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  1. Authors: Binghong Chen, Mengying Wang, Junjun Qiu, Keman Liao, Wenrui Zhang, Qi Lv, Chunhui Ma, Zhongrun Qian, Zhonggang Shi, Rong Liang, Yan Lin, Jiazhou Ye, Yongming Qiu and Yingying Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:237

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:209

  2. Radiation therapy (RT) with androgen deprivation therapy (ADT) is an effective therapy to suppress the locally advanced prostate cancer (PCa). However, we unexpectedly found that RT could also induce the andro...

    Authors: Dong Chen, Fu-Ju Chou, Yuhchyau Chen, Chi-Ping Huang, Hao Tian, Yaqin Wang, Yuanjie Niu, Bosen You, Shuyuan Yeh, Nianzeng Xing and Chawnshang Chang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:235
  3. Ocular adnexal B-cell lymphoma (OABL) is a rare subtype of non-Hodgkin lymphoma. The molecular characteristics of OABL remain poorly understood. We performed an integrated study to investigate the proteotransc...

    Authors: Jiahao Shi, Tianyu Zhu, Huimin Lin, Zhen Liu, Min Zhou, Ziyao Yu, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Xianqun Fan and Yixiong Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:234
  4. Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC).

    Authors: Nicole Gull, Michelle R. Jones, Pei-Chen Peng, Simon G. Coetzee, Tiago C. Silva, Jasmine T. Plummer, Alberto Luiz P. Reyes, Brian D. Davis, Stephanie S. Chen, Kate Lawrenson, Jenny Lester, Christine Walsh, Bobbie J. Rimel, Andrew J. Li, Ilana Cass, Yonatan Berg…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:232
  5. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0794-3.

    Authors: Guanqun Huang, Hui Jiang, Ye Lin, Wuzheng Xia, Yuanwei Luo, Yanpeng Wu, Weilong Cai, Xinke Zhou and Xianhan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:231
  6. The extravasation capability of hepatocellular carcinoma (HCC) cells plays a vital role in distant metastasis. However, the underlying mechanism of extravasation in HCC lung metastasis remains largely unclear.

    Authors: Xin Zhang, Liangliang Ren, Junhua Wu, Rongni Feng, Yunyang Chen, Ronggang Li, Meimei Wu, Mingzhu Zheng, Xing Gui Wu, Wanjun Luo, Hongle He, Yanming Huang, Miaoling Tang and Jun Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:230
  7. Airborne fine particulate matter (PM2.5) has been associated with lung cancer development and progression in never smokers. However, the molecular mechanisms underlying PM2.5-induced lung cancer remain largely...

    Authors: Qianqian Chen, Yiling Wang, Lin Yang, Liyuan Sun, Yuxin Wen, Yongyi Huang, Kaiping Gao, Wenhan Yang, Feng Bai, Lijuan Ling, Zizi Zhou, Xiaoming Zhang, Juan Xiong and Rihong Zhai
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:229
  8. Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in bo...

    Authors: Zengqi Tan, Yazhuo Jiang, Liang Liang, Jinpeng Wu, Lin Cao, Xiaoman Zhou, Zhihui Song, Zhenyu Ye, Ziyan Zhao, Hui Feng, Zewen Dong, Shuai Lin, Zhangjian Zhou, Yili Wang, Xiang Li and Feng Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:228
  9. CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon tumor antigen stimulation, and then differentiate into functional cells and migrate towards the tumor sites. Activate...

    Authors: Lu Zhang, Wen Zhang, Ziye Li, Shumeng Lin, Tiansheng Zheng, Bingjie Hao, Yaqin Hou, Yanfei Zhang, Kai Wang, Chenge Qin, Liduo Yue, Jing Jin, Ming Li and Lihong Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:227
  10. Neuroblastoma (NB), a childhood tumor derived from the sympathetic nervous system, presents with heterogeneous clinical behavior. While some tumors regress spontaneously without medical intervention, others ar...

    Authors: Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liaño-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, María Victoria Ruiz-Pérez, Susanne Schlisio, Oscar Bedoya-Reina and Marie Arsenian-Henriksson
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:226
  11. Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

    Authors: Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao, Jian-Wei Wang, Zi-Mu Zhang, Yong-Ping Zhang, Xiao-Lu Li, Yi Xie, Shui-Yan Wu, Xin-Ran Chu, Gen Li, Di Wu, Yan-Ling Chen, Juan-Juan Yu, Si-qi Jia…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:225
  12. The tumor microenvironment (TME) has been demonstrated to modulate the biological behavior of tumors intensively. Multiple stress conditions are widely observed in the TME of many cancer types, such as hypoxia...

    Authors: Yue Lv, Yinghao Lv, Zhen Wang, Kefei Yuan and Yong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:224
  13. Resistance to temozolomide (TMZ) is a major obstacle to preventing glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) play a variety of roles in GBM, the lncRNAs that regulate ...

    Authors: Zijie Gao, Jianye Xu, Yang Fan, Yanhua Qi, Shaobo Wang, Shulin Zhao, Xing Guo, Hao Xue, Lin Deng, Rongrong Zhao, Chong Sun, Ping Zhang and Gang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:223
  14. The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process.

    Authors: Chia-Hung Chien, Wen-Bin Yang, Jian-Ying Chuang, Jung-Shun Lee, Wei-An Liao, Chih-Yuan Huang, Pin-Yuan Chen, An-Chih Wu, Shun-Tai Yang, Chien-Cheng Lai, Pei-I Chi, Jui-Mei Chu, Siao Muk Cheng, Chan-Chuan Liu, Daw-Yang Hwang, Shang-Hung Chen…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:220
  15. The Hippo pathway functions as a tumor suppressor pathway in human cancers, while dysfunction of the Hippo pathway is frequently observed in malignancies. Although YAP/TAZ activity is tightly controlled by the...

    Authors: Dehai Wang, Zhongbo Li, Xin Li, Cheng Yan, Huijie Yang, Ting Zhuang, Xiao Wang, Yifeng Zang, Ziping Liu, Tianshi Wang, Rixia Jiang, Peng Su, Jian Zhu and Yinlu Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:219
  16. Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields mean...

    Authors: Xiaolin Wang, Jiahui Zhang, Guozhen Cao, Jinghan Hua, Ge Shan and Wenchu Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:218
  17. We aimed to determine the safety and efficacy of nintedanib, an oral anti-angiogenic tyrosine kinase inhibitor, in combination with pembrolizumab, an anti-PD1 immunotherapy, in patients with advanced solid tum...

    Authors: Capucine Baldini, Francois-Xavier Danlos, Andreea Varga, Matthieu Texier, Heloise Halse, Severine Mouraud, Lydie Cassard, Stéphane Champiat, Nicolas Signolle, Perrine Vuagnat, Patricia Martin-Romano, Jean-Marie Michot, Rastislav Bahleda, Anas Gazzah, Lisa Boselli, Delphine Bredel…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:217
  18. POLE and POLD1 encode the catalytic and proofreading subunits of DNA polymerase ε and polymerase δ, and play important roles in DNA replication and proofreading. POLE/POLD1 exonuclease domain mutations lead to lo...

    Authors: Xiaoting Ma, Lin Dong, Xiu Liu, Kai Ou and Lin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:216
  19. Leptin is important in physiological and pathological functions in various cancers, however, the significance and mechanisms of leptin in nasopharyngeal carcinoma remain ambiguous.

    Authors: Sheng-Dean Luo, Hsin-Ting Tsai, Chung-Feng Hwang, Tai‐Jan Chiu, Shau‐Hsuan Li, Ya-Ling Hsu, Chang-Chun Hsiao and Chang-Han Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:215
  20. One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The...

    Authors: Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Elena Okina, Mohammad Hossein Gholami, Kiavash Hushmandi, Mehrdad Hashemi, Azuma Kalu, Ali Zarrabi, Noushin Nabavi, Navid Rabiee, Esmaeel Sharifi, Hassan Karimi-Maleh, Milad Ashrafizadeh, Alan Prem Kumar and Yuzhuo Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:214
  21. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-022-02426-x

    Authors: Yi Cao, Yi Tu, Jianbo Xiong, Shengxing Tan, Lianghua Luo, Ahao Wu, Xufeng Shu, Zhigang Jie and Zhengrong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:213
  22. Identifying biomarkers related to the diagnosis and treatment of gastric cancer (GC) has not made significant progress due to the heterogeneity of tumors. Genes involved in histological classification and gene...

    Authors: Bo-Kyung Kim, Da-Mi Kim, Hyunkyung Park, Seon-Kyu Kim, Mi-Aie Hwang, Jungwoon Lee, Mi-Jung Kang, Jae-Eun Byun, Joo-Young Im, Minho Kang, Kyung Chan Park, Young Il Yeom, Seon-Young Kim, Haiyoung Jung, Dae-Hyuk Kweon, Jae-Ho Cheong…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:212
  23. Tumor cells exhibited phenotypic and molecular characteristics similar to their lineage progenitor cells. Liver developmental signaling pathways are showed to be associated with HCC development and oncogenesis...

    Authors: Lingxi Jiang, Xia Wang, Fangfang Ma, Xuelong Wang, Minmin Shi, Qian Yan, Ming Liu, Juan Chen, Chaoran Shi and Xin-yuan Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:211
  24. Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell neoplasms, are a major cause of blood cancer morbidity and mortality. CD38 (cyclic ADP ribose hydrolase) is a tran...

    Authors: Xu Wang, Xinfang Yu, Wei Li, Praveen Neeli, Ming Liu, Ling Li, Mingzhi Zhang, Xiaosheng Fang, Ken H. Young and Yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:210
  25. Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety ...

    Authors: Binghong Chen, Mengying Wang, Junjun Qiu, Keman Liao, Wenrui Zhang, Qi Lv, Chunhui Ma, Zhongrun Qian, Zhonggang Shi, Rong Liang, Yan Lin, Jiazhou Ye, Yongming Qiu and Yingying Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:209

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:237

  26. There is no universally accepted treatment for patients with advanced papillary renal cell carcinoma (PRCC). The presence of activating mutations in MET, as well as gain of chromosome 7, where the MET gene is loc...

    Authors: Roma Pahwa, Janhavi Dubhashi, Anand Singh, Parthav Jailwala, Alexei Lobanov, Craig J. Thomas, Michele Ceribelli, Kelli Wilson, Christopher J. Ricketts, Cathy D. Vocke, Catherine Wells, Donald P. Bottaro, W. Marston Linehan, Len Neckers and Ramaprasad Srinivasan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:208
  27. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0846-8.

    Authors: Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou and Xianhan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:207
  28. Authors: Shuangjian Jiang, Chengqiang Mo, Shengjie Guo, Jintao Zhuang, Bin Huang and Xiaopeng Mao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:206

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:495

  29. Authors: Xinnan Wu, Ruixiao Li, Qing Song, Chengcheng Zhang, Ru Jia, Zhifen Han, Lihong Zhou, Hua Sui, Xuan Liu, Huirong Zhu, Liu Yang, Yan Wang, Qing Ji and Qi Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:205

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:435

  30. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1046-x.

    Authors: Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang and Guoping Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:204
  31. Breast cancer is the leading female cancer type and the cause of cancer-related mortality worldwide. Adipocytes possess important functions of energy supply, metabolic regulation, and cytokine release, and are...

    Authors: Xiaomei Zhou, Jun Zhang, Wenchang Lv, Chongru Zhao, Yu Xia, Yiping Wu and Qi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:203
  32. The Hippo signaling pathway was found coordinately modulates cell regeneration and organ size. Its dysregulation contributes to uncontrolled cell proliferation and malignant transformation. YAP/TAZ are two cri...

    Authors: Yirao Zhang, Yang Wang, Hao Ji, Jie Ding and Keming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:202
  33. Breast cancer targeting diagnostic agent with effective imaging ability is important in guiding plan formulation, prediction, and curative effect evaluation of tumors in clinic. A tumor-targeting nanoprobe bas...

    Authors: Qiong Wu, Chanling Yuan, Ningzhi Liu, Jing Shu, Jiacheng Wang, Jiayi Qian, Liang Zeng, Hao Zhang, Xicheng Wang and Wenjie Mei
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:201
  34. The contribution of autophagy to cancer therapy resistance remains complex, mainly owing to the discrepancy of autophagy mechanisms in different therapy. However, the potential mechanisms of autophagy-mediated...

    Authors: Xin Lyu, Lizhong Zeng, Jie Shi, Zongjuan Ming, Wei Li, Boxuan Liu, Yang Chen, Bo Yuan, Ruiying Sun, Jingyan Yuan, Nannan Zhao, Xia Yang, Guoan Chen and Shuanying Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:200
  35. Large immunogenomic analyses have demonstrated the prognostic role of the functional orientation of the tumor microenvironment in adult solid tumors, this variable has been poorly explored in the pediatric cou...

    Authors: Shimaa Sherif, Jessica Roelands, William Mifsud, Eiman I. Ahmed, Christophe M. Raynaud, Darawan Rinchai, Abbirami Sathappan, Ata Maaz, Ayman Saleh, Erdener Ozer, Khalid A. Fakhro, Borbala Mifsud, Vésteinn Thorsson, Davide Bedognetti and Wouter R. L. Hendrickx
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:199
  36. NCAPD3 is one of the three non-SMC subunits of condensin II complex, which plays an important role in the chromosome condensation and segregation during mitosis. Notably, elevated levels of NCAPD3 are found in...

    Authors: Zuolei Jing, Qianmei Liu, Xinyuan He, Zhirong Jia, Zhizhong Xu, Bolin Yang and Ping Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:198
  37. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-022-02409-y.

    Authors: Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao and Jun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:197
  38. Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcino...

    Authors: Kohei Okuyama and Souichi Yanamoto
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:196
  39. DNA-based vaccines represent a simple, safe and promising strategy for harnessing the immune system to fight infectious diseases as well as various forms of cancer and thus are considered an important tool in ...

    Authors: Antonella Conforti, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Clay Shorrock, James A. Hayward, Yuhua Sun, Ben Minghwa Liang, Fabio Palombo, Brian Viscount and Luigi Aurisicchio
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:195
  40. Acquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting agent, has been a huge obstacle in treatment for metastatic castration-resistant prostate cancer (mCRPC). Recently, strategies tar...

    Authors: Liang Chen, Yarong Song, Teng Hou, Xuexiang Li, Lulin Cheng, Yunxue Li and Yifei Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:194
  41. Understanding the intricate signaling network involved in triple-negative breast cancer (TNBC) represents a challenge for developing novel therapeutic approaches. Here, we aim to provide novel mechanistic insi...

    Authors: Damiano Cosimo Rigiracciolo, Nijiro Nohata, Rosamaria Lappano, Francesca Cirillo, Marianna Talia, Sendi Rafael Adame-Garcia, Nadia Arang, Simone Lubrano, Ernestina Marianna De Francesco, Antonino Belfiore, J. Silvio Gutkind and Marcello Maggiolini
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:193
  42. Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of th...

    Authors: Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:192
  43. Downregulation of epithelial markers and upregulation of mesenchymal markers are the characteristics of the epithelial to mesenchymal transition (EMT) program, which provides the metastatic advantage of breast...

    Authors: Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen and Hai Rao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:191
  44. Circular RNAs (circRNAs) are essential participants in the development and progression of various malignant tumors. Previous studies have shown that cell migration-inducing protein (CEMIP) accelerates prostate...

    Authors: Ying Yu, Yarong Song, Lulin Cheng, Liang Chen, Bing Liu, Dingheng Lu, Xuexiang Li, Yunxue Li, Fang Lv and Yifei Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:188
  45. Circular RNA (circRNA) is a novel class noncoding RNA (ncRNA) that plays a critical role in various cancers, including prostate cancer (PCa). However, the clinical significance, biological function, and molecu...

    Authors: Lifeng Ding, Ruyue Wang, Qiming Zheng, Danyang Shen, Huan Wang, Zeyi Lu, Wenqin Luo, Haiyun Xie, Liangliang Ren, Minxiao Jiang, Chenhao Yu, Zhenwei Zhou, Yudong Lin, Haohua Lu, Dingwei Xue, Wenjing Su…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:187
  46. Epidermal growth factor receptor (EGFR) inhibitors, including cetuximab and panitumumab, are valuable therapeutics for colorectal cancer (CRC), but resistance to these inhibitors is common. The reason for such...

    Authors: Lu Yang, Arup Bhattacharya, Yun Li, Sandra Sexton, Xiang Ling, Fengzhi Li and Yuesheng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:184

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