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  1. Progress in recent years strengthened the concept of cellular tumor vaccinations. However, a crucial barrier to successful cancer immunotherapy is tumor-mediated immunosuppression. Tumor-derived soluble factor...

    Authors: Alexander Shimabukuro-Vornhagen, Andreas Draube, Tanja M Liebig, Achim Rothe, Matthias Kochanek and Michael S von Bergwelt-Baildon
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:47
  2. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator. This study was ...

    Authors: Xiao-Fei Yin, Jie Chen, Wei Mao, Yu-Hong Wang and Min-Hu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:46
  3. Chloride intracellular channel 1 (CLIC1) is expressed ubiquitously in human tissues and is involved in the regulation of cell cycle, cell proliferation and differentiation. Recent studies have shown that CLIC1...

    Authors: Liang Wang, Shiming He, Yanyang TU, Peigang Ji, Jianhai Zong, Jingyu Zhang, Fuqiang Feng, Jipei Zhao, Yongsheng Zhang and Guodong Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:44
  4. Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This study exa...

    Authors: Astrid Escudero-Esparza, Wen G Jiang and Tracey A Martin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:43
  5. Previous studies suggested that estrogen receptor alpha (ERα) plays an important role in the chemoresistance of breast cancers. However, large random trials failed to demonstrate any benefit of the concurrent ...

    Authors: Zhinong Jiang, Junlan Guo, Jianguo Shen, Mei Jin, Shuduo Xie and Linbo Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:42
  6. Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis. This mechanism of apoptosis is poorly und...

    Authors: John R Hornick, Suwanna Vangveravong, Dirk Spitzer, Carmen Abate, Francesco Berardi, Peter Goedegebuure, Robert H Mach and William G Hawkins
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:41
  7. Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. VEGF is believed to implicate poor prognosis in various cancers. The overexpress...

    Authors: Lei Yang, Shuo You, Vikas Kumar, Chaoyue Zhang and Ya Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:40
  8. We have reported previously that overexpression of glucose-regulated protein 78 (GRP78) promotes the invasion of hepatocellular carcinoma. However, whether GRP78 knockdown affects the extracellular matrix degr...

    Authors: Hongdan Li, Huijuan Song, Junsheng Luo, Jia Liang, Song Zhao and Rongjian Su
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:39
  9. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of diseases, including various ty...

    Authors: Ruimin Ma, Tao Jiang and Xixiong Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:38
  10. Vascular endothelial growth factor (VEGF) plays a critical role in tumor angiogenesis. Bevacizumab is a humanized monoclonal antibody that neutralizes VEGF. We examined the impact on radiation response by bloc...

    Authors: Tien Hoang, Shyhmin Huang, Eric Armstrong, Jens C Eickhoff and Paul M Harari
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:37
  11. RNA binding motif 5 (RBM5) is a tumor suppressor gene that modulates apoptosis through the regulation of alternative splicing of apoptosis-related genes. This study aimed to detect RBM5 expression in non-small...

    Authors: Hong Liang, Jie Zhang, Chen Shao, Lijing Zhao, Wei Xu, Leslie C Sutherland and Ke Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:36
  12. Stanniocalcin-1 (STC-1) is a potential marker of disseminated tumor cells (DTCs). The aim of this study was to examine STC-1 expression in peripheral blood (PB) and bone marrow (BM) of esophageal squamous cell...

    Authors: Haizhu Song, Biao Xu and Jun Yi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:35
  13. This study was designed to establish a biomarker risk model for predicting bone metastasis in stage III non-small cell lung cancer (NSCLC).

    Authors: Zhen Zhou, Zhi-Wei Chen, Xiao-Hua Yang, Lan Shen, Xing-Hao Ai, Shun Lu and Qing-Quan Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:34
  14. To determine whether early monitoring of the effects of bevacizumab in patients with recurrent high-grade gliomas, by a Perfusion Computed Tomography (PCT), may be a predictor of the response to treatment asse...

    Authors: Antonello Vidiri, Andrea Pace, Alessandra Fabi, Marta Maschio, Gaetano Marco Latagliata, Vincenzo Anelli, Francesca Piludu, Carmine Maria Carapella, Giuseppe Giovinazzo and Simona Marzi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:33
  15. Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknow...

    Authors: Ricardo Ribeiro, Cátia Monteiro, Virgínia Cunha, Maria José Oliveira, Mariana Freitas, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vítor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Anabela Mota-Pinto, Carlos Lopes…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:32
  16. The role of B Lymphocyte Stimulator (BLyS) in the survival of malignant B cells and the maintenance of normal B cell development and homeostasis has been intensively studied in the literature. However, the inf...

    Authors: Jing Zhu, Li Sun, Sensen Lin, Renping Zhao, Liqiang Zhou, Dongdong Fang, Liang Chen, Jin Liu, Wenting Shi, Luyong Zhang and Shengtao Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:31
  17. The mitogen-activated protein kinase (MAPK) signaling pathway participates in several steps of tumour development and is considered a prominent therapeutic target for the design of chemotherapeutic agents. We ...

    Authors: Yoshitaka Fujimori, Mikito Inokuchi, Yoko Takagi, Keiji Kato, Kazuyuki Kojima and Kenichi Sugihara
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:30
  18. Response gene to complement-32 (RGC-32) is comprehensively expressed in many kinds of tissues and has been reported to be expressed abnormally in different kinds of human tumors. However, the role of RGC-32 in...

    Authors: Liang Zhu, Hua Qin, Pei-Yuan Li, Sheng-Nan Xu, Hui-Fang Pang, Hui-Zhen Zhao, De-Min Li and Qiu Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:29
  19. The exact mechanism of the effects of hypoxia on the proliferation and apoptosis in carcinoma cells is still conflicting. This study investigated the variation of hypoxia-inducible factor-1α(HIF-1α) expression...

    Authors: Zhi-Jun Dai, Jie Gao, Xiao-Bin Ma, Kun Yan, Xiao-Xu Liu, Hua-Feng Kang, Zong-Zheng Ji, Hai-Tao Guan and Xi-Jing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:28
  20. Pure curcumin has been reported to down-regulate the expression of WT1 in leukemic cells. However, the molecular mechanism underlying the down-regulation of WT1 by curcumin is not completely delineated. The pu...

    Authors: Shen-meng Gao, Jun-jun Yang, Chi-qi Chen, Jun-jie Chen, Li-ping Ye, Lu-yao Wang, Jian-bo Wu, Chong-yun Xing and Kang Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:27
  21. Osteopontin (OPN), also known as SPP1 (secreted phosphoprotein), is an integrin binding glyco-phosphoprotein produced by a variety of tissues. In cancer patients expression of OPN has been associated with poor...

    Authors: Farbod Shojaei, Nathan Scott, Xiaolin Kang, Patrick B Lappin, Amanda A Fitzgerald, Shannon Karlicek, Brett H Simmons, Aidong Wu, Joseph H Lee, Simon Bergqvist and Eugenia Kraynov
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:26
  22. The aim of this study was to investigate prognostic value of excision repair cross-complementing 1 (ERCC1), BCL2-associated athanogene (BAG-1), the breast and ovarian cancer susceptibility gene 1 (BRCA1), ribo...

    Authors: Xue-Feng Leng, Ming-Wu Chen, Lei Xian, Lei Dai, Guang-Yao Ma and Man-Hong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:25
  23. Xenografts have been shown to provide a suitable source of tumor tissue for molecular analysis in the absence of primary tumor material. We utilized ES xenograft series for integrated microarray analyses to id...

    Authors: Neda Mosakhani, Mohamed Guled, Gayle Leen, Silvia Calabuig-Fariñas, Tarja Niini, Isidro Machado, Suvi Savola, Katia Scotlandi, José Antonio López-Guerrero, Antonio Llombart-Bosch and Sakari Knuutila
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:24
  24. Multidrug resistance is one of the main impediments to the successful treatment of colon cancer. Glucosylceramide synthase (GCS) which is related to multidrug resistance (MDR) can reduce the level of ceramide ...

    Authors: Min Song, Weidong Zang, Baohua Zhang, Jing Cao and Guanrui Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:23
  25. The nucleosome binding protein 1 (HMGN5/NSBP1) is a member of the HMGN protein family and is highly expressed in several kinds of cancer. Nevertheless, the role of NSBP1 in clear cell renal cell carcinoma (ccR...

    Authors: Shi-Qi Ji, Lin Yao, Xiao-Yu Zhang, Xue-Song Li and Li-Qun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:22
  26. Authors: Xiangan Tu, Jintao Zhuang, Wenwei Wang, Liang Zhao, Liangyun Zhao, Jiquan Zhao, Chunhua Deng, Shaopeng Qiu and Yuanyuan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:21

    The original article was published in Journal of Experimental & Clinical Cancer Research 2011 30:105

  27. Sexual function in patients with breast cancer especially in younger patients is an important issue from clinical and psychosocial perspectives. This study aimed to assess sexual function among Iranian breast ...

    Authors: Iraj Harirchi, Ali Montazeri, Fereshteh Zamani Bidokhti, Nina Mamishi and Kazem Zendehdel
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:20
  28. Epithelial ovarian cancer (EOC) is one of the leading causes of cancer deaths in women worldwide. Adrenomedullin (AM) is a multifunctional peptide which presents in various kinds of tumors.

    Authors: Boya Deng, Siyang Zhang, Yuan Miao, Zhuang Han, Xiaoli Zhang, Fang Wen and Yi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:19
  29. Sex determining region Y (SRY)-related high mobility groupbox 9 (SOX9) is an important transcription factor required for development, which regulates the expression of target genes in the associated pathway. T...

    Authors: Chun-Hui Zhou, Li-Ping Ye, Shi-Xing Ye, Yan Li, Xin-Yin Zhang, Xin-Yu Xu and Li-Yun Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:18
  30. Immunoglobulin D multiple myeloma (MM) is rare and has a poorer prognosis than other MM isotypes.

    Authors: Francesco Pisani, Maria Teresa Petrucci, Diana Giannarelli, Velia Bongarzoni, Marco Montanaro, Valerio De Stefano, Giacinto La Verde, Fabiana Gentilini, Anna Levi, Tommaso Za, Alessandro Moscetti, Luciana Annino and Maria Concetta Petti
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:17
  31. Antiangiogenic therapy is one of the most significant advances in anticancer treatment. The benefits of antiangiogenic therapies of late-stage cancers have been investigated but are still too limited.

    Authors: Yuan Xu, Qin Li, Xiao-Yu Li, Qiu-Ya Yang, Wei-Wei Xu and Gao-Lin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:16
  32. SPC-c-Raf-1-BxB transgenic mice develop genetically induced disseminated lung adenocarcinoma allowing examination of carcinogenesis and evaluation of novel treatment strategies. We report on assessment of lung...

    Authors: Thomas Rodt, Christian von Falck, Sabine Dettmer, Katja Hueper, Roman Halter, Ludwig Hoy, Matthias Luepke, Juergen Borlak and Frank Wacker
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:15
  33. Ovarian cancer is the most lethal gynecologic malignancy. It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbr...

    Authors: Ayako Kim, Yutaka Ueda, Tetsuji Naka and Takayuki Enomoto
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:14
  34. Previous therapy with anthracyclines (ANT) and conditioning regimen followed by hematopoietic stem cell transplantation (HSCT) represents a high risk for development of cardiotoxicity. The aim of this study wa...

    Authors: Lubica Roziakova, Eva Bojtarova, Martin Mistrik, Juraj Dubrava, Jozef Gergel, Nadezda Lenkova and Beata Mladosievicova
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:13
  35. Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies,...

    Authors: Xiao-Fen Lai, Cong-Xiang Shen, Zhong Wen, Yu-Hong Qian, Chao-Sheng Yu, Jun-Qi Wang, Ping-Neng Zhong and Hai-Li Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:12
  36. Environmental factors-induced dysfunction of esophageal squamous epithelium, including genomic DNA impairment and apoptosis, play an important role in the pathogenesis of esophageal squamous cell cancer. DNA d...

    Authors: Bao xiang Wang, Bang Liang Yin, Bin He, Chen Chen, Ming Zhao, Wei xing Zhang, Zhen Kun Xia, Yi zhi Pan, Jing qun Tang, Xin min Zhou and Ni Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:11
  37. Expression of the stem cell marker octamer 4 (Oct-4) in various neoplasms has been previously reported, but very little is currently known about the potential function of Oct-4 in this setting. The purpose of ...

    Authors: Zhenguang Chen, Tao Wang, Lie Cai, Chunhua Su, Beilong Zhong, Yiyan Lei and Andy Peng Xiang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:10
  38. Antigen-specific CD8+ cytotoxic T lymphocytes represent potent effector cells of the adaptive immune response against viruses as well as tumours. Therefore assays capable at exploring the generation and functi...

    Authors: Valentina Bordignon, Paola Cordiali-Fei, Monica Rinaldi, Emanuela Signori, Andrea Cottarelli, Manuela Zonfrillo, Fabrizio Ensoli, Guido Rasi and Maria Pia Fuggetta
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:9
  39. The management of patients with glioblastoma multiforme is difficult. Poor results have led to a search for novel therapeutic approaches. Gene therapy that could be both anti-invasive and antiangiogenic would ...

    Authors: Xin-Li Liu, Dan Zhao, Da-Peng Sun, Yang Wang, Yan Li, Feng-Qi Qiu and Ping Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:8
  40. The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-...

    Authors: Elisabetta Falvo, Lidia Strigari, Gennaro Citro, Carolina Giordano, Genoveva Boboc, Fabiana Fabretti, Vicente Bruzzaniti, Luca Bellesi, Paola Muti, Giovanni Blandino and Paola Pinnarò
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:7
  41. The purpose of this study is to determine the methylation status of Transforming growth factor-beta-inducible gene-h3 (TGFBI) and its correlation with paclitaxel chemoresistance in ovarian cancer. The methylat...

    Authors: Ning Wang, Hui Zhang, Qin Yao, Yankui Wang, Shuzhen Dai and Xingsheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:6
  42. One of the major components of telomerase is the human telomerase reverse transcriptase (hTERT) as the catalytic protein. hTERT mRNA expression are reported to be associated with prognosis and tumor progressio...

    Authors: Toshihiro Matsuo, Shoji Shimose, Tadahiko Kubo, Jun Fujimori, Yuji Yasunaga, Takashi Sugita and Mitsuo Ochi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:5
  43. Lung cancer represents the most frequent cause of death for cancer. In non-small cell lung cancer (NSCLC), which accounts for the vast majority of this disease, only early detection and treatment, when possibl...

    Authors: Claudia Abbruzzese, Stefano Mattarocci, Laura Pizzuti, Anna M Mileo, Paolo Visca, Barbara Antoniani, Gabriele Alessandrini, Francesco Facciolo, Rosario Amato, Lucia D'Antona, Massimo Rinaldi, Armando Felsani, Nicola Perrotti and Marco G Paggi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:4
  44. Transforming growth factor (TGF)-β is known to be produced by progressor tumors and to immobilize dendritic cells (DCs) within those tumors. Moreover, although TGF-β1 has been shown to promote tumor progressio...

    Authors: Kazuhiro Imai, Yoshihiro Minamiya, Souichi Koyota, Manabu Ito, Hajime Saito, Yusuke Sato, Satoru Motoyama, Toshihiro Sugiyama and Jun-ichi Ogawa
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:3
  45. This study aims to investigate the in vitro effects of Ulinastatin (UTI) and Taxotere (TXT) on cell proliferation; cell apoptosis; xenografted tumor growth; and expression of insulin-like growth factor receptor 1...

    Authors: Hong Wang, Xin Sun, Feng Gao, Biao Zhong, Yong-hua Zhang and Zhijun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:2
  46. Tissue factor pathway inhibitor-2 (TFPI-2) is an extracellular matrix associated broad-spectrum Kunitz-type serine proteinase inhibitor. Recently, down regulation of TFPI-2 was suggested to be involved in tumo...

    Authors: Qiao Zhang, Yao Zhang, Shi Z Wang, Ning Wang, Wei G Jiang, Yao H Ji and Shu L Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:1
  47. Both endoscopic and surgical approaches are employed in the treatment of early gastric cancer (EGC). The aim of this study was to establish appropriate treatment strategies for early gastric cancer.

    Authors: Hiroaki Ito, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Toshihisa Hosoya, Kosuke Sudo, Nikolas Eleftheriadis, Roberta Maselli, Chiyo Maeda, Yoko Wada, Norimasa Sando, Shigeharu Hamatani and Shin-ei Kudo
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:117
  48. Whether Folic acid is a potential drug that may prevent the progression of colorectal carcinoma and when to use are important healthy issues we focus on. Our study is to examine the effect of folic acid on the...

    Authors: Yan-Wei Lin, Ji-Lin Wang, Hui-Min Chen, Yan-Jie Zhang, Rong-Lu, Lin-Lin Ren, Jie Hong and Jing-Yuan Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:116
  49. Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guid...

    Authors: Maria Bonomi, Sara Pilotto, Michele Milella, Francesco Massari, Sara Cingarlini, Matteo Brunelli, Marco Chilosi, Giampaolo Tortora and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:115
  50. Zfx is a zinc finger protein of the Zfy family, whose members are highly conserved in vertebrates. Zfx is a shared transcriptional regulator of both embryonic stem cells (ESC) and hematopoietic stem cells (HSC...

    Authors: Youxin Zhou, Zuopeng Su, Yulun Huang, Ting Sun, Sansong Chen, Tingfeng Wu, Guilin Chen, Xueshun Xie, Bin Li and Ziwei Du
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:114

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