Skip to main content

Articles

Page 61 of 76

  1. Liver metastases occur in 46-93% of patients with neuroendocrine neoplasms (NENs). Presence and extension of liver metastases are considered important prognostic factors, as they may significantly impair the p...

    Authors: Michela Del Prete, Francesco Fiore, Roberta Modica, Vincenzo Marotta, Francesca Marciello, Valeria Ramundo, Antonella Di Sarno, Annachiara Carratù, Chiara de Luca di Roseto, Salvatore Tafuto, Fabiana Tatangelo, Robero Baldelli, Annamaria Colao and Antongiulio Faggiano
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:43
  2. Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), which accounts for approximately 10% of all acute myloid leukemia cases. It is a blood cancer that is formed by chromosomal muta...

    Authors: Sanjay Kumar, Clement G Yedjou and Paul B Tchounwou
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:42
  3. Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of ant...

    Authors: Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin and Håkan Billig
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:41
  4. The epithelial-to-mesenchymal transition (EMT) accompanied by the downregulation of E-cadherin has been thought to promote metastasis. Cyclooxygenase-2 (Cox-2) is presumed to contribute to cancer progression t...

    Authors: Ryoichi Fujii, Yorihisa Imanishi, Katsushi Shibata, Nobuya Sakai, Koji Sakamoto, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Hiroyuki Ozawa, Toshiki Tomita, Kaori Kameyama, Masato Fujii and Kaoru Ogawa
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:40
  5. Heparanase is an endo-β-D-glucuronidase that cleaves heparan sulfate chains of proteoglycans, resulting in the disassembly of the extracellular matrix. Heparanase has a central role in the development of vario...

    Authors: Olga Kazarin, Neta Ilan, Inna Naroditzky, Ofer Ben-Itzhak, Israel Vlodavsky and Gil Bar-Sela
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:39
  6. Gastric carcinoma (GC) is a common and lethal malignancy, and epithelial-mesenchymal transition (EMT) is believed to contribute to invasive and metastatic tumor growth. Aquaporin 3 (AQP3) is overexpressed in h...

    Authors: Jia Chen, Tao Wang, Yang-Chun Zhou, Fei Gao, Zhi-Hong Zhang, Hao Xu, Shou-Lin Wang and Li-Zong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:38
  7. Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature...

    Authors: Evandro Luís Niero, Bianca Rocha-Sales, Camila Lauand, Beatriz Araujo Cortez, Marcelo Medina de Souza, Paula Rezende-Teixeira, Marcel Shiniti Urabayashi, Adam Arai Martens, Jorge Henrique Neves and Gláucia Maria Machado-Santelli
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:37
  8. Berberine (BBR), a component from traditional Chinese medicine, has been shown to possess anti-tumor activity against a wide spectrum of cancer cells including human lung cancer, but the detailed mechanism und...

    Authors: Fang Zheng, Qin Tang, JingJing Wu, ShunYu Zhao, ZhanYang Liang, Liuning Li, WanYin Wu and Swei Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:36
  9. T regulatory cells (Tregs) contribute to the progression of head and neck squamous cell carcinoma (HNSCC) by suppressing antitumor immunity. However, little is known regarding the functional heterogeneity of T...

    Authors: Wei Sun, Wei-Jin Li, Chang-You Wu, Hua Zhong and Wei-Ping Wen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:35
  10. Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer. Investigation of the mechanism of invasion and metastasis of lung SCC will be of great help for the development of me...

    Authors: Dongsheng Yue, Hui Li, Juanjuan Che, Yi Zhang, Hsin-Hui K Tseng, Joy Q Jin, Thomas M Luh, Etienne Giroux-Leprieur, Minli Mo, Qingfeng Zheng, Huaiyin Shi, Hua Zhang, Xishan Hao, Changli Wang, David M Jablons and Biao He
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:34
  11. Recently, recurrent point mutations in the telomerase reverse transcriptase (TERT) promoter region have been found in many human cancers, leading to a new transcription factor binding site, increased induction of...

    Authors: Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann, Peter Schirmacher, Andreas von Deimling and Gunhild Mechtersheimer
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:33
  12. The expression of 5-hydroxymethylcytosine (5-hmC) and isocitrate dehydrogenase 2 (IDH2) is frequently downregulated in numerous cancers. 5-hmC and IDH2 expression in hepatocellular carcinoma (HCC) has yet to b...

    Authors: Wei-Ren Liu, Meng-Xin Tian, Lei Jin, Liu-Xiao Yang, Zhen-Bin Ding, Ying-Hao Shen, Yuan-Fei Peng, Jian Zhou, Shuang-Jian Qiu, Zhi Dai, Jia Fan and Ying-Hong Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:32
  13. While recent research has shown that expression of RABEX-5 in breast cancer and colorectal cancer has a crucial impact on tumor development, there is little information regarding RABEX-5 expression in prostate...

    Authors: Hongtuan Zhang, Shang Cheng, Andi Wang, Hui Ma, Bing Yao, Can Qi, Ranlu Liu, Shiyong Qi and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:31
  14. Elderly patients with metastatic melanoma have different disease characteristics and a poorer prognosis than younger patients. Data from clinical trials and expanded access programmes (EAPs) suggest ipilimumab...

    Authors: Vanna Chiarion Sileni, Jacopo Pigozzo, Paolo Antonio Ascierto, Antonio Maria Grimaldi, Michele Maio, Lorenza Di Guardo, Paolo Marchetti, Francesco de Rosa, Carmen Nuzzo, Alessandro Testori, Emilia Cocorocchio, Maria Grazia Bernengo, Michele Guida, Riccardo Marconcini, Barbara Merelli, Giorgio Parmiani…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:30
  15. Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the...

    Authors: Patrizia Vici, Luciano Mariani, Laura Pizzuti, Domenico Sergi, Luigi Di Lauro, Enrico Vizza, Federica Tomao, Silverio Tomao, Claudia Cavallotti, Francesca Paolini and Aldo Venuti
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:29
  16. Bone scanning (BS), liver ultrasonography (LUS), and chest radiography (CXR) are commonly recommended for baseline staging in patients with newly diagnosed breast cancer. The purpose of this study is to demons...

    Authors: Xuesong Chen, Lichun Sun, Yingying Cong, Tingting Zhang, Qiushi Lin, Qingwei Meng, Hui Pang, Yanbin Zhao, Yu Li, Li Cai and Xiaoqun Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:28
  17. In osteosarcoma, the presence of tumor-infiltrating macrophages positively correlates with patient survival in contrast to the negative effect of tumor-associated macrophages in patients with other tumors. Lip...

    Authors: Jens HW Pahl, Kitty MC Kwappenberg, Eleni M Varypataki, Susy J Santos, Marieke L Kuijjer, Susan Mohamed, Juul T Wijnen, Maarten JD van Tol, Anne-Marie Cleton-Jansen, R Maarten Egeler, Wim Jiskoot, Arjan C Lankester and Marco W Schilham
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:27
  18. Stanniocalcin 2 (STC2) is overexpressed in several types of human cancers, and its overexpression positively correlates to tumor progression and poor prognosis. However, the clinical significance of STC2 overe...

    Authors: Shaojun Lin, Qiaojuan Guo, Jiangmei Wen, Chao Li, Jin Lin, Xiaofei Cui, Nianli Sang and Jianji Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:26
  19. Expression of the non-receptor tyrosine kinase ETK/BMX has been reported in several solid tumors, but the underlying molecular mechanisms and its clinical significance in renal cell carcinoma (RCC) remain to b...

    Authors: Jintao Zhuang, Xiangan Tu, Kaiyuan Cao, Shengjie Guo, Xiaopeng Mao, Jincheng Pan, Bin Huang, Xu Chen, Yong Gao and Shaopeng Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:25
  20. CELLFOOD™ (CF) is a nutraceutical non-addictive, non-invasive, and completely non-toxic unique proprietary colloidal-ionic formula. Little is known about its effect on cancer cells in solid tumors. The aim of ...

    Authors: Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari and Rossella Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:24

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:290

  21. Dystrophic skin scarring commonly occurs following skin cancer resections. In particular, the cosmetic outcome of skin graft reconstructions, following epidermoidal carcinoma removal, is generally poor due to ...

    Authors: Emilia Migliano, Barbara Bellei, Flavio Andrea Govoni, Stefania Bucher and Mauro Picardo
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:23
  22. Authors: Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:22

    The original article was published in Journal of Experimental & Clinical Cancer Research 2010 29:135

  23. Sunitinib alone exhibits satisfactory efficacy in several mouse homografts and xenografts but unsatisfactory efficacy in many kinds of solid tumors in clinic. Different from animals, receiving a diagnosis of c...

    Authors: Guo-Hua Deng, Jie Liu, Jie Zhang, Ying Wang, Xing-Chen Peng, Yu-Quan Wei and Yu Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:21
  24. Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence and mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive prop...

    Authors: Xiaobin Cui, Zhimin Zhao, Dong Liu, Tao Guo, Su Li, Jianming Hu, Chunxia Liu, Lan Yang, Yuwen Cao, Jinfang Jiang, Weihua Liang, Wei Liu, Shugang Li, Lianghai Wang, Lidong Wang, Wenyi Gu…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:20
  25. Considering previous result in Non-Small Cell Lung Cancer (NSCLC), we investigated in human cancer cells the role of PARP3 in the regulation of telomerase activity.

    Authors: Tamara Fernández-Marcelo, Cristina Frías, Irene Pascua, Carmen de Juan, Jacqueline Head, Ana Gómez, Florentino Hernando, Jose-Ramon Jarabo, Eduardo Díaz-Rubio, Antonio-Jose Torres, Michèle Rouleau, Manuel Benito and Pilar Iniesta
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:19
  26. The chaperon heat shock protein 90 (HSP90) constitutes an important target for anti-tumor therapy due to its essential role in the stabilization of oncogenes. However, HSP90 is ubiquitously active to orchestra...

    Authors: Stefanie Trojandt, Angelika B Reske-Kunz and Matthias Bros
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:16
  27. Over the last decades, billions have been spent and huge efforts have been taken in basic and clinical cancer research [CA Cancer J Clin 63: 11-30]. About a decade ago, the arms race between drugs and cancer cell...

    Authors: Niels Eckstein, Lea Röper, Bodo Haas, Henrike Potthast, Ulrike Hermes, Christoph Unkrig, Frauke Naumann-Winter and Harald Enzmann
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:15
  28. NAD (P) H: quinone oxidoreductase 1 (NQO1) is a xenobiotic metabolizing enzyme that detoxifies chemical stressors and antioxidants, providing cytoprotection in normal tissues. However, high-level expression of...

    Authors: Yang Yang, Yan Zhang, Qunying Wu, Xuelian Cui, Zhenhua Lin, Shuangping Liu and Liyan Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:14
  29. Colorectal cancer is the third most commonly diagnosed cancer worldwide. Although surgery remains the best treatment for this disease, adjuvant chemotherapy and radiotherapy are also very important in clinical...

    Authors: Xiaoyu Wu, Wentao Liu, Qinhong Cao, Che Chen, Zhiwei Chen, Zhe Xu, Weisu Li, Fukun Liu and Xuequan Yao
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:13
  30. miRNAs are involved in osteosarcoma (OS) chemoresistance, and TWIST reportedly enhances cisplatin-induced OS cell apoptosis by inhibiting multiple signaling pathways. In this study, we profiled miRNAs differen...

    Authors: Yong Zhou, Zufa Huang, Song Wu, Xiaofang Zang, Min Liu and Jian Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:12
  31. Cholangiocarcinoma (CCA) is highly resistant to most of the known chemotherapeutic treatments. NAD(P)H-quinone oxidoreductase 1 (NQO1) is an antioxidant/detoxifying enzyme recently recognized as an important c...

    Authors: Ponsilp Zeekpudsa, Veerapol Kukongviriyapan, Laddawan Senggunprai, Banchob Sripa and Auemduan Prawan
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:11
  32. ErbB4 expression has been noted in various tumors, but its regulatory mechanism in esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to investigate whether miR-302b regulates...

    Authors: Mingxin Zhang, Qi Yang, Lingmin Zhang, Suna Zhou, Wenguang Ye, Qinglin Yao, Zongfang Li, Cheng Huang, Qinsheng Wen and Jingjie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:10
  33. Glioblastoma multiforme (GBM) is the most malignant type of glioma. Integrated classification based on mRNA expression microarrays and whole–genome methylation subdivides GBM into five subtypes: Classical, Mes...

    Authors: Rui Li, Kaiming Gao, Hui Luo, Xiefeng Wang, Yan Shi, Qingsheng Dong, WenKang Luan and Yongping You
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:9
  34. c-Jun NH2-terminal kinases (JNKs) are strongly activated by a stressful cellular environment, such as chemotherapy and oxidative stress. Autophagy is a protein-degradation system in which double-membrane vacuo...

    Authors: Guang Jia, Rui Kong, Zhi-Bin Ma, Bing Han, Yong-Wei Wang, Shang-Ha Pan, Ying-Hua Li and Bei Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:8
  35. The mechanism for inactivation of positive regulatory domain containing I (PRDM1), a newly identified tumour suppressor gene in extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT) has not been well defined....

    Authors: Li Liang, Lin Nong, Shuang Zhang, Jing Zhao, Hongjuan Ti, Ying Dong, Bo Zhang and Ting Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:7
  36. Hec1 (NDC80) is an integral part of the kinetochore and is overexpressed in a variety of human cancers, making it an attractive molecular target for the design of novel anticancer therapeutics. A highly potent...

    Authors: Lynn YL Huang, Ying-Shuan Lee, Jiann-Jyh Huang, Chia-chi Chang, Jia-Ming Chang, Shih-Hsien Chuang, Kuo-Jang Kao, Yung-Jen Tsai, Pei-Yi Tsai, Chia-Wei Liu, Her-Sheng Lin and Johnson YN Lau
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:6
  37. EGFR mutation detection has been widely applied in the prediction of TKIs therapy in Non-Small Cell Lung Cancer (NSCLC). Metastatic tumors rather than primary tumors were usually assayed for those patients in ...

    Authors: Bing Wei, Ke Yang, Jiuzhou Zhao, Yuxi Chang, Zihui Ma, Bing Dong, Yongjun Guo and Jie Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:5
  38. Colorectal cancer (CRC) arises as a consequence of genetic events such as gene mutation and epigenetic alteration. The aim of this study was to identify new hypermethylated candidate genes and methylation-base...

    Authors: Ji Wook Moon, Soo Kyung Lee, Jung Ok Lee, NamI Kim, Yong Woo Lee, Su Jin Kim, Ho Jin Kang, Jin Kim, Hyeon Soo Kim and Sun-Hwa Park
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:4
  39. Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate cancer stem cells such as leukemia stem cells, prostate tumor-initiating cells and so on. However, the mec...

    Authors: Xiaofei Zhao, Xiangguo Liu and Ling Su
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:3
  40. Gastric cancers have poor overall survival despite recent advancements in early detection methods, endoscopic resection techniques, and chemotherapy treatments. Vaccinia viral therapy has had promising therape...

    Authors: Kyong-Hwa Jun, Sepideh Gholami, Tae-Jin Song, Joyce Au, Dana Haddad, Joshua Carson, Chun-Hao Chen, Kelly Mojica, Pat Zanzonico, Nanhai G Chen, Qian Zhang, Aladar Szalay and Yuman Fong
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:2
  41. Several studies evaluated the prevalence of Lynch Syndrome (LS) in young onset colorectal cancer (CRC) patients and the results were extremely variable (5%-20%). Immunohistochemistry (IHC) for MMR proteins and...

    Authors: Vittoria Stigliano, Lupe Sanchez-Mete, Aline Martayan, Maria Diodoro, Beatrice Casini, Isabella Sperduti and Marcello Anti
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:1
  42. To assess the efficacy of intraoperative ultrasound-guided implantation of 125I seeds for the treatment of unresectable pancreatic carcinoma, and analyze the associated prognostic factors.

    Authors: Hao Wang, Junjie Wang, Yuliang Jiang, Jinna Li, Suqing Tian, Weiqiang Ran, Dianrong Xiu and Yang Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:106
  43. Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer. The purpose...

    Authors: Dong Yang, Min-Bin Chen, Li-Qiang Wang, Lan Yang, Chao-Ying Liu and Pei-Hua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:105
  44. Genome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) that located in the 8q24 was discovered. Single nu...

    Authors: Lijuan Li, Ruifen Sun, Yundan Liang, Xinmin Pan, Zhaohui Li, Peng Bai, Xiaofeng Zeng, Dongxian Zhang, Lin Zhang and Linbo Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:104
  45. To investigate the feasibility of dose escalation (86 Gy at 2 Gy/fraction) with intensity modulated radiation therapy (IMRT) in intermediate-risk prostate cancer without androgen deprivation therapy.

    Authors: Maria Grazia Petrongari, Valeria Landoni, Biancamaria Saracino, Sara Gomellini, Stefano Arcangeli, Giuseppe Iaccarino, Paola Pinnarò, Giorgio Arcangeli and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:103
  46. Both BRCA1 and epidermal growth factor receptor (EGFR) play a critical role in ovarian cancer progression. However, the crosstalk between BRCA1 and EGFR signaling pathways in ovarian cancer remains largely unk...

    Authors: Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Chun-Yan Li and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:102
  47. Recently, leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), a negative regulator of EGFR, was discovered is a novel agent for suppressing bladder cancer. The aim of this study was to investigate ...

    Authors: Lei Chang, Runlin Shi, Tao Yang, Fan Li, Guohao Li, Yonglian Guo, Bin Lang, Weimin Yang, Qianyuan Zhuang and Hua Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:101
  48. Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. The present treatment including surgery, chemotherapy and radiation, which have only 40% long-term cure rates, and usually cause tum...

    Authors: Xiao-Hong Tian, Wei-Jian Hou, Yan Fang, Jun Fan, Hao Tong, Shu-Ling Bai, Qu Chen, He Xu and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:100

Annual Journal Metrics

  • 2022 Citation Impact
    11.3 - 2-year Impact Factor
    11.5 - 5-year Impact Factor
    1.870 - SNIP (Source Normalized Impact per Paper)
    2.413 - SJR (SCImago Journal Rank)

    2023 Speed
    4 days submission to first editorial decision for all manuscripts (Median)
    100 days submission to accept (Median)

    2023 Usage 
    3,003,080 downloads
    3,022 Altmetric mentions