, Qi Wei, Liyuan Zhu, Xian Wang, Hongchuan Jin and Lifeng Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:142
  21. The transmembrane receptor Kremen2 has been reported to participate in the tumorigenesis and metastasis of gastric cancer. However, the role of Kremen2 in non-small cell lung cancer (NSCLC) and the underlying ...

    Authors: Yuxiao Sun, Yu Gao, Mingxin Dong, Jiuzhen Li, Xin Li, Ningning He, Huijuan Song, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Yan Wang, Liqing Du, Yang Liu, Qin Wang, Hezheng Zhai…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:140
  22. Breast cancer (BC) negatively impacts the health of women worldwide. Circular RNAs (circRNAs) are a group of endogenous RNAs considered essential regulatory factor in BC tumorigenesis and progression. However,...

    Authors: Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li and Shiyang Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:138

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:158

  23. Immune checkpoint blockade (ICB) elicits a strong and durable therapeutic response, but its application is limited by disparate responses and its associated immune-related adverse events (irAEs). Previously, i...

    Authors: Radhika Mishra, Ariunbuyan Sukhbaatar, Shiro Mori and Tetsuya Kodama
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:132
  24. Disulfidptosis, a new form of cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to the intracellular accumulation of disulfides. This discovery...

    Authors: Tingjin Zheng, Qingbo Liu, Feiyue Xing, Chong Zeng and Weidong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:137
  25. Increasing evidence indicates that the tumor microenvironment (TME) is a crucial determinant of cancer progression. However, the clinical and pathobiological significance of stromal signatures in the TME, as a...

    Authors: Jian-Zhong He, Yang Chen, Fa-Min Zeng, Qing-Feng Huang, Hai-Feng Zhang, Shao-Hong Wang, Shuai-Xia Yu, Xiao-Xiao Pang, Ye Liu, Xiu-E Xu, Jian-Yi Wu, Wen-Jun Shen, Zhan-Yu Li, En-Min Li and Li-Yan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:136
  26. Authors: Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safa Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos and Anna M. Blom
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:135

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:258

  27. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. Large-scale metabolomic data have associated metabolic alterations with the pathogenesis and progression of renal carcinoma a...

    Authors: Christofer Rupert, Carmela Dell’ Aversana, Laura Mosca, Vittorino Montanaro, Davide Arcaniolo, Marco De Sio, Antonio Bilancio, Lucia Altucci, Wulf Palinski, Roberto Pili and Filomena de Nigris
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:134
  28. Efforts to precisely assess tumor-specific T-cell immune responses still face major challenges, and the potential molecular mechanisms mediating hepatocellular carcinoma (HCC) microenvironment imbalance after ...

    Authors: Zheng-Rong Shi, Yu-Xin Duan, Fang Cui, Zhong-Jun Wu, Mao-Ping Li, Pei-Pei Song, Qi-Ling Peng, Wen-Tao Ye, Kun-Li Yin, Mei-Qing Kang, Yan-Xi Yu, Jian Yang, Wei Tang and Rui Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:133
  29. Hippo signaling was first identified in Drosophila as a key controller of organ size by regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this pathway is highly conserved in ...

    Authors: Juan Luo, Liang Deng, Hailin Zou, Yibo Guo, Tongyu Tong, Mingli Huang, Gengqiang Ling and Peng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:130
  30. Emerging studies have identified chronic psychological stress as an independent risk factor influencing breast cancer growth and metastasis. However, the effects of chronic psychological stress on pre-metasta...

    Authors: Yifeng Zheng, Neng Wang, Shengqi Wang, Juping Zhang, Bowen Yang and Zhiyu Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:129
  31. Castration-resistant prostate cancer (CRPC) is currently the main challenge for prostate cancer (PCa) treatment, and there is an urgent need to find novel therapeutic targets and drugs. Prohibitin (PHB1) is a ...

    Authors: Junmei Liu, Ranran Zhang, Tong Su, Qianqian Zhou, Lin Gao, Zongyue He, Xin Wang, Jian Zhao, Yuanxin Xing, Feifei Sun, Wenjie Cai, Xinpei Wang, Jingying Han, Ruixi Qin, Laurent Désaubry, Bo Han…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:128
  32. Ferroptosis has been linked to tumor progression and resistance to antineoplastic therapy. Long noncoding RNA (lncRNA) exerts a regulatory role in various biological processes of tumor cells, while the functio...

    Authors: Jianglin Zheng, Qing Zhang, Zhen Zhao, Yue Qiu, Yujie Zhou, Zhipeng Wu, Cheng Jiang, Xuan Wang and Xiaobing Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:127
  33. High grade serous ovarian cancer (HGSOC) is highly lethal, partly due to chemotherapy resistance and limited availability of targeted approaches. Cyclin dependent kinases 12 and 13 (CDK12/13) are promising the...

    Authors: Eleonora Cesari, Alessandra Ciucci, Marco Pieraccioli, Cinzia Caggiano, Camilla Nero, Davide Bonvissuto, Francesca Sillano, Marianna Buttarelli, Alessia Piermattei, Matteo Loverro, Floriana Camarda, Viviana Greco, Maria De Bonis, Angelo Minucci, Daniela Gallo, Andrea Urbani…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:126
  34. Increasing evidence shows that circular RNAs (circRNAs), a novel class of noncoding RNAs, play a crucial role in the development of cancers, including intrahepatic cholangiocarcinoma (iCCA). Nevertheless, thei...

    Authors: Wenwei Liao, Jinpeng Du, Lian Li, Xianquan Wu, Xing Chen, Qingbo Feng, Lin Xu, Xiangzheng Chen, Mingheng Liao, Jiwei Huang, Kefei Yuan and Yong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:125

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2024 43:55

  35. Authors: Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:124

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:192

  36. Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide. Increasing evidence suggests that the capacity for self-renewal, proliferation, and differentiation of pancreatic cancer stem cells ...

    Authors: Yutong Zhao, Cheng Qin, Bangbo Zhao, Yuanyang Wang, Zeru Li, Tianyu Li, Xiaoying Yang and Weibin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:122
  37. The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in neuroblastoma. An elevated expression of RE...

    Authors: Janardhan Keshav Karapurkar, Min-Seong Kim, Jencia Carminha Colaco, Bharathi Suresh, Neha Sarodaya, Dong-Ho Kim, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim and Suresh Ramakrishna
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:121
  38. MET-driven acquired resistance is emerging with unanticipated frequency in patients relapsing upon molecular therapy treatments. However, the determination of MET amplification remains challenging using both stan...

    Authors: Francesca Bersani, Francesca Picca, Deborah Morena, Luisella Righi, Francesca Napoli, Mariangela Russo, Daniele Oddo, Giuseppe Rospo, Carola Negrino, Barbara Castella, Marco Volante, Angela Listì, Vanessa Zambelli, Federica Benso, Fabrizio Tabbò, Paolo Bironzo…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:120
  39. Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality. Therapy resistance and significant side effects of current treat...

    Authors: Achinto Saha, Shengyuan Zhao, Austin Kindall, Carly Wilder, Chelsea A. Friedman, Rachel Clark, George Georgiou, Everett Stone, Dawit Kidane and John DiGiovanni
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:119
  40. The failure of novel therapies effective in preclinical animal models largely reflects the fact that current models do not really mimic the pathological/therapeutic features of glioblastoma (GBM), in which the...

    Authors: Feng Liu, Qian Zhou, Hai-feng Jiang, Ting-ting Zhang, Cheng Miao, Xiao-hong Xu, Jia-xing Wu, Song-lin Yin, Shi-jie Xu, Jing-yi Peng, Pan-pan Gao, Xuan Cao, Feng Pan, Ximiao He and Xiao Qian Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:118
  41. There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis, epithelial-mesenchymal transition (EMT), and immune microenvironment contribut...

    Authors: Li Long, Wei Xiong, Fenwang Lin, Jiazhen Hou, Guihua Chen, Taoxing Peng, Yihao He, Rui Wang, Qin Xu and Yongzhuo Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:117
  42. Bronchial premalignant lesions (PMLs) are composed primarily of cells resembling basal epithelial cells of the airways, which through poorly understood mechanisms have the potential to progress to lung squamou...

    Authors: Boting Ning, Andrew M. Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E. Lenburg, Jennifer E. Beane and Xaralabos Varelas
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:116
  43. Current clinical and observational evidence supports the EXTREME regimen as one of the standards of care for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) followed by the ...

    Authors: Kohei Okuyama, Tomofumi Naruse and Souichi Yanamoto
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:114

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