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  1. Renal cell carcinoma (RCC), the most common malignancy of the kidney, is refractory to standard therapy and has an incidence that continues to rise. Screening of plant extracts in search of new agents to treat...

    Authors: Richard T Williams, Alice L Yu, Mitchell B Diccianni, Emmanuel A Theodorakis and Ayse Batova
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:57
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:95

  2. Nucleobindin 2 (NUCB2) abnormal expression has been reported in gastric cancer and breast cancer. However, the role of NUCB2 in prostate cancer (PCa) remains unclear. The aim of the present study was to invest...

    Authors: Hongtuan Zhang, Can Qi, Liang Li, Fei Luo and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:56
    Content type: Research Published on:

  3. Neuroepithelial Transforming Gene 1 (NET1) is a well characterised oncoprotein and a proven marker of an aggressive phenotype in a number of cancers, including gastric adenocarcinoma. We aimed to investigate w...

    Authors: Conor Lahiff, Eoin Cotter, Rory Casey, Peter Doran, Graham Pidgeon, John Reynolds, Padraic MacMathuna and David Murray
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:55
    Content type: Research Published on:

  4. The prognostic value of metastasis-associated gene 1 (MTA1) in nasopharyngeal carcinoma (NPC) has been suggested. However, there is still no direct evidence that MTA1 promotes NPC growth in vivo. In this study...

    Authors: Qingcui Song, Hong Zhang, Min Wang, Wen Song, Min Ying, Yuan Fang, Yiyi Li, Yilan Chao and Xiaoxia Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:54
    Content type: Research Published on:

  5. The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relati...

    Authors: Yan Lin, Changjun Wang, Ying Zhong, Xin Huang, Li Peng, Guangliang Shan, Ke Wang and Qiang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:53
    Content type: Research Published on:

  6. RABEX-5, a guanine nucleotide exchange factor (GEF) for RAB-5, plays an important role in cell mobility and altered expression associated with tumor metastasis. This study aimed to investigate the role of RABE...

    Authors: Xiang Zhang, Jie Min, Yingjian Wang, Yan Li, Hongzhong Li, Qiang Liu, Xinjie Liang, Peng Mu and Hongyuan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:52
    Content type: Research Published on:

  7. It is well documented that cancer cells secrete angiogenic factors to recruit and sustain tumor vascular networks. However, little is known about the effects of endothelial cells on the behavior of tumor cells...

    Authors: Yao-Hui Wang, Yin-Ying Dong, Wei-Min Wang, Xiao-Ying Xie, Zhi-Ming Wang, Rong-Xin Chen, Jie Chen, Dong-Mei Gao, Jie-Feng Cui and Zheng-Gang Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:51
    Content type: Research Published on:

  8. Epidermal growth factor receptor (EGFR)-activating mutations are major determinants in predicting the tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC). Noninvasive test for ...

    Authors: Hye-Ryoun Kim, Sung Yong Lee, Dae-Sung Hyun, Min Ki Lee, Hyun-Kyung Lee, Chang-Min Choi, Sei-Hoon Yang, Young-Chul Kim, Yong Chul Lee, Sun Young Kim, Seung Hun Jang, Jae Cheol Lee and Kye Young Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:50
    Content type: Research Published on:

  9. Currently, no clearly superior management strategy exists for recurrent, platinum-resistant ovarian cancer. We tested the efficacy and safety of gemcitabine combined with oxaliplatin (GEMOX) in a multicentre p...

    Authors: Patrizia Vici, Domenico Sergi, Laura Pizzuti, Luciano Mariani, Maria Grazia Arena, Maddalena Barba, Marcello Maugeri-Saccà, Cristina Vincenzoni, Enrico Vizza, Giacomo Corrado, Giancarlo Paoletti, Federica Tomao, Silverio Tomao, Diana Giannarelli and Luigi Di Lauro
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:49
    Content type: Research Published on:

  10. In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in...

    Authors: Federica Tomao, Anselmo Papa, Luigi Rossi, Martina Strudel, Patrizia Vici, Giuseppe Lo Russo and Silverio Tomao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:48
    Content type: Review Published on:

  11. Completion lymph node dissection (CLND) is the gold standard treatment for patients with a positive sentinel lymph node (SLN) biopsy. Considering the morbidity associated with CLND it is important to identify ...

    Authors: Emilia Migliano, Barbara Bellei, Flavio Andrea Govoni, Giovanni Paolino, Caterina Catricalà, Stefania Bucher and Pietro Donati
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:47
    Content type: Research Published on:

  12. Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been cl...

    Authors: Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Hiroshi Okumura, Hiroshi Kurahara, Yasuto Uchikado, Tetsuro Setoyama, Yoshiaki Kita, Yuko Kijima, Yuka Nishizono, Akihiro Nakajo, Tetsuro Owaki, Shinichi Ueno and Shoji Natsugoe
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:46
    Content type: Research Published on:

  13. Osteopontin (OPN) plays important roles in the modulation of apoptosis, angiogenesis, immune response, and tumor invasion. Elevated osteopontin expression has been reported in the lung cancer tissues compared ...

    Authors: Yunzhen Chen, Haichun Liu, Wenliang Wu, Yi Li and Jianmin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:45
    Content type: Research Published on:

  14. Colonoscopy is widely regarded to be the gold standard for colorectal cancer (CRC) detection. Recent studies, however, suggest that the effectiveness of colonoscopy is mostly confined to tumors on the left sid...

    Authors: Samuel Chao, Jay Ying, Gailina Liew, Wayne Marshall, Choong-Chin Liew and Robert Burakoff
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:44
    Content type: Research Published on:

  15. N-Acetyl-Cysteine (NAC), a natural sulfur-containing amino acid derivative, and peroxisome proliferators activated receptor alpha (PPARα) ligand have been shown to have anticancer properties. However, the mech...

    Authors: Swei Sunny Hann, Fang Zheng and Shunyu Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:43
    Content type: Research Published on:

  17. Glioblastoma is the most common type of primary brain tumors. Cisplatin is a commonly used chemotherapeutic agent for Glioblastoma patients. Despite a consistent rate of initial responses, cisplatin treatment ...

    Authors: Yong Guo, Kuipo Yan, Jiasheng Fang, Qiang Qu, Ming Zhou and Fenghua Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:41
    Content type: Research Published on:

  18. Pegvisomant (PEGV) is widely used, alone or with somatostatin analogs (SSA), for GH-secreting pituitary tumors poorly controlled by SSAs alone. No information is available on specific indications for or relati...

    Authors: Antonio Bianchi, Ferdinando Valentini, Raffaella Iuorio, Maurizio Poggi, Roberto Baldelli, Marina Passeri, Antonella Giampietro, Linda Tartaglione, Sabrina Chiloiro, Marialuisa Appetecchia, Patrizia Gargiulo, Andrea Fabbri, Vincenzo Toscano, Alfredo Pontecorvi and Laura De Marinis
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:40
    Content type: Research Published on:

  19. Previous evidence has shown that the FOXP3 gene was involved in the pathogenesis of several tumors; however, the correlation between single nucleotide polymorphisms (SNPs) in the FOXP3 gene and the susceptibil...

    Authors: YanHui Chen, HengHui Zhang, WeiJia Liao, JinXue Zhou, GaiXia He, XingWang Xie, Ran Fei, LiLing Qin, Lai Wei and HongSong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:39
    Content type: Research Published on:

  20. Saquinavir, a protease inhibitor utilized in HIV infection, shows antitumor activity in various experimental models. In previous studies performed in our laboratory the drug was found to induce a substantial i...

    Authors: Riccardo Adamo, Alessandro Comandini, Angelo Aquino, Laura Bonmassar, Loredana Guglielmi, Enzo Bonmassar and Ornella Franzese
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:38
    Content type: Research Published on:

  21. Pulmonary carcinoma is the main cause of malignant pleural effusions (MPEs). However, there is no satisfactory marker for diagnosing MPEs caused by pulmonary carcinoma. The purpose of this study is to assess t...

    Authors: Ying Tang and Lijun Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:37
    Content type: Research Published on:

  22. This study investigates the expression of Lewis y antigen, integrin αv, β3 in epithelial ovarian cancer tissues. We further evaluate the relationship between their expression and chemotherapy resistance of ova...

    Authors: Jian Gao, Zhenhua Hu, Dawo Liu, Juanjuan Liu, Chuan Liu, Rui Hou, Song Gao, Danye Zhang, Shulan Zhang and Bei Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:36
    Content type: Research Published on:

  23. Ankyrin repeat domain 12 (ANKRD12), is encoding a 224 kDa nuclear protein and most conserved at its N-terminal ankyrin repeats region and the C-terminal co-activator interacting domain. The aim of this study w...

    Authors: Rui Bai, Dan Li, Zhong Shi, Xuefeng Fang, Weiting Ge and Shu Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:35
    Content type: Research Published on:

  24. The use of [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for detection of gastric cancer is often debated because FDG uptake varies for each patient. The purpose of this study was to ...

    Authors: Ryusuke Takebayashi, Kunihiko Izuishi, Yuka Yamamoto, Reiko Kameyama, Hirohito Mori, Tsutomu Masaki and Yasuyuki Suzuki
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:34
    Content type: Research Published on:

  25. The metastasis-associated gene 1 (MTA1) has been identified as one critical regulator of tumor metastasis. Previously, we identified miR-125b as a downregualted miRNA in non-small cell lung cancer (NSCLC) cell...

    Authors: Yiyi Li, Yilan Chao, Yuan Fang, Jian Wang, Min Wang, Hong Zhang, Min Ying, Xiaoxia Zhu and Haofei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:33
    Content type: Research Published on:

  26. To observe the influence of combination treatment with glibenclamide and CoCl2 on the growth and invasiveness of TA2 breast cancer, and to detect the protein and mRNA expression of MMP9.

    Authors: Zhe Rong, Li Li, Fei Fei, Lailong Luo and Yang Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:32
    Content type: Research Published on:

  27. Anticancer activities of cinnamic acid derivatives include induction of apoptosis by irreversible DNA damage leading to cell death. The present work aimed to compare the cytotoxic and genotoxic potential of ci...

    Authors: Evandro Luís de Oliveira Niero and Gláucia Maria Machado-Santelli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:31
    Content type: Research Published on:

  28. Several reports have described the potential effects of natural compounds as anti-cancer agents in vitro as well as in vivo. The aim of this study was to evaluate the anti-cancer effect of Limoniastrum guyonianum

    Authors: Mounira Krifa, Mahmoud Alhosin, Christian D Muller, Jean-Pierre Gies, Leila Chekir-Ghedira, Kamel Ghedira, Yves Mély, Christian Bronner and Marc Mousli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:30
    Content type: Research Published on:

  29. E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC).

    Authors: Min-Li Mo, Zhao Chen, Hai-Meng Zhou, Hui Li, Tomomi Hirata, David M Jablons and Biao He
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:29
    Content type: Research Published on:

  30. Previous reports have suggested that malignant transformations originate from adult stem cells, and may thus express the stem-cell-associated markers. The purpose of this study is to investigate the differenti...

    Authors: Laodong Li, Huina Yu, Xiaoyang Wang, Jinrong Zeng, Dangyu Li, Jingyan Lu, Changming Wang, Jiying Wang, Jianghong Wei, Ming Jiang and Biwen Mo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:28
    Content type: Research Published on:

  31. Medulloblastoma (MB) is the most common malignant brain tumor in childhood with a 5-year survival of approximately 60%. We have recently shown that treatment of human MB cells with 5-aza-2’-deoxycytidine (5-az...

    Authors: Ina Patties, Rolf-Dieter Kortmann and Annegret Glasow
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:27
    Content type: Research Published on:

  33. The aim of the study was to evaluate predictive and prognostic significance of microtubule-associated protein Tau in epithelial ovarian cancer (EOC) patients treated with paclitaxel and platinum-based chemothe...

    Authors: Marta Smoter, Lubomir Bodnar, Bartlomiej Grala, Rafal Stec, Krystyna Zieniuk, Wojciech Kozlowski and Cezary Szczylik
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:25
    Content type: Research Published on:

  34. Tumors are diseases characterized by uncontrolled cell growth and, in spite of the progress of medicine over the years, continue to represent a major threat to the health, requiring new therapies. Several synt...

    Authors: Carmen Petronzi, Michela Festa, Antonella Peduto, Maria Castellano, Jessica Marinello, Antonio Massa, Anna Capasso, Giovanni Capranico, Annalisa La Gatta, Mario De Rosa, Michele Caraglia and Rosanna Filosa
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:24
    Content type: Research Published on:

  35. Diagnostic imaging plays a relevant role in the care of patients with breast cancer (BC). Positron Emission Tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (FDG) has been widely proven to be a clinical tool...

    Authors: Valentina Bravatà, Alessandro Stefano, Francesco P Cammarata, Luigi Minafra, Giorgio Russo, Stefania Nicolosi, Sabina Pulizzi, Cecilia Gelfi, Maria C Gilardi and Cristina Messa
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:23
    Content type: Research Published on:

  37. Peritumoral activated hepatic stellate cells (HSCs) are versatile myofibroblast-like cells closely related with hepatocellular carcinoma (HCC) progression. So far, comprehensive comparison of gene expression o...

    Authors: Rui Liao, Han Wu, Yong Yi, Jia-Xing Wang, Xiao-Yan Cai, Hong-Wei He, Yun-Feng Cheng, Jian Zhou, Jia Fan, Jian Sun and Shuang-Jian Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:22
    Content type: Research Published on:

  38. Growing evidences indicate microRNAs play important roles in cancer development, progression, metastasis and may constitute robust biomarkers for cancer prognosis. The aim of this study was to identify the cli...

    Authors: Ming-Qi Fan, Chi-Bing Huang, Yan Gu, Ya Xiao, Jin-Xin Sheng and Lin Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:21
    Content type: Research Published on:

  39. Depletion of calcium (Ca2+) from the endoplasmic reticulum (ER) activates the ubiquitous store-operated Ca2+ entry (SOCE) pathway which sustains long-term Ca2+ signals and is critical for cellular functions. Stro...

    Authors: Guilin Li, Zhenxing Zhang, Renzhi Wang, Wenbin Ma, Ying Yang, Junji Wei and Yanping Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:20
    Content type: Research Published on:

  40. Toll-like receptor (TLR) agonists have important properties that can be exploited for immunotherapy against tumors. Locally injected immunostimulatory oligodeoxynucleotides containing CpG motifs (CpG-ODNs), wh...

    Authors: Rym Ben Abdelwahed, Jérémie Cosette, Sabrina Donnou, Lucile Crozet, Hanane Ouakrim, Wolf Herman Fridman, Catherine Sautès-Fridman, Aouni Mahjoub and Sylvain Fisson
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:18
    Content type: Research Published on:

  41. SOX7 is a transcription factor belonging to the SOX family. Its role in lung cancer is unknown.

    Authors: Takahide Hayano, Manoj Garg, Dong Yin, Makoto Sudo, Norihiko Kawamata, Shuo Shi, Wenwen Chien, Ling-wen Ding, Geraldine Leong, Seiichi Mori, Dong Xie, Patrick Tan and H Phillip Koeffler
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:17
    Content type: Research Published on:

  42. We explore the clinical and prognostic significance of expression of vascular endothelial growth factor receptor (VEGFR)-2, platelet-derived growth factor receptor (PDGFR)-β, and c-Met in patients with hepatoc...

    Authors: Jie Sheng Chu, Fei Jiao Ge, Bo Zhang, Yan Wang, Nicola Silvestris, Lie Jun Liu, Chuan Hua Zhao, Li Lin, Anna Elisabetta Brunetti, Ya Li Fu, Jun Wang, Angelo Paradiso and Jian Ming Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:16
    Content type: Research Published on:

  43. The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results wer...

    Authors: Yanlong Yang, Yuanliang Xie and Lei Xian
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:15
    Content type: Review Published on:

  44. Metabolic Syndrome (MS) has been correlated to breast carcinogenesis. MS is common in the general population (34%) and increases with age and body mass index. Although the link between obesity, MS and hormone ...

    Authors: Immacolata Capasso, Emanuela Esposito, Francesca Pentimalli, Maurizio Montella, Anna Crispo, Nicola Maurea, Massimiliano D’Aiuto, Alfredo Fucito, Maria Grimaldi, Ernesta Cavalcanti, Giuseppe Esposito, Giuseppe Brillante, Sergio Lodato, Tonino Pedicini, Giuseppe D’Aiuto, Gennaro Ciliberto…
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:14
    Content type: Research Published on:

  45. In a prospective multicenter phase II trial of radioembolization with yttrium-90 (90Y-RE) in chemorefractory liver-dominant metastatic colorectal cancer (mCRC), we showed that median survival was 12.6 months (95%...

    Authors: Elisa Melucci, Maurizio Cosimelli, Livio Carpanese, Giuseppe Pizzi, Francesco Izzo, Francesco Fiore, Rita Golfieri, Emanuela Giampalma, Isabella Sperduti, Cristiana Ercolani, Rosa Sciuto, Raffaello Mancini, Carlo Garufi, Maria Grazia Diodoro and Marcella Mottolese
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:13
    Content type: Research Published on:

  46. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies and tends to be relatively resistant to conventional therapies. Activated Ras oncogene mutations are found in up to 90% ...

    Authors: Niranjan Awasthi, Changhua Zhang, Stefan Hinz, Margaret A Schwarz and Roderich E Schwarz
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:12
    Content type: Research Published on:

  47. To investigate the role of HER-2/neu-mediated COX-2/P450arom signal in estrogen-dependent endometrial carcinoma.

    Authors: Shu Li, XiaoXin Ma, Li Ma, Cuicui Wang, YuanQi He and ZhiJuan Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:11
    Content type: Research Published on:

  48. Bladder transitional cell carcinoma greatly threatens human health all over the world. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows a strong apoptosis-inducing effect on a variety of c...

    Authors: Youguang Zhao, Ying Li, Liang Wang, Hang Yang, Qingtang Wang, Haiyan Qi, Shadan Li, Peng Zhou, Ping Liang, Qiwu Wang and Xiaowei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:10
    Content type: Research Published on:

  49. Although a previous meta-analysis reported no association between metabolic syndrome (MetS) and prostate cancer risk, a number of studies suggest that MetS may be associated with the aggressiveness and progres...

    Authors: Yu-zhu Xiang, Hui Xiong, Zi-lian Cui, Shao-bo Jiang, Qing-hua Xia, Yong Zhao, Guan-bin Li and Xun-bo Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:9
    Content type: Research Published on:

  50. MYST1 (also known as hMOF), a member of the MYST family of histone acetyltransferases (HATs) as an epigenetic mark of active genes, is mainly responsible for histone H4K16 acetylation in the cells. Recent stud...

    Authors: Yong Wang, Rui Zhang, Donglu Wu, Zhihua Lu, Wentao Sun, Yong Cai, Chunxi Wang and Jingji Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:8
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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