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  1. Drug resistance remains a great challenge in the treatment of gastric cancer. The goal of this study was to explore the anti-tumor effects and mechanism of cytokine-induced killer (CIK) cell combined with oxal...

    Authors: Qun Zhao, Hui Zhang, Yong Li, Jun Liu, Xiaojie Hu and Liqiao Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:118
    Content type: Research Published on:

  2. Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. Heterozygous carriers of ATM-mutations have an increased ri...

    Authors: Lin-Bo Gao, Xin-Min Pan, Hong Sun, Xia Wang, Li Rao, Li-Juan Li, Wei-Bo Liang, Mei-Li Lv, Wen-Zhong Yang and Lin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:117
    Content type: Research Published on:

  3. Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hype...

    Authors: Jang Hyun Lee, Jae-Kyung Pyon, Dong Wook Kim, Sang Han Lee, Hae Seon Nam, Chul Han Kim, Sang Gue Kang, Yoon Jin Lee, Mi Youn Park, Dong Jun Jeong and Moon Kyun Cho
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:116
    Content type: Research Published on:

  4. To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods.

    Authors: Xingguo Zhong, Maoming Xiong, Xiangling Meng and Renhua Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:115
    Content type: Research Published on:

  5. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus. It was found that CBX7 expression was upregul...

    Authors: Xiao-Wei Zhang, Li Zhang, Wei Qin, Xiao-Hong Yao, Lei-Zhen Zheng, Xin Liu, Jin Li and Wei-Jian Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:114
    Content type: Research Published on:

  7. Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of se...

    Authors: Xiao-yun Mao, Chui-feng Fan, Hua-chuan Zheng, Jing Wei, Fan Yao and Feng Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:112
    Content type: Research Published on:

  8. GTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities. However, the ...

    Authors: Zhen Qian, Jun Qian, Jiang Lin, Dong-ming Yao, Qin Chen, Run-bi Ji, Yun Li, Gao-fei Xiao and Jian-yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:111
    Content type: Research Published on:

  9. The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. C...

    Authors: Cheng-Jeng Tai, Chung-Huei Hsu, Shing-Chuan Shen, Woan-Ruoh Lee and Ming-Chung Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:110
    Content type: Review Published on:

  10. The incidence of malignant melanoma (MM) was occurring at a faster rate than for most neoplasm worldwide, and melanoma metastasis is still the most formidable problem. So it is necessarily to find some biomark...

    Authors: Man Li, Baogang Zhang, Baocun Sun, Xuan Wang, Xinchao Ban, Tao Sun, Zhiyong Liu and Xiulan Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:109
    Content type: Research Published on:

  12. To evaluate the expression of BCL-2 and BAD genes in tissues of breast carcinoma and investigate the relationship between the expression of BCL-2 and BAD in breast cancer cells with chemosensitivity.

    Authors: Bing Yu, Xin Sun, Hong-yan Shen, Feng Gao, Yuan-ming Fan and Zhi-jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:107
    Content type: Research Published on:

  13. Previous studies have shown that heat shock proteins (HSPs) were upregulated in various types of tumors and were associated with histological grade, recurrence and metastasis of malignant tumors. In this study...

    Authors: Jing Xu, Kangkai Wang, Xin Zhang, Yuanzheng Qiu, Donghai Huang, Wei Li, Xianzhong Xiao and Yongquan Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:106
    Content type: Research Published on:

  14. Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:105
    Content type: Erratum Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2010 29:90

  15. Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-β1 is associated with drug resistance in pancreatic cancer.

    Authors: Ying Chen, Guanzhen Yu, Danghui Yu and Minghua Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:104
    Content type: Research Published on:

  16. Recently, the anti-tumor activity of N-myc downstream-regulated gene 2 (NDRG2) was shown decreased expression in clear cell renal cell carcinoma (CCRCC), but the role of the down-expression of NDRG2 has not be...

    Authors: Jian-Jun Ma, Cheng-Gong Liao, Xue Jiang, Hua-Dong Zhao, Li-Bo Yao and Ting-Yi Bao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:103
    Content type: Research Published on:

  17. Ovarian cancer is the most fatal gynecologic malignancies in the world. Although, platinum based treatments are widely used, the disease becomes treatment refractory within two years, and novel treatment optio...

    Authors: Bulent Karabulut, Burcak Karaca, Umut Varol, Ugur Muslu, Burcu Cakar, Harika Atmaca, Aslı Kısım, Selim Uzunoglu and Ruchan Uslu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:102
    Content type: Research Published on:

  18. Sulfotransferase (SULT) plays an important role in the formation of estrogen which is usually conferred as a risk factor for breast cancer. Polymorphism of the SULT1A1 may be closely associated with breast can...

    Authors: Yiwei Jiang, Liheng Zhou, Tingting Yan, Zhenzhou Shen, Zhimin Shao and Jinsong Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:101
    Content type: Research Published on:

  19. Currently definitive 5-fluorouracil (5-FU)/cisplatin (CDDP) -based chemotherapy is recognized as one of the most promising treatments for esophageal cancer. A series of studies performed found genetic polymorp...

    Authors: Akiko Kuwahara, Motohiro Yamamori, Megumi Fujita, Tatsuya Okuno, Takao Tamura, Kaori Kadoyama, Noboru Okamura, Tsutomu Nakamura and Toshiyuki Sakaeda
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:100
    Content type: Research Published on:

  20. Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also ...

    Authors: Bo Chen, Xueli Wang, Weihong Zhao and Jianqing Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:99
    Content type: Research Published on:

  21. The novel gene HA117 is a multidrug resistance (MDR) gene expressed by all-trans retinoic acid-resistant HL-60 cells. In the present study, we compared the multidrug resistance of the HA117 with that of the cl...

    Authors: Lihua Zhao, Xianqing Jin, Youhua Xu, Yuxia Guo, Rui Liang, Zhenhua Guo, Tingfu Chen, Yanhui Sun and Xionghui Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:98
    Content type: Research Published on:

  23. Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis of gastrointestinal stromal tumors (GIST).

    Authors: Sean Caenepeel, Lisa Renshaw-Gegg, Angelo Baher, Tammy L Bush, Will Baron, Todd Juan, Raffi Manoukian, Andrew S Tasker, Anthony Polverino and Paul E Hughes
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:96
    Content type: Research Published on:

  24. Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the activity of bevacizumab and sorafenib. We hypothesized that these toxicities would correspond to favorable outcome in these drugs, th...

    Authors: Lokesh Jain, Tristan M Sissung, Romano Danesi, Elise C Kohn, William L Dahut, Shivaani Kummar, David Venzon, David Liewehr, Bevin C English, Caitlin E Baum, Robert Yarchoan, Giuseppe Giaccone, Jürgen Venitz, Douglas K Price and William D Figg
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:95
    Content type: Research Published on:

  25. To explore the therapeutic effects of thymidine kinase (TK) expressed by enhanced vector pGL3-basic- hTERTp-TK-EGFP-CMV driven by human telomerase reverse transcriptase promoter (hTERTp) as well as cytomegalov...

    Authors: Cong-Xiang Shen, Zhong Wen, Yu-Hong Qian, Shao-Feng Mu and Xiao-Fang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:94
    Content type: Research Published on:

  26. Nm23 gene was isolated as a metastatic suppressor gene. The antimetastatic effect of Nm23 has been an enigma for more than 10 years. Little is known about its molecular mechanisms. In this study we overexpress...

    Authors: Shangyang She, Boying Xu, Min He, Xiuwan Lan and Qiuyan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:93
    Content type: Research Published on:

  27. Tumor cell expression of Toll-like receptors (TLRs) can promote inflammation and cell survival in the tumor microenvironment. Toll-like receptor 4 (TLR4) signaling in tumor cells can mediate tumor cell immune ...

    Authors: Huan Yang, Huiqin Zhou, Ping Feng, Xiaoni Zhou, Huiyan Wen, Xiaofang Xie, Haiying Shen and Xueming Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:92
    Content type: Research Published on:

  28. Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant r...

    Authors: Nicole D Fer, Robert H Shoemaker and Anne Monks
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:91
    Content type: Research Published on:

  29. MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma.

    Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:90
    Content type: Research Published on:

  30. ECRG4 has been shown to be a candidate tumor suppressor in several tumors, but its role in glioma remains poorly understood. In this study, we examined the mRNA expression of ECRG4 and investigated its biologi...

    Authors: Wei Li, Xinrui Liu, Bo Zhang, Dongxue Qi, Lihong Zhang, Yuhong Jin and Hongfa Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:89
    Content type: Research Published on:

  31. This study explored the expression and function of Slug in human extrahepatic hilar cholangiocarcinoma (EHC) to identify its role in tumor progression.

    Authors: Ke-jun Zhang, Dong-sheng Wang, Shao-yan Zhang, Xue-long Jiao, Chun-wei Li, Xin-sheng Wang, Qin-chao Yu and Hai-ning Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:88
    Content type: Research Published on:

  32. Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most active chemotherapeutic agent in Lung Cancer. Here we repor...

    Authors: Syed H Jafri, Jonathan Glass, Runhua Shi, Songlin Zhang, Misty Prince and Heather Kleiner-Hancock
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:87
    Content type: Research Published on:

  33. Various strains of Bacillus thuringiensis (Bt) have been found to produce parasporal proteins that are cytotoxic to human cancer cells. This study aims to establish the binding affinity of purified Bt 18 toxin fo...

    Authors: Rebecca SY Wong, Shar M Mohamed, Vishna D Nadarajah and Ibrahim Azmi T Tengku
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:86
    Content type: Research Published on:

  34. To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian ca...

    Authors: Ying Ma, Lin Ma, Quan Guo and Shulan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:85
    Content type: Research Published on:

  35. Orthotopic models are important in cancer research. Here we developed orthotopic xenograft mouse model of metastatic lung cancer and glioblastoma with a specially designed system.

    Authors: Xi Feng Fei, Quan Bin Zhang, Jun Dong, Yi Diao, Zhi Min Wang, Ru Jun Li, Zi Cheng Wu, Ai Dong Wang, Qing Lan, Shi Ming Zhang and Qiang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:84
    Content type: Research Published on:

  36. The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy...

    Authors: Tatsuya Tanaka, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Takeyasu Katada, Midori Shiozaki, Yasuhiro Naganawa, Yoshitaka Fujii and Hiromitsu Takeyama
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:83
    Content type: Research Published on:

  37. Breast cancer is one of the most common diseases affecting women. Inherited susceptibility genes, BRCA1 and BRCA2, are considered in breast, ovarian and other common cancers etiology. BRCA1 and BRCA2 genes have b...

    Authors: Safinaz S Ibrahim, Elsayed E Hafez and Mervat M Hashishe
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:82
    Content type: Research Published on:

  38. We have previously reported that Myeov (MYEloma OVerexpressed gene) expression is enhanced in colorectal cancer (CRC) and that it promotes CRC cell proliferation and invasion. The role of Myeov in CRC migratio...

    Authors: Garrett Lawlor, Peter P Doran, Padraic MacMathuna and David W Murray
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:81
    Content type: Research Published on:

  39. Breast cancer stem cells (BCSCs) have been recently identified in breast carcinoma as CD44+CD24- cells, which exclusively retain tumorigenic activity and display stem cell-like properties. Using a mammosphere cul...

    Authors: Mingzhu Huang, Yuqing Li, Huanle Zhang and Feifei Nan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:80
    Content type: Research Published on:

  40. Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene. However, recent studies revealed that over expression of Cx26 ...

    Authors: Shinya Nomura, Kiyoshi Maeda, Eiji Noda, Toru Inoue, Shinya Fukunaga, Hisashi Nagahara and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:79
    Content type: Research Published on:

  41. Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (D...

    Authors: Feng Ye, Yan Yu, Yuting Hu, Weiguo Lu and Xing Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:78
    Content type: Research Published on:

  42. Total thyroidectomy is the treatment of choice in the majority of thyroid malignancies, preventing the risk of reoperative surgery due to recurrences. In order to assess the usefulness of such an approach, exp...

    Authors: Guglielmo Ardito, Luca Revelli, Alma Boninsegna, Alessandro Sgambato, Francesca Moschella, Maria Cristina Marzola, Erica Giustozzi, Nicola Avenia, Mauro Castelli and Domenico Rubello
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:77
    Content type: Research Published on:

  43. Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and un...

    Authors: Xian-ping Liu, Sheng-tao Zhou, Xing-yi Li, Xian-cheng Chen, Xia Zhao, Zhi-yong Qian, Li-na Zhou, Zhi-yong Li, Yu-mei Wang, Qian Zhong, Tao Yi, Zheng-yu Li, Xiang He and Yu-quan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:76
    Content type: Research Published on:

  44. Recent studies have shown that microRNAs (miRNAs) play roles in tumorigenesis and are reliable classifiers of certain cancer types and subtypes. However, the role of miRNAs in the pathogenesis and diagnosis of...

    Authors: Liqin Du, Jeoffrey J Schageman, Irnov, Luc Girard, Scott M Hammond, John D Minna, Adi F Gazdar and Alexander Pertsemlidis
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:75
    Content type: Research Published on:

  45. The tumor suppressor gene CDKN2A generates at least three different transcriptional variants, each of which is thought to encode a tumor suppressor. However, the inhibitory activities of these variants have not y...

    Authors: Wei Zhang, Jing Zhu, Jing Bai, Hui Jiang, Fangli Liu, An Liu, Peng Liu, Guohua Ji, Rongwei Guan, Donglin Sun, Wei Ji, Yang Yu, Yan Jin, Xiangning Meng and Songbin Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:74
    Content type: Research Published on:

  46. To retrospectively compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multidetector-row computed tomography (MDCT) in the assessment of the mandibular invasion by squamous cell carcinoma (...

    Authors: Antonello Vidiri, Antonino Guerrisi, Raul Pellini, Valentina Manciocco, Renato Covello, Oreste Mattioni, Isabella Guerrisi, Salvatore Di Giovanni, Giuseppe Spriano and Marcello Crecco
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:73
    Content type: Research Published on:

  47. Interleukin-10(IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Polymorphisms in the IL-10 gene promoter genetically determine interindividual differences in IL-10...

    Authors: Fanjun Kong, Jie Liu, Yongheng Liu, Bao Song, Hualing Wang and Wenchao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:72
    Content type: Research Published on:

  48. SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis.

    Authors: Jian-fang Liang, Hong-kun Wang, Hong Xiao, Ning Li, Cai-xia Cheng, Yu-ze Zhao, Yan-bo Ma, Jian-zhong Gao, Rui-bing Bai and Hui-xia Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:71
    Content type: Research Published on:

  49. Intra-arterial radioembolization with yttrium-90 microspheres ( 90Y-RE) is an increasingly used therapy for patients with unresectable liver malignancies. Over the last decade, radioactive holmium-166 poly(L-lact...

    Authors: Maarten LJ Smits, Johannes FW Nijsen, Maurice AAJ van den Bosch, Marnix GEH Lam, Maarten AD Vente, Julia E Huijbregts, Alfred D van het Schip, Mattijs Elschot, Wouter Bult, Hugo WAM de Jong, Pieter CW Meulenhoff and Bernard A Zonnenberg
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:70
    Content type: Research Published on:

  50. Positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism. We have analyzed the effect ...

    Authors: Seong-Jang Kim, Sang-Hyun Hwang, In Joo Kim, Min Ki Lee, Chang Hun Lee, Sang-Yull Lee and Eun Yup Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:69
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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