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  1. Content type: Research

    High-grade serous ovarian cancer (HGSOC) is the most lethal of all gynecological malignancies. Patients often suffer from chemoresistance. Several studies have reported that Fn14 could regulate migration, inva...

    Authors: An-Yue Wu, Li-Ying Gu, Wei Cang, Meng-Xing Cheng, Wen-Jing Wang, Wen Di, Lei Huang and Li-Hua Qiu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:176

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  2. Content type: Research

    Head and neck squamous-cell carcinoma (HNSCC) ranks sixth among cancers worldwide. Though several molecular mechanisms of tumor initiation and progression of HNSCC are known, others remain unclear. Significanc...

    Authors: Sourabh Soni, Munish Kumar Saroch, Bal Chander, Narendra Vijay Tirpude and Yogendra S. Padwad

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:175

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  3. Content type: Research

    Non-small cell lung cancer (NSCLC) is a devastating disease with a heterogeneous prognosis, and the molecular mechanisms underlying tumor progression remain elusive. Mammalian Eps15 homology domain 1 (EHD1) pl...

    Authors: Ting Wang, Ying Xing, Qingwei Meng, Hailing Lu, Wei Liu, Shi Yan, Yang Song, Xinyuan Xu, Jian Huang, Yue Cui, Dexin Jia and Li Cai

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:174

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  4. Content type: Research

    Breast cancer angiogenesis is key for metastasis and predicts a poor prognosis. Angiotensin-converting enzyme 2 (ACE2), as a member of the renin-angiotensin system (RAS), was reported to restrain the progressi...

    Authors: Qi Zhang, Sihong Lu, Tianfu Li, Liang Yu, Yunjian Zhang, Huijuan Zeng, Xueke Qian, Jiong Bi and Ying Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:173

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  5. Content type: Research

    Thousands of long noncoding RNAs (lncRNAs) are aberrantly expressed in various types of cancers, however our understanding of their role in the disease is still very limited.

    Authors: Morvarid Saeinasab, Ahmad Reza Bahrami, Jovanna González, Francesco P. Marchese, Dannys Martinez, Seyed Javad Mowla, Maryam M. Matin and Maite Huarte

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:172

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  6. Content type: Review

    Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and re...

    Authors: Yuanliang Yan, Xi Chen, Xiang Wang, Zijin Zhao, Wenfeng Hu, Shuangshuang Zeng, Jie Wei, Xue Yang, Long Qian, Shuyi Zhou, Lunquan Sun, Zhicheng Gong and Zhijie Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:171

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  7. Content type: Research

    Cancer stem cells (CSCs) require stromal signals for maintaining pluripotency and self-renewal capacities to confer tumor metastasis. Resolvin D1 (RvD1), an endogenous anti-inflammatory lipid mediator, has rec...

    Authors: Liankang Sun, Yufeng Wang, Liang Wang, Bowen Yao, Tianxiang Chen, Qing Li, Zhikui Liu, Runkun Liu, Yongshen Niu, Tao Song, Qingguang Liu and Kangsheng Tu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:170

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  8. Content type: Research

    FGFR3 plays an important role in the development of bladder cancer (BCa). Hsa_circ_0068871 is a circRNA generated from several exons of FGFR3. However, the potential functional role of hsa_circ_0068871 in BCa ...

    Authors: Weipu Mao, Xin Huang, Longsheng Wang, Ziwei Zhang, Mengnan Liu, Yan Li, Ming Luo, Xudong Yao, Jie Fan and Jiang Geng

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:169

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  9. Content type: Research

    Chimeric antigen receptor (CAR)-engineered T cells have displayed outstanding performance in the treatment of patients with hematological malignancies. However, their efficacy against solid tumors has been lar...

    Authors: Yitian Wang, Wei Yu, Jian Zhu, Junjie Wang, Kaishun Xia, Chengzhen Liang and Huimin Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:168

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  10. Content type: Research

    Xenotropic and polytropic retrovirus receptor 1 (XPR1), a previously identified cellular receptor for several murine leukemia viruses, plays a role in many pathophysiological processes. However, the role of XP...

    Authors: Wei-chao Chen, Qiu-li Li, Qimei Pan, Hua-yong Zhang, Xiao-yan Fu, Fan Yao, Jian-ning Wang and An-kui Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:167

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  11. Content type: Research

    Acquired drug resistance is a constraining factor in clinical treatment of glioblastoma (GBM). However, the mechanisms of chemoresponsive tumors acquire therapeutic resistance remain poorly understood. Here, w...

    Authors: Zhuoran Zhang, Jianxing Yin, Chenfei Lu, Yutian Wei, Ailiang Zeng and Yongping You

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:166

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  12. Content type: Research

    miRNAs play crucial role in the progression of K-Ras-mutated nonsmall cell lung cancer (NSCLC). However, most studies have focused on miRNAs that target K-Ras. Here, we investigated miRNAs regulated by mutant ...

    Authors: Hua Jin, Yoonjeong Jang, Nian Cheng, Qing Li, Peng-Fei Cui, Zhi-Wei Zhou, Hu-Lin Jiang, Myung-Haing Cho, Kenneth D. Westover, Qun-You Tan and Cheng-Xiong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:165

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  13. Content type: Research

    Metastasis remains the main cause of cancer-related death for gastric cancer (GC) patients, but the mechanisms are poorly understood. Using The Cancer Genome Atlas (TCGA) data base and bioinformatics analyses,...

    Authors: Jia-Xing Zhang, Wei-Ling He, Zi-Hao Feng, Dong-Liang Chen, Ying Gao, Ying He, Kai Qin, Zhou-San Zheng, Cui Chen, Hui-Wen Weng, Miao Yun, Sheng Ye, Rui-Hua Xu and Dan Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:164

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  14. Content type: Research

    ALKBH5 regulated the malignant behavior of breast cancer and glioblastoma. However, the expression and function of ALKBH5 in epithelial ovarian cancer have not yet been determined. In the present study, we inv...

    Authors: Hongtao Zhu, Xiaoling Gan, Xingwei Jiang, Shuai Diao, Huan Wu and Jianguo Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:163

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  15. Content type: Review

    Pancreatic cancer is one of the most lethal type of cancers, with an overall five-year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited therapeutic options. To date, no ...

    Authors: Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli and Chun-Wai Mai

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:162

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  16. Content type: Research

    Long non-coding RNAs (lncRNAs) have been identified to play an important role in the development and progression of various tumors, including colorectal cancer (CRC). However, the regulatory molecular mechanis...

    Authors: Jing Li, Meirong He, Wen Xu and Silin Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:161

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  17. Content type: Research

    Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to En...

    Authors: Luigi Mele, Marcella la Noce, Francesca Paino, Tarik Regad, Sarah Wagner, Davide Liccardo, Gianpaolo Papaccio, Angela Lombardi, Michele Caraglia, Virginia Tirino, Vincenzo Desiderio and Federica Papaccio

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:160

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  18. Content type: Research

    Tripartite motif 47 (TRIM47), a member of the TRIM family proteins, plays a key role in many types of cancers including colorectal cancer (CRC). We found that levels of TRIM47 mRNA and protein were increased s...

    Authors: Qian Liang, Chaotao Tang, Mingyu Tang, Qingwei Zhang, Yunjie Gao and Zhizheng Ge

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:159

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  19. Content type: Research

    RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migrat...

    Authors: Maureen Keller, Fatéméh Dubois, Sylvain Teulier, Alexandre P. J. Martin, Jérôme Levallet, Elodie Maille, Solenn Brosseau, Nicolas Elie, Alexander Hergovich, Emmanuel Bergot, Jacques Camonis, Gérard Zalcman and Guénaëlle Levallet

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:158

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  20. Content type: Research

    Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness. Epidermal growth factor rec...

    Authors: Yuning Liao, Zhiqiang Guo, Xiaohong Xia, Yuan Liu, Chuyi Huang, Lili Jiang, Xuejun Wang, Jinbao Liu and Hongbiao Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:157

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  21. Content type: Review

    Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that...

    Authors: N. A. Seebacher, A. E. Stacy, G. M. Porter and A. M. Merlot

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:156

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  22. Content type: Research

    As most lung cancer patients present with invasive, metastatic disease, it is vital to investigate anti-metastatic treatments for non-small cell lung cancer (NSCLC). Houttuynia cordata is commonly used as a Chine...

    Authors: Rilei Jiang, Cheng Hu, Qian Li, Ziyu Cheng, Ling Gu, Hongxiao Li, Yuanyuan Guo, Qirui Li, Yueyang Lu, Ke Li, Meijuan Chen and Xu Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:155

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  23. Content type: Research

    Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose phosphate pathway (PPP), a branch of glycolysis, is an important metabolic pathway for the survival and biosynthesis of cancer cells...

    Authors: Zhaoyu Qin, Chan Xiang, Fan Zhong, Yang Liu, Qiongzhu Dong, Kai Li, Wenhao Shi, Chen Ding, Lunxiu Qin and Fuchu He

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:154

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  24. Content type: Research

    Hepatocellular carcinoma (HCC) is the major histological type of liver cancer with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNA) has been proved to be associated with various cancer type...

    Authors: Yu-Gang Wang, Tao Wang, Min Shi and Bo Zhai

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:153

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  25. Content type: Research

    With the rapid development of the high throughput detection techniques, tumor-related Omics data has become an important source for studying the mechanism of tumor progression including breast cancer, one of t...

    Authors: Fen Lin, Yu-Jie Xie, Xin-Ke Zhang, Tie-Jun Huang, Hong-Fa Xu, Yan Mei, Hu Liang, Hao Hu, Si-Ting Lin, Fei-Fei Luo, Yan-Hong Lang, Li-Xia Peng, Chao-Nan Qian and Bi-Jun Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:152

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  26. Content type: Research

    Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. An increasing number of studies have recently focused on the malignant functions of cancer-associated fibroblasts (CAFs) in numer...

    Authors: Xiaoning Wang, Xing Qin, Ming Yan, Jianbo Shi, Qin Xu, Zhihui Li, Wenjun Yang, Jianjun Zhang and Wantao Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:151

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  27. Content type: Research

    Deregulated ErbB signaling plays an important role in tumorigenesis of pancreatic cancer. However, patients with pancreatic cancer benefit little from current existed therapies targeting the ErbB signaling. He...

    Authors: Tingting Lin, Qun Ren, Weimin Zuo, Ruxue Jia, Linhui Xie, Rong Lin, Hu Zhao, Jin Chen, Yan Lei, Ping Wang, Huiyue Dong, Lianghu Huang, Jinquan Cai, Yonghai Peng, Zongyang Yu, Jianming Tan…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:150

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  28. Content type: Research

    The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mech...

    Authors: Mingjing Shen, Zhonghua Xu, Weihua Xu, Kanqiu Jiang, Fuquan Zhang, Qifeng Ding, Zhonghen Xu and Yongbing Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:149

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  29. Content type: Research

    Recent Clinical trials of administration of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in combination with standard first-line chemotherapy have failed to improve survival in patie...

    Authors: Tianze Liu, Lizi Jin, Wenjing Lu, Hairun Gan, Zhidong Lin, Miao Chen, Jiani Liu, Fan Zhang, Siyang Wang, Hongyu Zhang, Wuguo Deng and Hongtao Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:148

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  30. Content type: Research

    Ionizing radiation (IR) therapy is the standard first-line treatment for newly diagnosed patients with glioblastoma (GBM), the most common and malignant primary brain tumor. However, the effects of IR are limi...

    Authors: Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang, Yanxin Li and Haizhong Feng

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:147

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  31. Content type: Review

    The recent developments in immuno-oncology have opened an unprecedented avenue for the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered a very promising strategy to activate ...

    Authors: Alessandra Lopes, Gaëlle Vandermeulen and Véronique Préat

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:146

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  32. Content type: Research

    Abnormal expression or distribution of connexin 32 (Cx32) is associated with hepatocarcinogenesis, but the role of Cx32 and the underlying mechanisms are still unclear.

    Authors: Yuke Xiang, Qin Wang, Yunquan Guo, Hui Ge, Yile Fu, Xiyan Wang and Liang Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:145

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  33. Content type: Retraction Note

    The authors are retracting this article [1] because it overlaps significantly with a previously published article by Moody et al. [2] without proper citation. All authors agree with this retraction.

    Authors: Ke-ting Que, Yun Zhou, Yu You, Zhen Zhang, Xiao-ping Zhao, Jian-ping Gong and Zuo-jin Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:144

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:268

  34. Content type: Research

    Bladder cancer (BC) is a common type of cancer that involves tumors of the urinary system and poses a serious threat to human health. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regula...

    Authors: Liying Miao, Hong Yue Liu, Cuixing Zhou and Xiaozhou He

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:143

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  35. Content type: Correction

    In the publication of this article [1], there is an error in Fig. 5G (panel 2, group of InmiR-26a + siSCR in HCT-8/5-FU, treated with 284.3 μM).

    Authors: Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu and Li Jia

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:142

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:316

  36. Content type: Research

    Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. They are typically characterized by a high incidence of local recurrence, which is the most common cause of death in HNSCC p...

    Authors: Mahrou Vahabi, Claudio Pulito, Andrea Sacconi, Sara Donzelli, Marco D’Andrea, Valentina Manciocco, Raul Pellini, Paola Paci, Giuseppe Sanguineti, Lidia Strigari, Giuseppe Spriano, Paola Muti, Pier Paolo Pandolfi, Sabrina Strano, Shahrokh Safarian, Federica Ganci…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:141

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  37. Content type: Research

    Autophagy, a process for degrading intracellular substances to maintain basal metabolic turnover, is known to be perturbed in gastric cancer. Programmed cell death-1 (PD-1) with its ligand (PD-L1) are importan...

    Authors: Xiaojuan Wang, William K. K. Wu, Jing Gao, Zhongwu Li, Bin Dong, Xiaoting Lin, Yilin Li, Yanyan Li, Jifang Gong, Changsong Qi, Zhi Peng, Jun Yu and Lin Shen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:140

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  38. Content type: Research

    Nuciferine (NF), extracted from the leaves of N. nucifera Gaertn, has been shown to exhibit anti-tumor and anti-viral pharmacological properties. It can also penetrate the blood brain barrier (BBB). However, the ...

    Authors: Zizhuo Li, Yaodong Chen, Tingting An, Pengfei Liu, Jiyuan Zhu, Haichao Yang, Wei Zhang, Tianxiu Dong, Jian Jiang, Yu Zhang, Maitao Jiang and Xiuhua Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:139

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  39. Content type: Research

    SOX11 is a transcription factor that plays an important role in mantle cell lymphoma development. However, its functional role in head and neck squamous cell carcinoma (HNSCC) remains unknown.

    Authors: Junwei Huang, Eoon Hye Ji, Xinyuan Zhao, Li Cui, Kaori Misuno, Mian Guo, Zhigang Huang, Xiaohong Chen and Shen Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:138

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  40. Content type: Research

    There is growing evidence that tripartite motif-containing protein 44 (TRIM44) plays crucial role in tumor development. However, the underlying mechanism of this deubiquitinating enzyme remains unclear.

    Authors: Chuan-Yuan Wei, Lu Wang, Meng-Xuan Zhu, Xin-Yi Deng, Dao-He Wang, Si-Min Zhang, Jiang-Hui Ying, Xin Yuan, Qiang Wang, Tian-Fan Xuan, An-Qi He, Fa-Zhi Qi and Jian-Ying Gu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:137

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  41. Content type: Research

    Mitochondrial Ca2+ plays a critical role in tumorigenesis, including cell proliferation and metastasis. Mitochondrial calcium uniporter regulator 1 (MCUR1) has been shown to be frequently upregulated in HCC and p...

    Authors: Mingpeng Jin, Jiaojiao Wang, Xiaoying Ji, Haiyan Cao, Jianjun Zhu, Yibing Chen, Jin Yang, Zheng Zhao, Tingting Ren and Jinliang Xing

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:136

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  43. Content type: Review

    Immune checkpoint inhibitor therapy has changed clinical practice for patients with different cancers, since these agents have demonstrated a significant improvement of overall survival and are effective in ma...

    Authors: Francesca Di Modugno, Cristina Colosi, Paola Trono, Giuseppe Antonacci, Giancarlo Ruocco and Paola Nisticò

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:117

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  44. Content type: Research

    The transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) signaling pathways are both constitutively activated in triple-negative breast cancer (TNBC). We are interested in isolating the nat...

    Authors: Lei Di, Li-Juan Liu, Yong-Ming Yan, Rong Fu, Yi Li, Ying Xu, Yong-Xian Cheng and Zhao-Qiu Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:134

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  45. Content type: Research

    Glioblastoma multiforme (GBM) is the most common and aggressive form of astrocytoma among adult brain tumors. Multiple studies have shown that long non-coding RNAs (lncRNAs) play important roles in acting as m...

    Authors: Weining Wu, Tianfu Yu, Youzhi Wu, Wei Tian, Junxia Zhang and Yingyi Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:133

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  46. Content type: Research

    Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed, we elaborated the impact of CD44v6 and Tspan8 on the ...

    Authors: Zhe Wang, Hanxue Sun, Jan Provaznik, Thilo Hackert and Margot Zöller

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:132

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  47. Content type: Research

    Dysfunction of p53 is a key cause of cancer development, while CCDC106 can reduce p53 stability and is associated with lung cancer. However, the roles of CCDC106 in other cancer types and its upstream regulato...

    Authors: Yichong Ning, Chunqing Wang, Xin Liu, Yan Du, Shunlian Liu, Kaili Liu, Jianlin Zhou and Chang Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:131

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  48. Content type: Research

    Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted therapy for HCC. Selective tyrosine kinase inhibitors have shown promise ...

    Authors: Teng Luo, Shou-Guo Zhang, Ling-Fei Zhu, Fei-Xiang Zhang, Wei Li, Ke Zhao, Xiao-Xue Wen, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Hui-Ying Gao, Lin Wang, Xiao-Ming Yang and Chang-Yan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:130

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  49. Content type: Research

    Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to tr...

    Authors: Quanfu Huang, Qiuguo Wang, Dong Li, Xiao Wei, Yijuan Jia, Zheng Zhang, Bo Ai, Xiaonian Cao, Tao Guo and Yongde Liao

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:129

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  50. Content type: Meeting Report

    Cell-to-cell communication has a critical role during tumor development and progression, allowing cancer cell to re-program not only the surrounding tumor microenvironment, but also cells located at distant si...

    Authors: Claudia Chiodoni, Maria Teresa Di Martino, Francesca Zazzeroni, Michele Caraglia, Massimo Donadelli, Stefania Meschini, Carlo Leonetti and Katia Scotlandi

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:128

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Journal of Experimental & Clinical Cancer Research

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