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  1. Glycolysis metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options. The ubiq...

    Authors: Liang Zhao, Min Kang, Xiaomeng Liu, Zhenran Wang, Yan Wang, Haiqiang Chen, Wenhui Liu, Shiqian Liu, Baibei Li, Chong Li, Antao Chang and Bo Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:330
  2. Aerobic glycolysis has been recognized as one of the growth-promoting metabolic alterations of cancer cells. Emerging evidence indicates that nuclear factor κB (NF-κB) plays significant roles in metabolic adap...

    Authors: Lingjun Chen, Xianyi Lin, Yiming Lei, Xuan Xu, Qi Zhou, Yan Chen, Huiling Liu, Jie Jiang, Yidong Yang, Fengping Zheng and Bin Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:329
  3. Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additi...

    Authors: Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:328
  4. Central nervous system (CNS) metastases are a major cause of death in patients with cancer. Tumor cells must survive during their migration and dissemination in various sites and niches. The brain is considere...

    Authors: Maria M. Caffarel and Mounia S. Braza
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:327
  5. Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a combinatorial in situ immunomodulation strategy based on the administration of...

    Authors: Valeria Lucarini, Ombretta Melaiu, Silvia D’Amico, Fabio Pastorino, Patrizia Tempora, Marco Scarsella, Marco Pezzullo, Adele De Ninno, Valentina D’Oria, Michele Cilli, Laura Emionite, Paola Infante, Lucia Di Marcotullio, Maria Antonietta De Ioris, Giovanni Barillari, Rita Alaggio…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:326
  6. Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heteroge...

    Authors: Andrea Anichini, Alessandra Molla, Gabriella Nicolini, Valentina Eleonora Perotti, Francesco Sgambelluri, Alessia Covre, Carolina Fazio, Maria Fortunata Lofiego, Anna Maria Di Giacomo, Sandra Coral, Antonella Manca, Maria Cristina Sini, Marina Pisano, Teresa Noviello, Francesca Caruso, Silvia Brich…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:325
  7. Aerotaxis, the chemotactism to oxygen, is well documented in prokaryotes. We previously reported for the first time that non-tumorigenic breast epithelial cells also display unequivocal directional migration t...

    Authors: Ivan Mikaelian, Rudy Gadet, Mathieu Deygas, Philippe Bertolino, Anca Hennino, Germain Gillet, Ruth Rimokh, Sid-Ali Berremila, Michel Péoc’h and Philippe Gonzalo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:324
  8. Intratumoral heterogeneity is the primary challenge in the treatment of glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion between different molecular phenotypes contribute to th...

    Authors: Zijie Gao, Jianye Xu, Yang Fan, Zongpu Zhang, Huizhi Wang, Mingyu Qian, Ping Zhang, Lin Deng, Jie Shen, Hao Xue, Rongrong Zhao, Teng Zhou, Xing Guo and Gang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:323
  9. Cancer stem cells (CSCs) are regarded as the "seed cells" for tumorigenesis, metastasis, recurrence and drug resistance. However, specific surface markers of CSCs of different origins have not been documented.

    Authors: Rou Zhao, Baoyu He, Qingli Bie, Jinghe Cao, Haoran Lu, Zhixin Zhang, Jing Liang, Li Wei, Huabao Xiong and Bin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:322
  10. Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor clinical outcomes and respond poorly to current therapies. Epigenetic deregulation is very common in MYC-d...

    Authors: Matthew J. Kling, Varun Kesherwani, Nitish K. Mishra, Gracey Alexander, Erin M. McIntyre, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter and Nagendra K. Chaturvedi
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:321
  11. In the last two decades, clinical oncology has been revolutionized by the advent of targeted drugs. However, the efficacy of these therapies is significantly limited by primary and acquired resistance, that re...

    Authors: Sabrina Rizzolio, Silvia Giordano and Simona Corso
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:319
  12. Tumour hypoxia is a known and extensively researched phenomenon that occurs in both solid and haematological malignancies. As cancer cells proliferate, demand for oxygen can outstrip supply reducing tumour oxy...

    Authors: Bill Harris, Sana Saleem, Natalie Cook and Emma Searle
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:318
  13. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1188-x.

    Authors: Zhikui Liu, Yufeng Wang, Liang Wang, Bowen Yao, Liankang Sun, Runkun Liu, Tianxiang Chen, Yongshen Niu, Kangsheng Tu and Qingguang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:317
  14. Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow s...

    Authors: Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi and Hongxi Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:316
  15. Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a specific subpopulation of cells necessary for cancer initiation and metastasis; however, the mechanisms by which they acquire met...

    Authors: Donatella Delle Cave, Silvia Buonaiuto, Bruno Sainz Jr, Marco Fantuz, Maria Mangini, Alessandro Carrer, Annalisa Di Domenico, Tea Teresa Iavazzo, Gennaro Andolfi, Carme Cortina, Marta Sevillano, Christopher Heeschen, Vincenza Colonna, Marco Corona, Antonio Cucciardi, Martina Di Guida…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:315
  16. Beta-1,3-galactosyltransferase-4 (B3GALT4) plays a critical regulatory role in tumor biology. However, the role of B3GALT4 in modulating the tumor microenvironment (TME) of neuroblastoma (NB) remains unknown.

    Authors: Yong-Liang Sha, Yun Liu, Jia-Xing Yang, Yang-Yang Wang, Bao-Cheng Gong, Yan Jin, Tong-Yuan Qu, Fan-Tong Xia, Lei Han and Qiang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:314
  17. Authors: Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang and Jinhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:313

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:284

  18. Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great pote...

    Authors: Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad and Oliver Strobel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:312
  19. Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis. Super enhancers (SEs) are large clusters of enhancers that play impo...

    Authors: Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang and Yujie Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:311
  20. The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is expressed in several types of tumors. That fact, together with the role of HER3 in promoting cell proliferation, implica...

    Authors: Lucía Gandullo-Sánchez, Alberto Ocaña and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:310
  21. Aberrant activation of the MET receptor in cancer is sustained by genetic alterations or, more frequently, by transcriptional upregulations. A fraction of MET-amplified or mutated tumors are sensible to MET ta...

    Authors: Cristina Chiriaco, Chiara Donini, Marco Cortese, Stefano Ughetto, Chiara Modica, Ilaria Martinelli, Alessia Proment, Letizia Vitali, Lara Fontani, Monica Casucci, Paolo Maria Comoglio, Silvia Giordano, Dario Sangiolo, Valeria Leuci and Elisa Vigna
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:309
  22. Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via se...

    Authors: Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao and Daming Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:307

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:320

  23. Authors: Chongyang Li, Chaowei Deng, Guangzhao Pan, Xue Wang, Kui Zhang, Zhen Dong, Gaichao Zhao, Mengqin Tan, Xiaosong Hu, Shaomin Shi, Juan Du, Haoyan Ji, Xiaowen Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:306

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:230

  24. Molecular tumor boards (MTBs) match molecular alterations with targeted anticancer drugs upon failure of the available therapeutic options. Special and local needs are most likely to emerge through the compara...

    Authors: Gennaro Ciliberto, Marco Canfora, Irene Terrenato, Chiara Agnoletto, Francesco Agustoni, Loredana Amoroso, Gustavo Baldassarre, Giuseppe Curigliano, Angelo Delmonte, Antonella De Luca, Michelangelo Fiorentino, Vanesa Gregorc, Toni Ibrahim, Chiara Lazzari, Angela Mastronuzzi, Paolo Pronzato…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:305
  25. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with ...

    Authors: Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu and Shuwen Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:303
  26. Adenosine is a potent immunosuppressant whose levels in the tumor microenvironment (TME) are often much higher than those in normal tissues. Binding of adenosine to its receptor A2aR activates a cascade of gen...

    Authors: Yu Bai, Xin Zhang, Jie Zheng, Ziyi Liu, Zhenfan Yang and Xiaolin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:302
  27. Early metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the ma...

    Authors: Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen and Xin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:301
  28. Neoadjuvant programmed death receptor-1 (PD-1) inhibitors have drawn increasing attention in locally advanced head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the safety and effica...

    Authors: Xiaotao Huang, Qiaodan Liu, Guihua Zhong, Yingpeng Peng, Ye Liu, Lizhong Liang, Haiyu Hong, Weineng Feng, Shuang Yang, Yaqin Zhang, Shiping Xian, Zhanyu Li, Yuling Zhou, Zhaoyuan Zhang, Wen Jiang, Jun Liang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:300
  29. Therapeutic strategies engaging the immune system against malignant cells have revolutionized the field of oncology. Proficiency of dendritic cells (DCs) for antigen presentation and immune response has spurre...

    Authors: Natacha Jugniot, Jeremy J. Dahl and Ramasamy Paulmurugan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:299
  30. The introduction of functional in-silico models, in addition to in-vivo tumor models, opens up new and unlimited possibilities in cancer research and drug development. The world's first digital twin of the A54...

    Authors: Christian Baumgartner
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:298
  31. Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear.

    Authors: Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu and Xiaojun Zha
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:297
  32. Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer (GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC-LM) remains unknown. Exosomes have been id...

    Authors: Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:296
  33. Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients. Here, we aimed to uncover ...

    Authors: Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Hai-Kun Wang, Jia-Hao Jiang and Jian-Yong Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:295
  34. The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly found to be mutated in age-related clon...

    Authors: Kanak Joshi, Lei Zhang, Peter Breslin S.J., Ameet R. Kini and Jiwang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:294
  35. Protein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating arginine methylation in cancer and are increasingly recognized as potential drug targets. Inhibitors targeting PRM...

    Authors: Shuangjie Liu, Zhuonan Liu, Chiyuan Piao, Zhe Zhang, Chuize Kong, Lei Yin and Xi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:293
  36. The management of sub-totally resected sporadic vestibular schwannoma (VS) may include observation, re-resection or irradiation. Identifying the optimal choice can be difficult due to the disease’s variable pr...

    Authors: Moran Amit, Tongxin Xie, Frederico O. Gleber-Netto, Patrick J. Hunt, Gautam U. Mehta, Diana Bell, Deborah A. Silverman, Ismail Yaman, Yi Ye, Jared K. Burks, Gregory N. Fuller, Paul W. Gidley, Marc-Elie Nader, Shaan M. Raza and Franco DeMonte
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:292
  37. Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:291

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:21

  38. Authors: Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari and Rossella Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:290

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:24

  39. Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high specificity and low toxicity have emerged as a powerful technology of targeted protein degradation for biomedical applications. FOXM1,...

    Authors: Kun Wang, Xiaoyong Dai, Albert Yu, Chunyan Feng, Kewei Liu and Laiqiang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:289
  40. Pancreatic ductal adenocarcinoma is prone to metastasis, resulting in short survival and low quality of life. LncRNAs are pivotal orchestrators that participate in various tumor progress. The underlying role a...

    Authors: Min Zhou, Shutao Pan, Tingting Qin, Chunle Zhao, Taoyuan Yin, Yang Gao, Yuhui Liu, Zhenxiong Zhang, Yongkang Shi, Yu Bai, Jun Gong, Xingjun Guo, Min Wang and Renyi Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:288
  41. Lymph node metastasis is one of most common determinants of the stage and prognosis of gastric cancer (GC). However, the key molecular events and mechanisms mediating lymph node metastasis remain elusive.

    Authors: Yongxu Jia, Qian Yan, Yinli Zheng, Lei Li, Baifeng Zhang, Zhiwei Chang, Zehua Wang, Hong Tang, Yanru Qin and Xin-Yuan Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:287
  42. Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic acids and mediate intercellular communication among multiple cells in the tumour environment. Small extracell...

    Authors: Kewen Qian, Wenyan Fu, Tian Li, Jian Zhao, Changhai Lei and Shi Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:286
  43. Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance...

    Authors: Manuel Gámez-Chiachio, Ángela Molina-Crespo, Carmen Ramos-Nebot, Jeannette Martinez-Val, Lidia Martinez, Katja Gassner, Francisco J. Llobet, Mario Soriano, Alberto Hernandez, Marco Cordani, Cristina Bernadó-Morales, Eva Diaz, Alejandro Rojo-Sebastian, Juan Carlos Triviño, Laura Sanchez, Ruth Rodríguez-Barrueco…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:285
  44. Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cel...

    Authors: Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang and Jinhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:284

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:313

  45. Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic de...

    Authors: Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Alexander W. Loftus, Moeez Rathore, Ali Vaziri-Gohar, John M. Asara, Jordan M. Winter and Luke D. Rothermel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:283
  46. Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their s...

    Authors: Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger and Naris Nilubol
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:282
  47. Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development of many diseases, including tumors. This study aimed to investigate the potential roles of ci...

    Authors: Xiaopei Hao, Yao Zhang, Xiaoli Shi, Hanyuan Liu, Zhiying Zheng, Guoyong Han, Dawei Rong, Chuanyong Zhang, Weiwei Tang and Xuehao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:281

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