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  1. Although the addition of bevacizumab to 1st line chemotherapy provides a significant survival benefit for advanced colorectal cancer, the magnitudes of both advantages and toxicities have not been extensively inv...

    Authors: Fotios Loupakis, Emilio Bria, Vanja Vaccaro, Federica Cuppone, Michele Milella, Paolo Carlini, Chiara Cremolini, Lisa Salvatore, Alfredo Falcone, Paola Muti, Isabella Sperduti, Diana Giannarelli and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:58
  2. Constitutively decreased TGFBR1 allelic expression is emerging as a potent modifier of colorectal cancer risk in mice and humans. This phenotype was first observed in mice, then in lymphoblastoid cell lines from ...

    Authors: Boris Pasche, Kari B Wisinski, Maureen Sadim, Virginia Kaklamani, Michael J Pennison, Qinghua Zeng, Naresh Bellam, Jacquelyn Zimmerman, Nengjun Yi, Kui Zhang, John Baron, Daniel O Stram and M Geoffrey Hayes
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:57
  3. VEGF is a well-validated target for antiangiogenic intervention in cancer. To date, RNAi technology has been proven to be a promising approach for targeted therapy. DDP is frequently used as a first-line drug ...

    Authors: Yong P Ma, Yang Yang, Shuang Zhang, Xiang Chen, Na Zhang, Wei Wang, Zhi X Cao, Yu Jiang, Xia Zhao, Yu Q Wei and Hong X Deng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:56
  4. It has been demonstrated that certain NK-1 antagonists could reduce proliferation of several cancer cell lines, however, it is unknown whether SR140333 exerts proliferation inhibition in breast cancer cell line.

    Authors: Wei-Qing Huang, Ji-Gang Wang, Lei Chen, Hong-Jun Wei and Hua Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:55
  5. DNA-damage-inducible transcript 3 (DDIT3), a candidate tumor suppressor gene (TSG), has been found involved in the regulation of cellular growth and differentiation. The epigenetic changes of TSGs are recently re...

    Authors: Ya-li Wang, Jun Qian, Jiang Lin, Dong-ming Yao, Zhen Qian, Zhao-hui Zhu and Jian-yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:54
  6. MUC5AC is a secretory mucin normally expressed in the surface muconous cells of stomach and bronchial tract. It has been known that MUC5AC de novo expression occurred in the invasive ductal carcinoma and pancreat...

    Authors: Sadaaki Yamazoe, Hiroaki Tanaka, Tetsuji Sawada, Ryosuke Amano, Nobuya Yamada, Masaichi Ohira and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:53
  7. Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required. In this study we generated a novel 'suicide gene' armed on...

    Authors: Ju-Feng Zhang, Fang Wei, Hui-Ping Wang, Hui-Ming Li, Wei Qiu, Peng-Kang Ren, Xia-Fang Chen and Qian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:52
  8. Signal transducer and activator of transcription 3 (Stat3) is a member of the Janus-activated kinase(Jak)/Stat signaling pathway. Abnormal activation of Stat3 plays a critical role in metastasis and invasion i...

    Authors: Chen Huang, Guang Yang, Tao Jiang, Kejian Huang, Jun Cao and Zhengjun Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:51
  9. Fas/FasL system is a major regulator of apoptosis. The mechanisms by which Fas mediates cisplatin resistance remain unclear. The aim of this study is to explore the effect of Fas over-expression on cisplatin r...

    Authors: Wei Wu, Hai-dong Wang, Wei Guo, Kang Yang, Yun-ping Zhao, Yao-guang Jiang and Ping He
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:49
  10. Glypican 3 (GPC-3) is an oncofoetal protein that is expressed in most hepatocellular carcinomas (HCC). Since it is a potential target for T cell immunotherapy, we investigated the generation of functional, GPC...

    Authors: James O'Beirne, Farzin Farzaneh and Phillip M Harrison
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:48
  11. The main hindrance to the diffusion of proton therapy facilities is the high cost for gantry installations. An alternative technical option is provided by fixed-beam treatment rooms, where the patient is rotat...

    Authors: Salvatore Devicienti, Lidia Strigari, Marco D'Andrea, Marcello Benassi, Vincenzo Dimiccoli and Maurizio Portaluri
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:47
  12. A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin exp...

    Authors: Dan-Dan Yu, Chun-Ting Wang, Hua-Shan Shi, Zhi-Yong Li, Li Pan, Qing-Zhong Yuan, Fei Leng, Yuan Wen, Xiang Chen and Yu-Quan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:46
  13. We performed expression profiling of two neuroblastoma cell lines, SK-N-BE(2) and SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and cyclooxygenases (C...

    Authors: Petr Chlapek, Martina Redova, Karel Zitterbart, Marketa Hermanova, Jaroslav Sterba and Renata Veselska
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:45
  14. To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features.

    Authors: Xiang Hu, Ai-Xi Yu, Bai-Wen Qi, Tao Fu, Gang Wu, Min Zhou, Jun Luo and Jun-Hua Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:43
  15. Calcifying epithelioma of Malherbe, or Pilomatricoma, is considered an uncommon cutaneous neoplasia, normally occurring in children as a solitary, firm, asymptomatic, hard, subcutaneous, slowly growing nodule ...

    Authors: Francesco M Solivetti, Fulvia Elia, Alessandra Drusco, Chiara Panetta, Ada Amantea and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:42
  16. In our previous study, it was well defined that IGFBP7 was an important tumor suppressor gene in colorectal cancer (CRC). We aimed to uncover the downstream molecules responsible for IGFBP7's behaviour in this st...

    Authors: Wenjing Ruan, Yinghong Wang, Yu Ma, Xiaoming Xing, Jie Lin, Jing Cui and Maode Lai
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:41
  17. The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated...

    Authors: Vanessa F Bernardes, Frederico O Gleber-Netto, Sílvia F Sousa, Tarcília A Silva and Maria Cássia F Aguiar
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:40
  18. Definitions of basal-like breast cancer phenotype vary, and microarray-based expression profiling analysis remains the gold standard for the identification of these tumors. Immunohistochemical identification o...

    Authors: Radzislaw Kordek, Piotr Potemski, Renata Kusinska, Elzbieta Pluciennik and Andrzej Bednarek
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:39
  19. The objective of this study was to evaluate the efficacy and safety of pemetrexed plus cisplatin/carboplatin in locally advanced or metastatic non-small cell lung cancer (NSCLC) patients previously treated wit...

    Authors: Guan-Zhong Zhang, Shun-Chang Jiao and Zhao-Ting Meng
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:38
  20. To investigate whether dendritic cell (DC) precursors, recruited by injection of chemokine ligand 3 (CCL3) and CCL20, induce anti-tumor immunity against gastric cancer induced by a DC vaccine expressing melanoma ...

    Authors: Songbing He, Liang Wang, Yugang Wu, Dechun Li and Yanyun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:37
  21. Analysis of gene expression and gene mutation may add information to be different from ordinary pathological tissue diagnosis. Since samples obtained endoscopically are very small, it is desired that more sens...

    Authors: Koji Nonogaki, Akihiro Itoh, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroshi Matsubara, Yuya Itoh, Yosuke Nakamura, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Masatoshi Ishigami, Yoshiaki Katano, Hidemi Goto and Yoshiki Hirooka
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:36
  22. This study explored the response of nasopharyngeal carcinoma cells to TGF-β1-induced growth suppression and investigated the roles of the TGF-β/Smad signaling pathway in nasopharyngeal carcinoma cells.

    Authors: Jian Xiao, Qi Xiang, Ye-Chen Xiao, Zhi-Jian Su, Zhi-Feng Huang, Qi-Hao Zhang, Yi Tan, Xiao-Kun Li and Ya-Dong Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:35
  23. PIK3CA is one of the genes most frequently mutated in human cancers and it is a potential target for personalized therapy. The aim of this study was to assess the frequency and type of PIK3CA mutations in gastric...

    Authors: Stefano Barbi, Ivana Cataldo, Giovanni De Manzoni, Samantha Bersani, Simona Lamba, Silvia Mattuzzi, Alberto Bardelli and Aldo Scarpa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:32
  24. In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved in pr...

    Authors: Ke Zheng, Hong-Yuan Li, Xin-Liang Su, Xiao-Yi Wang, Tian Tian, Fan Li and Guo-Sheng Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:31
  25. The past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal...

    Authors: Razvan T Radulescu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:30
  26. MicroRNAs are non-coding RNA molecules that posttranscriptionally regulate expression of target genes and have been implicated in the progress of cancer proliferation, differentiation and apoptosis. The aim of...

    Authors: Bao Song, Chuanxi Wang, Jie Liu, Xingwu Wang, Liyan Lv, Ling Wei, Li Xie, Yan Zheng and Xianrang Song
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:29
  27. The secreted protein acidic and rich in cysteine (SPARC) plays a pivotal role in regulating cell-matrix interactions and tumor angiogenesis, proliferation, and migration. Detection of SPARC gene methylation may b...

    Authors: Jun Gao, Jian Song, Haojie Huang, Zhaoshen Li, Yiqi Du, Jia Cao, Minghui Li, Shunli Lv, Han Lin and Yanfang Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:28
  28. Circulating bone marrow-derived endothelial progenitor cells (EPCs) have been reported to participate in tumor angiogenesis and growth; however, the role of circulating EPCs in tumor progression is controversi...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Weiqi Li, Zhen Cai, Shilong Xiong and Jie Bao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:27
  29. Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of var...

    Authors: Zhuanyi Yang, Ying Wang, Jiasheng Fang, Fenghua Chen, Jinfang Liu, Jun Wu and Yanjin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:26
  30. Giant cell tumor is an infrequent and unpredictable bony lesion. Although numerous attempts have been made to predict the behaviour of GCT, there are no definite biological or histological parameters to determ...

    Authors: Faisham W Ismail, Aminudin M Shamsudin, Zulmi Wan, Salzihan M Daud and Mutum S Samarendra
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:25
  31. Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commo...

    Authors: Fang-Zhen Shen, Bing-Yuan Zhang, Yu-Jie Feng, Zhuo-Xia Jia, Bing An, Chang-Chang Liu, Xi-Yun Deng, Anil D Kulkarni and Yun Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:24
  32. Anti-HER-2 antibodies targeting distinct epitopes have different biological functions on cancer cells. In a previous study, we demonstrated that anti-HER-2 engineering antibody ChA21 was able to bind to subdom...

    Authors: AnLi Zhang, Hua Xue, XiaoGuang Ling, Yi Gao, Feng Yang, LianSheng Cheng, Jing Liu and Qiang Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:23
  33. It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PP...

    Authors: Takayuki Yoshizaki, Wataru Motomura, Sachie Tanno, Shima Kumei, Yumiko Yoshizaki, Satoshi Tanno and Toshikatsu Okumura
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:22
  34. Taurolidine (TRD) represents an anti-infective substance with anti-neoplastic activity in many malignant cell lines. So far, the knowledge about the cell death inducing mechanisms and pathways activated by TRD...

    Authors: Ansgar M Chromik, Adrien Daigeler, Daniel Bulut, Annegret Flier, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Peter R Ritter, Ulrich Mittelkötter, Stephan A Hahn and Waldemar Uhl
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:21
  35. To retrospectively review the incidence, treatment efficacy, we followed up newly diagnosed chronic myelogenous leukemia (CML) patients residing in Shanghai during 2001-2006.

    Authors: Ai-Hua Wang, Yan-Yan Wang, Yu Yao, Zi-Zhen Xu, Li Zhou, Li Wang, Li Zhang, Yu Chen, Zhi-Xiang Shen, Jiong Hu and Jun-Min Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:20
  36. Hereditary hemochromatosis (HH) is an autosomal recessive disorder mainly associated with homozygosity for the C282Y and H63D mutations in the hemochromatosis (HFE) gene. The reports about the C282Y and H63D m...

    Authors: Fei Jin, Li-Shuai Qu and Xi-Zhong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:18
  37. To better search for potential markers for hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify potential metastasis biomarkers associated with HCC.

    Authors: Long Wu, Chun-Wei Peng, Jin-Xuan Hou, Yan-Hua Zhang, Chuang Chen, Liang-Dong Chen and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:17
  38. The chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis. This study investigated the expression of CXCR4, CCR7, CXCL12, CCL21, and EGFR to illustrate the role of these b...

    Authors: Yixin Liu, Ru Ji, Jingyong Li, Qiang Gu, Xiulan Zhao, Tao Sun, Jinjing Wang, Jiangbo Li, Qiuyue Du and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:16
  39. The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer.

    Authors: Bunzo Nakata, Ryosuke Amano, Shigetomi Nakao, Tatsuro Tamura, Osamu Shinto, Toshiki Hirakawa, Yoshihiro Okita, Nobuya Yamada and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:15
  40. Genome-wide RNA interference screening study revealed that loss of expression of insulin-like growth factor binding protein 7 (IGFBP7) is a critical step in development of a malignant melanoma (MM), and this s...

    Authors: Rong-Yi Chen, Hong-Xiang Chen, Jia-Xi Lin, Wei-Bing She, Ping Jiang, Li Xu and Ya-Ting Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:13
  41. Prospective, randomized, pilot clinical study was conducted to evaluate the beneficial effects of inositol hexaphosphate (IP6) + Inositol in breast cancer patients treated with adjuvant therapy.

    Authors: Ivan Bačić, Nikica Družijanić, Robert Karlo, Ivan Škifić and Stjepan Jagić
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:12
  42. The Sézary syndrome is an aggressive leukemic form of cutaneous T cell lymphoma and there is no cure of this disease. Until now there is no true animal model for Sézary syndrome, by which new drugs against the...

    Authors: Udo Doebbeling
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:11
  43. SIAH proteins are the human members of an highly conserved family of E3 ubiquitin ligases. Several data suggest that SIAH proteins may have a role in tumor suppression and apoptosis. Previously, we reported th...

    Authors: Heriberto Bruzzoni-Giovanelli, Plinio Fernandez, Lucía Veiga, Marie-Pierre Podgorniak, Darren J Powell, Marco M Candeias, Samia Mourah, Fabien Calvo and Mónica Marín
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:10
  44. Accelerated hypofractionation is an attractive approach for adjuvant whole breast radiotherapy. In this study we evaluated the adverse effects at least 3 years post an accelerated hypofractionated whole breast...

    Authors: Paola Pinnarò, Antonella Soriani, Valeria Landoni, Carolina Giordano, Maria Papale, Annelisa Marsella, Laura Marucci, Giorgio Arcangeli and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:9

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