Articles

The cytosol activity of thymidine phosphorylase in endometrial cancer

Thymidine phosphorylase (TP) is identical with platelet-derived endothelial cell growth factor (PD-ECGF) which promotes angiogenesis. The aim of this study was to evaluate the cytosol activity of TP in tumor s...

Authors: Elżbieta Miszczak-Zaborska, Robert Kubiak, Andrzej Bieńkiewicz and Jacek Bartkowiak

Antitumor efficacy of combination of interferon-gamma-inducible protein 10 gene with gemcitabine, a study in murine model

Interferon-γ-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects.

Authors: Kai Mei, Lian Wang, Ling Tian, Jingrui Yu, Zhixuan Zhang and Yuquan Wei

Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer

To identify the roles of CXCL12 and CXCR4 and the associated mechanism involved in perineural invasion of prostate cancer.

Authors: Shiwu Zhang, Lisha Qi, Man Li, Danfang Zhang, Shaoyan Xu, Ning Wang and Baocun Sun

Endostatin and anastellin inhibit distinct aspects of the angiogenic process

Endostatin and anastellin, fragments of collagen type XVIII and fibronectin, respectively, belong to a family of endogenous inhibitors of angiogenesis which inhibit tumor growth and metastasis in a number of m...

Authors: David M Neskey, Anthony Ambesi, Kevin M Pumiglia and Paula J McKeown-Longo

Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma

To observe the effects of thalidomide on melanoma tumor growth and blood supply patterns in C57 mice.

Authors: Shiwu Zhang, Man Li, Yanjun Gu, Zhiyong Liu, Shaoyan Xu, Yanfeng Cui and Baocun Sun

Prolonged response to first-line erlotinib for advanced lung adenocarcinoma

A 58-year-old, non-smoking female of Philippine origin presented with painful thoracic and neck nodal relapse of lung adenocarcinoma almost 5 years after left pneumonectomy for stage II non-small-cell lung can...

Authors: Michael Copeman

Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance: Sticker sarcoma

Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic ...

Authors: Enrico P Spugnini, Ivan Dotsinsky, Nikolay Mudrov, Gennaro Citro, Alfredo D'Avino and Alfonso Baldi

Use of an orthovoltage X-ray treatment unit as a radiation research system in a small-animal cancer model

We explore the use of a clinical orthovoltage X-ray treatment unit as a small-animal radiation therapy system in a tumoral model of cervical cancer.

Authors: Luis-Alberto Medina, Blanca-Ivone Herrera-Penilla, Mario-Alberto Castro-Morales, Patricia García-López, Rafael Jurado, Enrique Pérez-Cárdenas, José Chanona-Vilchis and María-Ester Brandan

Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice

Treatment failure after radiotherapy of head and neck squamous cell carcinoma (HNSCC) could be a significant problem. Our objective is to sensitize SCCVII cells to ionizing radiation in vitro and in vivo through ...

Authors: Jian Zou, Xiaoming Qiao, Huiping Ye, Yuqiong Yang, Xuelian Zheng, Houyu Zhao and Shixi Liu

Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160

The RON receptor tyrosine kinase regulates epithelial cell homeostasis and tumorigenesis by transducing multiple signals through its functional domains. The present study was to determine the significance of t...

Authors: Yi Lu, Hang-Ping Yao and Ming-Hai Wang

Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy

The activity of dihydropyrimidine dehydrogenase (DPD), the key enzyme of pyrimidine catabolism, is thought to be an important determinant for the occurrence of severe toxic reactions to 5-fluorouracil (5-FU), ...

Authors: Ursula Amstutz, Simone Farese, Stefan Aebi and Carlo R Largiadèr

NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues

Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa ...

Authors: Ibrahim Meteoglu, Ibrahim H Erdogdu, Nezih Meydan, Muhan Erkus and Sabri Barutca

Positron Emission Tomography (PET) radiotracers in oncology – utility of 18F-Fluoro-deoxy-glucose (FDG)-PET in the management of patients with non-small-cell lung cancer (NSCLC)

PET (Positron Emission Tomography) is a nuclear medicine imaging method, frequently used in oncology during the last years. It is a non-invasive technique that provides quantitative in vivo assessment of physi...

Authors: Evelina Miele, Gian Paolo Spinelli, Federica Tomao, Angelo Zullo, Filippo De Marinis, Giulia Pasciuti, Luigi Rossi, Federica Zoratto and Silverio Tomao

Prognostic implication of p27^Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study

p27^Kip1 plays a major role as a negative regulator of the cell cycle. The regulation of p27^Kip1 degradation is mediated by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependen...

Authors: Zheng Liu, Qiang Fu, Jiaju Lv, Facheng Wang and Kejia Ding

Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells a...

Authors: Ai-Rong Qian, Wei Zhang, Jian-Ping Cao, Peng-Fei Yang, Xiang Gao, Zhe Wang, Hui-Yun Xu, Yuan-Yuan Weng and Peng Shang

Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population

Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interactions between polymorphisms of repair genes and tobacco...

Authors: Mayumi Kasahara, Kayo Osawa, Kana Yoshida, Aiko Miyaishi, Yasunori Osawa, Natsuko Inoue, Akimitsu Tsutou, Yoshiki Tabuchi, Kenichi Tanaka, Masahiro Yamamoto, Etsuji Shimada and Juro Takahashi

Role of Smac/DIABLO in cancer progression

Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to...

Authors: Gustavo Martinez-Ruiz, Vilma Maldonado, Gisela Ceballos-Cancino, Juan P Reyes Grajeda and Jorge Melendez-Zajgla

Erratum to: Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis in the colon of AOM-treated rat

Authors: Qing Lu, Bo Jiang, Chen Lin and Tao Shan

Efficient inhibition of murine breast cancer growth and metastasis by gene transferred mouse survivin Thr34→Ala mutant

Metastasis in breast cancer is a vital concern in treatment because most women with primary breast cancer have micrometastases to distant sites at diagnosis. As a member of the inhibitor of apoptosis protein (...

Authors: Xing-Chen Peng, Li Yang, Li-Ping Yang, Yong-Qiu Mao, Han-Shuo Yang, Ji-Yan Liu, Dong-Mei Zhang, li-Juan Chen and Yu-Quan Wei

Gene expression subtraction of non-cancerous lung from smokers and non-smokers with adenocarcinoma, as a predictor for smokers developing lung cancer

Lung cancer is the commonest cause of cancer death in developed countries. Adenocarcinoma is becoming the most common form of lung cancer. Cigarette smoking is the main risk factor for lung cancer. Long-term c...

Authors: David Stav, Ilan Bar and Judith Sandbank

Sp1 is involved in H₂O₂-induced PUMA gene expression and apoptosis in colorectal cancer cells

Reactive oxygen species (ROS) are intricately involved in tumor progression through effects on proliferation, apoptosis and metastasis. But how ROS works is not well understood. In previous study, we found PUM...

Authors: Xinying Wang, Jing Wang, Shiyong Lin, Yan Geng, Jide Wang and Bo Jiang

Reliability and accuracy of interview data in non-smoking female lung cancer case-control study

Valid interview data is critical to the final results of the study. The purpose of this study was to investigate the reliability of epidemiological data obtained in non-smoking female lung cancer case-control ...

Authors: Desheng Huang, Peng Guan, Hailong Shi, Qincheng He and Baosen Zhou

HSV-tk/GCV gene therapy mediated by EBV-LMP1 for EBV-associated cancer

To investigate the feasibility of gene therapy in treating Epstein-Barr virus (EBV)-associated cancer by employing the suicide gene, herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV), which uses t...

Authors: Yang Lifang, Tang Min, Ai Midan and Cao Ya

Comparison of CT and PET-CT based planning of radiation therapy in locally advanced pancreatic carcinoma

To compare computed tomography (CT) with co-registered positron emission tomography-computed tomography (PET-CT) as the basis for delineating gross tumor volume (GTV) in unresectable, locally advanced pancreat...

Authors: Erkan Topkan, Ali A Yavuz, Mehmet Aydin, Cem Onal, Fuat Yapar and Melek N Yavuz

A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy

β-(1,3)/(1,6) D-glucan, a component of the fungal cell wall, has been shown to stimulate the immune system, enhance hematopoiesis, amplify killing of opsonized tumor cells and increase neutrophil chemotaxis an...

Authors: Alan B Weitberg

Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients

Patients with hereditary non-poliposys colorectal cancer (HNPCC) have better prognosis than sporadic colorectal cancer (CRC). Aim of our retrospective study was to compare the overall survival between sporadic...

Authors: Vittoria Stigliano, Daniela Assisi, Maurizio Cosimelli, Raffaele Palmirotta, Diana Giannarelli, Marcella Mottolese, Lupe Sanchez Mete, Raffaello Mancini and Vincenzo Casale

Identification of genes down-regulated during lung cancer progression: A cDNA array study

Lung cancer remains a major health challenge in the world. Survival for patients with stage I disease ranges between 40–70%. This suggests that a significant proportion of patients with stage I NSCLC may actua...

Authors: Mara Campioni, Vincenzo Ambrogi, Eugenio Pompeo, Gennaro Citro, Mauro Castelli, Enrico P Spugnini, Antonio Gatti, Pierluigi Cardelli, Laura Lorenzon, Alfonso Baldi and Tommaso C Mineo

Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145

The management of hormone-refractory prostate cancer (HRPC) still remains as an important challenge of daily oncology practice. Docetaxel has proved to be a first line treatment choice. All-trans retinoic acid...

Authors: Yuksel Kucukzeybek, Mustafa K Gul, Ercument Cengiz, Cigdem Erten, Burcak Karaca, Gurbuz Gorumlu, Harika Atmaca, Selim Uzunoglu, Bulent Karabulut, Ulus A Sanli and Ruchan Uslu

The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression

To explore the relationship between the integration of mitochondrial DNA(mtDNA) in the nuclei of cervical epithelium cells and the expression of c-myc.

Authors: Daozhen Chen, Wenqun Xue and Jinying Xiang

In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wild-type p53 could be transiently phosphorylated at multiple sites

Infected cells recognize viral replication as a DNA damage stress and elicit the host surveillance mechanism to anti-virus infection. Modulation of the activity of tumor suppressor p53 is a key event in the re...

Authors: Lina Sun, Ge Zhang, Zongfang Li, Tusheng Song, Chen Huang and Lusheng Si

Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions

Reported data indicate that cancer cells have increased rates of glucose metabolism, as determined by 18FDG-PET imaging in patients with malignancies. The results of many studies have demonstrated that the exp...

Authors: Paola Parente, Antonella Coli, Guido Massi, Antonella Mangoni, Manuela M Fabrizi and Giulio Bigotti

Follicular dendritic cell sarcoma of the neck: Report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin

Follicular dendritic cell (FDC) sarcoma is a rare neoplasm arising in lymph nodes but also in extranodal sites from accessory cells of the immune system that are essential for the function of antigen presentat...

Authors: Francesco Pisani, Mirella Marino, Steno Sentinelli and Maria Concetta Petti

Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007

Quality of life in patients with breast cancer is an important outcome. This paper presents an extensive overview on the topic ranging from descriptive findings to clinical trials.

Authors: Ali Montazeri

Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes

Many kinds of Chinese herb had been confirmed to have the character of anti-tumor, clinical reports about anti-tumor effects of Chinese herb had also been found in recent years, but most of the reports were fo...

Authors: Yun Lu, Chang-Sheng Li and Qian Dong

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer

To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus.

Authors: Eiji Toyoda, Ryuichiro Doi, Kazuhiro Kami, Tomohiko Mori, Daisuke Ito, Masayuki Koizumi, Atsushi Kida, Kazuyuki Nagai, Tatsuo Ito, Toshihiko Masui, Michihiko Wada, Masatoshi Tagawa and Shinji Uemoto

Radioguided breast surgery for occult lesion localization – correlation between two methods

The detection of sub-clinical breast lesions has increased with screening mammography. Biopsy techniques can offer precision and agility in its execution, as well as patient comfort. This trial compares radiog...

Authors: Marcelo Moreno, Janete Eunice Wiltgen, Benito Bodanese, Ricardo Ludwig Schmitt, Bianca Gutfilen and Lea Mirian Barbosa da Fonseca

Pancreatitis after percutaneous ethanol injection into HCC: a minireview of the literature

Deaths after percutaneous ethanol injection (PEI) into hepatocellular carcinoma (HCC) may occur within a few hours to a few days following the procedure because of hemoperitoneum and haemorrhage from oesophage...

Authors: Enrico M Zardi, Francesco Di Matteo, Daniele Santini, Valentina Uwechie, Pierfilippo Crucitti, Massimiliano Carassiti, Antonio Picardi, Eleonora Perrella, Marco Caricato, Giuseppe Tonini, Roberto Coppola and Antonella Afeltra

siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells

The c-Myc and human telomerase reverse transcriptase gene (hTERT) gene are frequently deregulated and overexpressed in malignancy. hTERT activity is induced by c-Myc and strategies designed to inhibit c-Myc ex...

Authors: Huang Hao, Yu Nancai, Fu Lei, Wei Xiong, Su Wen, Huang Guofu, Wu yanxia, Huang Hanju, Liu Qian and Xiao Hong

Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis in the colon of AOM-treated rat

To evaluate the relationship between Aberrant Crypt Foci (ACF) and tumorigenesis, we observed the sequential development from ACF to tumor in the colon of azoxymethane-exposed wistar rats.

Authors: Qing Lu, Bo Jiang, Chen Lin and Tao Shan

Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization

A novel human nuclear receptor interaction protein (NRIP) has recently been discovered by Chen SL et al, which may play a role in enhancing the transcriptional activity of steroid nuclear receptors in prostate...

Authors: Chih-Ping Han, Ming-Yung Lee, Shu-Ling Tzeng, Chung-Chin Yao, Po-Hui Wang, Ya-Wen Cheng, Show-Li Chen, Teresa S Wu, Yeu-Sheng Tyan and Lai-Fong Kok

Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study

DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methyl...

Authors: Hong Fan, Feng Zhang, Jiabo Hu, Dongsheng Liu and Zhujiang Zhao

Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells

Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane. Expression of the heparanase gene is associated with...

Authors: Xin Hong, Feng Jiang, Steven N Kalkanis, Zheng Gang Zhang, Xuepeng Zhang, Xuguang Zheng, Hao Jiang, Tom Mikkelsen and Michael Chopp

Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2

Homeodomain-interacting protein kinase-2 (HIPK2) plays an essential role in restraining tumor progression as it may regulate, by itself or within multiprotein complexes, many proteins (mainly transcription fac...

Authors: Rosa Puca, Lavinia Nardinocchi and Gabriella D'Orazi

Low-molecular-weight heparins are superior to vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review

Cancer and its therapies increase the risk of venous thromboembolism. Compared to patients without cancer, patients with cancer anticoagulated for venous thromboembolism are more likely to develop recurrent th...

Authors: Elie A Akl, Maddalena Barba, Sandeep Rohilla, Irene Terrenato, Francesca Sperati, Paola Muti and Holger J Schünemann

The influence of survivin shRNA on the cell cycle and the invasion of SW480 cells of colorectal carcinoma

The objective was to understand the influence of Survivin plasmid with short hairpin RNA (shRNA) on the cell cycle, invasion, and the silencing effect of Survivin gene in the SW480 cell of colorectal carcinoma.

Authors: Liu Zhonghong, Lin Lianjie, Zheng Changqing, He Ying, Jin Yu and Lin Yan

Non-protein coding RNA biomarkers and differential expression in cancers: a review

In these years a huge number of human transcripts has been found that do not code for proteins, named non-protein coding RNAs. In most cases, small (miRNAs, snoRNAs) and long RNAs (antisense RNA, dsRNA, and lo...

Authors: Massimo Mallardo, Palmiro Poltronieri and Oscar Fernando D'Urso

Role of retinoic receptors in lung carcinogenesis

Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions. Retinoids have been used as chemopreventive and anti...

Authors: Krisztina Bogos, Ferenc Renyi-Vamos, Gabor Kovacs, Jozsef Tovari and Balazs Dome

Temporal trends in breast cancer presentation in the third world

Third world breast cancer is characterized by late presentation, occurrence at relatively young ages and dismal mortality. This poor outcome has encouraged patients to patronize quacks and alternative healers....

Authors: Stanley NC Anyanwu

Monitoring of people and workers exposure to the electric, magnetic and electromagnetic fields in an Italian national cancer Institute

The paper reports the electric, magnetic and electromagnetic fields (emf) measurements carried out in the Regina Elena National Cancer Institute (NCI). Several devices, used in diagnostics and in medical cures, c...

Authors: Anna Maria Di Nallo, Lidia Strigari, Claudia Giliberti, Angelico Bedini, Raffaele Palomba and Marcello Benassi

CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells

The cellular apoptosis susceptibility (CAS) protein is regarded as a proliferation-associated protein that associates with tumour proliferation as it associates with microtubule and functions in the mitotic sp...

Authors: Ching-Fong Liao, Shue-Fen Luo, Li-Tzu Li, Chuang-Yu Lin, Ying-Chun Chen and Ming-Chung Jiang