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  1. In 2009, treatment guidelines were updated to recommend KRAS testing at diagnosis for patients with metastatic colorectal cancer (mCRC). We investigated KRAS testing rates over time and compared characteristics o...

    Authors: Gebra Cuyun Carter, Pamela B Landsman-Blumberg, Barbara H Johnson, Paul Juneau, Steven J Nicol, Li Li and Veena Shankaran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:29
  2. Increasing evidence showed that miRNAs serve as modulators of human cancer, either as oncogene or tumor suppressors. Cisplatin resistance is the most common cause of chemotherapy failure in gastric cancer (GC)...

    Authors: Xiaoying Zhou, Wujuan Jin, Hongyan Jia, Jin Yan and Guoxin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:28
  3. miRNA-184 is an oncogene in human hepatocellular carcinoma but acts as a tumor suppressor in tongue squamous cell carcinoma. Studies have shown that miR-184 was down-regulated in glioma and TNFα-induced protei...

    Authors: Zhe Cheng, Hang Zhou Wang, Xuetao Li, Zhiwu Wu, Yong Han, Yanyan Li, Guilin Chen, Xueshun Xie, Yulun Huang, Ziwei Du and Youxin Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:27
  4. The role of chemotherapy in the treatment of metastatic male breast cancer patients remains unknown, and the only available evidence stem from small, retrospective series evaluating outdated drugs and/or regim...

    Authors: Luigi Di Lauro, Laura Pizzuti, Maddalena Barba, Domenico Sergi, Isabella Sperduti, Marcella Mottolese, Pietro Del Medico, Franca Belli, Patrizia Vici, Ruggero De Maria and Marcello Maugeri-Saccà
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:26
  5. SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteogly...

    Authors: Carolina M Vicente, Marcelo A Lima, Helena B Nader and Leny Toma
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:25
  6. Traditional subjective method for the analysis of time-intensity curves (TICs) from breast dynamic contrast enhanced MRI (DCE-MRI) presented a low specificity. Hence, a semi-automatic quantitative method was p...

    Authors: Jiandong Yin, Jiawen Yang, Lu Han, Qiyong Guo and Wei Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:24
  7. Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that pred...

    Authors: Kai-Ming Gao, Xin-cheng Chen, Jun-xia Zhang, Yingyi Wang, Wei Yan and Yong-Ping You
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:23
  8. Osteosarcoma is the most common malignancy of bone. HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic...

    Authors: Tu Hu, Nengbin He, Yunsong Yang, Chengqian Yin, Nianli Sang and Qingcheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:22
  9. Huachansu (HCS), a class of toxic steroids extracted from toad venom, which has been shown to be a valuable anticancer drug in many kinds of cancers. However, the effect of HCS on bladder cancer has not been e...

    Authors: Tao Yang, Runlin Shi, Lei Chang, Kun Tang, Ke Chen, Gan Yu, Yuanfeng Tian, Yonglian Guo, Wei He, Xiaodong Song, Hua Xu and Zhangqun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:21
  10. Aberrant insulin-like growth factor-binding protein 7 (IGFBP-7) expression has been found in various cancers such as prostate, breast, and colon. IGFBP-7 induced the apoptosis of tumor and potentially predicte...

    Authors: Li-Hsuen Chen, Dai-Wei Liu, Junn-Liang Chang, Peir-Rong Chen, Lee-Ping Hsu, Hon-Yi Lin, Yu-Fu Chou, Chia-Fong Lee, Miao-Chun Yang, Yu-Hsuan Wen, Wen-Lin Hsu and Ching-Feng Weng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:20
  11. Colorectal cancers are significant causes of morbidity and mortality and existing therapies often perform poorly for individuals afflicted with advanced disease. Oncolytic virotherapy is an emerging therapeuti...

    Authors: Steven J Conrad, Mohamed El-Aswad, Esaw Kurban, David Jeng, Brian C Tripp, Charles Nutting, Robert Eversole, Charles Mackenzie and Karim Essani
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:19
  12. Long noncoding RNAs (lncRNAs) have been identified as having functional roles in cancer biology and are deregulated in many cancers. The present study aimed to determine the expression, roles and functional me...

    Authors: Liang Deng, Shi-Bin Yang, Feng-Feng Xu and Ji-Hong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:18
  13. Extranodal NK/T-cell lymphoma (ENKL) is an aggressive hematological malignancy associated with Epstein–Barr virus (EBV) infection. It is often resistant to conventional chemotherapy and has a poor prognosis. I...

    Authors: Ting Wu, Songmei Wang, Jinfeng Wu, Zhiguang Lin, Xianxian Sui, Xiaoping Xu, Norio Shimizu, Bobin Chen and Xuanyi Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:17
  14. To detect genetic expression profile alterations after papillary thyroid carcinoma (PTC) cells transfected with chemokine receptor CXCR7 gene by gene microarray, and gain insights into molecular mechanisms of ...

    Authors: Hengwei Zhang, Xuyong Teng, Zhangyi Liu, Lei Zhang and Zhen Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:16
  15. Prostate cancer (PCa) is the most common male cancer in Europe and the US. The early diagnosis relies on prostate specific antigen (PSA) serum test, even if it showed clear limits. Among the new tests currentl...

    Authors: Roberta Merola, Luigi Tomao, Anna Antenucci, Isabella Sperduti, Steno Sentinelli, Serena Masi, Chiara Mandoj, Giulia Orlandi, Rocco Papalia, Salvatore Guaglianone, Manuela Costantini, Giuseppe Cusumano, Giovanni Cigliana, Paolo Ascenzi, Michele Gallucci and Laura Conti
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:15
  16. Glioblastoma (GBM) is the most common and malignant primary brain tumor. In contrast to some other tumor types, aberrant glucose metabolism is an important component of GBM growth and chemoresistance. Recent s...

    Authors: Han Shen, Stephanie Decollogne, Pierre J Dilda, Eric Hau, Sylvia A Chung, Peter P Luk, Philip J Hogg and Kerrie L McDonald
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:14
  17. Kinesins play a key role in the development and progression of many human cancers. The present study investigated the expression and clinical significance of kinesin family member 26B (KIF26B) in colorectal ca...

    Authors: Jingtao Wang, Feifei Cui, Xiao Wang, Yingming Xue, Jian Chen, Yang Yu, Huijun Lu, Meng Zhang, Huamei Tang and Zhihai Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:13
  18. Follicle-stimulating hormone receptor (FSHR) is expressed on the endothelial surface of blood vessels associated with solid tumor periphery, where angiogenesis is known to occur. The correlation between FSHR e...

    Authors: François Planeix, Mohammad-Ahsan Siraj, François-Clément Bidard, Blaise Robin, Christophe Pichon, Xavier Sastre-Garau, Martine Antoine and Nicolae Ghinea
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:12
  19. Agonistic CD40 antibodies have been demonstrated to activate antigen-presenting cells (APCs) and enhance antitumour T cell responses, thereby providing a new therapeutic option in cancer immunotherapy. In agon...

    Authors: Yong Zhang, Xiaoyan Hu, Yue Hu, Kai Teng, Kai Zhang, Yamei Zheng, Xiaohua Hong, Kunwu Yu, Yan Wang and Li Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:11
  20. Aim of this study was to investigate for the presence of existing prognostic factors in patients with bone metastases (BMs) from RCC since bone represents an unfavorable site of metastasis for renal cell carci...

    Authors: Matteo Santoni, Alessandro Conti, Giuseppe Procopio, Camillo Porta, Toni Ibrahim, Sandro Barni, Francesco Maria Guida, Andrea Fontana, Alfredo Berruti, Rossana Berardi, Francesco Massari, Bruno Vincenzi, Cinzia Ortega, Davide Ottaviani, Giacomo Carteni, Gaetano Lanzetta…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:10
  21. Authors: Angela Rizzo, Sara Iachettini, Pasquale Zizza, Chiara Cingolani, Manuela Porru, Simona Artuso, Malcolm Stevens, Marc Hummersone, Annamaria Biroccio, Erica Salvati and Carlo Leonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:9

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:81

  22. Evidence supports an important role for miR-203 in the regulation of the proliferation, migration and invasion of prostate cancer (PCa) cells. However, the exact mechanisms of miR-203 in PCa are not entirely c...

    Authors: Jun Xiang, Cuidong Bian, Hao Wang, Shengsong Huang and Denglong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:8
  23. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has been demonstrated to be an important player in various human malignancies; it is thought to promote tumor growth by cell cycle regulating. Ho...

    Authors: Liwen Hu, Yuanyuan Wu, Deli Tan, Hui Meng, Kai Wang, Yun Bai and Kang Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:7
  24. Transcription factor CP2 (TFCP2) is overexpressed in hepatocellular carcinoma(HCC) and correlated with the progression of the disease. Here we report the use of an integrated systems biology approach to identi...

    Authors: Xiao Xu, Zhikun Liu, Lin Zhou, Haiyang Xie, Jun Cheng, Qi Ling, Jianguo Wang, Haijun Guo, Xuyong Wei and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:6
  25. Aberrant methylation of genes is one of the most common epigenetic modifications involved in the development of urothelial carcinoma. However, it is unknown the predictive role of methylation to contralateral ...

    Authors: Lei Zhang, Gengyan Xiong, Dong Fang, Xuesong Li, Jin Liu, Weimin Ci, Wei Zhao, Nirmish Singla, Zhisong He and Liqun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:5
  26. Pediatric acute myeloid leukemia (AML) comprises up to 20% of all childhood leukemia. Recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. The epigenetic silencing ...

    Authors: Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Shao-Yan Hu, Fang Fang, Lan Cao, Pei-Fang Xiao, Xiao-Juan Du, Li-Chao Sun, Zhi-Heng Li, Na-Na Wang, Guang-Hao Su, Yan-Hong Li, Gang Li, He Zhao, Yi-Ping Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:4
  27. Epithelial-to mesenchymal transition (EMT) involves in metastasis, causing loss of epithelial polarity. Metastasis is the major cause of carcinoma-induced death, but mechanisms are poorly understood. Here we i...

    Authors: Xianliang Chen, Xiaoying Guan, Huiyu Zhang, Xiaobin Xie, Hongyan Wang, Jie Long, Tonghui Cai, Shuhua Li, Zhen Liu and Yajie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:3
  28. Ovarian malignancies are often diagnosed in advanced stage and at the same time resistance to treatment, both intrinsic and developed during treatment, is sometimes observed. These facts underscore the need fo...

    Authors: Karolina Tecza, Jolanta Pamula-Pilat, Zofia Kolosza, Natalia Radlak and Ewa Grzybowska
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:2
  29. Classical Kaposi’s Sarcoma (cKS) is a rare vascular tumor, which develops in subjects infected with Human Herpesvirus-8 (HHV-8). Beside the host predisposing factors, viral genetic variants might possibly be r...

    Authors: Paola Cordiali-Fei, Elisabetta Trento, Marta Giovanetti, Alessandra Lo Presti, Alessandra Latini, Massimo Giuliani, Giovanna D’Agosto, Valentina Bordignon, Eleonora Cella, Francesca Farchi, Carmela Ferraro, Ilaria Lesnoni La Parola, Carlo Cota, Isabella Sperduti, Antonella Vento, Antonio Cristaudo…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:1
  30. Metastasis have considered as an important clinical obstacle in the treatment of human cancer including bladder cancer. Post-transcriptional regulation has emerged as robust effectors of metastasis. MiRNAs are...

    Authors: Gan Yu, Weimin Yao, Wei Xiao, Heng Li, Hua Xu and Bin Lang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:779
  31. Identification of a gene expression signature in primary breast tumors that could classify patients by lymph node status would allow patients to avoid the morbidities of surgical disruption of the lymph nodes....

    Authors: Craig D Shriver, Matthew T Hueman and Rachel E Ellsworth
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:116
  32. Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrate...

    Authors: Xin Zhu, Jia-jie Xu, Si-si Hu, Jian-guo Feng, Lie-hao Jiang, Xiu-xiu Hou, Jun Cao, Jing Han, Zhi-qiang Ling and Ming-hua Ge
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:114

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:304

  33. MicroRNAs (miRNAs) have been reported to play crucial roles in regulating a variety of genes pivotal for tumor metastasis. MicroRNA-301a (miR-301a) is overexpressed and displays oncogenic activity in many canc...

    Authors: Wenpeng Zhang, Tao Zhang, Runsen Jin, Hongchao Zhao, Jin Hu, Bo Feng, Lu Zang, Minhua Zheng and Mingliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:113
  34. Carfilzomib (CFZ) is a proteasome inhibitor that selectively and irreversibly binds to its target and has been approved in the US for treatment of relapsed and refractory multiple myeloma. Phase 1B studies of ...

    Authors: Amanda F Baker, Neale T Hanke, Barbara J Sands, Liliana Carbajal, Janet L Anderl and Linda L Garland
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:111
  35. The Y-box binding protein 1 (YB-1) possesses pleiotropic functions through its interactions with various cellular proteins, and its high expression levels make it a potential useful prognostic biomarker for ca...

    Authors: Ying Wu, Ke-yong Wang, Zhi Li, Yun-peng Liu, Hiroto Izumi, Hidetaka Uramoto, Yoshifumi Nakayama, Ken-ichi Ito and Kimitoshi Kohno
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:112
  36. The choice of drugs for treatment of advanced gastric cancer (GC) is empirical. The purpose of the current study was to benchmark ex vivo the sensitivity of GC tumor cells from patients to standard cytotoxic a...

    Authors: Bo Hultman, Haile Mahteme, Magnus Sundbom, Martin Ljungman, Rolf Larsson and Peter Nygren
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:110
  37. The echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene rearrangements occur in approximately 5% of lung adenocarcimomas (ACA), leading to ALK overexpress...

    Authors: Jiandong Wang, Qin Shen, Qunli Shi, Bo Yu, Xuan Wang, Kai Cheng, Guangming Lu and Xiaojun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:109
  38. Histone acetyltransferase (HAT) inhibitors can inhibit proliferation and induce apoptosis in cancer cell lines. The novel cell-permeable p300/CREB-binding protein (CBP)-selective HAT inhibitor HATi II can redu...

    Authors: Li-Xiao Xu, Zhi-Heng Li, Yan-Fang Tao, Rong-Hu Li, Fang Fang, He Zhao, Gang Li, Yan-Hong Li, Jian Wang, Xing Feng and Jian Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:108
  39. In our previous study, parathyroid hormone-like hormone (PTHLH) which encodes parathyroid hormone-related protein (PTHrP) was revealed to be up-regulated in oral squamous cell carcinoma (OSCC) compared with pa...

    Authors: Zhongjing Lv, Xiangbing Wu, Wei Cao, ZongZe Shen, Lizhen Wang, FuRong Xie, JianJun Zhang, Tong Ji, Ming Yan and WanTao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:100
  40. Brachyury overexpression has been reported in various human malignant neoplasms, but its expression and function in hepatocellular carcinoma progression and metastasis remains unknown. The present study aimed ...

    Authors: Rui Du, Shanshan Wu, Xiaoning Lv, Henghu Fang, Sudong Wu and Jingbo Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:105
  41. Pancreatic ductal adenocarcinoma has proven to be one of the most chemo-resistant among all solid organ malignancies. Several mechanisms of resistance have been described, though few reports of strategies to o...

    Authors: Rouzbeh Daylami, Diego J Muilenburg, Subbulakshmi Virudachalam and Richard J Bold
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:102
  42. Epithelial–mesenchymal transition (EMT) contributes to the progression and metastasis of cancer cells and is associated with a more invasive phenotype of cancer. The Wnt/β-catenin signaling pathway is one of t...

    Authors: Lisha Qi, Baocun Sun, Zhiyong Liu, Runfen Cheng, Yixian Li and Xiulan Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:107
  43. The optimal laboratory assay for detecting KRAS mutations in different biospecimens from patients with metastatic colorectal cancer (mCRC), and the clinical relevance of these gene alterations is still in questio...

    Authors: Jian-Ming Xu, Xiao-Jing Liu, Fei-Jiao Ge, Li Lin, Yan Wang, Manish R Sharma, Ze-Yuan Liu, Stefania Tommasi and Angelo Paradiso
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:104
  44. Intrahepatic cholangiocarcinoma (IHCC) is the second most frequent primary malignant liver tumor following hepatocellular carcinoma. It is a highly fatal disease and has few therapeutics. The CXC chemokine lig...

    Authors: Shengqiang Zhao, Jing Wang and Chengyong Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:103
  45. Increasing evidences have documented that microRNAs (miRNAs) act as oncogenes or tumor suppressors in gastric cancer (GC). In this study, we aimed to investigate the expression of miR-133b in a large number of...

    Authors: Lihua Guo, Hua Bai, Dongling Zou, Tao Hong, Jie Liu, Jiaqiang Huang, Pengfei He, Qi Zhou and Jinsheng He
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:99

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:220

  46. The ubiquitous second messenger Ca2+ has been demonstrated to play an important role in cancer progression. Store-operated Ca2+ entry (SOCE) is the main Ca2+ entry pathway regulating intracellular Ca2+ concentrat...

    Authors: Meng Zhu, Lei Chen, Pengfei Zhao, Hua Zhou, Chen Zhang, Shengping Yu, Yu Lin and Xuejun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:98
  47. Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosi...

    Authors: Francesco Maria Solivetti, Flora Desiderio, Antonino Guerrisi, Antonio Bonadies, Carlo Ludovico Maini, Simona Di Filippo, Valerio D’Orazi, Isabella Sperduti and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:96
  48. There has been a “rising tide” in mastectomy utilization that can be attributed to more skin-sparing mastectomies (SSMs) performed concurrently with immediate breast reconstruction. We report our experience of...

    Authors: Roy De Vita, Ernesto Maria Buccheri, Marcello Pozzi and Giovanni Zoccali
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:78

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