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  1. LKB1, also known as STK11, is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. Recent studies have indicated that LKB1 is related to breast tumorigenesis and ...

    Authors: Juan Li, Jie Liu, Pingping Li, Xiaona Mao, Wenjie Li, Jin Yang and Peijun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:70
  2. Neoadjuvant treatment plays a crucial role in the therapy of advanced esophageal cancer. However, response to radiochemotherapy varies widely. Proton pump inhibitors (PPIs) have been demonstrated to impact on ...

    Authors: Kirsten Lindner, Christiane Borchardt, Maren Schöpp, Anja Bürgers, Christian Stock, Damian J Hussey, Jörg Haier and Richard Hummel
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:73
  3. The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and R...

    Authors: Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran and Chun-Meng Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:64
  4. PCDH8 is a novel tumor suppressor gene, and frequently inactivated by promoter methylation in human cancers. However, there is little information regarding PCDH8 methylation in non-muscle invasive bladder canc...

    Authors: Ying-Li Lin, Yan-Ling Wang, Jian-Guo Ma and Wen-Ping Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:68
  5. Laparoscopic prostatectomy (LRP) may activate clotting system influencing the risk of perioperative thrombosis in patients with prostate cancer. Moreover, different anaesthetic techniques can also modify coagu...

    Authors: Maria Sofra, Anna Antenucci, Michele Gallucci, Chiara Mandoj, Rocco Papalia, Claudia Claroni, Ilaria Monteferrante, Giulia Torregiani, Valeria Gianaroli, Isabella Sperduti, Luigi Tomao and Ester Forastiere
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:63
  6. The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers. The discovery of tumor associated miRNAs in serum of patients supported ...

    Authors: Yougang Feng, Jun Liu, Yongming Kang, Yue He, Bo Liang, Ping Yang and Zhou Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:67
  7. Gastric cancer (GC) remains to have a poor prognosis via diverse process of cancer progression. Dihydropyrimidinase-like 3 (DPYSL3) is a cell adhesion molecule that has been reported to be involved in the metasta...

    Authors: Mitsuro Kanda, Shuji Nomoto, Hisaharu Oya, Dai Shimizu, Hideki Takami, Soki Hibino, Ryoji Hashimoto, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara and Yasuhiro Kodera
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:66
  8. Epigenetic alterations of specific genes have been reported to be related to colorectal cancer (CRC) transformation and would also appear to be involved in the early stages of colorectal carcinogenesis. Little...

    Authors: Claudia Rengucci, Giulia De Maio, Andrea Casadei Gardini, Mattia Zucca, Emanuela Scarpi, Chiara Zingaretti, Giovanni Foschi, Maria Maddalena Tumedei, Chiara Molinari, Luca Saragoni, Maurizio Puccetti, Dino Amadori, Wainer Zoli and Daniele Calistri
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:65
  9. Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and surviva...

    Authors: Samantha Kaufhold and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:62
  10. Karyopherin alpha 2 (KPNA2) promotes tumor growth in hepatocellular carcinoma (HCC). We aimed to determine the content and clinical significance of mechanism underlying.

    Authors: Zhe-yuan Hu, Sheng-xian Yuan, Yuan Yang, Wei-ping Zhou and Hua Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:61
  11. Enhancer of zeste homolog 2 (EZH2), a member of the polycomb group proteins, has been shown to promote cancer progression and breast cancer stem cell (CSC) expansion. Breast CSCs are associated with resistance...

    Authors: Bisrat G Debeb, Yun Gong, Rachel L Atkinson, Nour Sneige, Lei Huo, Ana Maria Gonzalez-Angulo, Mien-Chie Hung, Vicente Valero, Naoto T Ueno and Wendy A Woodward
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:58
  12. Serous tubal intraepithelial carcinoma (STIC) and the p53 signature in tubal mucosa have been supported to be precursor lesions in high-grade serous carcinoma (HGSC) of the fallopian tube, ovary, and peritoneu...

    Authors: Yiying Wang, Lingmin Li, Yue Wang, Zeng Yuan, Wenjing Zhang, Kenneth D Hatch and Wenxin Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:60
  13. Local hyperthermia of tumor in conjunction with chemotherapy is a promising strategy for cancer treatment. The aim of this study was to evaluate the efficacy of intratumoral delivery of clinically approved mag...

    Authors: Min Jeong Jeon, Cheol-Hee Ahn, Hyeonjin Kim, In Jae Chung, Seulhee Jung, Young-Hwa Kim, Hyewon Youn, Jin Wook Chung and Young Il Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:57
  14. To study the expression of D2R, MGMT and VEGF for clinical significance in pituitary adenomas, and to predict the potential curative medical therapy of dopamine agonists, temozolomide and bevacizumab on pituit...

    Authors: Youwei Wang, Junyang Li, Mamatemin Tohti, Yuebing Hu, Sheng Wang, Wanchun Li, Zhenfeng Lu and Chiyuan Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:56
  15. Previous studies have shown that class-I histone deacetylase (HDAC) 8 mRNA is upregulated in urothelial cancer tissues and urothelial cancer cell lines compared to benign controls. Using urothelial cancer cell...

    Authors: Maria Lehmann, Michèle J Hoffmann, Annemarie Koch, Scott M Ulrich, Wolfgang A Schulz and Günter Niegisch
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:59
  16. To understand the involvement of structural maintenance of chromosome 4 (SMC4) in the development and progression of hepatocellular carcinoma (HCC).

    Authors: Bo Zhou, Hongxu Chen, Dong Wei, Yi Kuang, Xiaobiao Zhao, Guangyao Li, Jun Xie and Ping Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:55

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:223

  17. microRNAs (miRNAs) are a class of small non-coding RNAs that play important roles in carcinogenesis. In the present study, we investigated the effect of miR-212 on pancreatic ductal adenocarcinoma (PDAC) and i...

    Authors: Chenchao Ma, Kate Nong, Bo Wu, Bo Dong, Yueqing Bai, Hongda Zhu, Weiwei Wang, Xinyu Huang, Zhou Yuan and Kaixing Ai
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:54
  18. Nasopharyngeal carcinoma (NPC) is a common malignant tumor observed in the populations of southern China and Southeast Asia. However, little is known about the effects of purinergic signal on the behavior of N...

    Authors: Guang Yang, Shenghong Zhang, Yanling Zhang, Qiming Zhou, Sheng Peng, Tao Zhang, Changfu Yang, Zhenyu Zhu and Fujun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:53
  19. Although the EGF receptor tyrosine kinase inhibitors (EGFR-TKI) gefitinib have shown dramatic effects against EGFR mutant lung cancer, patients become resistant by various mechanisms, including gatekeeper EGFR-T7...

    Authors: Yiqing Qu, Xiuxiu Wu, Yunhong Yin, Yan Yang, Dedong Ma and Hao Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:52
  20. Butein has various functions in human diseases including cancer. While anti-cancer effects of butein have been revealed, it is urgent to understand a unique role of butein against cancer. In this study, we dem...

    Authors: Sung-Gook Cho, Sang-Mi Woo and Seong-Gyu Ko
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:51
  21. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processe...

    Authors: Qin Qin, Wei Furong and Li Baosheng
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:50
  22. The aim of this study was to evaluate the ability of a 41-gene signature derived from breast cancer stem cells (BCSCs) to estimate the risk of metastasis and survival in breast cancer patients.

    Authors: Zhi-Qiang Yin, Jian-Jun Liu, Ying-Chun Xu, Jian Yu, Guo-Hui Ding, Feng Yang, Lei Tang, Bao-Hong Liu, Yue Ma, Yu-Wei Xia, Xiao-Lin Lin and Hong-Xia Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:49
  23. Non Muscle Invasive Bladder Transitional Cancer (NMIBC) and Muscle Invasive Bladder Transitional Cancer (MIBC)/invasive have different gene profile and clinical course. NMIBC prognosis is not completely predic...

    Authors: Renato Franco, Silvia Zappavigna, Vincenzo Gigantino, Amalia Luce, Monica Cantile, Margherita Cerrone, Gaetano Facchini, Sisto Perdonà, Sandro Pignata, Giuseppe Di Lorenzo, Sergio Chieffi, Giovanni Vitale, Marco De Sio, Alessandro Sgambato, Gerardo Botti, Ali Munaim Yousif…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:48
  24. Epidermal growth factor receptor (EGFR) overexpression has been associated with prognostic and predictive value in inflammatory breast cancer (IBC). Epidermal growth factor receptor 2 (HER2) overexpression is ...

    Authors: Zhaomei Mu, Teresa Klinowska, Xiaoshen Dong, Emily Foster, Chris Womack, Sandra V Fernandez and Massimo Cristofanilli
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:47
  25. The anti-mullerian hormone (AMH) is a member of the transforming growth factor β (TGF-β) superfamily, which is responsible of the regression of the mullerian duct. AMH is expressed in the normal endometrium, w...

    Authors: Pietro G Signorile, Francesca Petraglia and Alfonso Baldi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:46
  26. Inflammation increases the risk of colorectal cancer (CRC). We and others have described a role for TLR4, the receptor for LPS, in colon cancer. To explore the relationships between TLR4 expression and CRC, we...

    Authors: Daniel A Sussman, Rebeca Santaolalla, Pablo A Bejarano, Monica T Garcia-Buitrago, Maria T Perez, Maria T Abreu and Jennifer Clarke
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:45
  27. Mutations in epigenetic modifiers were reported in patients with acute myeloid leukaemia (AML) including mutations in DNA methyltransferase 3A gene (DNMT3A) in 20%-30% patients and mutations in isocitrate dehydro...

    Authors: Rimma Berenstein, Igor Wolfgang Blau, Asiye Kar, Ruhiye Cay, Annette Sindram, Claudia Seide and Olga Blau
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:44
  28. Liver metastases occur in 46-93% of patients with neuroendocrine neoplasms (NENs). Presence and extension of liver metastases are considered important prognostic factors, as they may significantly impair the p...

    Authors: Michela Del Prete, Francesco Fiore, Roberta Modica, Vincenzo Marotta, Francesca Marciello, Valeria Ramundo, Antonella Di Sarno, Annachiara Carratù, Chiara de Luca di Roseto, Salvatore Tafuto, Fabiana Tatangelo, Robero Baldelli, Annamaria Colao and Antongiulio Faggiano
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:43
  29. Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), which accounts for approximately 10% of all acute myloid leukemia cases. It is a blood cancer that is formed by chromosomal muta...

    Authors: Sanjay Kumar, Clement G Yedjou and Paul B Tchounwou
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:42
  30. Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of ant...

    Authors: Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin and HÃ¥kan Billig
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:41
  31. The epithelial-to-mesenchymal transition (EMT) accompanied by the downregulation of E-cadherin has been thought to promote metastasis. Cyclooxygenase-2 (Cox-2) is presumed to contribute to cancer progression t...

    Authors: Ryoichi Fujii, Yorihisa Imanishi, Katsushi Shibata, Nobuya Sakai, Koji Sakamoto, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Hiroyuki Ozawa, Toshiki Tomita, Kaori Kameyama, Masato Fujii and Kaoru Ogawa
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:40
  32. Heparanase is an endo-β-D-glucuronidase that cleaves heparan sulfate chains of proteoglycans, resulting in the disassembly of the extracellular matrix. Heparanase has a central role in the development of vario...

    Authors: Olga Kazarin, Neta Ilan, Inna Naroditzky, Ofer Ben-Itzhak, Israel Vlodavsky and Gil Bar-Sela
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:39
  33. Gastric carcinoma (GC) is a common and lethal malignancy, and epithelial-mesenchymal transition (EMT) is believed to contribute to invasive and metastatic tumor growth. Aquaporin 3 (AQP3) is overexpressed in h...

    Authors: Jia Chen, Tao Wang, Yang-Chun Zhou, Fei Gao, Zhi-Hong Zhang, Hao Xu, Shou-Lin Wang and Li-Zong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:38
  34. Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature...

    Authors: Evandro Luís Niero, Bianca Rocha-Sales, Camila Lauand, Beatriz Araujo Cortez, Marcelo Medina de Souza, Paula Rezende-Teixeira, Marcel Shiniti Urabayashi, Adam Arai Martens, Jorge Henrique Neves and Gláucia Maria Machado-Santelli
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:37
  35. Berberine (BBR), a component from traditional Chinese medicine, has been shown to possess anti-tumor activity against a wide spectrum of cancer cells including human lung cancer, but the detailed mechanism und...

    Authors: Fang Zheng, Qin Tang, JingJing Wu, ShunYu Zhao, ZhanYang Liang, Liuning Li, WanYin Wu and Swei Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:36
  36. T regulatory cells (Tregs) contribute to the progression of head and neck squamous cell carcinoma (HNSCC) by suppressing antitumor immunity. However, little is known regarding the functional heterogeneity of T...

    Authors: Wei Sun, Wei-Jin Li, Chang-You Wu, Hua Zhong and Wei-Ping Wen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:35
  37. Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer. Investigation of the mechanism of invasion and metastasis of lung SCC will be of great help for the development of me...

    Authors: Dongsheng Yue, Hui Li, Juanjuan Che, Yi Zhang, Hsin-Hui K Tseng, Joy Q Jin, Thomas M Luh, Etienne Giroux-Leprieur, Minli Mo, Qingfeng Zheng, Huaiyin Shi, Hua Zhang, Xishan Hao, Changli Wang, David M Jablons and Biao He
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:34
  38. Recently, recurrent point mutations in the telomerase reverse transcriptase (TERT) promoter region have been found in many human cancers, leading to a new transcription factor binding site, increased induction of...

    Authors: Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann, Peter Schirmacher, Andreas von Deimling and Gunhild Mechtersheimer
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:33
  39. The expression of 5-hydroxymethylcytosine (5-hmC) and isocitrate dehydrogenase 2 (IDH2) is frequently downregulated in numerous cancers. 5-hmC and IDH2 expression in hepatocellular carcinoma (HCC) has yet to b...

    Authors: Wei-Ren Liu, Meng-Xin Tian, Lei Jin, Liu-Xiao Yang, Zhen-Bin Ding, Ying-Hao Shen, Yuan-Fei Peng, Jian Zhou, Shuang-Jian Qiu, Zhi Dai, Jia Fan and Ying-Hong Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:32
  40. While recent research has shown that expression of RABEX-5 in breast cancer and colorectal cancer has a crucial impact on tumor development, there is little information regarding RABEX-5 expression in prostate...

    Authors: Hongtuan Zhang, Shang Cheng, Andi Wang, Hui Ma, Bing Yao, Can Qi, Ranlu Liu, Shiyong Qi and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:31
  41. Elderly patients with metastatic melanoma have different disease characteristics and a poorer prognosis than younger patients. Data from clinical trials and expanded access programmes (EAPs) suggest ipilimumab...

    Authors: Vanna Chiarion Sileni, Jacopo Pigozzo, Paolo Antonio Ascierto, Antonio Maria Grimaldi, Michele Maio, Lorenza Di Guardo, Paolo Marchetti, Francesco de Rosa, Carmen Nuzzo, Alessandro Testori, Emilia Cocorocchio, Maria Grazia Bernengo, Michele Guida, Riccardo Marconcini, Barbara Merelli, Giorgio Parmiani…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:30
  42. Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the...

    Authors: Patrizia Vici, Luciano Mariani, Laura Pizzuti, Domenico Sergi, Luigi Di Lauro, Enrico Vizza, Federica Tomao, Silverio Tomao, Claudia Cavallotti, Francesca Paolini and Aldo Venuti
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:29
  43. Bone scanning (BS), liver ultrasonography (LUS), and chest radiography (CXR) are commonly recommended for baseline staging in patients with newly diagnosed breast cancer. The purpose of this study is to demons...

    Authors: Xuesong Chen, Lichun Sun, Yingying Cong, Tingting Zhang, Qiushi Lin, Qingwei Meng, Hui Pang, Yanbin Zhao, Yu Li, Li Cai and Xiaoqun Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:28
  44. In osteosarcoma, the presence of tumor-infiltrating macrophages positively correlates with patient survival in contrast to the negative effect of tumor-associated macrophages in patients with other tumors. Lip...

    Authors: Jens HW Pahl, Kitty MC Kwappenberg, Eleni M Varypataki, Susy J Santos, Marieke L Kuijjer, Susan Mohamed, Juul T Wijnen, Maarten JD van Tol, Anne-Marie Cleton-Jansen, R Maarten Egeler, Wim Jiskoot, Arjan C Lankester and Marco W Schilham
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:27
  45. Stanniocalcin 2 (STC2) is overexpressed in several types of human cancers, and its overexpression positively correlates to tumor progression and poor prognosis. However, the clinical significance of STC2 overe...

    Authors: Shaojun Lin, Qiaojuan Guo, Jiangmei Wen, Chao Li, Jin Lin, Xiaofei Cui, Nianli Sang and Jianji Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:26
  46. Expression of the non-receptor tyrosine kinase ETK/BMX has been reported in several solid tumors, but the underlying molecular mechanisms and its clinical significance in renal cell carcinoma (RCC) remain to b...

    Authors: Jintao Zhuang, Xiangan Tu, Kaiyuan Cao, Shengjie Guo, Xiaopeng Mao, Jincheng Pan, Bin Huang, Xu Chen, Yong Gao and Shaopeng Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:25
  47. CELLFOODâ„¢ (CF) is a nutraceutical non-addictive, non-invasive, and completely non-toxic unique proprietary colloidal-ionic formula. Little is known about its effect on cancer cells in solid tumors. The aim of ...

    Authors: Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari and Rossella Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:24

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:290

  48. Dystrophic skin scarring commonly occurs following skin cancer resections. In particular, the cosmetic outcome of skin graft reconstructions, following epidermoidal carcinoma removal, is generally poor due to ...

    Authors: Emilia Migliano, Barbara Bellei, Flavio Andrea Govoni, Stefania Bucher and Mauro Picardo
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:23
  49. Authors: Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:22

    The original article was published in Journal of Experimental & Clinical Cancer Research 2010 29:135

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