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  1. N6-methyladenosine (m6A) modification is the most common chemical modification in mammalian mRNAs, and it plays important roles by regulating several cellular processes. Previous studies report that m6A is implic...

    Authors: Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, Wenwu Dong, Liang Shao, Liang He, Xiaoyu Ji, Ping Zhang and Hao Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:42

    Content type: Research

    Published on:

  2. Cancer cells have an imbalance in oxidation-reduction (redox) homeostasis. Understanding the precise mechanisms and the impact of the altered redox microenvironment on the immunologic reaction to tumors is lim...

    Authors: Xiang Li, Shaomin Wang, Wei Mu, Jennifer Barry, Anna Han, Richard L. Carpenter, Bing-Hua Jiang, Stephen C. Peiper, Mỹ G. Mahoney, Andrew E. Aplin, Hong Ren and Jun He

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:41

    Content type: Research

    Published on:

  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ilaria Romito, Manuela Porru, Maria Rita Braghini, Luca Pompili, Nadia Panera, Annalisa Crudele, Daniela Gnani, Cristiano De Stefanis, Marco Scarsella, Silvia Pomella, Stefano Levi Mortera, Emmanuel de Billy, Adrian Libenzio Conti, Valeria Marzano, Lorenza Putignani, Manlio Vinciguerra…

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:40

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:364

  4. Glioblastoma is one of the most devastating cancer worldwide based on its locally aggressive behavior and because it cannot be cured by current therapies. Defects in alternative splicing process are frequent i...

    Authors: Antonio C. Fuentes-Fayos, Jesús M. Pérez-Gómez, Miguel E. G-García, Juan M. Jiménez-Vacas, Cristóbal Blanco-Acevedo, Rafael Sánchez-Sánchez, Juan Solivera, Joshua J. Breunig, Manuel D. Gahete, Justo P. Castaño and Raúl M. Luque

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:39

    Content type: Research

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  5. Tyrosine kinase inhibitors (TKIs) alone and in combination with immune checkpoint inhibitors (ICIs) have been shown to be beneficial for the survival of metastatic renal cell carcinoma (mRCC) patients, but res...

    Authors: Wentao Liu, Dianyun Ren, Wei Xiong, Xin Jin and Liang Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:38

    Content type: Research

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  6. When genes responsible for normal embryonic development are abnormally expressed in adults, it can lead to tumor development. This can suggest that the same mechanism that controls embryonic differentiation ca...

    Authors: Jordi Canals, Alfons Navarro, Cristina Vila, Josep M. Canals, Tania Díaz, Melissa Acosta-Plasencia, Coralí Cros-Font, Bing Han, Yangyi He and Mariano Monzó

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:37

    Content type: Research

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  7. Lung adenocarcinoma (LUAD)  is the most common subtype of lung cancer. Patient prognosis is poor, and the existing therapeutic strategies for LUAD are far from satisfactory. Recently, targeting N6-methyladenos...

    Authors: Lifang Ma, Xiangfei Xue, Xiao Zhang, Keke Yu, Xin Xu, Xiaoting Tian, Yayou Miao, Fanyu Meng, Xiaoxin Liu, Susu Guo, Shiyu Qiu, Yikun Wang, Jiangtao Cui, Wanxin Guo, You Li, Jinjing Xia…

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:36

    Content type: Research

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  8. Glioblastoma (GBM) treatment has remained almost unchanged for more than 20 years. The current standard of care involves surgical resection (if possible) followed by concomitant radiotherapy and chemotherapy. ...

    Authors: Mathilde Bausart, Véronique Préat and Alessio Malfanti

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:35

    Content type: Review

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  9. Acute myeloid leukemia (AML) is characterized by accumulation of aberrantly differentiated hematopoietic myeloid progenitor cells. The karyotyping-silent NUP98-NSD1 fusion is a molecular hallmark of pediatric ...

    Authors: Zivojin Jevtic, Vittoria Matafora, Francesca Casagrande, Fabio Santoro, Saverio Minucci, Massimilliano Garre’, Milad Rasouli, Olaf Heidenreich, Giovanna Musco, Jürg Schwaller and Angela Bachi

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:34

    Content type: Research

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  10. Depletion of certain ribosomal proteins induces p53 activation, which is mediated mainly by ribosomal protein L5 (RPL5) and/or ribosomal protein L11 (RPL11). Therefore, RPL5 and RPL11 may link RPs and p53 acti...

    Authors: Hongyan Li, Hong Zhang, Guomin Huang, Zhitong Bing, Duling Xu, Jiadi Liu, Hongtao Luo and Xiaoli An

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:33

    Content type: Research

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  11. tRNA-derived fragments (tRFs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of tRFs to colorectal cancer (CRC) remain largely unknown.

    Authors: Ying Han, Yinghui Peng, Shanshan Liu, Xinwen Wang, Changjing Cai, Cao Guo, Yihong Chen, Le Gao, Qiaoqiao Huang, Min He, Edward Shen, Jie Long, Jian Yu, Hong Shen and Shan Zeng

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:32

    Content type: Research

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  12. The role of the microbiota in human health and disease is well established, including its effects on several cancer types. However, the role of microbial dysbiosis in prostate cancer development, progression, ...

    Authors: Paul Vinu Salachan and Karina Dalsgaard Sørensen

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:31

    Content type: Review

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  13. Authors: Hao Peng, Jian Zhang, Pan-Pan Zhang, Lei Chen, Ling-Long Tang, Xiao-Jing Yang, Qing-Mei He, Xin Wen, Ying Sun, Na Liu, Ying-Qin Li and Jun Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:30

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:11

  14. Cancer stem cells (CSCs) are generated under irregular microenvironment in vivo, of which mimic is quite difficult due to the lack of enough information of the factors responsible for cancer initiation. Here, ...

    Authors: Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra, Xiaoying Fu, Mohamad Al Kadi, Akimasa Seno, David S. Salomon and Masaharu Seno

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:29

    Content type: Research

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  15. Estrogen-related receptor α (ERRα) has been reported to play a critical role in endometrial cancer (EC) progression. However, the underlying mechanism of ERRα-mediated lipid reprogramming in EC remains elusive...

    Authors: Xiaodan Mao, Huifang Lei, Tianjin Yi, Pingping Su, Shuting Tang, Yao Tong, Binhua Dong, Guanyu Ruan, Alexander Mustea, Jalid Sehouli and Pengming Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:28

    Content type: Research

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  16. The RAS oncogene is both the most frequently mutated oncogene in human cancer and the first confirmed human oncogene to be discovered in 1982. After decades of research, in 2013, the Shokat lab achieved a seminal...

    Authors: Albert K. Kwan, Gary A. Piazza, Adam B. Keeton and Caio A. Leite

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:27

    Content type: Review

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  17. Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 (SF3B1R625H), but its functional effects and underlying molecular mechanisms remain largely unexplored.

    Authors: Jing Guo, Chuzhong Li, Qiuyue Fang, Yulou Liu, Dawei Wang, Yiyuan Chen, Weiyan Xie and Yazhuo Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:26

    Content type: Research

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  18. Oncogenic KRAS mutations are prevalent in human cancers, but effective treatment of KRAS-mutant malignancies remains a major challenge in the clinic. Increasing evidence suggests that aberrant metabolism plays a ...

    Authors: Zhang Yang, Shun-Qing Liang, Liang Zhao, Haitang Yang, Thomas M. Marti, Balazs Hegedüs, Yanyun Gao, Bin Zheng, Chun Chen, Wenxiang Wang, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid and Ren-Wang Peng

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:25

    Content type: Research

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  19. The development of lethal cancer metastasis depends on the dynamic interactions between cancer cells and the tumor microenvironment, both of which are embedded in the extracellular matrix (ECM). The acquisitio...

    Authors: Jingjing Zhang, Yun Li, Hua Liu, Jiahui Zhang, Jie Wang, Jia Xia, Yu Zhang, Xiang Yu, Jinyan Ma, Masha Huang, Jiahui Wang, Liangzhe Wang, Qian Li, Rutao Cui, Wen Yang, Yingjie Xu…

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:24

    Content type: Research

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  20. Recent data indicated that macrophages may mutually interact with cancer cells to promote tumor progression and chemoresistance, but the interaction in cholangiocarcinoma (CCA) is obscure.

    Authors: Tao Yang, Zhengdong Deng, Lei Xu, Xiangyu Li, Tan Yang, Yawei Qian, Yun Lu, Li Tian, Wei Yao and Jianming Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:23

    Content type: Research

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  21. Epithelial-mesenchymal transition (EMT) has been associated with the angiogenesis and oncogenic phenotypes of multiple malignant tumors including bladder cancer (BCa). Circular RNAs (circRNAs) are recognized a...

    Authors: Feng Qiu, Qiuchen Liu, Yanfu Xia, Hengxi Jin, Yuxin Lin and Xiaojun Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:22

    Content type: Research

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  22. Follicular lymphoma (FL) is a B-cell non-Hodgkin lymphoma of germinal center (GC) origin with a distinctive tumor microenvironment (TME) and a unique spectrum of mutations. Despite the important therapeutic ad...

    Authors: Rada Amin and Mounia S. Braza

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:21

    Content type: Review

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  23. The long non-coding RNA (lncRNA), MALAT1, plays a key role in the development of different cancers, and its expression is associated with worse prognosis in patients. However, its mechanism of action and its r...

    Authors: Carmela Ferri, Anna Di Biase, Marco Bocchetti, Silvia Zappavigna, Sarah Wagner, Pauline Le Vu, Amalia Luce, Alessia Maria Cossu, Jayakumar Vadakekolathu, Amanda Miles, David J. Boocock, Alex Robinson, Melanie Schwerdtfeger, Virginia Tirino, Federica Papaccio, Michele Caraglia…

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:20

    Content type: Research

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  24. Colorectal carcinoma (CRC) is the third most common cancer and second most common cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) and methyltransferase-like 3 (METTL3) ...

    Authors: Jiashu Pan, Feng Liu, Xiaoli Xiao, Ruohui Xu, Liang Dai, Mingzhe Zhu, Hanchen Xu, Yangxian Xu, Aiguang Zhao, Wenjun Zhou, Yanqi Dang and Guang Ji

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:19

    Content type: Research

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  25. Neuronal-origin HuD (ELAVL4) is an RNA binding protein overexpressed in neuroblastoma (NB) and certain other cancers. The RNA targets of this RNA binding protein in neuroblastoma cells and their role in promot...

    Authors: Kausik Bishayee, Khadija Habib, Uddin Md. Nazim, Jieun Kang, Aniko Szabo, Sung-Oh Huh and Ali Sadra

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:18

    Content type: Research

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  26. Dysregulation of RNA binding protein (RBP) expression has been confirmed to be causally linked with tumorigenesis. The detailed biological effect and underlying mechanisms of the RBP GRSF1 in hepatocellular ca...

    Authors: Lili Han, Chen Huang, Xiaofei Wang and Dongdong Tong

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:17

    Content type: Research

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  27. KRAS is the predominant oncogene mutated in pancreatic ductal adenocarcinoma (PDAC), the fourth cause of cancer-related deaths worldwide. Mutant KRAS-driven tumors are metabolically programmed to support their...

    Authors: Maria Saliakoura, Matteo Rossi Sebastiano, Ioanna Nikdima, Chiara Pozzato and Georgia Konstantinidou

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:16

    Content type: Research

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  28. Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have not yielded success. Metabolic reprogrammi...

    Authors: Shuohui Dong, Shuo Liang, Zhiqiang Cheng, Xiang Zhang, Li Luo, Linchuan Li, Wenjie Zhang, Songhan Li, Qian Xu, Mingwei Zhong, Jiankang Zhu, Guangyong Zhang and Sanyuan Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:15

    Content type: Research

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  29. Chemoresistance is a main obstacle in gastric cancer (GC) treatment, but its molecular mechanism still needs to be elucidated. Here, we aim to reveal the underlying mechanisms of nanoparticle albumin-bound pac...

    Authors: Mengxuan Zhu, Pengfei Zhang, Shan Yu, Cheng Tang, Yan Wang, Zhenbin Shen, Weidong Chen, Tianshu Liu and Yuehong Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:14

    Content type: Research

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  30. Increasing evidence has suggested inositol polyphosphate 5-phosphatase family contributes to tumorigenesis and tumor progression. However, the role of INPP5F in hepatocellular carcinoma (HCC) and its underlyin...

    Authors: Qianlei Zhou, Jianhong Lin, Yongcong Yan, Shiyu Meng, Hao Liao, Ruibin Chen, Gui He, Yue Zhu, Chuanchao He, Kai Mao, Jie Wang, Jianlong Zhang, Zhenyu Zhou and Zhiyu Xiao

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:13

    Content type: Research

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  31. The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within the tumor and its microenvironment is...

    Authors: Tal Flieswasser, Astrid Van den Eynde, Jonas Van Audenaerde, Jorrit De Waele, Filip Lardon, Carsten Riether, Hans de Haard, Evelien Smits, Patrick Pauwels and Julie Jacobs

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:12

    Content type: Review

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  32. Currently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs.

    Authors: Chunyan Gu, Yajun Wang, Lulin Zhang, Li Qiao, Shanliang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nianguang Li, Yibei Xiao, Jinao Duan…

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:11

    Content type: Research

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  33. Tumor-associated macrophages (TAMs) have a leading position in the tumor microenvironment. Previously, we have demonstrated that M1-like TAMs activated by exosome-transferred THBS1 promote malignant migration ...

    Authors: Yuanhe You, Zhuowei Tian, Zhong Du, Kailiu Wu, Guisong Xu, Meilu Dai, Yan’an Wang and Meng Xiao

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:10

    Content type: Research

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  34. Multiple myeloma (MM) is an incurable plasma cell malignancy. Although Dexamethasone (Dex) is the most widely used therapeutic drug in MM treatment, patients develop Dex resistance leading to progressive disea...

    Authors: Li Du, Wei Liu, Grace Aldana-Masangkay, Alex Pozhitkov, Flavia Pichiorri, Yuan Chen and Steven T. Rosen

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:8

    Content type: Research

    Published on:

  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking, Tanja Groll, Katharina Pardon, Heathcliff D. Garcia, Tim Hensel, Dennis Gürgen, Anton G. Henssen, Angelika Eggert, Katja Steiger, Stefan Burdach and Günther H. S. Richter

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:7

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:322

  36. Lymph node metastasis is the main cause of poor prognosis of head and neck squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is an emerging epigenetic regulatory mechanism for gene...

    Authors: Dan Yu, Min Pan, Yanshi Li, Tao Lu, Zhihai Wang, Chuan Liu and Guohua Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:6

    Content type: Research

    Published on:

  37. Long non-coding RNAs (lncRNA) have an essential role in progression and chemoresistance of hepatocellular carcinoma (HCC). In-depth study of specific regulatory mechanisms is of great value in providing potent...

    Authors: Jie Mei, Wenping Lin, Shaohua Li, Yuhao Tang, Zhiwei Ye, Lianghe Lu, Yuhua Wen, Anna Kan, Jingwen Zou, Chengyou Yu, Wei Wei and Rongping Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:5

    Content type: Research

    Published on:

  38. Therapeutic resistance occurs in most patients with multiple myeloma (MM). One of the key mechanisms for MM drug resistance comes from the interaction between MM cells and adipocytes that inhibits drug-induced...

    Authors: Zhiming Wang, Jin He, Duc-hiep Bach, Yung-hsing Huang, Zongwei Li, Huan Liu, Pei Lin and Jing Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:4

    Content type: Research

    Published on:

  39. Drug resistance to sorafenib greatly limited the benefits of treatment in patients with hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) participate in the development of drug resistance. The key miRNA regul...

    Authors: Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Cheng Zhang, Wei Guo, Yu Xu, Rakesh Sharma, Zhe-Sheng Chen, Yi-Chao Zheng, Ning Wang and Yibin Feng

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:3

    Content type: Research

    Published on:

  40. B-cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy has obtained promising results in relapsed or refractory multiple myeloma (R/R MM), while some patients do not response, or rel...

    Authors: Yuanyan Tang, Haisen Yin, Xinying Zhao, Dan Jin, Yan Liang, Tao Xiong, Lu Li, Wen Tang, Jiangzhao Zhang, Min Liu, Zhuojun Yu, Huimin Liu, Sibin Zang and Zhiping Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:2

    Content type: Research

    Published on:

  41. Immune checkpoint inhibitor-related cardiotoxicity is one of the most lethal adverse effects, and thus, the identification of underlying mechanisms for developing strategies to overcome it has clinical importa...

    Authors: Yaxin Chen, Yanzhuo Liu, Yang Wang, Xuewei Chen, Chenlong Wang, Xuehan Chen, Xi Yuan, Lilong Liu, Jing Yang and Xiaoyang Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:1

    Content type: Research

    Published on:

  42. Authors: Jinxiao Li, Man Hu, Na Liu, Huarong Li, Zhaomin Yu, Qian Yan, Minfeng Zhou, Yayuan Wang, Yanjuan Song, Guangtao Pan, Fengxia Liang and Rui Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:404

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:248

  43. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13046-021-02204-1

    Authors: Shan Zhou, Jinping Lu, Yuejin Li, Chan Chen, Yongqiang Cai, Gongjun Tan, Zhengke Peng, Zhenlin Zhang, Zigang Dong, Tiebang Kang and Faqing Tang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:401

    Content type: Retraction Note

    Published on:

  44. Authors: Jian Zhang, Xin Wen, Xian-Yue Ren, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Na Liu and Jun Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:400

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:109

  45. Most cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues, which support the increased demand for biosynthesis and promote tumor pr...

    Authors: Yiwei Huang, Zhencong Chen, Tao Lu, Guoshu Bi, Ming Li, Jiaqi Liang, Zhengyang Hu, Yuansheng Zheng, Jiacheng Yin, Junjie Xi, Zongwu Lin, Cheng Zhan, Wei Jiang, Qun Wang and Lijie Tan

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:398

    Content type: Research

    Published on:

  46. Authors: Xin Peng, Shaolu Zhang, Wenhui Jiao, Zhenxing Zhong, Yuqi Yang, Francois X. Claret, Moshe Elkabets, Feng Wang, Ran Wang, Yuxu Zhong, Zhe-Sheng Chen and Dexin Kong

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:396

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:374

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