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  1. Activation of wild-type p53 in response to genotoxic stress occurs through different mechanisms including protein conformation, posttranslational modifications, and nuclear localization, leading to DNA binding...

    Authors: Alessia Garufi, Valentina Ubertini, Francesca Mancini, Valerio D’Orazi, Silvia Baldari, Fabiola Moretti, Gianluca Bossi and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:87
  2. MicroRNAs are stable and easy to detect in plasma. The plasma levels of microRNAs are often changed in disease conditions, including cancer. This makes circulating microRNAs a novel class of biomarkers for can...

    Authors: Zanxi Fang, Jing Tang, Yongying Bai, Huayue Lin, Hanyu You, Hongwei Jin, Lingqing Lin, Pan You, Juan Li, Zhang Dai, Xianming Liang, Yuanhui Su, Qing Hu, Fen Wang and Zhong-Ying Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:86
  3. Acidity is a hallmark of malignant tumor, representing a very efficient mechanism of chemoresistance. Proton pump inhibitors (PPI) at high dosage have been shown to sensitize chemoresistant human tumor cells a...

    Authors: Bi-Yun Wang, Jian Zhang, Jia-Lei Wang, Si Sun, Zhong-Hua Wang, Lei-Ping Wang, Qun-Ling Zhang, Fang-Fang Lv, En-Ying Cao, Zhi-Min Shao, Stefano Fais and Xi-Chun Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:85

    The Research to this article has been published in Journal of Experimental & Clinical Cancer Research 2015 34:109

  4. At skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active ...

    Authors: Luigi Laino, Fulvia Elia, Flora Desiderio, Alessandra Scarabello, Isabella Sperduti, Carlo Cota and Aldo DiCarlo
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:84
  5. T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10–15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysi...

    Authors: V. D’Angelo, A. Iannotta, M. Ramaglia, A. Lombardi, M. R. Zarone, V. Desiderio, M. C. Affinita, G. Pecoraro, M. Di Martino, P. Indolfi, F. Casale and M. Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:83
  6. Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therape...

    Authors: Augusto Pessina, Carlo Leonetti, Simona Artuso, Anna Benetti, Enrico Dessy, Luisa Pascucci, Daniela Passeri, Augusto Orlandi, Angiola Berenzi, Arianna Bonomi, Valentina Coccè, Valentina Ceserani, Anna Ferri, Marta Dossena, Pietro Mazzuca, Emilio Ciusani…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:82
  7. Endoretroviruses account for circa 8 % of all transposable elements found in the genome of humans and other animals. They represent a genetic footprint of ancestral germ-cell infections of exoviruses that is t...

    Authors: David Díaz-Carballo, Ali Haydar Acikelli, Jacqueline Klein, Holger Jastrow, Philipp Dammann, Thomas Wyganowski, Cihan Guemues, Sebastian Gustmann, Walter Bardenheuer, Sascha Malak, Nora Sophia Tefett, Veria Khosrawipour, Urs Giger-Pabst, Andrea Tannapfel and Dirk Strumberg
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:81
  8. Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug...

    Authors: Shuai Zhao, Jian Huang and Jun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:80
  9. Long noncoding RNAs (lncRNAs) have recently emerged as important regulators in governing fundamental biological processes, and many of which are likely to have functional roles in tumorigenesis. Maternally exp...

    Authors: Weizhao Peng, Shuang Si, Qingxia Zhang, Chaofeng Li, Fang Zhao, Fang Wang, Jia Yu and Ren Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:79
  10. Considering previous data and the need to incorporate new biomarkers for the prognosis of solid tumours into the clinic, our aim in this work consists of evaluating the potential clinical use of telomeres and ...

    Authors: Tamara Fernández-Marcelo, Ana Gómez, Irene Pascua, Carmen de Juan, Jacqueline Head, Florentino Hernando, Jose-Ramón Jarabo, Joaquín Calatayud, Antonio-José Torres-García and Pilar Iniesta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:78
  11. Metformin is the first line of oral antidiabetic drug in the biguanide class for treatment of type 2 diabetes. Increasing evidence has suggested that it is a potential anti-tumor drug. However, the mechanisms ...

    Authors: Qi Pan, Guo-Liang Yang, Jiang-Hua Yang, Shi-Long Lin, Ning Liu, Shan-Shan Liu, Meng-Yao Liu, Lian-Hua Zhang, Yi-Ran Huang, Ru-long Shen, Qiang Liu, Jian-Xin Gao and Juan-Jie Bo
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:77
  12. Aberrant microRNA (miRNA) expression plays an essential role in osteosarcoma (OS) pathogenesis. Recent studies have shown that dysregulation of miRNA expression is associated with increased tumorigenesis and p...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Shinichi Ikeda, Tatsuya Iwasaki and Hiroshi Tsumura
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:76
  13. Transmembrane protein 158 (TMEM158) is a recently identified upregulated gene during Ras-induced senescence. Its association with various cancers has been recently reported. However, the expression and biologi...

    Authors: Zhongping Cheng, Jing Guo, Li Chen, Ning Luo, Weihong Yang and Xiaoyan Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:75
  14. Liver tumors are increasingly treated with radioembolization. Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrat...

    Authors: Andor F. van den Hoven, Marnix G.E.H. Lam, Shaphan Jernigan, Maurice A.A.J. van den Bosch and Gregory D. Buckner
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:74
  15. Growing evidence suggests that microRNAs (miRNAs) play an important role in tumor development, progression and metastasis. Aberrant miR-106b expression has been reported in several cancers. However, the role a...

    Authors: Guang-jun Zhang, Jian-shui Li, He Zhou, Hua-xu Xiao, Yu Li and Tong Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:73
  16. Primitive sarcoma of the breast is a rare and challenging disease at high risk of recurrence and with poor prognosis. There are controversies in the diagnosis and management of such solid tumor due to its rari...

    Authors: Vittorio Pasta, Massimo Monti, Michela Cialini, Massimo Vergine, Paolo Urciuoli, Annunziata Iacovelli, Silvio Rea and Valerio D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:72
  17. Vitamin D3 and its analogues have recently been shown to enhance the anti-tumour effects of 5- Fluorouracil (5-FU) both in vitro and in xenograft mouse model of colon cancer. This study measured the potential ...

    Authors: Bassem Refaat, Adel Galal El-Shemi, Osama Adnan Kensara, Amr Mohamed Mohamed, Shakir Idris, Jawwad Ahmad and Athar Khojah
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:71
  18. The role of human papillomavirus (HPV) may be involved in the development of esophageal cancer (EC) and the polymorphic immune response gene transporter associated with antigen processing (TAP) may be involved...

    Authors: Ningjing Zou, Lan Yang, Ling Chen, Tingting Li, Tingting Jin, Hao Peng, Shumao Zhang, Dandan Wang, Ranran Li, Chunxia Liu, Jinfang Jiang, Lianghai Wang, Weihua Liang, Jianming Hu, Shugang Li, Chuanyue Wu…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:70
  19. The evasion of cell death is one of the hallmarks of cancer, contributing to both tumor progression and resistance to therapy. Dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine...

    Authors: Martina Broecker-Preuss, Jan Viehof, Holger Jastrow, Nina Becher-Boveleth, Dagmar Fuhrer and Klaus Mann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:69
  20. Acute myeloid leukemia (AML) is a heterogeneous neoplasm of the bone marrow with poor prognosis. In clinical practice new prognostic factors are still needed. MicroRNAs (miRs), small endogenous noncoding RNAs,...

    Authors: Aleksandra Butrym, Justyna Rybka, Dagmara Baczyńska, Andrzej Tukiendorf, Kazimierz Kuliczkowski and Grzegorz Mazur
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:68
  21. Hypoxia is a common feature of solid tumors, including HCC. And hypoxia has been reported to play an important role in HCC progression. However, the potential mechanism of miRNAs in hypoxia mediating HCC progr...

    Authors: Chengli Du, Xiaoyu Weng, Wendi Hu, Zhen Lv, Heng Xiao, Chaofeng Ding, Owusu-anash K. Gyabaah, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:67
  22. The Yin Yang 1 (YY1) transcription factor has been identified to target a plethora of potential target genes, which are important for cell proliferation and differentiation. Although the role that YY1 plays in...

    Authors: Guowei Zhao, Qiang Li, Aiqin Wang and Jian Jiao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:66
  23. Halofuginone (HF) is a low-molecular-weight alkaloid that has been demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β (TGF-β) function and, to present antiangiogenic, antiprol...

    Authors: Patricia A. Assis, Lorena L. De Figueiredo-Pontes, Ana Silvia G. Lima, Vitor Leão, Larissa A. Cândido, Carolina T. Pintão, Aglair B. Garcia, Fabiano P. Saggioro, Rodrigo A Panepucci, Fernando Chahud, Arnon Nagler, Roberto P. Falcão and Eduardo M. Rego
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:65
  24. The role of insulin in the pathogenesis of cancer has been increasingly emphasized because of the high incidence of obesity and metabolic syndrome and their correlated complication including cancer. This study...

    Authors: Zhao Wei, Li Liang, Liu Junsong, Chen Rui, Chang Shuai, Qiu Guanglin, He Shicai, Wang Zexing, Wang Jin, Che Xiangming and Wang Shufeng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:64
  25. The purpose of this study was to develop a cost-effective approach for the determination of EGFR and KRAS mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal ...

    Authors: Guohua Xie, Fang Xie, Ping Wu, Xiangliang Yuan, Yanhui Ma, Yunchuan Xu, Li Li, Ling Xu, Ming Yang and Lisong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:63
  26. There is growing evidence that emerging malignancies in solid tissues might be kept under control by physical intercellular contacts with normal fibroblasts.

    Authors: Andrey Alexeyenko, Twana Alkasalias, Tatiana Pavlova, Laszlo Szekely, Vladimir Kashuba, Helene Rundqvist, Peter Wiklund, Lars Egevad, Peter Csermely, Tamas Korcsmaros, Hayrettin Guven and George Klein
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:62
  27. Piwi-interacting RNAs (piRNAs) are small RNAs of 27–30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is...

    Authors: Jonas Busch, Bernhard Ralla, Monika Jung, Zofia Wotschofsky, Elena Trujillo-Arribas, Philipp Schwabe, Ergin Kilic, Annika Fendler and Klaus Jung
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:61
  28. Developmental pluripotency-associated 4 (Dppa4) gene plays an important role in self-renewal and pluripotency sustainability in embryonic stem cells. It is re-expressed in several malignant tumors and is ident...

    Authors: Meng Zhang, Feifei Cui, Su Lu, Huijun Lu, Yingming Xue, Jingtao Wang, Jian Chen, Senlin Zhao, Shaofei Ma, Yu Zhang, Yang Yu, Zhihai Peng and Huamei Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:60
  29. Our pilot study using miRNA PCR array found that miRNA-29b (miR-29b) is differentially expressed in primary cultured CD133-positive A549 cells compared with CD133-negative A549 cells.

    Authors: Hongyan Wang, Xiaoying Guan, Yongsheng Tu, Shaoqiu Zheng, Jie Long, Shuhua Li, Cuiling Qi, Xiaobin Xie, Huiqiu Zhang and Yajie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:59
  30. Three-dimensional (3D) culture models are considered to recapitulate the cell microenvironment in solid tumors, including the extracellular matrix (ECM), cell-cell interactions, and signal transduction. These ...

    Authors: Chujie Bai, Min Yang, Zhengfu Fan, Shu Li, Tian Gao and Zhiwei Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:58
  31. The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12–14 months. The search for novel and more efficient chemo-agents against thi...

    Authors: Li-sen Qin, Pi-feng Jia, Zhi-qing Zhang and Shi-ming Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:57
  32. Treatment of blast phase chronic myeloid leukemia (BP-CML) remains a challenge, and the median survival is less than 6 months. Because effective treatments are lacking, we studied tight targeting of blast cris...

    Authors: Bailing Zu, Yi Shi, Min Xu, Guoling You, Zhenglan Huang, Miao Gao and Wenli Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:56

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:57

  33. DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia (AML) with normal karyotype. Although various recurrent somatic mutations of DNMT3A hav...

    Authors: Rimma Berenstein, Igor Wolfgang Blau, Nikola Suckert, Claudia Baldus, Antonio Pezzutto, Bernd Dörken and Olga Blau
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:55
  34. T-type Ca2+ channels are often aberrantly expressed in different human cancers and participate in the regulation of cell cycle progression, proliferation and death. Methods: RT-PCR, Q-PCR, western blotting and wh...

    Authors: Weifeng Huang, Chunjing Lu, Yong Wu, Shou Ouyang and Yuanzhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:54
  35. There is increasing evidence to suggest that miRNAs play an important role in predicting cancer survival. To identify a panel of miRNA signature that can divided tumor from normal bladder using miRNA expressio...

    Authors: Hui Zhou, Kun Tang, Haibing Xiao, Jin Zeng, Wei Guan, Xiaolin Guo, Hua Xu and Zhangqun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:53
  36. Bone marrow mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with tumor growth and progression. However, the roles of tumor-resident MSCs in cancer have not been thoroughly clarif...

    Authors: Wei Li, Ying Zhou, Jin Yang, Xu Zhang, Huanhuan Zhang, Ting Zhang, Shaolin Zhao, Ping Zheng, Juan Huo and Huiyi Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:52
  37. Dying tumor cells after irradiation could promote the proliferation of living tumor cells might cause tumor relapse and treatment failure. Our previous study showed that activated caspase-3 after irradiation p...

    Authors: Zhengxiang Zhang, Min Wang, Ling Zhou, Xiao Feng, Jin Cheng, Yang Yu, Yanping Gong, Ying Zhu, Chuanyuan Li, Ling Tian and Qian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:51
  38. Mucin-1 (MUC1, CD227), more widely known as CA15-3, is an abundantly expressed epithelial cell surface antigen and has evolved to be the most predictive serum tumour marker in breast cancer. PankoMab-GEXâ„¢, whi...

    Authors: Sabine Heublein, Doris Mayr, Markus Egger, Uwe Karsten, Steffen Goletz, Martin Angele, Julia Gallwas, Udo Jeschke and Nina Ditsch
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:50
  39. Accumulating evidence suggests that dysregulated snoRNA may play a role in the development of malignancy. In the present study, we investigated the role of SNORD78 in the tumorigenesis of non-small cell lung c...

    Authors: Di Zheng, Jie Zhang, Jian Ni, Jie Luo, Jiying Wang, Liang Tang, Ling Zhang, Li Wang, Jianfang Xu, Bo Su and Gang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:49
  40. P21-activated kinase 4 (PAK4), an effector of the Rho family protein Cdc42, is an important oncogene whose expression is increased in many human cancers and is generally positively correlated with advanced dis...

    Authors: Songwang Cai, Zhiqiang Ye, Xiaohong Wang, Yuhang Pan, Yimin Weng, Sen Lao, Hongbo Wei and Lian Li
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:48
  41. Hepatocellular carcinoma (HCC) is a common malignancy worldwide, which is especially prevalent in Asia. Elucidating the molecular basis of HCC is crucial to develop targeted diagnostic tools and novel therapie...

    Authors: Fei He, Jie Li, JianFeng Xu, Sheng Zhang, YaPing Xu, WenXiu Zhao, ZhenYu Yin and XiaoMin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:47
  42. Prostate cancer is one of the most common malignancies in men. The mucin 1 (MUC1) heterodimeric oncoprotein is overexpressed in human prostate cancers with aggressive pathologic and clinical features, resultin...

    Authors: Jing Li, SongTao Xiang, QiouHong Zhang, JingJing Wu, Qing Tang, JianFu Zhou, LiJun Yang, ZhiQiang Chen and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:46
  43. One-third of estrogen (ER+) and/or progesterone receptor-positive (PGR+) breast tumors treated with Tamoxifen (TAM) do not respond to initial treatment, and the remaining 70% are at risk to relapse in the futu...

    Authors: Subha Madhavan, Yuriy Gusev, Salendra Singh and Rebecca B Riggins
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:45
  44. CD133 and Nestin, as the markers of cancer stem cells, have recently been reported frequently in the pathogenesis and development of human gliomas. However, the prognostic role of CD133 and Nestin in gliomas s...

    Authors: Bin Wu, Caixing Sun, Fang Feng, Minghua Ge and Liang Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:44
  45. Measurement of prostate-specific antigen (PSA) advanced the diagnostic and prognostic potential for prostate cancer (PCa). However, due to PSA’s lack of specificity, novel biomarkers are needed to improve risk...

    Authors: Igor Tsaur, Kristina Thurn, Eva Juengel, Kilian M. Gust, Hendrik Borgmann, Rene Mager, Georg Bartsch, Elsie Oppermann, Hanns Ackermann, Karen Nelson, Axel Haferkamp and Roman A. Blaheta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:43
  46. For the successful therapeutic use of inhibitors of the vascular endothelial growth factor receptor (VEGFR) pathway detailed knowledge of the mechanisms leading to tumor progression is indispensable. The main ...

    Authors: Caren Jayasinghe, Nektaria Simiantonaki, Sylvia Habedank and Charles James Kirkpatrick
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:42
  47. Baicalein, a natural flavonoid obtained from the Scutellaria baicalensis root, has been reported to inhibit growth of human lung cancer. However, the detailed mechanism underlying this has not been well elucid...

    Authors: Fang Zheng, Jingjing Wu, Shunyu Zhao, Qingmei Luo, Qing Tang, LiJun Yang, Liuning Li, WanYing Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:41
  48. The Forkhead box M1 (FOXM1) is an oncogenic transcription factor and plays a significant role in cell EMT, proliferation, metastasis in a multitude of human solid tumors including colorectal cancer (CRC). Howe...

    Authors: KanKan Yang, LinHua Jiang, You Hu, Jing Yu, HenFeng Chen, YiZhou Yao and XinGuo Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:40

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:130

  49. Innervation interacts with enteric immune responses. Chronic intestinal inflammation is associated with increased risk of colorectal cancer. We aimed to study potential extrinsic neuronal modulation of intesti...

    Authors: Verena Liu, Alexandra Dietrich, Michael S Kasparek, Petra Benhaqi, Marlon R Schneider, Michael Schemann, Hendrik Seeliger and Martin E Kreis
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:39
  50. Ovarian cancer remains still the leading cause of death of gynecological malignancy, in spite of first-line chemotherapy with cisplatin and paclitaxel. Although initial response is favorably, relapses are comm...

    Authors: Caroline van Haaften, Arnoud Boot, Willem E Corver, Jaap DH van Eendenburg, Baptist JMZ Trimbos and Tom van Wezel
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:38

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  • Citation Impact 2023
    Journal Impact Factor: 11.4
    5-year Journal Impact Factor: 11.4
    Source Normalized Impact per Paper (SNIP): 1.770
    SCImago Journal Rank (SJR): 2.806

    Speed 2023
    Submission to first editorial decision (median days): 5
    Submission to acceptance (median days): 100

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