Luo SD, Chen WC, Wu CN, Yang YH, Li SH, Fang FM, Huang TL, Wang YM, Chiu TJ, Wu SC: Low-dose aspirin use significantly improves the survival of late-stage NPC: a propensity score-matched cohort study in taiwan. Cancers (Basel). 2020;12(6):1551.
Mahdavifar N, Towhidi F, Makhsosi BR, Pakzad R, Moini A, Ahmadi A, Lotfi S, Salehiniya H. Incidence and mortality of nasopharynx cancer and its relationship with human development index in the world in 2012. World J Oncol. 2016;7:109–18.
Article
PubMed
PubMed Central
Google Scholar
Lo EJ, Bell D, Woo J, Li G, Hanna EY, El-Naggar AK, Sturgis EM. Human papillomavirus & WHO type I nasopharyngeal carcinoma. Laryngoscope. 2010;120(Suppl 4):S185.
Article
PubMed
Google Scholar
Niedobitek G. Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma. Mol Pathol. 2000;53:248–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsao SW, Tsang CM, Lo KW: Epstein-Barr virus infection and nasopharyngeal carcinoma. Philos Trans R Soc Lond B Biol Sci. 2017;372(1732):20160270.
Wolf H, zur Hausen H, Becker V. EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nat New Biol. 1973;244:245–7.
Article
CAS
PubMed
Google Scholar
Lee HS, Chang MS, Yang HK, Lee BL, Kim WH. Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. Clin Cancer Res. 2004;10:1698–705.
Article
CAS
PubMed
Google Scholar
Okekpa SI, Rabiatul Basria S M N Mydin, Mangantig E, Azmi NSA, Zahari SNS, Kaur G, Musa Y. Nasopharyngeal Carcinoma (NPC) risk factors: a systematic review and meta-analysis of the association with lifestyle, diets, socioeconomic and sociodemographic in Asian region. Asian Pac J Cancer Prev. 2019;20:3505–14.
Yu G, Hsu WL, Coghill AE, Yu KJ, Wang CP, Lou PJ, Liu Z, Jones K, Vogt A, Wang M, et al. Whole-exome sequencing of nasopharyngeal carcinoma families reveals novel variants potentially involved in nasopharyngeal carcinoma. Sci Rep. 2019;9:9916.
Article
PubMed
PubMed Central
CAS
Google Scholar
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371:569–78.
Article
PubMed
Google Scholar
Hoyo C, Cook MB, Kamangar F, Freedman ND, Whiteman DC, Bernstein L, Brown LM, Risch HA, Ye W, Sharp L, et al. Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int J Epidemiol. 2012;41:1706–18.
Article
PubMed
PubMed Central
Google Scholar
Genkinger JM, Spiegelman D, Anderson KE, Bernstein L, van den Brandt PA, Calle EE, English DR, Folsom AR, Freudenheim JL, Fuchs CS, et al. A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. Int J Cancer. 2011;129:1708–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ma Y, Yang Y, Wang F, Zhang P, Shi C, Zou Y, Qin H. Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One. 2013;8: e53916.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu YT, Fan YY, Xu CH, Lin XL, Lu YK, Zhang XL, Zhang CX, Chen YM. Habitual consumption of soy products and risk of nasopharyngeal carcinoma in Chinese adults: a case-control study. PLoS One. 2013;8: e77822.
Article
CAS
PubMed
PubMed Central
Google Scholar
Feng R, Chang ET, Liu Z, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, et al. Body mass index, body shape, and risk of nasopharyngeal carcinoma: a population-based case-control study in Southern China. Cancer Med. 2019;8:1835–44.
Article
PubMed
PubMed Central
Google Scholar
Liu YT, Dai JJ, Xu CH, Lu YK, Fan YY, Zhang XL, Zhang CX, Chen YM. Greater intake of fruit and vegetables is associated with lower risk of nasopharyngeal carcinoma in Chinese adults: a case-control study. Cancer Causes Control. 2012;23:589–99.
Article
PubMed
Google Scholar
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292–5.
Article
CAS
PubMed
Google Scholar
Wauman J, Zabeau L, Tavernier J. The leptin receptor complex: heavier than expected? Front Endocrinol (Lausanne). 2017;8:30.
Article
Google Scholar
Ando S, Barone I, Giordano C, Bonofiglio D, Catalano S. The multifaceted mechanism of leptin signaling within tumor microenvironment in driving breast cancer growth and progression. Front Oncol. 2014;4:340.
PubMed
PubMed Central
Google Scholar
da Rocha RG, Santos EMS, Santos EM, Gomes ESB, Ramos GV, Aguiar KM, Goncalves BR, Santos SHS, De Paula AMB, Guimaraes ALS, Farias LC. Leptin impairs the therapeutic effect of ionizing radiation in oral squamous cell carcinoma cells. J Oral Pathol Med. 2019;48:17–23.
Article
PubMed
CAS
Google Scholar
Harbuzariu A, Rampoldi A, Daley-Brown DS, Candelaria P, Harmon TL, Lipsey CC, Beech DJ, Quarshie A, Ilies GO, Gonzalez-Perez RR. Leptin-Notch signaling axis is involved in pancreatic cancer progression. Oncotarget. 2017;8:7740–52.
Article
PubMed
Google Scholar
Sengupta S, den Boon JA, Chen IH, Newton MA, Dahl DB, Chen M, Cheng YJ, Westra WH, Chen CJ, Hildesheim A, et al. Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma. Cancer Res. 2006;66:7999–8006.
Article
CAS
PubMed
Google Scholar
Peng Y, Croce CM. The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 2016;1:15004.
Article
PubMed
PubMed Central
Google Scholar
Si W, Shen J, Zheng H, Fan W. The role and mechanisms of action of microRNAs in cancer drug resistance. Clin Epigenetics. 2019;11:25.
Article
PubMed
PubMed Central
Google Scholar
Tan G, Tang X, Tang F. The role of microRNAs in nasopharyngeal carcinoma. Tumour Biol. 2015;36:69–79.
Article
PubMed
CAS
Google Scholar
Liu X, Lv XB, Wang XP, Sang Y, Xu S, Hu K, Wu M, Liang Y, Liu P, Tang J, et al. MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. Cell Cycle. 2012;11:2495–506.
Article
CAS
PubMed
Google Scholar
Zhu HM, Jiang XS, Li HZ, Qian LX, Du MY, Lu ZW, Wu J, Tian XK, Fei Q, He X, Yin L. miR-184 inhibits tumor invasion, migration and metastasis in nasopharyngeal carcinoma by targeting notch2. Cell Physiol Biochem. 2018;49:1564–76.
Article
CAS
PubMed
Google Scholar
Li M, Huang H, Cheng F, Hu X, Liu J. miR-141-3p promotes proliferation and metastasis of nasopharyngeal carcinoma by targeting NME1. Adv Med Sci. 2020;65:252–8.
Article
PubMed
Google Scholar
Xia B, Lin M, Dong W, Chen H, Li B, Zhang X, Hou Y, Lou G. Upregulation of miR-874-3p and miR-874-5p inhibits epithelial ovarian cancer malignancy via SIK2. J Biochem Mol Toxicol. 2018;32: e22168.
Article
PubMed
CAS
Google Scholar
Yuan RB, Zhang SH, He Y, Zhang XY, Zhang YB. MiR-874-3p is an independent prognostic factor and functions as an anti-oncomir in esophageal squamous cell carcinoma via targeting STAT3. Eur Rev Med Pharmacol Sci. 2018;22:7265–73.
PubMed
Google Scholar
Jiang T, Guan LY, Ye YS, Liu HY, Li R. MiR-874 inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma by targeting SOX12. Am J Cancer Res. 2017;7:1310–21.
CAS
PubMed
PubMed Central
Google Scholar
Sellam LS, Zappasodi R, Chettibi F, Djennaoui D, Yahi-AitMesbah N, Amir-Tidadini ZC, Touil-Boukoffa C, Ouahioune W, Merghoub T, Bourouba M. Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism. Arch Biochem Biophys. 2020;690: 108479.
Article
CAS
PubMed
Google Scholar
Shan G, Tang T. Expression of cyclin D1 and cyclin E in urothelial bladder carcinoma detected in tissue chips using a quantum dot immunofluorescence technique. Oncol Lett. 2015;10:1271–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Qu C, Yan C, Cao W, Li F, Qu Y, Guan K, Si C, Yu Z, Qu Z. miR-128-3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1. IUBMB Life. 2020;72:465–75.
Article
CAS
PubMed
Google Scholar
Zeng FF, Xu CH, Liu YT, Fan YY, Lin XL, Lu YK, Zhang CX, Chen YM. Choline and betaine intakes are associated with reduced risk of nasopharyngeal carcinoma in adults: a case-control study. Br J Cancer. 2014;110:808–16.
Article
CAS
PubMed
Google Scholar
Wang C, Lin XL, Fan YY, Liu YT, Zhang XL, Lu YK, Xu CH, Chen YM. Diet quality scores and risk of nasopharyngeal carcinoma in chinese adults: a case-control study. Nutrients. 2016;8:112.
Article
PubMed
PubMed Central
CAS
Google Scholar
Irungu CW, Oburra HO, Ochola B. Prevalence and predictors of malnutrition in nasopharyngeal carcinoma. Clin Med Insights Ear Nose Throat. 2015;8:19–22.
Article
PubMed
PubMed Central
Google Scholar
Reichlin S. Is leptin a secretion of the brain? J Clin Endocrinol Metab. 1999;84:2267–9.
Article
CAS
PubMed
Google Scholar
Solberg R, Aas V, Thoresen GH, Kase ET, Drevon CA, Rustan AC, Reseland JE. Leptin expression in human primary skeletal muscle cells is reduced during differentiation. J Cell Biochem. 2005;96:89–96.
Article
CAS
PubMed
Google Scholar
Bain GH, Collie-Duguid E, Murray GI, Gilbert FJ, Denison A, McKiddie F, Ahearn T, Fleming I, Leeds J, Phull P, et al. Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas. Br J Cancer. 2016;114: e18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fan YL, Li XQ. Expression of leptin and its receptor in thyroid carcinoma: distinctive prognostic significance in different subtypes. Clin Endocrinol (Oxf). 2015;83:261–7.
Article
CAS
Google Scholar
Geng Y, Wang J, Wang R, Wang K, Xu Y, Song G, Wu C, Yin Y. Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients. Biomed Pharmacother. 2012;66:419–24.
Article
CAS
PubMed
Google Scholar
Duan X, Tang P, Zhang H, Yu Z. Expression of leptin and adiponectin in esophageal squamous cell carcinoma and their clinical significance. Zhonghua Zhong Liu Za Zhi. 2014;36:839–43.
CAS
PubMed
Google Scholar
Gallina S, Sireci F, Lorusso F, Di Benedetto DV, Speciale R, Marchese D, Costantino C, Napoli G, Tessitore V, Cucco D, et al. The immunohistochemical peptidergic expression of leptin is associated with recurrence of malignancy in laryngeal squamous cell carcinoma. Acta Otorhinolaryngol Ital. 2015;35:15–22.
CAS
PubMed
PubMed Central
Google Scholar
Cascio S, Bartella V, Auriemma A, Johannes GJ, Russo A, Giordano A, Surmacz E. Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha. Oncogene. 2008;27:540–7.
Article
CAS
PubMed
Google Scholar
Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J, Russo A, Sulkowski S, Surmacz E. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res. 2006;12:1447–53.
Article
CAS
PubMed
Google Scholar
Xie W, Liu L, He H, Yang K: Prognostic value of hypoxia-inducible factor-1 alpha in nasopharyngeal carcinoma: a meta-analysis. Int J Biol Markers 2018:1724600818778756.
Hosney M, Sabet S, El-Shinawi M, Gaafar KM, Mohamed MM. Leptin is overexpressed in the tumor microenvironment of obese patients with estrogen receptor positive breast cancer. Exp Ther Med. 2017;13:2235–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu YJ, Shao YF, Zhao X, Geng YT, Wang K, Yin YM. Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis. J Cancer Res Clin Oncol. 2011;137:1841–8.
Article
CAS
PubMed
Google Scholar
Khabaz MN, Abdelrahman A, Butt N, Damnhory L, Elshal M, Aldahlawi AM, Ashoor S, Al-Maghrabi B, Dobson P, Brown B, et al. Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer. BMC Womens Health. 2017;17:105.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chen L, Lin G, Chen K, Liang R, Wan F, Zhang C, Tian G, Zhu X. VEGF promotes migration and invasion by regulating EMT and MMPs in nasopharyngeal carcinoma. J Cancer. 2020;11:7291–301.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29:212–26.
Article
CAS
PubMed
Google Scholar
Xu M, Cao FL, Li N, Gao X, Su X, Jiang X. Leptin induces epithelial-to-mesenchymal transition via activation of the ERK signaling pathway in lung cancer cells. Oncol Lett. 2018;16:4782–8.
PubMed
PubMed Central
Google Scholar
Yan D, Avtanski D, Saxena NK, Sharma D. Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem. 2012;287:8598–612.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liberti MV, Locasale JW. The warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41:211–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dong Y, Tu R, Liu H, Qing G. Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat. Signal Transduct Target Ther. 2020;5:124.
Kim JW, Zeller KI, Wang Y, Jegga AG, Aronow BJ, O’Donnell KA, Dang CV. Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol. 2004;24:5923–36.
Chen X, Liang R, Zhu X. Anti-EGFR therapies in nasopharyngeal carcinoma. Biomed Pharmacother. 2020;131: 110649.
Article
CAS
PubMed
Google Scholar
Chu C, Niu X, Ou X, Hu C. LAPTM4B knockdown increases the radiosensitivity of EGFR-overexpressing radioresistant nasopharyngeal cancer cells by inhibiting autophagy. Onco Targets Ther. 2019;12:5661–77.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zheng LS, Yang JP, Cao Y, Peng LX, Sun R, Xie P, Wang MY, Meng DF, Luo DH, Zou X, et al. SPINK6 promotes metastasis of nasopharyngeal carcinoma via binding and activation of epithelial growth factor receptor. Cancer Res. 2017;77:579–89.
Article
CAS
PubMed
Google Scholar
Wang A, Bao Y, Wu Z, Zhao T, Wang D, Shi J, Liu B, Sun S, Yang F, Wang L, Qu L. Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer. Cell Death Dis. 2019;10:154.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lin XM, Hu L, Gu J, Wang RY, Li L, Tang J, Zhang BH, Yan XZ, Zhu YJ, Hu CL, et al. Choline kinase alpha mediates interactions between the epidermal growth factor receptor and mechanistic target of rapamycin complex 2 in hepatocellular carcinoma cells to promote drug resistance and xenograft tumor progression. Gastroenterology. 2017;152:1187–202.
Article
CAS
PubMed
Google Scholar
Barbato C, Frisone P, Braccini L, D'Aguanno S, Pieroni L, Ciotti MT, Catalanotto C, Cogoni C, Ruberti F: Silencing of Ago-2 interacting protein SERBP1 relieves KCC2 repression by miR-92 in neurons. Cells 2022, 11.
Niaz S. The AGO proteins: an overview. Biol Chem. 2018;399:525–47.
Article
CAS
PubMed
Google Scholar
Treiber T, Treiber N, Meister G. Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat Rev Mol Cell Biol. 2019;20:5–20.
Article
CAS
PubMed
Google Scholar
Pfaff J, Meister G. Argonaute and GW182 proteins: an effective alliance in gene silencing. Biochem Soc Trans. 2013;41:855–60.
Article
CAS
PubMed
Google Scholar
Li X, Wang X, Cheng Z, Zhu Q. AGO2 and its partners: a silencing complex, a chromatin modulator, and new features. Crit Rev Biochem Mol Biol. 2020;55:33–53.
Article
CAS
PubMed
Google Scholar
Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell. 2004;15:185–97.
Article
CAS
PubMed
Google Scholar
Hu B, Zhong L, Weng Y, Peng L, Huang Y, Zhao Y, Liang XJ. Therapeutic siRNA: state of the art. Signal Transduct Target Ther. 2020;5:101.
Article
CAS
PubMed
PubMed Central
Google Scholar