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  1. Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic de...

    Authors: Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Alexander W. Loftus, Moeez Rathore, Ali Vaziri-Gohar, John M. Asara, Jordan M. Winter and Luke D. Rothermel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:283
  2. Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their s...

    Authors: Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger and Naris Nilubol
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:282
  3. Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development of many diseases, including tumors. This study aimed to investigate the potential roles of ci...

    Authors: Xiaopei Hao, Yao Zhang, Xiaoli Shi, Hanyuan Liu, Zhiying Zheng, Guoyong Han, Dawei Rong, Chuanyong Zhang, Weiwei Tang and Xuehao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:281
  4. Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- and second-line settings. However, only 15–20% of pati...

    Authors: Anna Tosi, Beatrice Parisatto, Anna Menegaldo, Giacomo Spinato, Maria Guido, Annarosa Del Mistro, Rossana Bussani, Fabrizio Zanconati, Margherita Tofanelli, Giancarlo Tirelli, Paolo Boscolo-Rizzo and Antonio Rosato
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:279
  5. Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant feat...

    Authors: Hashem Khanbabaei, Saeedeh Ebrahimi, Juan Luis García-Rodríguez, Zahra Ghasemi, Hossein Pourghadamyari, Milad Mohammadi and Lasse Sommer Kristensen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:278
  6. Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite accumulating understanding of OC in the post-genomic era, the preclinical knowledge stil...

    Authors: Tianyu Qin, Junpeng Fan, Funian Lu, Li Zhang, Chen Liu, Qiyue Xiong, Yang Zhao, Gang Chen and Chaoyang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:277
  7. The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important roles related to the hallmarks of cancer. In cancer, multiple components of the ECM have b...

    Authors: Ancuta Jurj, Calin Ionescu, Ioana Berindan-Neagoe and Cornelia Braicu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:276
  8. Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Her...

    Authors: Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Xiangyuan Luo, Xiaoping Chen, Bixiang Zhang, Danfei Liu, Yangyang Feng, Mengyu Sun, Wenjie Huang and Limin Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:275
  9. Severe hypoxia is a prominent character of pancreatic ductal adenocarcinoma (PDAC) microenvironment. In the process of gemcitabine based chemotherapy, PDAC cells are insulted from replication stresses co-induc...

    Authors: Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi and Bo Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:274
  10. Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being ...

    Authors: Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla and Isabella Saggio
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:273
  11. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0717-3

    Authors: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:272
  12. Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but now it has also been found to suppress cancer by inducing c...

    Authors: Peijie Zheng, Chuntao Zhou, Liuyi Lu, Bin Liu and Yuemin Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:271
  13. Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in various types of cancer. Current developments in transcriptome analyses unveiled the existence...

    Authors: Jiwei Zhang, Tao Pan, Weiwei Zhou, Ya Zhang, Gang Xu, Qi Xu, Si Li, Yueying Gao, Zhengtao Wang, Juan Xu and Yongsheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:270
  14. Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers resistant to conventional therapies. TCE are antibody-like proteins that simultaneously ...

    Authors: Margherita Passariello, Asami Yoshioka, Kota Takahashi, Shu-ichi Hashimoto, Toshikazu Inoue, Koji Nakamura and Claudia De Lorenzo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:269
  15. As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the...

    Authors: Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang and Peng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:268
  16. Circular RNA (circRNA) is crucial to the progression of hepatocellular cancer (HCC). In addition, Mitochondrial calcium uniporter regulatory factor 1 (MCUR1) is commonly overexpressed in HCC to increase cellul...

    Authors: Yi Li, Anqi Wu, Lin Chen, Aiting Cai, Yuhao Hu, Zhou Zhou, Qianyi Qi, Yixuan Wu, Donglin Xia, Peixin Dong, Shaoqing Ju and Feng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:267
  17. Colorectal cancer (CRC) remains largely incurable when diagnosed at the metastatic stage. Despite some advances in precision medicine for this disease in recent years, new molecular targets, as well as prognos...

    Authors: Margherita Pergolizzi, Laura Bizzozero, Federica Maione, Elena Maldi, Claudio Isella, Marco Macagno, Elisa Mariella, Alberto Bardelli, Enzo Medico, Caterina Marchiò, Guido Serini, Federica Di Nicolantonio, Federico Bussolino and Marco Arese
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:266
  18. As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically-applicable way. The int...

    Authors: Karama Asleh, Nazia Riaz and Torsten O. Nielsen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:265
  19. Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE),...

    Authors: Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng and Wael El-Rifai
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:264
  20. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1244-6..

    Authors: Xiaocheng Cao, Lihua Liu, Qing Yuan, Xiang Li, Yinghong Cui, Kaiqun Ren, Chang Zou, A. Chen, Chang Xu, Yebei Qiu, Meifang Quan, Jiansong Zhang, Jianguo Cao and Xiangding Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:263
  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wanxu Huang, Hua Li, Qingsong Yu, Wei Xiao and Dan Ohtan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:262

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:100

  22. Metastasis is the main cause of mortality in cervical cancer (CC). Circular RNAs (circRNAs) have been demonstrated to play a crucial role in carcinoma biology. However, the expression and function of circRNAs ...

    Authors: Leilei Liang, Yunshu Zhu, Jian Li, Jia Zeng and Lingying Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:261
  23. Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC metastasis remain to be fully understood. With the increas...

    Authors: Yanliang Wang, Yu Chen Feng, Yujin Gan, Liu Teng, Li Wang, Ting La, Peilin Wang, Yue Gu, Lei Yan, Na Li, Lina Zhang, Limeng Wang, Rick F. Thorne, Xu Dong Zhang, Huixia Cao and Feng-Min Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:260
  24. Radiation-induced bystander effect (RIBE) can promote tumor metastasis contributing to the failure of radiotherapy for esophageal squamous cell carcinoma (ESCC). Aberrant expression of DJ-1 has been identified...

    Authors: Junjie Gu, Yuanyuan Sun, Jiahang Song, Ruiling Zhao, Xiaoke Di, Yumeng Zhang, Xiaolin Ge, Shu Zhang, Yun Gu and Xinchen Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:259
  25. Pancreatic cancer is one of the most difficult cancers to detect early and most patients die from complications arising due to distant organ metastases. The lack of bona fide early biomarkers is one of the pri...

    Authors: Harrys Kishore Charles Jacob, Rossana Signorelli, John Lalith Charles Richard, Tyler Kashuv, Shweta Lavania, Ashley Middleton, Beatriz Aguilar Gomez, Anthony Ferrantella, Haleh Amirian, Junyi Tao, Ayse Burcu Ergonul, Melinda Minucci Boone, Marco Hadisurya, Weiguo Andy Tao, Anton Iliuk, Manoj Kumar Kashyap…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:258
  26. G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated...

    Authors: Yuan Li, Yibo Fan, Jinbang Xu, Longfei Huo, Ailing W. Scott, Jiankang Jin, Boxuan Yang, Shan Shao, Lang Ma, Ying Wang, Xiaodan Yao, Melissa Pool Pizzi, Matheus Sewastjanow Da Silva, Guoliang Zhang, Lijuan Zhuo, Eun Jeong Cho…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:257
  27. Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for TNBC. However, response to radiotherapy is ...

    Authors: Shayan Khozooei, Konstanze Lettau, Francesca Barletta, Tina Jost, Simone Rebholz, Soundaram Veerappan, Mirita Franz-Wachtel, Boris Macek, George Iliakis, Luitpold V. Distel, Daniel Zips and Mahmoud Toulany
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:256
  28. Malignant pleural mesothelioma is a highly aggressive tumor associated with asbestos exposure. There are few effective treatment options for mesothelioma, and patients have a very poor prognosis. Mesothelioma ...

    Authors: Paola Muti, Andrea Sacconi, Claudio Pulito, Giulia Orlandi, Sara Donzelli, Aldo Morrone, James Jiulian, Gerard P. Cox, Martin Kolb, Gregory Pond, Peter Kavsak, Mark Norman Levine, Giovanni Blandino and Sabrina Strano
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:255
  29. The progression of nasopharyngeal carcinoma (NPC) is profoundly affected by Epstein-Barr virus (EBV) infection. However, the role of EBV in the intercommunication between NPC and surrounding stromal cells has ...

    Authors: Po-Ju Lee, Yun-Hua Sui, Tzu-Tung Liu, Ngan-Ming Tsang, Chen-Han Huang, Ting-Yi Lin, Kai-Ping Chang and Shu-Chen Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:254
  30. Tumor-associated macrophages (TAMs), which form a large part of the tumor microenvironment, are normally regulated by metabolic reprogramming. However, the potential mechanisms of the immune-metabolism interac...

    Authors: Minghao Xu, Chenhao Zhou, Jialei Weng, Zhaoshuo Chen, Qiang Zhou, Jian Gao, Guoming Shi, Aiwu Ke, Ning Ren, Huichuan Sun and Yinghao Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:253
  31. The accumulating evidence confirms that long non-coding RNAs (lncRNAs) play a critical regulatory role in the progression of renal cell carcinoma (RCC). But, the application of lncRNAs in gene therapy remains ...

    Authors: Weipu Mao, Keyi Wang, Wentao Zhang, Shuqiu Chen, Jinbo Xie, Zongtai Zheng, Xue Li, Ning Zhang, Yuanyuan Zhang, Haimin Zhang, Bo Peng, Xudong Yao, Jianping Che, Junhua Zheng, Ming Chen and Wei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:252
  32. Gastric cancer (GC) is one of the most common malignant tumors in China. Circular RNAs (circRNAs) are novel non-coding RNAs with important regulatory roles in cancer progression. IGF2BP3 has been found to play...

    Authors: Qiang Ma, Feifei Yang, Bo Huang, Xiaojuan Pan, Wei Li, Ting Yu, Xiaolin Wang, Lingyu Ran, Kun Qian, Hui Li, Haiping Li, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:251
  33. Tyrosine kinase inhibitors (TKIs) such as sunitinib are multitarget antiangiogenic agents in clear cell renal cell carcinoma (ccRCC). They are widely used in the treatment of advanced/metastatic renal cancer. ...

    Authors: Wei Li, Kun Ye, Xurui Li, Xinlin Liu, Mou Peng, Fang Chen, Wei Xiong, Yinhuai Wang and Liang Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:250
  34. Hepatocellular carcinoma (HCC) remains difficult to treat due to limited effective treatment options. While the proteasome inhibitor bortezomib has shown promising preclinical activity in HCC, clinical trials ...

    Authors: Jhin Jieh Lim, Lissa Hooi, Yock Young Dan, Glenn K. Bonney, Lei Zhou, Pierce K.-H. Chow, Cheng Ean Chee, Tan Boon Toh and Edward K.-H. Chow
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:249
  35. FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in many types of cancer. Its highest mutation rate is found in head and neck squamous cell carcinoma (HNSCC), in which FAT1 is the seco...

    Authors: Zhuo Georgia Chen, Nabil F. Saba and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:248
  36. Authors: Gonçalo Outeiro-Pinho, Daniela Barros-Silva, Elena Aznar, Ana-Isabel Sousa, Márcia Vieira-Coimbra, Jorge Oliveira, Céline S. Gonçalves, Bruno M. Costa, Kerstin Junker, Rui Henrique and Carmen Jerónimo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:247

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:98

  37. Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumor...

    Authors: Xu Zhang, Yeye Guo, Ta Xiao, Jie Li, Aiyuan Guo, Li Lei, Chong Jin, Qi Long, Juan Su, Mingzhu Yin, Hong Liu, Chao Chen, Zhe Zhou, Susi Zhu, Juan Tao, Shuo Hu…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:246
  38. Treatment with PARP inhibitors (PARPi) is primarily effective against high-grade serous ovarian cancers (HGSOC) with BRCA1/2 mutations or other deficiencies in homologous recombination (HR) repair mechanisms. How...

    Authors: Francesco Morra, Francesco Merolla, Giovanna Damia, Francesca Ricci, Silvia Varricchio, Gennaro Ilardi, Laura Arenare, Daniela Califano, Virginia Napolitano, Robert Fruscio, Rosa Marina Melillo, Luca Palazzo and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:245
  39. Nasopharyngeal carcinoma (NPC) arises from the epithelial cells located in the nasopharynx and has a distinct geographic distribution. Chronic Epstein-Barr virus (EBV) infection, as its most common causative a...

    Authors: Jianyun Jiang and Hongmei Ying
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:244
  40. Solid tumors subjected to intermittent hypoxia are characterized by resistance to chemotherapy and immune-killing by effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular ...

    Authors: Iris C. Salaroglio, Dimas Carolina Belisario, Muhlis Akman, Sofia La Vecchia, Martina Godel, Dario Pasquale Anobile, Giacomo Ortone, Sabrina Digiovanni, Simona Fontana, Costanzo Costamagna, Menachem Rubinstein, Joanna Kopecka and Chiara Riganti
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:243
  41. Uterine serous cancer (USC) is the most common non-endometrioid subtype of uterine cancer, and is also the most aggressive. Most patients will die of progressively chemotherapy-resistant disease, and the devel...

    Authors: Li Zhang, Chi-Lam Au-Yeung, Chunxian Huang, Tsz-Lun Yeung, Sammy Ferri-Borgogno, Barrett C. Lawson, Suet-Ying Kwan, Zheng Yin, Stephen T. Wong, Vienna Thomas, Karen H. Lu, Kay-Pong Yip, James S. K. Sham and Samuel C. Mok
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:242
  42. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal prognosis. Although combined treatment with gemcitabine and albumin-bound paclitaxel has improved the prognosis of PDAC, both intri...

    Authors: Siyuan Zeng, Bin Lan, Xiaofan Ren, Shuman Zhang, Daniel Schreyer, Markus Eckstein, Hai Yang, Nathalie Britzen-Laurent, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Isabella Kutschick, Susanne Pfeffer, Peter Bailey, Andrew Biankin, Robert Grützmann…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:241
  43. Cancer-associated fibroblast (CAF) is an ideal target for cancer treatment. Recent studies have focused on eliminating CAFs and their effects by targeting their markers or blocking individual CAF-secreted fact...

    Authors: Haibo Qiu, Xu Zhang, Jiali Qi, Jiangwen Zhang, Yin Tong, Lei Li, Li Fu, Yan-Ru Qin, Xinyuan Guan and Liyi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:240
  44. Vascular endothelial growth factor D (VEGFD), a member of the VEGF family, is implicated in angiogenesis and lymphangiogenesis, and is deemed to be expressed at a low level in cancers. S-nitrosylation, a NO (n...

    Authors: Qiangqiang He, Meiyu Qu, Tingyu Shen, Yana Xu, Jiahao Luo, Dan Tan, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng and Ximei Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:239
  45. Epithelial ovarian cancer (EOC) is the leading cause of deaths among patients with gynecologic malignancies. In recent years, cancer stem cells (CSCs) have attracted great attention, which have been regarded a...

    Authors: Fei Sun, Yunjian Wei, Zheng Liu, Qiuling Jie, Xiaohui Yang, Ping Long, Jun Wang, Ying Xiong, Qi Li, Song Quan and Yanlin Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:238
  46. Authors: Binghong Chen, Mengying Wang, Junjun Qiu, Keman Liao, Wenrui Zhang, Qi Lv, Chunhui Ma, Zhongrun Qian, Zhonggang Shi, Rong Liang, Yan Lin, Jiazhou Ye, Yongming Qiu and Yingying Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:237

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:209

  47. Radiation therapy (RT) with androgen deprivation therapy (ADT) is an effective therapy to suppress the locally advanced prostate cancer (PCa). However, we unexpectedly found that RT could also induce the andro...

    Authors: Dong Chen, Fu-Ju Chou, Yuhchyau Chen, Chi-Ping Huang, Hao Tian, Yaqin Wang, Yuanjie Niu, Bosen You, Shuyuan Yeh, Nianzeng Xing and Chawnshang Chang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:235

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