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  1. Environmental factors-induced dysfunction of esophageal squamous epithelium, including genomic DNA impairment and apoptosis, play an important role in the pathogenesis of esophageal squamous cell cancer. DNA d...

    Authors: Bao xiang Wang, Bang Liang Yin, Bin He, Chen Chen, Ming Zhao, Wei xing Zhang, Zhen Kun Xia, Yi zhi Pan, Jing qun Tang, Xin min Zhou and Ni Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:11
  2. Expression of the stem cell marker octamer 4 (Oct-4) in various neoplasms has been previously reported, but very little is currently known about the potential function of Oct-4 in this setting. The purpose of ...

    Authors: Zhenguang Chen, Tao Wang, Lie Cai, Chunhua Su, Beilong Zhong, Yiyan Lei and Andy Peng Xiang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:10
  3. Antigen-specific CD8+ cytotoxic T lymphocytes represent potent effector cells of the adaptive immune response against viruses as well as tumours. Therefore assays capable at exploring the generation and functi...

    Authors: Valentina Bordignon, Paola Cordiali-Fei, Monica Rinaldi, Emanuela Signori, Andrea Cottarelli, Manuela Zonfrillo, Fabrizio Ensoli, Guido Rasi and Maria Pia Fuggetta
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:9
  4. The management of patients with glioblastoma multiforme is difficult. Poor results have led to a search for novel therapeutic approaches. Gene therapy that could be both anti-invasive and antiangiogenic would ...

    Authors: Xin-Li Liu, Dan Zhao, Da-Peng Sun, Yang Wang, Yan Li, Feng-Qi Qiu and Ping Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:8
  5. The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-...

    Authors: Elisabetta Falvo, Lidia Strigari, Gennaro Citro, Carolina Giordano, Genoveva Boboc, Fabiana Fabretti, Vicente Bruzzaniti, Luca Bellesi, Paola Muti, Giovanni Blandino and Paola Pinnarò
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:7
  6. The purpose of this study is to determine the methylation status of Transforming growth factor-beta-inducible gene-h3 (TGFBI) and its correlation with paclitaxel chemoresistance in ovarian cancer. The methylat...

    Authors: Ning Wang, Hui Zhang, Qin Yao, Yankui Wang, Shuzhen Dai and Xingsheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:6
  7. One of the major components of telomerase is the human telomerase reverse transcriptase (hTERT) as the catalytic protein. hTERT mRNA expression are reported to be associated with prognosis and tumor progressio...

    Authors: Toshihiro Matsuo, Shoji Shimose, Tadahiko Kubo, Jun Fujimori, Yuji Yasunaga, Takashi Sugita and Mitsuo Ochi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:5
  8. Lung cancer represents the most frequent cause of death for cancer. In non-small cell lung cancer (NSCLC), which accounts for the vast majority of this disease, only early detection and treatment, when possibl...

    Authors: Claudia Abbruzzese, Stefano Mattarocci, Laura Pizzuti, Anna M Mileo, Paolo Visca, Barbara Antoniani, Gabriele Alessandrini, Francesco Facciolo, Rosario Amato, Lucia D'Antona, Massimo Rinaldi, Armando Felsani, Nicola Perrotti and Marco G Paggi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:4
  9. Transforming growth factor (TGF)-β is known to be produced by progressor tumors and to immobilize dendritic cells (DCs) within those tumors. Moreover, although TGF-β1 has been shown to promote tumor progressio...

    Authors: Kazuhiro Imai, Yoshihiro Minamiya, Souichi Koyota, Manabu Ito, Hajime Saito, Yusuke Sato, Satoru Motoyama, Toshihiro Sugiyama and Jun-ichi Ogawa
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:3
  10. This study aims to investigate the in vitro effects of Ulinastatin (UTI) and Taxotere (TXT) on cell proliferation; cell apoptosis; xenografted tumor growth; and expression of insulin-like growth factor receptor 1...

    Authors: Hong Wang, Xin Sun, Feng Gao, Biao Zhong, Yong-hua Zhang and Zhijun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:2
  11. Tissue factor pathway inhibitor-2 (TFPI-2) is an extracellular matrix associated broad-spectrum Kunitz-type serine proteinase inhibitor. Recently, down regulation of TFPI-2 was suggested to be involved in tumo...

    Authors: Qiao Zhang, Yao Zhang, Shi Z Wang, Ning Wang, Wei G Jiang, Yao H Ji and Shu L Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:1
  12. Both endoscopic and surgical approaches are employed in the treatment of early gastric cancer (EGC). The aim of this study was to establish appropriate treatment strategies for early gastric cancer.

    Authors: Hiroaki Ito, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Toshihisa Hosoya, Kosuke Sudo, Nikolas Eleftheriadis, Roberta Maselli, Chiyo Maeda, Yoko Wada, Norimasa Sando, Shigeharu Hamatani and Shin-ei Kudo
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:117
  13. Whether Folic acid is a potential drug that may prevent the progression of colorectal carcinoma and when to use are important healthy issues we focus on. Our study is to examine the effect of folic acid on the...

    Authors: Yan-Wei Lin, Ji-Lin Wang, Hui-Min Chen, Yan-Jie Zhang, Rong-Lu, Lin-Lin Ren, Jie Hong and Jing-Yuan Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:116
  14. Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guid...

    Authors: Maria Bonomi, Sara Pilotto, Michele Milella, Francesco Massari, Sara Cingarlini, Matteo Brunelli, Marco Chilosi, Giampaolo Tortora and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:115
  15. Zfx is a zinc finger protein of the Zfy family, whose members are highly conserved in vertebrates. Zfx is a shared transcriptional regulator of both embryonic stem cells (ESC) and hematopoietic stem cells (HSC...

    Authors: Youxin Zhou, Zuopeng Su, Yulun Huang, Ting Sun, Sansong Chen, Tingfeng Wu, Guilin Chen, Xueshun Xie, Bin Li and Ziwei Du
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:114
  16. Clusterin is a cytoprotective chaperone protein involved in numerous physiological processes, carcinogenesis, tumor growth and tissue remodelling. The purpose of this study was to investigate whether clusterin...

    Authors: Mohamed K Hassan, Hidemichi Watari, Yimin Han, Takashi Mitamura, Masayoshi Hosaka, Lei Wang, Shinya Tanaka and Noriaki Sakuragi
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:113
  17. The Three-amino acid-loop-extension (TALE) superfamily of homeodomain-containing transcription factors have been implicated in normal hematopoiesis and in leukemogenesis and are important survival, differentiatio...

    Authors: Judith A Rosales-Aviña, Jorge Torres-Flores, Adriana Aguilar-Lemarroy, Carmen Gurrola-Díaz, Georgina Hernández-Flores, Pablo C Ortiz-Lazareno, José M Lerma-Díaz, Ruth de Celis, Óscar González-Ramella, Esperanza Barrera-Chaires, Alejandro Bravo-Cuellar and Luis F Jave-Suárez
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:112
  18. Epidermal growth factor receptor (EGFR) mutation is strongly associated with the therapeutic effect of tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer (NSCLC). Nevertheless, tumor ti...

    Authors: Yi Liu, Bing Liu, Xiao-Yan Li, Jian-Jie Li, Hai-Feng Qin, Chuan-Hao Tang, Wan-Feng Guo, Hai-Xu Hu, Sha Li, Cui-Jing Chen, Bing Liu, Hong-Jun Gao and Xiao-Qing Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:111
  19. miR-15a and miR-16-1(miR-15a/16-1) have been implicated as tumor suppressors in chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemic cells. However the mechanism of inhibiting the prolife...

    Authors: Shen-meng Gao, Chong-yun Xing, Chi-qi Chen, Si-si Lin, Pei-hong Dong and Fu-jun Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:110
  20. To investigate the expression of cyclin-dependent kinase 8 (CDK8) and β-catenin in colon cancer and evaluate the role of CDK8 in the proliferation, apoptosis and cell cycle progression of colon cancer cells, e...

    Authors: Song-Bing He, Yin Yuan, Lei Wang, Min-Jing Yu, Yi-Bei Zhu and Xing-Guo Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:109
  21. The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneo...

    Authors: Francesca Paolini, Angelo Carbone, Maria Benevolo, Vitaliano Silipo, Francesca Rollo, Renato Covello, Paolo Piemonte, Pasquale Frascione, Rodolfo Capizzi, Caterina Catricalà and Aldo Venuti
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:108
  22. Adiponectin is inversely related to BMI, positively correlates with insulin sensitivity, and has anti-atherogenic effects. In recent years, adiponectin has been well studied in the field of oncology. Adiponect...

    Authors: Tomoya Tsukada, Sachio Fushida, Shinichi Harada, Shiroh Terai, Yasumichi Yagi, Jun Kinoshita, Katsunobu Oyama, Hidehiro Tajima, Hideto Fujita, Itasu Ninomiya, Takashi Fujimura and Tetsuo Ohta
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:107
  23. We evaluated the expression of human trophoblastic cell-surface marker (Trop-2) and the potential of hRS7 - a humanized monoclonal anti-Trop-2 antibody - as a therapeutic strategy against treatment-refractory ...

    Authors: Rhoda Raji, Federica Guzzo, Luisa Carrara, Joyce Varughese, Emiliano Cocco, Stefania Bellone, Marta Betti, Paola Todeschini, Sara Gasparrini, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter Schwartz, Thomas J Rutherford, Natalia Buza, Sergio Pecorelli…
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:106
  24. Specific peptide ligands to cell surface receptors have been extensively used in tumor research and clinical applications. Phage display technology is a powerful tool for the isolation of cell-specific peptide...

    Authors: Xiangan Tu, Jintao Zhuang, Wenwei Wang, Liang Zhao, Liangyun Zhao, Jiquan Zhao, Chunhua Deng, Shaopeng Qiu and Yuanyuan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:105

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2012 31:21

  25. MDR1 gene encoding P-glycoprotein is an ATP-dependent drug efflux transporter and related to drug resistance of yolk sac carcinoma. Ultrasound microbubble-mediated delivery has been used as a novel and effecti...

    Authors: Yun He, Yang Bi, Yi Hua, Dongyao Liu, Sheng Wen, Qiang Wang, Mingyong Li, Jing Zhu, Tao Lin, Dawei He, Xuliang Li, Zhigang Wang and Guanghui Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:104
  26. Cancer stem cells (CSCs) play an important role in cancer initiation, relapse and metastasis. To date, no specific medicine has been found to target CSCs as they are resistant to most conventional therapies an...

    Authors: Weiru Xu, Hongsheng Lin, Ying Zhang, Xinyi Chen, Baojin Hua, Wei Hou, Xin Qi, Yingxia Pei, Xiaoyun Zhu, Zhizheng Zhao and Liangliang Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:103
  27. Breast cancer is one of the most diagnosed cancers in females, frequently with fatal outcome, so that new strategies for modulating cell proliferation in the mammary tissue are urgently needed. There is some, ...

    Authors: Maren Fedrowitz, Ralf Hass, Catharina Bertram and Wolfgang Löscher
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:102
  28. Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apo...

    Authors: Monika Kosacka, Paweł Piesiak, Aneta Kowal, Marcin Gołecki and Renata Jankowska
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:101
  29. A broad population-based assay to detect individuals with Lynch Syndrome (LS) before they develop cancer would save lives and healthcare dollars via cancer prevention. LS is caused by a germline mutation in a ...

    Authors: Samar Hassen, Bruce M Boman, Nawab Ali, Marcie Parker, Chandra Somerman, Zohra J Ali-Khan Catts, Akhtar A Ali and Jeremy Z Fields
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:100
  30. DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer. DNMT methyltransferase 1 (DNMT1), which plays a significa...

    Authors: Yi Zhang, Fu-qiang Chen, Ye-hong Sun, Shu-yan Zhou, Ti-yuan Li and Rui Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:98
  31. Brain-derived neurotrophic factor (BDNF) and its receptor Tropomysin-related kinase B (TrkB) are commonly up-regulated in a variety of human tumors. However, the roles of BDNF/TrkB in hepatocellular carcinoma ...

    Authors: Dawei Guo, Xuezhong Hou, Hongbin Zhang, Wenyu Sun, Lei Zhu, Jian Liang and Xiaofeng Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:97
  32. Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or del...

    Authors: Rachel Purcell, Margaret Childs, Rudolf Maibach, Carina Miles, Clinton Turner, Arthur Zimmermann and Michael Sullivan
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:96
  33. Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for poly...

    Authors: Kuniyasu Soda
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:95
  34. A substantial body of literature has accumulated during the past 20 years showing the plasma concentrations of 5-fluorouracil (5-FU) to correlate with clinical response and/or toxicity in colorectal cancer, an...

    Authors: Akiko Kuwahara, Motohiro Yamamori, Kaori Kadoyama, Kohshi Nishiguchi, Tsutomu Nakamura, Ikuya Miki, Takao Tamura, Tatsuya Okuno, Hideaki Omatsu and Toshiyuki Sakaeda
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:94
  35. Previously, adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) database were reviewed to confirm platinum agent-associated hypersensitivity reactions. The present study was per...

    Authors: Kaori Kadoyama, Akiko Kuwahara, Motohiro Yamamori, JB Brown, Toshiyuki Sakaeda and Yasushi Okuno
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:93
  36. Cancer gene therapy by retroviral vectors is mainly limited by the level of transduction. Retroviral gene transfer requires target cell division. Cell synchronization, obtained by drugs inducing a reversible i...

    Authors: Laetitia Finzi, Aurore Kraemer, Claude Capron, Severine Noullet, Diane Goere, Christophe Penna, Bernard Nordlinger, Josette Legagneux, Jean-Fançois Emile and Robert Malafosse
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:92
  37. Breast and ovarian cancers are among the 10 leading cancer types in females with mortalities of 15% and 6%, respectively. Despite tremendous efforts to conquer malignant diseases, the war on cancer declared by Ri...

    Authors: Niels Eckstein
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:91
  38. Previous data demonstrate that JMJD2A is a cancer-associated gene and may be involved in human breast cancer by demethylation of H3K9me3. The aim of this study was to investigate depressive effects on JMJD2A b...

    Authors: Bei-Xu Li, Ming-Chang Zhang, Cheng-Liang Luo, Peng Yang, Hui Li, Hong-Mei Xu, Hong-Fei Xu, Yi-Wen Shen, Ai-Min Xue and Zi-Qin Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:90
  39. Clear cell renal cell carcinoma, a solid growing tumor, is the most common tumor in human kidney. Evaluating the usefulness of β-galactoside binding galectin-3 as a diagnostic marker for this type of cancer co...

    Authors: Tamara Straube, Alexandra F Elli, Christoph Greb, Axel Hegele, Hans-Peter Elsässer, Delphine Delacour and Ralf Jacob
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:89
  40. Protein kinase C epsilon (PKCε), an oncogene overexpressed in several human cancers, is involved in cell proliferation, migration, invasion, and survival. However, its roles in clear cell renal cell carcinoma ...

    Authors: Bin Huang, Kaiyuan Cao, Xiubo Li, Shengjie Guo, Xiaopeng Mao, Zhu Wang, Jintao Zhuang, Jincheng Pan, Chengqiang Mo, Junxing Chen and Shaopeng Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:88
  41. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the unde...

    Authors: Rebecca SY Wong
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:87
  42. matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis. Aquaporin-3 (AQP3) also plays a critic...

    Authors: Hao Xu, Yong Xu, Wenjie Zhang, Lizong Shen, Li Yang and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:86
  43. Lymph node involvement and tumor-induced lymphangiogenesis appear as the earliest features of esophageal squamous cell carcinoma (ESCC), although the molecular regulatory mechanisms involved have remained uncl...

    Authors: Chunhua Su, Zhenguang Chen, Honghe Luo, Yihua Su, Wangkai Liu, Lie Cai, Tao Wang, Yiyan Lei and Beilong Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:85
  44. Toll-like receptor 9 (TLR9) is a cellular DNA-receptor whose activation with cognate ligands triggers an immune reaction, with increased production of inflammatory cytokines. The aim of this study was to exami...

    Authors: Hanna Ronkainen, Pasi Hirvikoski, Saila Kauppila, Katri S Vuopala, Timo K Paavonen, Katri S Selander and Markku H Vaarala
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:84
  45. Metastasis-associated in colon cancer 1 (MACC1) is demonstrated to be up-regulated in several types of cancer, and can serve as biomarker for cancer invasion and metastasis. To investigate the relations betwee...

    Authors: Ruitao Zhang, Huirong Shi, Zhimin Chen, Qinghua Wu, Fang Ren and Haoliang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:83
  46. The inflammatory enzyme indoleamine 2, 3-dioxygenase (IDO) participates in immune tolerance and promotes immune escape of IDO+ tumors. A recent hypothesis suggested that IDO may contribute to the differentiati...

    Authors: Jingyan Sun, Jinpu Yu, Hui Li, Lili Yang, Feng Wei, Wenwen Yu, Juntian Liu and Xiubao Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:82
  47. Hyperglycemia is among the major side effects of dexamethasone (DEX). Glucose or glucocorticoid (GC) regulates the expression of thioredoxin-interacting protein (TXNIP) that controls the production of reactive...

    Authors: Ellen Friday, Johnathan Ledet and Francesco Turturro
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:81
  48. Glioblastoma multiforme (GBM) carries a dismal prognosis primarily due to its aggressive proliferation in the brain regulated by complex molecular mechanisms. One promising molecular target in GBM is over-expr...

    Authors: Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang and Jinhuan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:80
  49. Ubiquitin Carboxyl-Terminal Hydrolase-L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed throughout the central and peripheral nervous system and in cells of the diffuse neuroendocrine system. A...

    Authors: Katy S Orr, Zhanzhong Shi, W Mark Brown, Kathleen A O'Hagan, Terence R Lappin, Perry Maxwell and Melanie J Percy
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:79

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