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  1. Acquired radioresistance of cancer cells remains a fundamental barrier to attaining the maximal efficacy of radiotherapy for the treatment of breast cancer. Anti-apoptotic proteins, such as Bcl-2 and Bcl-xL, p...

    Authors: Ji-Yu Li, Yu-Yang Li, Wei Jin, Qing Yang, Zhi-Ming Shao and Xing-Song Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:102
  2. Alpha B-crystallin (αB-crystallin) has been suggested to play an important role in the development of solid tumors. However, the association between αB-crystallin expression and clinicopathological characteris...

    Authors: Yuan Mao, Da-Wei Zhang, Hong Lin, Lin Xiong, Ying Liu, Qing-Dong Li, Jun Ma, Qing Cao, Ren-Jie Chen, Jin Zhu and Zhen-Qing Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:101
  3. The genetic pathways of aggressive changes of bone tumors are still poorly understood. It is very important to analyze DNA copy number alterations (DCNAs), to identify the molecular events in the step of progr...

    Authors: Masahiko Kanamori, Akimi Sano, Taketoshi Yasuda, Takeshi Hori and Kayo Suzuki
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:100
  4. Ku80 is crucially implicated in DNA repair, apoptosis, and chemoresistance. In this study, we aimed to assess the expression of Ku80 in clinical lung adenocarcinoma specimens, and investigate its role in the r...

    Authors: Qingshan Ma, Ping Li, Minyu Xu, Jinzhi Yin, Zhenzhong Su, Wei Li and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:99
  5. Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early int...

    Authors: Xiao-Tong Wang, Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao and Yu-Bo Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:98
  6. Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis. MicroRNAs (miRNAs) are a class of small non-coding RNAs, approximately 21–25 nucleotides in length. Recently, some researc...

    Authors: Qiong Wang, Pengcun Li, Ailin Li, Wei Jiang, Hong Wang, Jinhuan Wang and Keliang Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:97
  7. Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs) to c...

    Authors: Prisco Piscitelli, Maddalena Barba, Massimo Crespi, Massimo Di Maio, Antonio Santoriello, Massiliamo D’Aiuto, Alfredo Fucito, Arturo Losco, Francesca Pentimalli, Pasquale Maranta, Giovanna Chitano, Alberto Argentiero, Cosimo Neglia, Alessandro Distante, Gian luca Di Tanna, Maria Luisa Brandi…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:96
  8. Epidemiological studies revealed significantly lower mortality rates in cancer patients receiving cardiac glycosides, which turned on interest in the anticancer properties of these drugs. However, cardiac glyc...

    Authors: Francesca Cuozzo, Marisa Raciti, Laura Bertelli, Rosanna Parente and Livia Di Renzo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:95
  9. DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance...

    Authors: Xiao-Lin Zhu, Zhang-Feng Wang, Wen-Bin Lei, Hui-Wen Zhuang, Wei-Jian Hou, Yi-Hui Wen and Wei-Ping Wen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:94
  10. Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma...

    Authors: Guo-Cai Li, Qing-Hai Ye, Qiong-Zhu Dong, Ning Ren, Hu-Liang Jia and Lun-Xiu Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:93
  11. Leukemia, a heterogeneous clonal disorder of hematopoietic progenitor cells, presents a world-wide health problem, especially in childhood. F1F0 ATPase, an inner mitochondrial enzyme, is expressed on the plasm...

    Authors: Zhao Wen-Li, Wang Jian, Tao Yan-Fang, Feng Xing, Li Yan-Hong, Zhu Xue-Ming, Zhang Min, Ni Jian and Pan Jian
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:92
  12. In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation in t...

    Authors: Michele Maio, Paolo Ascierto, Alessandro Testori, Ruggero Ridolfi, Emilio Bajetta, Paola Queirolo, Michele Guida, Antonella Romanini, Vanna Chiarion-Sileni, Jacopo Pigozzo, Anna Maria Di Giacomo, Mario Calandriello, Guido Didoni, Marck van Baardewijk, Cyril Konto and Carlo Lucioni
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:91
  13. Type IV collagen (ColIV) is the most important scaffold for the basement membrane (BM) proteins, and plays an important role in regulating and limiting tumour invasion and metastasis.

    Authors: Hai-Xia Fan, Hai-Xia Li, Dong Chen, Zhong-Xiuzi Gao and Jin-Hua Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:90
  14. p73 and p63 are two structural and functional homologs of p53, and their biological functions in cancer progression have attracted attention due to the presence of variants generated by genetic polymorphisms. ...

    Authors: Xiao Guan, Ning Zhang, Yongshuo Yin, Beihua Kong, Qifeng Yang, Zhiyan Han and Xingsheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:89
  15. Among patients undergoing follow-up after surgery for melanoma, ultrasound (US) very often reveals lymph nodes in groin area, that do not show clear characters of a metastatic lesion yet that have atypical US ...

    Authors: Francesco M Solivetti, Fulvia Elia, Dario Graceffa and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:88
  16. Prognosis of advanced ovarian carcinomas (AOC) remains poor with a 5-year survival of 30%. Benefit from high-dose chemotherapy (HDC) in this disease has not been demonstrated to date.

    Authors: Renaud Sabatier, Anthony Gonçalves, François Bertucci, Maria-Antonietta Capiello, Frédérique Rousseau, Eric Lambaudie, Christian Chabannon, Patrice Viens and Jean-Marc Extra
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:87
  17. Exposure to anthracyclines (ANT) during childhood represents a high risk for development of late cardiotoxicity. Cardiotoxicity is usually detected only when clinical symptoms or progressive cardiac dysfunctio...

    Authors: Beata Mladosievicova, Dagmar Urbanova, Eva Radvanska, Peter Slavkovsky and Iveta Simkova
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:86
  18. Glioma is the most common primary malignant central nervous system tumor in adult, and is usually not curable in spite of various therapeutic approaches. Clarification of the oncogenic process in its early sta...

    Authors: Tomoo Matsutani, Takaki Hiwasa, Masaki Takiguchi, Takashi Oide, Mitoshi Kunimatsu, Naokatsu Saeki and Yasuo Iwadate
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:85
  19. Mesothelin, a secreted protein, is overexpressed in some cancers, including pancreatic cancer. Rescent studies have shown that overexpression of mesothelin significantly increased tumor cell proliferation, and...

    Authors: Chunning Zheng, Wei Jia, Yong Tang, HuiLiang Zhao, Yingsheng Jiang and Shaochuan Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:84
  20. Metastasis via the lymphatic system is promoted by lymphangiogenesis. Alterations of the lymphatic channels during the progression of metastasis to regional lymph nodes (LNs) remain unexplored. To examine whet...

    Authors: Ryuki Ozasa, Jun Ohno, Teruaki Iwahashi and Kunihisa Taniguchi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:83
  21. Neuro-oncological population well expresses the complexity of neurological disability due to the multiple neurological deficits that affect these patients. Moreover, due to the therapeutical opportunities surv...

    Authors: Michelangelo Bartolo, Chiara Zucchella, Andrea Pace, Alessandro Marco De Nunzio, Mariano Serrao, Giorgio Sandrini and Francesco Pierelli
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:82
  22. It is well known that genetic alternation of epidermal growth factor receptor (EGFR) plays critical roles in tumorgenesis of lung cancer and can predict outcome of non-small-cell lung cancer treatment, especially...

    Authors: Jian Zhu, Yuyan Wang, Jianchun Duan, Hua Bai, Zhijie Wang, Lai Wei, Jun Zhao, Minglei Zhuo, Shuhang Wang, Lu Yang, Tongtong An, Meina Wu and Jie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:80
  23. It is mandatory to confirm the absence of mutations in the KRAS gene before treating metastatic colorectal cancers with epidermal growth factor receptor inhibitors, and similar regulations are being considered fo...

    Authors: Sylwia Jancik, Jiri Drabek, Jitka Berkovcova, Yong Zhong Xu, Marcela Stankova, Jiri Klein, Vitezslav Kolek, Josef Skarda, Tomas Tichy, Ivona Grygarkova, Danuta Radzioch and Marian Hajduch
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:79
  24. The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above t...

    Authors: Laure Bobyk, Magali Edouard, Pierre Deman, Julia Rousseau, Jean-François Adam, Jean-Luc Ravanat, François Estève, Jacques Balosso, Rolf F Barth and Hélène Elleaume
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:78
  25. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have become a treatment option in non-small-cell lung cancer (NSCLC) patients. However, despite their use in this disease, a significan...

    Authors: Samuel Murray, Vasilios Karavasilis, Mattheos Bobos, Evangelia Razis, Savvas Papadopoulos, Christos Christodoulou, Paris Kosmidis and George Fountzilas
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:77
  26. Treatment protocols for nasopharyngeal carcinoma (NPC) developed in the past decade have significantly improved patient survival. In most NPC patients, however, the disease is diagnosed at late stages, and for...

    Authors: Adel M Zaatar, Chun Ren Lim, Chin Wei Bong, Michelle Mei Lin Lee, Jian Jiek Ooi, David Suria, Rakesh Raman, Samuel Chao, Hengxuan Yang, Soon Bin Neoh and Choong-Chin Liew
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:76
  27. Although hypoxia is known to promote hepatoma cell invasion and migration, little is known regarding the molecular mechanisms of this process. Our previous research showed that loss of Tg737 is associated with...

    Authors: Nan You, Weihui Liu, Lijun Tang, Xiao Zhong, Ru Ji, Ning Zhang, Desheng Wang, Yong He, Kefeng Dou and Kaishan Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:75
  28. The efficiency of HSV-tk/GCV system is not high because of insufficient gene transfer and incompletely initiative of host antineoplastic potency. The present study was designed to assess the antitumor efficacy...

    Authors: Shuhui Hong, Ping Zhang, Hui Zhang, Lin Jia, Xun Qu, Qifeng Yang, Fengnian Rong and Beihua Kong
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:74
  29. To study the hypothesis that gemcitabine treatment augments the chemoresistance to gemcitabine by clusterin (sCLU) upregulation. Clusterin inhibition could augment the chemosensitivity of human pancreatic canc...

    Authors: Yong Tang, Fenghua Liu, Chunning Zheng, Shaochuan Sun and Yingsheng Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:73

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2013 32:42

  30. It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pathophysiol...

    Authors: Ingun Heiene Tveteraas, Kristin Meisdalen Müller, Monica Aasrum, John Ødegård, Olav Dajani, Tormod Guren, Dagny Sandnes and Thoralf Christoffersen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:72
  31. Expression levels of CD133, a cancer stem cell marker, and of the α-subunit of the dystroglycan (α-DG) complex, have been previously reported to be altered in colorectal cancers.

    Authors: Claudio Coco, Gian Franco Zannoni, Emanuele Caredda, Stefano Sioletic, Alma Boninsegna, Mario Migaldi, Gianluca Rizzo, Luca Reggiani Bonetti, Giannicola Genovese, Egidio Stigliano, Achille Cittadini and Alessandro Sgambato
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:71
  32. Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly unders...

    Authors: Rong Biaoxue, Jiang Xiling, Yang Shuanying, Zhang Wei, Cai Xiguang, Wang Jinsui and Zhang Min
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:70
  33. Although significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas signaling, which remains poorly understood. We previously ...

    Authors: Urszula Daniluk, Celine Kerros, Rong-Hua Tao, Jillian F Wise, Xue Ao, Zuzana Berkova and Felipe Samaniego
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:69
  34. Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins...

    Authors: Anke Van den Broeck, Hugo Vankelecom, Rudy Van Eijsden, Olivier Govaere and Baki Topal
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:68
  35. Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear. NF-E2-related factor 2 (Nrf2) is abundan...

    Authors: Lingmin Zhang, Ning Wang, Suna Zhou, Wenguang Ye, Guixia Jing and Mingxin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:66
  36. EGFR mutation is a strong predictive factor of EGFR-TKIs therapy. However, at least 10% of patients with EGFR wild-type are responsive to TKIs, suggesting that other determinants of outcome besides EGFR mutati...

    Authors: Fen Wang, Shuhang Wang, Zhijie Wang, Jianchun Duan, Tongtong An, Jun Zhao, Hua Bai and Jie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:65
  37. Prolyl hydroxylase domain 3 (PHD3) is a hypoxia inducible factor-α (HIFα) regulator; it degrades HIFα in the presence of oxygen. Recently, there have been an increasing number of studies about the role of PHD3...

    Authors: Qi-Lian Liang, Zhou-Yu Li, Yuan Zhou, Qiu-Long Liu, Wen-Ting Ou and Zhi-Gang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:64
  38. Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therap...

    Authors: Gabriella D’Orazi, Cinzia Rinaldo and Silvia Soddu
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:63
  39. Evidence indicates that CYP1A1 MspI polymorphism might be a possible risk factor for several malignancies. A growing body of literature has been devoted to the association of CYP1A1 MspI polymorphism with acut...

    Authors: Wenlei Zhuo, Liang Zhang, Yan Wang, Bo Zhu and Zhengtang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:62
  40. Iodine 125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. Here, we aim to comprehensively elucidate the biological effects induced by 125I...

    Authors: Zhen-Huan Ma, Yong Yang, Lei Zou and Kai-Yuan Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:61
  41. Cardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil(5-FU) and it can have detrimental effects both in patients and workers involved in the preparation of che...

    Authors: Monica Lamberti, Stefania Porto, Monica Marra, Silvia Zappavigna, Anna Grimaldi, Daniela Feola, Delia Pesce, Silvio Naviglio, Annamaria Spina, Nicola Sannolo and Michele Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:60
  42. Invasive ductal carcinoma is the most common type of breast malignancy, with varying molecular features and resistance to treatment. Although CD44+/CD24- cells are believed to act as breast cancer stem cells a...

    Authors: Yan Lin, Ying Zhong, Heng Guan, Xiaohui Zhang and Qiang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:59
  43. The purpose of the current study was to determine whether a tropical ginger derived compound 1’-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wi...

    Authors: Vinita Batra, Zanobia Syed, Jennifer N Gill, Malari A Coburn, Patrick Adegboyega, John DiGiovanni, J Michael Mathis, Runhua Shi, John L Clifford and Heather E Kleiner-Hancock
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:57
  44. The progression of many solid tumors is characterized by the release of tumor-associated proteases and the detection of tumor specific proteolytic activity in serum specimens is a promising diagnostic tool in ...

    Authors: Peter Findeisen, Victor Costina, Diego Yepes, Ralf Hofheinz and Michael Neumaier
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:56
  45. It is still technically difficult to collect high purity cancer cells from tumor tissues, which contain noncancerous cells. We hypothesized that xenograft models of NOG mice expressing enhanced green fluoresce...

    Authors: Kentaro Shima, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takaho Okada, Naoaki Sakata, Noriyuki Omura, Yo Kitamura, Fuyuhiko Motoi, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Naoto Ishii, Akira Horii and Michiaki Unno
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:55
  46. Lung cancer is the major cause of cancer death globally, it is often diagnosed at an advanced stage and has one of the lowest survival rates of any type of cancer. The common interest in the field of lung canc...

    Authors: Peng Guan, Zhihua Yin, Xuelian Li, Wei Wu and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:54

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