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  1. Research

    YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer

    Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved in drug resistance and poor prognosis of many neoplastic diseases or cancers. However, investigations...

    Wei Li, Yuanyuan Cao, Jinling Xu, Ying Wang, Weijie Li, Qian Wang, Ziwei Hu, Yaping Hao, Li Hu, Yawen Sun, Guanglin Xu and Guizhen Ao

    Journal of Experimental & Clinical Cancer Research 2017 36:144

    Published on: 16 October 2017

  2. Research

    circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

    Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is la...

    Rongfang He, Peng Liu, Xiaoming Xie, Yujuan Zhou, Qianjin Liao, Wei Xiong, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng and Hailin Tang

    Journal of Experimental & Clinical Cancer Research 2017 36:145

    Published on: 16 October 2017

  3. Research

    Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification

    This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast can...

    Cristiana Ercolani, Caterina Marchiò, Anna Di Benedetto, Alessandra Fabi, Letizia Perracchio, Patrizia Vici, Francesca Sperati, Simonetta Buglioni, Vincenzo Arena, Edoardo Pescarmona, Anna Sapino, Irene Terrenato and Marcella Mottolese

    Journal of Experimental & Clinical Cancer Research 2017 36:143

    Published on: 13 October 2017

  4. Research

    SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

    Our previous studies reported that SHC SH2-domain binding protein 1 (SHCBP1) functions as an oncogene via promoting cell proliferations in synovial sarcoma (SS) cells. However, whether SHCBP1 has any effect on...

    Changliang Peng, Hui Zhao, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Cheng Zhang, Jie Zhao, Ji Li, Guanghui Cheng, Dongjin Wu, Chunzheng Gao and Xiuwen Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:141

    Published on: 11 October 2017

  5. Research

    The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines

    The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway. The direct induction of this pathway by Forskolin (FSK) is also known...

    Enrica Flori, Eleonora Rosati, Giorgia Cardinali, Daniela Kovacs, Barbara Bellei, Mauro Picardo and Vittoria Maresca

    Journal of Experimental & Clinical Cancer Research 2017 36:142

    Published on: 11 October 2017

  6. Research

    IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells

    Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is cr...

    Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini and Marina Fabbi

    Journal of Experimental & Clinical Cancer Research 2017 36:140

    Published on: 11 October 2017

  7. Research

    Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway

    Prostate cancer (PCa) is one of the most frequent tumors and leading cause of cancer deaths among males worldwide. The majority of deaths are due to recurrence and subsequent development of the metastatic canc...

    Pei-Jie Zhou, Wei Xue, Jinliang Peng, Yanqing Wang, Lianzi Wei, Ziqiang Yang, Helen He Zhu, Yu-Xiang Fang and Wei-Qiang Gao

    Journal of Experimental & Clinical Cancer Research 2017 36:139

    Published on: 10 October 2017

  8. Research

    MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma

    miR-203a-3p was reported as a tumor suppressor and disregulated in many malignancies including nasopharyngeal carcinoma (NPC). However, its function in tumor growth and metastasis in NPC has rarely been reported.

    Ning Jiang, Xuesong Jiang, Zhenzhang Chen, Xue Song, Lirong Wu, Dan Zong, Dan Song, Li Yin, Dejun Wang, Cheng Chen, Xiuhua Bian and Xia He

    Journal of Experimental & Clinical Cancer Research 2017 36:138

    Published on: 5 October 2017

  9. Research

    The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway

    Chemo-resistance is a leading cause of tumor relapse and treatment failure in patients with ovarian cancer. The identification of effective strategies to overcome drug resistance will have a significant clinic...

    Shanyang He, Gang Niu, Jianhong Shang, Yalan Deng, Zhiyong Wan, Cai Zhang, Zeshan You and Hongwei Shen

    Journal of Experimental & Clinical Cancer Research 2017 36:137

    Published on: 4 October 2017

  10. Research

    Human mesenchymal stromal cells as cellular drug-delivery vectors for glioblastoma therapy: a good deal?

    Glioblastoma (GB) is the most malignant brain tumor in adults. It is characterized by angiogenesis and a high proliferative and invasive capacity. Standard therapy (surgery, radiotherapy and chemotherapy with ...

    Anne Clavreul, Milad Pourbaghi-Masouleh, Emilie Roger, Nolwenn Lautram, Claudia N. Montero-Menei and Philippe Menei

    Journal of Experimental & Clinical Cancer Research 2017 36:135

    Published on: 29 September 2017

  11. Research

    β-catenin-mediated YAP signaling promotes human glioma growth

    Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression.We and others find that YAP is up-regulated in human gliomas a...

    Yan Wang, Peng Pan, Zhaohao Wang, Yu Zhang, Peng Xie, Decheng Geng, Yang Jiang, Rutong Yu and Xiuping Zhou

    Journal of Experimental & Clinical Cancer Research 2017 36:136

    Published on: 29 September 2017

  12. Research

    Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling

    Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC...

    Jie Lin, Wansong Lin, Yunbin Ye, Liping Wang, Xiaoyan Chen, Shengbing Zang and Aimin Huang

    Journal of Experimental & Clinical Cancer Research 2017 36:134

    Published on: 29 September 2017

  13. Research

    Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway

    Extranodal NK/T cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma with poor prognosis. Resveratrol (RSV, 3,5,4′-trihydroxystilbene), a natural nontoxic phenolic compound found in the skin of gr...

    Xianxian Sui, Canjing Zhang, Jianan Zhou, Shengxuan Cao, Chen Xu, Feng Tang, Xiuling Zhi, Bobin Chen, Songmei Wang and Lianhua Yin

    Journal of Experimental & Clinical Cancer Research 2017 36:133

    Published on: 26 September 2017

  14. Research

    High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

    Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for glioma patients. Thus, the development of novel targeted thera...

    Chenglong Yue, Mingshan Niu, Qian Qian Shan, Ting Zhou, Yiming Tu, Peng Xie, Lei Hua, Rutong Yu and Xuejiao Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:132

    Published on: 25 September 2017

  15. Research

    miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses

    As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miR...

    Tao Jiang, Ling Ye, Zhongbo Han, Yuan Liu, Yinxue Yang, Zhihai Peng and Junwei Fan

    Journal of Experimental & Clinical Cancer Research 2017 36:131

    Published on: 22 September 2017

  16. Research

    The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

    The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype. However, little is known about the mol...

    Zhi-hang Zhou, Jin-wen Song, Wen Li, Xue Liu, Liu Cao, Lu-ming Wan, Ying-xia Tan, Shou-ping Ji, Yu-mei Liang and Feng Gong

    Journal of Experimental & Clinical Cancer Research 2017 36:130

    Published on: 19 September 2017

  17. Research

    PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a

    The purpose of this study was to elucidate the regulation of programmed death ligand 1 (PDL1), lactate dehydrogenase A (LDHA) and miR-34a in triple negative breast cancer (TNBC) and to explore the function and...

    Xiaojia Huang, Xinhua Xie, Hua Wang, Xiangsheng Xiao, Lu Yang, Zhi Tian, Xiaofang Guo, Lijuan Zhang, Hailin Tang and Xiaoming Xie

    Journal of Experimental & Clinical Cancer Research 2017 36:129

    Published on: 15 September 2017

  18. Review

    Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research

    The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically t...

    Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti and Giorgio Stanta

    Journal of Experimental & Clinical Cancer Research 2017 36:128

    Published on: 13 September 2017

  19. Research

    Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway

    The prognosis of human astrocytoma is poor, and the molecular alterations underlying its pathogenesis still needed to be elucidated. Nucleolar and spindle associated protein 1 (NUSAP1) was observed in several ...

    Xianqiu Wu, Benke Xu, Chao Yang, Wentao Wang, Dequan Zhong, Zhan Zhao, Longshuang He, Yuanjun Hu, Lili Jiang, Jun Li, Libing Song and Wei Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:127

    Published on: 12 September 2017

  20. Research

    p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

    As an important cellular stress sensor phosphoprotein p53 can trigger cell cycle arrest and apoptosis and regulate autophagy. The p53 activity mainly depends on its transactivating function, however, how p53 c...

    Alessia Garufi, Giuseppa Pistritto, Silvia Baldari, Gabriele Toietta, Mara Cirone and Gabriella D’Orazi

    Journal of Experimental & Clinical Cancer Research 2017 36:126

    Published on: 11 September 2017

  21. Research

    Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

    Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed.

    Zihang Xu, Fei Zhang, Chao Bai, Chao Yao, Hairong Zhong, Chunpu Zou and Xiao Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:124

    Published on: 11 September 2017

  22. Research

    ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population

    ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with β-catenin and inhibits CBP function as a co-activator of Wnt/β-catenin-mediated transcription. Given its ability to i...

    Yi Liu, Hui Chen, Peiming Zheng, Yingxia Zheng, Qin Luo, Guohua Xie, Yanhui Ma and Lisong Shen

    Journal of Experimental & Clinical Cancer Research 2017 36:125

    Published on: 11 September 2017

  23. Research

    Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

    Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-smal...

    Xiaomin Feng, Hao Liu, Zhijie Zhang, Yixue Gu, Huisi Qiu and Zhimin He

    Journal of Experimental & Clinical Cancer Research 2017 36:123

    Published on: 8 September 2017

  24. Research

    High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods

    Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy on detection of DNA alternations based on a large n...

    Dan Su, Dadong Zhang, Kaiyan Chen, Jing Lu, Junzhou Wu, Xinkai Cao, Lisha Ying, Qihuang Jin, Yizhou Ye, Zhenghua Xie, Lei Xiong, Weimin Mao and Fugen Li

    Journal of Experimental & Clinical Cancer Research 2017 36:121

    Published on: 7 September 2017

  25. Research

    (S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1

    Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes ...

    Xuanxuan Dai, Guilong Guo, Peng Zou, Ri Cui, Weiqian Chen, Xi Chen, Changtian Yin, Wei He, Rajamanickam Vinothkumar, Fan Yang, Xiaohua Zhang and Guang Liang

    Journal of Experimental & Clinical Cancer Research 2017 36:120

    Published on: 7 September 2017

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