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Articles
Page 1 of 64
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Citation: Journal of Experimental & Clinical Cancer Research 2022 41:237
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Correction: 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:236 -
Targeting the radiation-induced ARv7-mediated circNHS/miR-512-5p/XRCC5 signaling with Quercetin increases prostate cancer radiosensitivity
Radiation therapy (RT) with androgen deprivation therapy (ADT) is an effective therapy to suppress the locally advanced prostate cancer (PCa). However, we unexpectedly found that RT could also induce the andro...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:235 -
Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker
Ocular adnexal B-cell lymphoma (OABL) is a rare subtype of non-Hodgkin lymphoma. The molecular characteristics of OABL remain poorly understood. We performed an integrated study to investigate the proteotransc...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:234 -
Correction: A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:233 -
DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers
Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC).
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:232 -
Retraction Note: LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0794-3.
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:231 -
ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42
The extravasation capability of hepatocellular carcinoma (HCC) cells plays a vital role in distant metastasis. However, the underlying mechanism of extravasation in HCC lung metastasis remains largely unclear.
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:230 -
PM2.5 promotes NSCLC carcinogenesis through translationally and transcriptionally activating DLAT-mediated glycolysis reprograming
Airborne fine particulate matter (PM2.5) has been associated with lung cancer development and progression in never smokers. However, the molecular mechanisms underlying PM2.5-induced lung cancer remain largely...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:229 -
Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer
Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in bo...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:228 -
Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review
CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon tumor antigen stimulation, and then differentiate into functional cells and migrate towards the tumor sites. Activate...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:227 -
Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma
Neuroblastoma (NB), a childhood tumor derived from the sympathetic nervous system, presents with heterogeneous clinical behavior. While some tumors regress spontaneously without medical intervention, others ar...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:226 -
Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:225 -
Noncoding RNAs as sensors of tumor microenvironmental stress
The tumor microenvironment (TME) has been demonstrated to modulate the biological behavior of tumors intensively. Multiple stress conditions are widely observed in the TME of many cancer types, such as hypoxia...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:224 -
PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition
Resistance to temozolomide (TMZ) is a major obstacle to preventing glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) play a variety of roles in GBM, the lncRNAs that regulate ...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:223 -
Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death
Emerging evidence has demonstrated that radiotherapy (RT) can not only cause direct damage to cancer cells but also lead to immunogenic cell death (ICD), which involves the activation of host antitumor immune ...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:222 -
Correction: TRIM6 promotes colorectal cancer cells proliferation and response to thiostrepton by TIS21/FoxM1
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:221 -
SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma
The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process.
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:220 -
DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer
The Hippo pathway functions as a tumor suppressor pathway in human cancers, while dysfunction of the Hippo pathway is frequently observed in malignancies. Although YAP/TAZ activity is tightly controlled by the...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:219 -
Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance
Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields mean...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:218 -
Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers
We aimed to determine the safety and efficacy of nintedanib, an oral anti-angiogenic tyrosine kinase inhibitor, in combination with pembrolizumab, an anti-PD1 immunotherapy, in patients with advanced solid tum...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:217 -
POLE/POLD1 mutation and tumor immunotherapy
POLE and POLD1 encode the catalytic and proofreading subunits of DNA polymerase ε and polymerase δ, and play important roles in DNA replication and proofreading. POLE/POLD1 exonuclease domain mutations lead to lo...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:216 -
Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis
Leptin is important in physiological and pathological functions in various cancers, however, the significance and mechanisms of leptin in nasopharyngeal carcinoma remain ambiguous.
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:215 -
Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:214 -
Retraction Note: microRNA-15b-5p encapsulated by M2 macrophage-derived extracellular vesicles promotes gastric cancer metastasis by targeting BRMS1 and suppressing DAPK1 transcription
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-022-02426-x
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:213 -
Synaptotagmin 11 scaffolds MKK7–JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis
Identifying biomarkers related to the diagnosis and treatment of gastric cancer (GC) has not made significant progress due to the heterogeneity of tumors. Genes involved in histological classification and gene...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:212 -
PITX2C increases the stemness features of hepatocellular carcinoma cells by up-regulating key developmental factors in liver progenitor
Tumor cells exhibited phenotypic and molecular characteristics similar to their lineage progenitor cells. Liver developmental signaling pathways are showed to be associated with HCC development and oncogenesis...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:211 -
Expanding anti-CD38 immunotherapy for lymphoid malignancies
Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell neoplasms, are a major cause of blood cancer morbidity and mortality. CD38 (cyclic ADP ribose hydrolase) is a tran...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:210 -
Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling
Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety ...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:209 -
Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma
There is no universally accepted treatment for patients with advanced papillary renal cell carcinoma (PRCC). The presence of activating mutations in MET, as well as gain of chromosome 7, where the MET gene is loc...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:208 -
Retraction Note: Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0846-8.
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:207 -
Correction: Human bone marrow mesenchymal stem cells-derived microRNA-205-containing exosomes impede the progression of prostate cancer through suppression of RHPN2
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:206 -
Correction: JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:205 -
Retraction Note: Knockdown of FOXO3a induces epithelialmesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the βcatenin/TCF4 pathway through SPRY2
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1046-x.
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:204 -
The pleiotropic roles of adipocyte secretome in remodeling breast cancer
Breast cancer is the leading female cancer type and the cause of cancer-related mortality worldwide. Adipocytes possess important functions of energy supply, metabolic regulation, and cytokine release, and are...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:203 -
The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms
The Hippo signaling pathway was found coordinately modulates cell regeneration and organ size. Its dysregulation contributes to uncontrolled cell proliferation and malignant transformation. YAP/TAZ are two cri...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:202 -
Fast detection, a precise and sensitive diagnostic agent for breast cancer
Breast cancer targeting diagnostic agent with effective imaging ability is important in guiding plan formulation, prediction, and curative effect evaluation of tumors in clinic. A tumor-targeting nanoprobe bas...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:201 -
Essential role for STAT3/FOXM1/ATG7 signaling-dependent autophagy in resistance to Icotinib
The contribution of autophagy to cancer therapy resistance remains complex, mainly owing to the discrepancy of autophagy mechanisms in different therapy. However, the potential mechanisms of autophagy-mediated...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:200 -
The immune landscape of solid pediatric tumors
Large immunogenomic analyses have demonstrated the prognostic role of the functional orientation of the tumor microenvironment in adult solid tumors, this variable has been poorly explored in the pediatric cou...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:199 -
NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer
NCAPD3 is one of the three non-SMC subunits of condensin II complex, which plays an important role in the chromosome condensation and segregation during mitosis. Notably, elevated levels of NCAPD3 are found in...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:198 -
Retraction Note: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-022-02409-y.
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:197 -
TMEM16A as a potential treatment target for head and neck cancer
Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcino...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:196 -
Linear DNA amplicons as a novel cancer vaccine strategy
DNA-based vaccines represent a simple, safe and promising strategy for harnessing the immune system to fight infectious diseases as well as various forms of cancer and thus are considered an important tool in ...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:195 -
Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism
Acquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting agent, has been a huge obstacle in treatment for metastatic castration-resistant prostate cancer (mCRPC). Recently, strategies tar...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:194 -
Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)
Understanding the intricate signaling network involved in triple-negative breast cancer (TNBC) represents a challenge for developing novel therapeutic approaches. Here, we aim to provide novel mechanistic insi...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:193 -
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of th...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:192 -
The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression
Downregulation of epithelial markers and upregulation of mesenchymal markers are the characteristics of the epithelial to mesenchymal transition (EMT) program, which provides the metastatic advantage of breast...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:191 -
CircCEMIP promotes anoikis-resistance by enhancing protective autophagy in prostate cancer cells
Circular RNAs (circRNAs) are essential participants in the development and progression of various malignant tumors. Previous studies have shown that cell migration-inducing protein (CEMIP) accelerates prostate...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:188 -
circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA
Circular RNA (circRNA) is a novel class noncoding RNA (ncRNA) that plays a critical role in various cancers, including prostate cancer (PCa). However, the clinical significance, biological function, and molecu...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:187 -
Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer
Epidermal growth factor receptor (EGFR) inhibitors, including cetuximab and panitumumab, are valuable therapeutics for colorectal cancer (CRC), but resistance to these inhibitors is common. The reason for such...
Citation: Journal of Experimental & Clinical Cancer Research 2022 41:184
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Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy
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