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  1. Epithelial–mesenchymal transition (EMT) contributes to the progression and metastasis of cancer cells and is associated with a more invasive phenotype of cancer. The Wnt/β-catenin signaling pathway is one of t...

    Authors: Lisha Qi, Baocun Sun, Zhiyong Liu, Runfen Cheng, Yixian Li and Xiulan Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:107
    Content type: Research article Published on:

  2. The optimal laboratory assay for detecting KRAS mutations in different biospecimens from patients with metastatic colorectal cancer (mCRC), and the clinical relevance of these gene alterations is still in questio...

    Authors: Jian-Ming Xu, Xiao-Jing Liu, Fei-Jiao Ge, Li Lin, Yan Wang, Manish R Sharma, Ze-Yuan Liu, Stefania Tommasi and Angelo Paradiso
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:104
    Content type: Research Published on:

  4. Intrahepatic cholangiocarcinoma (IHCC) is the second most frequent primary malignant liver tumor following hepatocellular carcinoma. It is a highly fatal disease and has few therapeutics. The CXC chemokine lig...

    Authors: Shengqiang Zhao, Jing Wang and Chengyong Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:103
    Content type: Research Published on:

  5. Increasing evidences have documented that microRNAs (miRNAs) act as oncogenes or tumor suppressors in gastric cancer (GC). In this study, we aimed to investigate the expression of miR-133b in a large number of...

    Authors: Lihua Guo, Hua Bai, Dongling Zou, Tao Hong, Jie Liu, Jiaqiang Huang, Pengfei He, Qi Zhou and Jinsheng He
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:99
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:220

  6. The ubiquitous second messenger Ca2+ has been demonstrated to play an important role in cancer progression. Store-operated Ca2+ entry (SOCE) is the main Ca2+ entry pathway regulating intracellular Ca2+ concentrat...

    Authors: Meng Zhu, Lei Chen, Pengfei Zhao, Hua Zhou, Chen Zhang, Shengping Yu, Yu Lin and Xuejun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:98
    Content type: Research Published on:

  7. SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis in many cancers, but their association with survival in breast cancer has not been determined. The purpose of this study was to asses...

    Authors: Yu-Wen Cao, Wen-Qin Li, Guo-Xing Wan, Yi-Xiao Li, Xiao-Ming Du, Yu-Cong Li and Feng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:97
    Content type: Research Published on:

  8. Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosi...

    Authors: Francesco Maria Solivetti, Flora Desiderio, Antonino Guerrisi, Antonio Bonadies, Carlo Ludovico Maini, Simona Di Filippo, Valerio D’Orazi, Isabella Sperduti and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:96
    Content type: Research Published on:

  9. The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signal...

    Authors: Shulin Zhang, Yi-Lin Yang, Yucheng Wang, Bin You, Yuyuan Dai, Geraldine Chan, David Hsieh, Il-Jin Kim, Li Tai Fang, Alfred Au, Hubert J Stoppler, Zhidong Xu, David M Jablons and Liang You
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:93
    Content type: Research Published on:

  10. There has been a “rising tide” in mastectomy utilization that can be attributed to more skin-sparing mastectomies (SSMs) performed concurrently with immediate breast reconstruction. We report our experience of...

    Authors: Roy De Vita, Ernesto Maria Buccheri, Marcello Pozzi and Giovanni Zoccali
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:78
    Content type: Research Published on:

  11. The mechanism behind poor survival of acute myeloid leukemia (AML) patients with 1-barabinofuranosylcytosine (Ara-C) based treatment remains unclear. This study aimed to assess the pharmacogenomic effects of A...

    Authors: Haixia Wan, Jianyi Zhu, Fangyuan Chen, Fei Xiao, Honghui Huang, Xiaofeng Han, Lu Zhong, Hua Zhong, Lan Xu, Beiwen Ni and Jihua Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:90
    Content type: Research Published on:

  12. Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing compounds with good safety profiles which have been investigated for their benefits and application in health and disease for more than fif...

    Authors: Afshin Amini, Samar Masoumi-Moghaddam, Anahid Ehteda and David Lawson Morris
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:92
    Content type: Research Published on:

  13. Breast cancer patients with positive estrogen receptor (ER) have a better prognosis. However, no prognostic miRNA signature was reported in the ER-positive breast cancer. The aim of the study was to identify a...

    Authors: Xin Zhou, Xiaping Wang, Zebo Huang, Lei Xu, Wei Zhu and Ping Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:94
    Content type: Research Published on:

  14. Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. H...

    Authors: Mingxu Guan, Gaetano Romano, Roberta Coroniti and Earl E Henderson
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:91
    Content type: Review Published on:

  15. Poor prognosis of medullary thyroid cancer (MTC) with suspicious ultrasound (US) features has been reported. The aim of the study was to investigate the association between preoperative US presentation and agg...

    Authors: Pierpaolo Trimboli, Luca Giovanella, Stefano Valabrega, Massimiliano Andrioli, Roberto Baldelli, Nadia Cremonini, Fabio Rossi, Leo Guidobaldi, Agnese Barnabei, Francesca Rota, Antonella Paoloni, Laura Rizza, Giorgio Fattorini, Maurizio Latini, Claudio Ventura, Paolo Falasca…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:87
    Content type: Research Published on:

  16. Identification of novel molecular biomarkers will improve the management of patients with gastric cancer (GC). Prenyl diphosphate synthase subunit 2 (PDSS2) is required for coenzyme Q10 biosynthesis and acts a...

    Authors: Mitsuro Kanda, Shuji Nomoto, Hisaharu Oya, Ryoji Hashimoto, Hideki Takami, Dai Shimizu, Fuminori Sonohara, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Kenta Murotani, Michitaka Fujiwara…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:88
    Content type: Research Published on:

  17. We aimed at investigating the outcomes of female patients with stage IIIB-IV adenocarcinoma of the lung according to EGFR and K-Ras mutational status.

    Authors: Virginia Rotella, Lorenzo Fornaro, Enrico Vasile, Carmelo Tibaldi, Laura Boldrini, Antonio Chella, Armida D'Incecco, Giovanna Cirigliano, Aldo Chioni, Cristiana Lupi, Elisa Sensi, Laura Ginocchi, Simona Giovannelli, Maria Cristina Pennucci, Gabriella Fontanini and Editta Baldini
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:77
    Content type: Research Published on:

  18. Resistance to Fas-mediated apoptosis limits the efficacy of currently available chemotherapy regimens. We identified CD74, which is known to be overexpressed in hematological malignancies, as one of the factor...

    Authors: Zuzana Berkova, Shu Wang, Xue Ao, Jillian F Wise, Frank K Braun, Abdol H Rezaeian, Lalit Sehgal, David M Goldenberg and Felipe Samaniego
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:80
    Content type: Research Published on:

  19. Many long non-coding RNAs(lncRNAs) have been found to be a good marker for several tumors. Using lncRNA-mining approach, we aimed to identify lncRNA expression signature that can predict breast cancer patient ...

    Authors: Jin Meng, Ping Li, Qing Zhang, Zhangru Yang and Shen Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:84
    Content type: Research Published on:

  20. The pentacyclic acridinium salt RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino [4,3,2-kl] acridinium methosulfate, compound 1) is one of the most interesting DNA G-quadruplex binding molecules due to its high eff...

    Authors: Angela Rizzo, Sara Iachettini, Pasquale Zizza, Chiara Cingolani, Manuela Porru, Simona Artuso, Malcolm Stevens, Marc Hummersone, Annamaria Biroccio, Erica Salvati and Carlo Leonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:81
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2015 34:9

  21. Unlike metastatic colorectal cancer (CRC) there are to date few reports concerning the predictive value of molecular biomarkers on the clinical outcome in stage II/III CRC patients receiving adjuvant chemother...

    Authors: Thomas Thomaidis, Annett Maderer, Andrea Formentini, Susanne Bauer, Mario Trautmann, Michael Schwarz, Wiebke Neumann, Jens Martin Kittner, Arno Schad, Karl-Heinrich Link, Johannes Wilhelm Rey, Arndt Weinmann, Arthur Hoffman, Peter Robert Galle, Marko Kornmann and Markus Moehler
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:83
    Content type: Research Published on:

  22. Human cancer cells can transfer signaling molecules to neighboring and distant cells predisposing them to malignant transformation. This process might contribute to tumor progression and invasion through deliv...

    Authors: Mohamed Abdouh, Shufeng Zhou, Vincenzo Arena, Manuel Arena, Anthoula Lazaris, Ronald Onerheim, Peter Metrakos and Goffredo Orazio Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:86
    Content type: Research Published on:

  23. We previously identified platelet-activating factor receptor (PAFR) as being overexpressed in ovarian cancer and found that its ligand PAF evoked EGFR phosphorylation using the phospho-antibody microarray. Epi...

    Authors: Yi Yu, Mingxing Zhang, Xiaoyan Zhang, Qingqing Cai, Zhiling Zhu, Wei Jiang and Congjian Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:85
    Content type: Research Published on:

  24. Previous studies investigating the association between EPHX1 polymorphisms (Tyr113His and His139Arg) and cancer risk have yielded inconsistent results. This meta-analysis was performed to derive a more precise...

    Authors: Xiaoqin Yang, Yubing Wang and Guiping Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:82
    Content type: Research Published on:

  26. MICA/B are major ligands for NK cell activating receptor NKG2D and previous studies showed that the serum level of soluble MICA (sMICA) is an independent prognostic factor for advanced human hepatocellular car...

    Authors: Liang Fang, Jiuyu Gong, Ying Wang, Rongrong Liu, Zengshan Li, Zhe Wang, Yun Zhang, Chunmei Zhang, Chaojun Song, Angang Yang, Jenny P -Y Ting, Boquan Jin and Lihua Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:76
    Content type: Research Published on:

  27. DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase I belongs to the family of poly(ADP-ribose)-binding proteins...

    Authors: Cinzia Tesauro, Grazia Graziani, Barbara Arnò, Laura Zuccaro, Alessia Muzi, Ilda D'Annessa, Elettra Santori, Lucio Tentori, Carlo Leonetti, Paola Fiorani and Alessandro Desideri
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:71
    Content type: Research Published on:

  28. Recent evidence suggests that aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas including gastric cancer. Speckle-type PO...

    Authors: Chunyan Zeng, Yao Wang, Quqin Lu, Jiang Chen, Junyan Zhang, Tao Liu, Nonghua Lv and Shiwen Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:75
    Content type: Research Published on:

  29. Conventional Sanger sequencing reliably detects the majority of genetic mutations associated with hereditary cancers, such as single-base changes and small insertions or deletions. However, detection of genomi...

    Authors: Debora Mancini-DiNardo, Thaddeus Judkins, Nick Woolstenhulme, Collin Burton, Jeremy Schoenberger, Matthew Ryder, Adam Murray, Natalia Gutin, Aaron Theisen, Jayson Holladay, Jonathan Craft, Christopher Arnell, Kelsey Moyes and Benjamin Roa
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:74
    Content type: Research Published on:

  30. Prostate cancer gene expression marker 1 (PCGEM1) is a long non-coding RNA (lncRNA) overexpressed in prostate cancer (PCa) cells that promotes PCa initiation and progression, and protects against chemotherapy-ind...

    Authors: Jin-Hua He, Jing-zhi Zhang, Ze-Ping Han, Li Wang, Yu Bing Lv and Yu-Guang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:72
    Content type: Research Published on:

  31. LKB1, also known as STK11, is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. Recent studies have indicated that LKB1 is related to breast tumorigenesis and ...

    Authors: Juan Li, Jie Liu, Pingping Li, Xiaona Mao, Wenjie Li, Jin Yang and Peijun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:70
    Content type: Research Published on:

  32. Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to human disease including cancer. Previous miRNA microarray analysis illustrated that miR-320c is down-regulated in ...

    Authors: Xiao Wang, Jian Wu, Yiwei Lin, Yi Zhu, Xianglai Xu, Xin Xu, Zhen Liang, Shiqi Li, Zhenghui Hu, Xiangyi Zheng and Liping Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:69
    Content type: Research Published on:

  33. Neoadjuvant treatment plays a crucial role in the therapy of advanced esophageal cancer. However, response to radiochemotherapy varies widely. Proton pump inhibitors (PPIs) have been demonstrated to impact on ...

    Authors: Kirsten Lindner, Christiane Borchardt, Maren Schöpp, Anja Bürgers, Christian Stock, Damian J Hussey, Jörg Haier and Richard Hummel
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:73
    Content type: Research Published on:

  34. The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and R...

    Authors: Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran and Chun-Meng Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:64
    Content type: Review Published on:

  35. PCDH8 is a novel tumor suppressor gene, and frequently inactivated by promoter methylation in human cancers. However, there is little information regarding PCDH8 methylation in non-muscle invasive bladder canc...

    Authors: Ying-Li Lin, Yan-Ling Wang, Jian-Guo Ma and Wen-Ping Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:68
    Content type: Research Published on:

  36. Laparoscopic prostatectomy (LRP) may activate clotting system influencing the risk of perioperative thrombosis in patients with prostate cancer. Moreover, different anaesthetic techniques can also modify coagu...

    Authors: Maria Sofra, Anna Antenucci, Michele Gallucci, Chiara Mandoj, Rocco Papalia, Claudia Claroni, Ilaria Monteferrante, Giulia Torregiani, Valeria Gianaroli, Isabella Sperduti, Luigi Tomao and Ester Forastiere
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:63
    Content type: Research Published on:

  37. The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers. The discovery of tumor associated miRNAs in serum of patients supported ...

    Authors: Yougang Feng, Jun Liu, Yongming Kang, Yue He, Bo Liang, Ping Yang and Zhou Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:67
    Content type: Research Published on:

  38. Gastric cancer (GC) remains to have a poor prognosis via diverse process of cancer progression. Dihydropyrimidinase-like 3 (DPYSL3) is a cell adhesion molecule that has been reported to be involved in the metasta...

    Authors: Mitsuro Kanda, Shuji Nomoto, Hisaharu Oya, Dai Shimizu, Hideki Takami, Soki Hibino, Ryoji Hashimoto, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara and Yasuhiro Kodera
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:66
    Content type: Research Published on:

  39. Epigenetic alterations of specific genes have been reported to be related to colorectal cancer (CRC) transformation and would also appear to be involved in the early stages of colorectal carcinogenesis. Little...

    Authors: Claudia Rengucci, Giulia De Maio, Andrea Casadei Gardini, Mattia Zucca, Emanuela Scarpi, Chiara Zingaretti, Giovanni Foschi, Maria Maddalena Tumedei, Chiara Molinari, Luca Saragoni, Maurizio Puccetti, Dino Amadori, Wainer Zoli and Daniele Calistri
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:65
    Content type: Research Published on:

  40. Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and surviva...

    Authors: Samantha Kaufhold and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:62
    Content type: Review Published on:

  41. Karyopherin alpha 2 (KPNA2) promotes tumor growth in hepatocellular carcinoma (HCC). We aimed to determine the content and clinical significance of mechanism underlying.

    Authors: Zhe-yuan Hu, Sheng-xian Yuan, Yuan Yang, Wei-ping Zhou and Hua Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:61
    Content type: Research Published on:

  42. Enhancer of zeste homolog 2 (EZH2), a member of the polycomb group proteins, has been shown to promote cancer progression and breast cancer stem cell (CSC) expansion. Breast CSCs are associated with resistance...

    Authors: Bisrat G Debeb, Yun Gong, Rachel L Atkinson, Nour Sneige, Lei Huo, Ana Maria Gonzalez-Angulo, Mien-Chie Hung, Vicente Valero, Naoto T Ueno and Wendy A Woodward
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:58
    Content type: Research Published on:

  43. Serous tubal intraepithelial carcinoma (STIC) and the p53 signature in tubal mucosa have been supported to be precursor lesions in high-grade serous carcinoma (HGSC) of the fallopian tube, ovary, and peritoneu...

    Authors: Yiying Wang, Lingmin Li, Yue Wang, Zeng Yuan, Wenjing Zhang, Kenneth D Hatch and Wenxin Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:60
    Content type: Research Published on:

  44. Local hyperthermia of tumor in conjunction with chemotherapy is a promising strategy for cancer treatment. The aim of this study was to evaluate the efficacy of intratumoral delivery of clinically approved mag...

    Authors: Min Jeong Jeon, Cheol-Hee Ahn, Hyeonjin Kim, In Jae Chung, Seulhee Jung, Young-Hwa Kim, Hyewon Youn, Jin Wook Chung and Young Il Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:57
    Content type: Research Published on:

  45. To study the expression of D2R, MGMT and VEGF for clinical significance in pituitary adenomas, and to predict the potential curative medical therapy of dopamine agonists, temozolomide and bevacizumab on pituit...

    Authors: Youwei Wang, Junyang Li, Mamatemin Tohti, Yuebing Hu, Sheng Wang, Wanchun Li, Zhenfeng Lu and Chiyuan Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:56
    Content type: Research Published on:

  46. Previous studies have shown that class-I histone deacetylase (HDAC) 8 mRNA is upregulated in urothelial cancer tissues and urothelial cancer cell lines compared to benign controls. Using urothelial cancer cell...

    Authors: Maria Lehmann, Michèle J Hoffmann, Annemarie Koch, Scott M Ulrich, Wolfgang A Schulz and Günter Niegisch
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:59
    Content type: Research Published on:

  47. To understand the involvement of structural maintenance of chromosome 4 (SMC4) in the development and progression of hepatocellular carcinoma (HCC).

    Authors: Bo Zhou, Hongxu Chen, Dong Wei, Yi Kuang, Xiaobiao Zhao, Guangyao Li, Jun Xie and Ping Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:55
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:223

  48. microRNAs (miRNAs) are a class of small non-coding RNAs that play important roles in carcinogenesis. In the present study, we investigated the effect of miR-212 on pancreatic ductal adenocarcinoma (PDAC) and i...

    Authors: Chenchao Ma, Kate Nong, Bo Wu, Bo Dong, Yueqing Bai, Hongda Zhu, Weiwei Wang, Xinyu Huang, Zhou Yuan and Kaixing Ai
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:54
    Content type: Research Published on:

  49. Nasopharyngeal carcinoma (NPC) is a common malignant tumor observed in the populations of southern China and Southeast Asia. However, little is known about the effects of purinergic signal on the behavior of N...

    Authors: Guang Yang, Shenghong Zhang, Yanling Zhang, Qiming Zhou, Sheng Peng, Tao Zhang, Changfu Yang, Zhenyu Zhu and Fujun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:53
    Content type: Research Published on:

  50. Although the EGF receptor tyrosine kinase inhibitors (EGFR-TKI) gefitinib have shown dramatic effects against EGFR mutant lung cancer, patients become resistant by various mechanisms, including gatekeeper EGFR-T7...

    Authors: Yiqing Qu, Xiuxiu Wu, Yunhong Yin, Yan Yang, Dedong Ma and Hao Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:52
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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