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  1. Nuclear casein kinase and cyclin-dependent kinase substrate (NUCKS), a novel gene first reported in 2001, is a member of the high mobility group (HMG) family. Although very little is known regarding the biolog...

    Authors: Erhu Zhao, Liying Feng, Longchang Bai and Hongjuan Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:194

    Content type: Research

    Published on:

  2. Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 ...

    Authors: Shuangshuang Mao, Zhiliang Lu, Sufei Zheng, Hao Zhang, Guochao Zhang, Feng Wang, Jianbing Huang, Yuanyuan Lei, Xinfeng Wang, Chengming Liu, Nan Sun and Jie He

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:193

    Content type: Research

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  3. The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo...

    Authors: Yuhao Zhang, Xiuchao Geng, Qiang Li, Jianglong Xu, Yanli Tan, Menglin Xiao, Jia Song, Fulin Liu, Chuan Fang and Hong Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:192

    Content type: Review

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  4. Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be in...

    Authors: Sifeng Tao, Qiang Chen, Chen Lin and Haiying Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:191

    Content type: Research

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  5. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients’ poor prognosis. However, the functions of ...

    Authors: Xiang Zhang, Dawei Wang, Boke Liu, Xingwei Jin, Xianjin Wang, Junwei Pan, Weichao Tu and Yuan Shao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:190

    Content type: Research

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  6. Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)...

    Authors: Alberto Ocaña and Atanasio Pandiella

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:189

    Content type: Review

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  7. Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t...

    Authors: Yilan Yang, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Xiaomao Guo and Xiaoli Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:188

    Content type: Review

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  8. Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modif...

    Authors: Shanshan Zhao, Xue Zhang, Shuo Chen and Song Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:187

    Content type: Review

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  9. Bladder cancer (BC) is a common genitourinary malignancy worldwide. Circular RNAs (circRNAs) participate in cancer development, including BC; thus, the roles of circRNAs in this process have attracted signific...

    Authors: Mingming Jin, Shengjie Lu, Yue Wu, Chen Yang, Chunzi Shi, Yanqiu Wang and Gang Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:186

    Content type: Research

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  10. Molecular oxygen (O2) is a universal electron acceptor that is eventually synthesized into ATP in the mitochondrial respiratory chain of all metazoans. Therefore, hypoxia biology has become an organizational prin...

    Authors: Mingyao Huang, Liang Yang, Xueqiang Peng, Shibo Wei, Qing Fan, Shuo Yang, Xinyu Li, Bowen Li, Hongyuan Jin, Bo Wu, Jingang Liu and Hangyu Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:185

    Content type: Review

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  11. The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant gene...

    Authors: Andrew Brennan, James T. Leech, Neil M. Kad and Jody M. Mason

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:184

    Content type: Review

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  12. NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown.

    Authors: Tie Xu, Yulan Zeng, Linli Shi, Qin Yang, Yeshan Chen, Gang Wu, Guiling Li and Shuangbing Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:183

    Content type: Research

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  13. Glioma is the most common and lethal primary brain tumor in adults, and angiogenesis is one of the key factors contributing to its proliferation, aggressiveness, and malignant transformation. However, the disc...

    Authors: Yang Jiang, Jinpeng Zhou, Junshuang Zhao, Haiying Zhang, Long Li, Hao Li, Lian Chen, Jiangfeng Hu, Wei Zheng and Zhitao Jing

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:182

    Content type: Research

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  14. Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers. In the present study, we investigated w...

    Authors: Qiwen Ben, Wei An, Yunwei Sun, Aihua Qian, Jun Liu, Duowu Zou and Yaozong Yuan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:181

    Content type: Research

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  15. Triple-negative breast cancer (TNBC) is a uniquely aggressive cancer with high rates of relapse due to resistance to chemotherapy. TNBC expresses higher levels of programmed cell death-ligand 1 (PD-L1) compare...

    Authors: Simona Camorani, Margherita Passariello, Lisa Agnello, Silvia Esposito, Francesca Collina, Monica Cantile, Maurizio Di Bonito, Ilya V. Ulasov, Monica Fedele, Antonella Zannetti, Claudia De Lorenzo and Laura Cerchia

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:180

    Content type: Research

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  16. Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-A...

    Authors: Hao Zhang, Changhao Zhu, Zhiwei He, Shiyu Chen, Lin Li and Chengyi Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:179

    Content type: Research

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  17. Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...

    Authors: Juncheng Cui, Dylan Dean, Francis J. Hornicek, Zhiwei Chen and Zhenfeng Duan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:178

    Content type: Review

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  18. A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizi...

    Authors: Assunta De Luca, Francesco Ripa di Meana, Branka Vujovic, Aldo Morrone, Chiara Degirolamo, Gennaro Ciliberto and Tiziana Lavalle

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:177

    Content type: Commentary

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  19. Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. The communication between tumor-derived exosomes and macrophages has a critical role in facilitating...

    Authors: Manman Liang, Xingwu Chen, Lijing Wang, Lilong Qin, Hanli Wang, Zhengui Sun, Wenying Zhao and Biao Geng

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:176

    Content type: Research

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  20. Overexpression of eukaryotic translation initiation factor 3H (EIF3H) predicts cancer progression and poor prognosis, but the mechanism underlying EIF3H as an oncogene remains unclear in esophageal squamous ce...

    Authors: Xiaobin Guo, Rui Zhu, Aiping Luo, Honghong Zhou, Fang Ding, Hongxin Yang and Zhihua Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:175

    Content type: Research

    Published on:

  21. Inhibition of p38 MAPK signalling leads to glioblastoma multiform (GBM) tumourigenesis. Nevertheless, the molecular mechanism that induces p38 MAPK signalling pathway silencing during GBM genesis has yet to be...

    Authors: Yang Xu, Qian Sun, Fan’en Yuan, Huimin Dong, Huikai Zhang, Rongxin Geng, Yangzhi Qi, Xiaoxing Xiong, Qianxue Chen and Baohui Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:174

    Content type: Research

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  22. A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance ...

    Authors: Cheng Yang, Jiayu Zhang, Yukui Ma, Chunfu Wu, Wei Cui and Lihui Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:173

    Content type: Review

    Published on:

  23. Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored.

    Authors: Xiang Li, Chen Zhang, Ting Zhao, Zhongping Su, Mengjing Li, Jiancheng Hu, Jianfei Wen, Jiajia Shen, Chao Wang, Jinshun Pan, Xianmin Mu, Tao Ling, Yingchang Li, Hao Wen, Xiaoren Zhang and Qiang You

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:172

    Content type: Research

    Published on:

  24. The Covid-19 pandemic has challenged hard the national health systems worldwide. According to the national policy issued in March 2020 in response to the evolving Covid-19 pandemic, several hospitals were re-c...

    Authors: Fabio Pelle, Sonia Cappelli, Franco Graziano, Loredana Piarulli, Flavia Cavicchi, Domenico Magagnano, Assunta De Luca, Roy De Vita, Marcello Pozzi, Maurizio Costantini, Antonio Varanese, Massimo Panimolle, Pietro Paolo Gullo, Maddalena Barba, Patrizia Vici, Enrico Vizza…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:171

    Content type: Commentary

    Published on:

  25. The platinum-based chemotherapy is the first-line regimen for the treatment of Non-small cell lung cancer (NSCLC). However, the therapeutic efficiency is largely limited by tenacious chemo-insensitivity that r...

    Authors: Boshi Wang, Tiantian Jing, Weilin Jin, Jinnan Chen, Chengsi Wu, Mingrong Wang and Yizhen Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:170

    Content type: Research

    Published on:

  26. cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found that CREB5 was involved in the occurrence and develo...

    Authors: Shuyang Wang, Junfeng Qiu, Lei Liu, Cailin Su, Lu Qi, Chengmei Huang, Xiaoning Chen, Yaxin Zhang, Yaping Ye, Yanqing Ding, Li Liang and Wenting Liao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:168

    Content type: Research

    Published on:

  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Weiwei Sheng, Xiaoyang Shi, Yiheng Lin, Jingtong Tang, Chao Jia, Rongxian Cao, Jian Sun, Guosen Wang, Lei Zhou and Ming Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:167

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:16

  28. Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For the purpose of exploring roles of th...

    Authors: Xiang Qing, Guo-lin Tan, Huo-wang Liu, Wei Li, Jin-gang Ai, Shan-shan Xiong, Meng-qing Yang and Tian-sheng Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:166

    Content type: Research

    Published on:

  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li and Hua Tang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:165

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:14

  30. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zichao Li, Luying Zhang, Mingquan Gao, Mei Han, Kaili Liu, Zhuang Zhang, Zhi Gong, Lifei Xing, Xianzhou Shi, Kui Lu and Hui Gao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:164

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:8

  31. As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies are needed to improve cancer therapy outcomes. Numerous pathways have been shown to contribute to migration and invasi...

    Authors: Madiha Kanwal, Michal Smahel, Mark Olsen, Jana Smahelova and Ruth Tachezy

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:163

    Content type: Review

    Published on:

  32. Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metas...

    Authors: Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang yang, Hongjing Zang, Jiadi Luo, Qiuyuan Wen and Songqing Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:162

    Content type: Review

    Published on:

  33. Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) ...

    Authors: Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André and Catarina Brito

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:161

    Content type: Research

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  34. Colorectal cancer (CRC) is one of the causes of cancer-related death worldwide. The aim of our study was to disclose the expression pattern and underlying molecular mechanism of circular RNA TADA2A (circTADA2A...

    Authors: Zhen Li, Hongyu Yao, Shihao Wang, Guobin Li and Xiaoming Gu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:160

    Content type: Research

    Published on:

  35. Emerging evidence has shown that dysregulated expression of long noncoding RNAs (lncRNAs) is implicated in liver hepatocellular carcinoma (HCC). However, the role and molecular mechanism of differentially expr...

    Authors: Hui He, Yawei Wang, Peng Ye, Dehui Yi, Ying Cheng, Haibo Tang, Zhi Zhu, Xun Wang and Shi Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:159

    Content type: Research

    Published on:

  36. Chemoresistance is emerging as a major barrier to successful treatment in acute myeloid leukemia (AML), and evasion of apoptosis is among the fundamental underlying mechanisms. Therefore, unraveling molecular ...

    Authors: Yihua Pang, Yanan Zhao, Yan Wang, Xinlu Wang, Ruiqing Wang, Na Liu, Peng Li, Min Ji, Jingjing Ye, Tao Sun, Jingxin Li, Daoxin Ma, Fei Lu and Chunyan Ji

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:158

    Content type: Research

    Published on:

  37. Many cancer-associated single nucleotide polymorphisms (SNPs) are located in the genomic regions of long non-coding RNAs (lncRNAs). Mechanisms of these SNPs in connection to cancer risk are not fully understood.

    Authors: Tienan Feng, Nannan Feng, Tengteng Zhu, Qiang Li, Qi Zhang, Yu Wang, Ming Gao, Baosen Zhou, Herbert Yu, Min Zheng and Biyun Qian

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:157

    Content type: Research

    Published on:

  38. Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the...

    Authors: Chongru Zhao, Min Wu, Ning Zeng, Mingchen Xiong, Weijie Hu, Wenchang Lv, Yi Yi, Qi Zhang and Yiping Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:156

    Content type: Review

    Published on:

  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yanxia Huang, Jing Zhang, Lidan Hou, Ge Wang, Hui Liu, Rui Zhang, Xiaoyu Chen and Jinshui Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:155

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:194

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kun Qiao, Shipeng Ning, Lin Wan, Hao Wu, Qin Wang, Xingda Zhang, Shouping Xu and Da Pang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:154

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:418

  41. Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute...

    Authors: Rosamaria Lappano, Marianna Talia, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Domenica Scordamaglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Andrew H. Sims and Marcello Maggiolini

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:153

    Content type: Research

    Published on:

  42. Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting g...

    Authors: Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Martina Vitale, Emanuela Pilozzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio and Giuseppe Pugliese

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:152

    Content type: Research

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  43. Pancreatic cancer (PC) is one of the most aggressive cancers and has an extremely poor prognosis worldwide. Long noncoding RNA (lncRNA) has been reported to be a potential prognostic biomarker in the initiatio...

    Authors: Qing Han, Junhe Li, Jianping Xiong and Zhiwang Song

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:151

    Content type: Research

    Published on:

  44. Hepatocellular carcinoma (HCC) is one of the most prevalent common cancer worldwide with high mortality. Transforming growth factor-β (TGF-β) signaling pathway was reported dysregulated during liver cancer for...

    Authors: Zhao Huang, Jingyuan Wen, Jingjing Yu, Jingyu Liao, Sha Liu, Ning Cai, Huifang Liang, Xiaoping Chen, Zeyang Ding and Bixiang Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:150

    Content type: Research

    Published on:

  45. Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed cell death ligand 1 (PD-L1) promoted cancer progression and drug resistance, and facilitated tumor immune evasion. Ho...

    Authors: Weijun Hong, Min Xue, Jun Jiang, Yajuan Zhang and Xiwen Gao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:149

    Content type: Research

    Published on:

  46. Collagens are the most abundant proteins in extra cellular matrix and important components of tumor microenvironment. Recent studies have showed that aberrant expression of collagens can influence tumor cell b...

    Authors: Ting Wang, Haojie Jin, Jingying Hu, Xi Li, Haoyu Ruan, Huili Xu, Lin Wei, Weihua Dong, Fei Teng, Jianren Gu, Wenxin Qin, Xiaoying Luo and Yujun Hao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:148

    Content type: Research

    Published on:

  47. Colorectal cancer (CRC) is one of the most common malignancies, and it’s expected that the CRC burden will substantially increase in the next two decades. New biomarkers for targeted treatment and associated m...

    Authors: Xiaojuan Wang, Fan Wu, Han Wang, Xiaoyuan Duan, Rong Huang, Amannisa Tuersuntuoheti, Luying Su, Shida Yan, Yuechao Zhao, Yan Lu, Kai Li, Jinjie Yao, Zhiwen Luo, Lei Guo, Jianmei Liu, Xiao Chen…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:147

    Content type: Research

    Published on:

  48. The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. Abundant evidence has indicated that STAT-...

    Authors: Ming Hong, Selena Lee, Jacob Clayton, Wildman Yake and Jinke Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:146

    Content type: Research

    Published on:

  49. Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear. This study aims to verify the role and the underlying mechanisms ...

    Authors: Shi-Jie Wang, Dong Chao, Wei Wei, Gang Nan, Jia-Yue Li, Fen-Ling Liu, Ling Li, Jian-Li Jiang, Hong-Yong Cui and Zhi-Nan Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:145

    Content type: Research

    Published on:

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