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  1. It was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells. We showed in an ...

    Authors: Dana Hamam, Mohamed Abdouh, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:80
    Content type: Research Published on:

  3. Increasing evidence supports the association of CTNND1 with tumor development and progression. However, the mechanism and clinical significance of CTNND1 deregulation in hepatocellular carcinoma (HCC) remains ...

    Authors: Bo Tang, Fang Tang, Zhenran Wang, Guangying Qi, Xingsi Liang, Bo Li, Shengguang Yuan, Jie Liu, Shuiping Yu and Songqing He
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:82
    Content type: Research Published on:

  4. Long non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development and progression. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a novel long non-codin...

    Authors: Yonghao Zhan, Junhao Lin, Yuchen Liu, Mingwei Chen, Xiaoying Chen, Chengle Zhuang, Li Liu, Wen Xu, Zhicong Chen, Anbang He, Qiaoxia Zhang, Xiaojuan Sun, Guoping Zhao and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:83
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:185

  5. The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal tran...

    Authors: Samantha Kaufhold, Hermes Garbán and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:84
    Content type: Review Published on:

  6. Hepatectomy generally offers the best chance of long-term survival for patients with hepatocellular carcinoma (HCC). Many studies have shown that hepatectomy accelerates tumor metastasis, but the mechanism rem...

    Authors: Xiu-Yan Huang, Zi-Li Huang, Bin Xu, Zi Chen, Thomas Joseph Re, Qi Zheng, Zhao-You Tang and Xin-Yu Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:85
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:102

  7. Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in low-grade gliomas and secondary glioblastomas (sGBM). Because they yield the same oncometabolite, D-2-hydroxygl...

    Authors: Hao-Yuan Wang, Kai Tang, Ting-Yu Liang, Wei-Zhong Zhang, Ji-Ye Li, Wen Wang, Hui-Min Hu, Ming-Yang Li, Hui-Qing Wang, Xiao-Zheng He, Zhi-Yuan Zhu, Yan-Wei Liu and Shi-Zhong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:86
    Content type: Research Published on:

  8. The role of HBV X protein (HBx) in the development of hepatocellular carcinoma (HCC) has been well studied. However, little is known about the molecular functions of HBV whole-X protein (HBwx), a protein fused...

    Authors: Yu Zhang, Hongli Liu, Ruitian Yi, Taotao Yan, Yingli He, Yingren Zhao and Jinfeng Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:87
    Content type: Research Published on:

  9. Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor progression and plays an important role in cancer invasion and metastasis. RNF8 is an ubiquitin E3 ligase with RING domain, and plays e...

    Authors: Jingyu Kuang, Li Li, Limei Guo, Yanrong Su, Yuxuan Wang, Yongjie Xu, Xiaozhen Wang, Shucong Meng, Liandi Lei, Luzheng Xu and Genze Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:88
    Content type: Research Published on:

  10. Increasing evidence suggests that microRNAs (miRNAs) play critical roles in malignant transformation, tumor progression and metastasis. Aberrant miR-655-3p expression has been associated with several cancers. ...

    Authors: Gang Wu, Kunming Zheng, Shuguan Xia, Yawei Wang, Xiangyu Meng, Xiaoming Qin and Ying Cheng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:89
    Content type: Research Published on:

  11. Glioma is one of the most common and aggressive primary malignant tumor in the brain. Accumulating evidences indicated that aberrantly expressed non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNA...

    Authors: Chun-Chun Ma, Zhang Xiong, Guan-Nan Zhu, Chao Wang, Gang Zong, Hong-Liang Wang, Er-Bao Bian and Bing Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:90
    Content type: Research Published on:

  12. MUC4 is a high molecular weight membrane protein that is overexpressed in pancreatic cancer (PC) and is associated with the development and progression of this disease. However, the exact mechanisms through wh...

    Authors: Jie Tang, Yi Zhu, Kunling Xie, Xiaoyu Zhang, Xiaofei Zhi, Weizhi Wang, Zheng Li, Qun Zhang, Linjun Wang, Jiwei Wang and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:91
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:34

  14. MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human malignant tumors. In the present study, we analyzed the role miR-155-3p plays in Hepatocellular carcinoma (HCC), which has been rep...

    Authors: Bo Tang, Biao Lei, Guangying Qi, Xingsi Liang, Fang Tang, Shengguang Yuan, Zhenran Wang, Shuiping Yu and Songqing He
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:93
    Content type: Research Published on:

  15. Medulloblastoma (MB) is the most common pediatric brain tumor. Current treatment regimes consisting of primary surgery followed by radio- and chemotherapy, achieve 5-year overall survival rates of only about 6...

    Authors: Ina Patties, Rolf-Dieter Kortmann, Franziska Menzel and Annegret Glasow
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:94
    Content type: Research Published on:

  16. Authors: Liang Feng, Hang-Ping Yao, Sharad Sharma, Yong-Qing Zhou, Jianwei Zhou, Ruiwen Zhang and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:95
    Content type: Erratum Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:70

  17. Authors: Adel Galal El-Shemi, Ahmad Mohammed Ashshi, Youjin Na, Yan Li, Mohammed Basalamah, Faisal Ahmad Al-Allaf, Eonju Oh, Bo-Kyeong Jung and Chae-Ok YUN
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:96
    Content type: Erratum Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:74

  18. Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is freq...

    Authors: Shuai Zhao, Yang Cao, Shi-bo Liu, Xu-an Wang, Run-fa Bao, Yi-jun Shu, Yun-ping Hu, Yi-jian Zhang, Lin Jiang, Fei Zhang, Hai-bin Liang, Huai-feng Li, Qiang Ma, Yi Xu, Zheng Wang, Yi-chi Zhang…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:97
    Content type: Research Published on:

  19. Growing evidence suggests that SALL4 plays a vital role in tumor progression and metastasis. However, the molecular mechanism of SALL4 promoting esophageal squamous cell carcinoma (ESCC) remains to be elucidated.

    Authors: Jing He, Mingxia Zhou, Xinfeng Chen, Dongli Yue, Li Yang, Guohui Qin, Zhen Zhang, Qun Gao, Dan Wang, Chaoqi Zhang, Lan Huang, Liping Wang, Bin Zhang, Jane Yu and Yi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:98
    Content type: Research Published on:

  20. Long non-coding RNAs (lncRNAs) have been proved to act as key molecules in cancer development and progression. Dysregulation of lncRNAs is discovered in various tumor tissues and cancer cells where they can se...

    Authors: Jianfa Li, Chengle Zhuang, Yuchen Liu, Mingwei Chen, Yincong Chen, Zhicong Chen, Anbang He, Junhao Lin, Yonghao Zhan, Li Liu, Wen Xu, Guoping Zhao, Yinglu Guo, Hanwei Wu, Zhiming Cai and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:99
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:321

  21. Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins, is overexpressed in high-grade gliomas and plays an oncogenic function in glioma biology. However, little is known about the role of TRIM11 i...

    Authors: Xiaolin Wang, Weiping Shi, Hongcan Shi, Shichun Lu, Kang Wang, Chao Sun, Jiansheng He, Weiguo Jin, Xiaoxia Lv, Hui Zou and Yusheng Shu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:100
    Content type: Research Published on:

  22. Serum miRNAs profiles between papillary thyroid carcinoma (PTC) patients with non-131I and 131I-avid lung metastases are differentially expressed. These miRNAs have to be further validated and the role of these m...

    Authors: Chen-Tian Shen, Zhong-Ling Qiu, Hong-Jun Song, Wei-Jun Wei and Quan-Yong Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:101
    Content type: Research Published on:

  23. Authors: Xiu-Yan Huang, Zi-Li Huang, Bin Xu, Zi Chen, Thomas Joseph Re, Qi Zheng, Zhao-You Tang and Xin-Yu Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:102
    Content type: Erratum Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:85

  24. The role of immune response is emerging as a key factor in the complex multistep process of cancer. Tumor microenvironment contains different types of immune cells, which contribute to regulate the fine balanc...

    Authors: Laura Paladini, Linda Fabris, Giulia Bottai, Carlotta Raschioni, George A. Calin and Libero Santarpia
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:103
    Content type: Review Published on:

  25. The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outc...

    Authors: Alessandra Fabi, Paola Malaguti, Sabrina Vari and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:104
    Content type: Review Published on:

  26. The prognosis of non-small-cell lung cancer (NSCLC) is poor yet mechanistic understanding and therapeutic options remain limited. We investigated the biological and clinical significance of microRNA-130b and i...

    Authors: Jianwei Tian, Liping Hu, Xiao Li, Jian Geng, Meng Dai and Xiaoyan Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:105
    Content type: Research Published on:

  27. Interleukin-9 (IL-9) was discovered as a helper T cell growth factor. It has long been recognized as an important regulator in allergic inflammation. Recent years it was discovered to induce cell growth and di...

    Authors: Xiao Lv, Lili Feng, Xueling Ge, Kang Lu and Xin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:106
    Content type: Research Published on:

  28. HM-3 is a polypeptide inhibiting angiogenesis. Recent reports suggest that the antitumor effect of angiogenesis inhibitors administered alone might be limited. Cancer stem cells can survive the lack of oxygen ...

    Authors: Changhong Zhao, Junjin He, Haoran Cheng, Zhaohao Zhu and Hanmei Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:107
    Content type: Research Published on:

  29. Activating transcription factor 2 (ATF2) is a basic helix-loop-helix transcription factor, which has been shown to participate in the pathobiology of numerous cancers. However, the role of ATF2 in renal cell c...

    Authors: Deng-shuang Wu, Cheng Chen, Zhen-jie Wu, Bing Liu, Li Gao, Qing Yang, Wei Chen, Jun-ming Chen, Yi Bao, Le Qu and Lin-hui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:108
    Content type: Research Published on:

  30. Metastasis remains the major cause of death in nasopharyngeal carcinoma (NPC). Yippee-like 3 (YPEL3) plays an important role in tumorigenesis. However, its function and mechanism in NPC has not been systematic...

    Authors: Jian Zhang, Xin Wen, Xian-Yue Ren, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Na Liu and Jun Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:109
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:214

  31. 1-methylnicotinamide (1-MNA), an endogenous metabolite of nicotinamide, has recently gained interest due to its anti-inflammatory and anti-thrombotic activities linked to the COX-2/PGI2 pathway. Given the previou...

    Authors: Agnieszka Blazejczyk, Marta Switalska, Stefan Chlopicki, Andrzej Marcinek, Jerzy Gebicki, Marcin Nowak, Anna Nasulewicz-Goldeman and Joanna Wietrzyk
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:110
    Content type: Research Published on:

  32. Nestin expression has been reported to be associated with the prognosis of many solid tumors including human hepatocellular carcinoma (HCC). The present study aimed to identify the role, if any, of Nestin in t...

    Authors: Yan Zhang, Shan Zeng, Junli Ma, Ganlu Deng, Yanlin Qu, Cao Guo and Hong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:111
    Content type: Research Published on:

  33. Polyphyllin I (PPI), a bioactive phytochemical extracted from the Rhizoma of Paris polyphylla, has been reported to exhibit anti-cancer activity. However, the detailed mechanism underlying this remains to be eluc...

    Authors: Longmei Li, JingJing Wu, Fang Zheng, Qing Tang, WanYin Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:112
    Content type: Research Published on:

  34. Osteosarcoma is the most common primary malignancy of bone. Its treatment relies on the administration of neoadjuvant and adjuvant chemotherapy combined with surgery. Alternative to common intravenous (i.v.) a...

    Authors: Bernhard Robl, Sander Martijn Botter, Giovanni Pellegrini, Olga Neklyudova and Bruno Fuchs
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:113
    Content type: Research Published on:

  35. It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory cytokines to facilitate the development of radiation-induced liver disease. However, little is known on whether ...

    Authors: Yinying Dong, Xiaoyun Shen, Mingyan He, Zhifeng Wu, Qiongdan Zheng, Yaohui Wang, Yuhan Chen, Sifan Wu, Jiefeng Cui and Zhaochong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:114
    Content type: Research Published on:

  36. Synaptojanin 2 Binding Protein (SYNJ2BP) is essential to cell proliferation. Previous studies show that SYNJ2BP participates in sprouting angiogenesis, which plays an important part in several abnormal conditi...

    Authors: Xiao Liu, Jiangjiao Zhou, Ning Zhou, Jianwei Zhu, Yong Feng and Xiongying Miao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:115
    Content type: Research Published on:

  37. Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer...

    Authors: Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino and Alessandra Micera
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:116
    Content type: Review Published on:

  38. Low nutrient environment is a major obstacle to solid tumor growth. However, many tumors have developed adaptive mechanisms to circumvent the requirement for exogenous growth factors.

    Authors: Xin Li, Guizhong Zhang, Qian Chen, Yingxue Lin, Junxin Li, Qingguo Ruan, Youhai Chen, Guang Yu and Xiaochun Wan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:117
    Content type: Research Published on:

  39. Human T-cell leukemia virus (HTLV-1) is a lymphotropic retrovirus associated to adult T cell leukemia (ATL) and to non-neoplastic inflammatory conditions affecting the central nervous system, lung or skin. The...

    Authors: Maria Pia Fuggetta, Valentina Bordignon, Andrea Cottarelli, Beatrice Macchi, Caterina Frezza, Paola Cordiali-Fei, Fabrizio Ensoli, Stefania Ciafrè, Francesca Marino-Merlo, Antonio Mastino and Giampietro Ravagnan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:118
    Content type: Research Published on:

  41. Claudin-6 (CLDN6), a member of claudin transmembrane protein family, has recently been reported to be undetectable or at low levels in human breast cancer cell lines and tissues and plays a role in suppression...

    Authors: Yafang Liu, Xiangshu Jin, Yanru Li, Yang Ruan, Yan Lu, Minlan Yang, Dongjing Lin, Peiye Song, Yantong Guo, Shuai Zhao, Bing Dong, Yinping Xie, Qihua Dang and Chengshi Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:120
    Content type: Research Published on:

  42. The advent of targeted therapeutics in human cancer has begun to find novel druggable targets and, in this context, the endothelin-1 receptor (ET-1R), namely ETA receptor (ETAR) and ETB receptor, among the GPCR f...

    Authors: Laura Rosanò and Anna Bagnato
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:121
    Content type: Review Published on:

  43. The most abundant cells in the extensive desmoplastic stroma of pancreatic adenocarcinomas are the pancreatic stellate cells, which interact with the carcinoma cells and strongly influence the progression of t...

    Authors: Vegard Tjomsland, Dagny Sandnes, Ewa Pomianowska, Smiljana Torbica Cizmovic, Monica Aasrum, Ingvild Johnsen Brusevold, Thoralf Christoffersen and Ivar P. Gladhaug
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:122
    Content type: Research Published on:

  44. Resistance to anticancer agents is a major obstacle for successful chemotherapy in tongue squamous cancer. Sam68 is an oncogenic-related protein in oral tongue squamous cell carcinoma functions as a signaling ...

    Authors: Shuwei Chen, Huan Li, Shimin Zhuang, Ji Zhang, Fan Gao, Xidi Wang, WenKuan Chen and Ming Song
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:123
    Content type: Research Published on:

  45. Malignant gliomas are the most common primary brain tumors in adults and challenging cancers for diagnosis and treatment. They remain a disease for which non-invasive, diagnostic and/or prognostic novel biomar...

    Authors: Giulia Regazzo, Irene Terrenato, Manuela Spagnuolo, Mariantonia Carosi, Gaetana Cognetti, Lucia Cicchillitti, Francesca Sperati, Veronica Villani, Carmine Carapella, Giulia Piaggio, Andrea Pelosi and Maria Giulia Rizzo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:124
    Content type: Research Published on:

  46. Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression...

    Authors: Anbang He, Yuchen Liu, Zhicong Chen, Jianfa Li, Mingwei Chen, Li Liu, Xinhui Liao, Zhaojie Lv, Yonghao Zhan, Chengle Zhuang, Junhao Lin, Weiren Huang and Hongbing Mei
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:125
    Content type: Research Published on:

  47. The heregulin-1ß/HER3-driven pathway is implicated in several epithelial malignancies and its blockade is currently undergoing clinical investigation. Paradoxically, the status and the regulation of this pathw...

    Authors: Corina Buta, Eva Benabou, Marie Lequoy, Hélène Régnault, Dominique Wendum, Fatiha Merabtene, Hamza Chettouh, Lynda Aoudjehane, Filomena Conti, Yves Chrétien, Olivier Scatton, Olivier Rosmorduc, Françoise Praz, Laetitia Fartoux and Christèle Desbois-Mouthon
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:126
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:154

  48. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. The average survival and 5-year survival rates of HCC patients still remains poor. Thus, there is an urgent need to better un...

    Authors: Fuqiang Yin, Lipei Shu, Xia Liu, Ting Li, Tao Peng, Yueli Nan, Shu Li, Xiaoyun Zeng and Xiaoqiang Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:127
    Content type: Research Published on:

  49. Brain stereotactic biopsy (SB) followed by conventional histopathology and immunohistochemistry (IHC) is the gold standard approach for primary central nervous system lymphoma (PCNSL) diagnosis. Flow cytometry...

    Authors: Iole Cordone, Serena Masi, Mariantonia Carosi, Antonello Vidiri, Francesco Marchesi, Mirella Marino, Stefano Telera, Alessia Pasquale, Andrea Mengarelli, Laura Conti, Edoardo Pescarmona, Andrea Pace and Carmine M. Carapella
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:128
    Content type: Research Published on:

  50. In addition to treating acute promyelocytic leukemia, arsenic trioxide (ATO) suppresses other solid tumors, including chondrosarcoma. However, the effects of ATO on metastasis in chondrosarcoma cells, and the ...

    Authors: Xing Bao, Tingting Ren, Yi Huang, Shidong Wang, Fan Zhang, Kuisheng Liu, Bingxin Zheng and Wei Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:129
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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