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  1. Mammalian target of rapamycin (mTOR) inhibitors are associated with dermatological adverse events. The chief aim of this study was to examine the relation between the signal transducer and activator of transcr...

    Authors: Kazuhiro Yamamoto, Atsushi Uda, Akira Mukai, Kazuhiko Yamashita, Manabu Kume, Hiroo Makimoto, Toshinori Bito, Chikako Nishigori, Takeshi Hirano and Midori Hirai
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:83
  2. Patients with advanced melanoma are faced with a poor prognosis and, until recently, limited treatment options. Ipilimumab, a novel immunotherapy that blocks cytotoxic T-lymphocyte-associated antigen-4, was th...

    Authors: Maresa Altomonte, Anna Maria Di Giacomo, Paola Queirolo, Paolo Antonio Ascierto, Francesco Spagnolo, Emilio Bajetta, Luana Calabrò, Riccardo Danielli, Francesco de Rosa, Michela Maur, Vanna Chiarion-Sileni, Pier Francesco Ferrucci, Diana Giannarelli, Alessandro Testori, Ruggero Ridolfi and Michele Maio
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:82
  3. Feasibility of whole breast hypofractionated radiotherapy schedules in breast conserving therapy is recognized however concerns remain about the role of the boost dose on the overall treatment’s potential toxi...

    Authors: Valeria Landoni, Carolina Giordano, Annelisa Marsella, Biancamaria Saracino, Maria Grazia Petrongari, Anna Maria Ferraro, Lidia Strigari and Paola Pinnarò
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:80
  4. Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway regulates multiple cellular processes such as cell proliferation, evasion from apoptosis, migration, glucose meta...

    Authors: Roberta Gonnella, Roberta Santarelli, Antonella Farina, Marisa Granato, Gabriella D’Orazi, Alberto Faggioni and Mara Cirone
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:79
  5. Three-dimensional (3D) minimally invasive video-assisted thyroidectomy (MIVAT) was carried out with a 4-mm, 3D 0-degree stereoscopic endoscope. The procedure was applied on 3 patients who underwent total thyro...

    Authors: Giuseppe Mercante, Paolo Battaglia, Valentina Manciocco, Giovanni Cristalli, Raul Pellini and Giuseppe Spriano
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:78
  6. Nucleobindin 2 (NUCB2) protein, a novel oncoprotein, is overexpressed in breast cancer. To date, there have been no published data regarding the role of NUCB2 protein expression in prostate cancer (PCa). There...

    Authors: Hongtuan Zhang, Can Qi, Andi Wang, Bing Yao, Liang Li, Yuzhuo Wang and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:77
  7. Metastasis is the major cause of cancer-related death in patients with gastric cancer, and aberrant expression of various microRNAs (miRNAs) is associated with cancer metastasis.

    Authors: Zishu Wang, Jin Wang, Yan Yang, Bo Hao, Rui Wang, Yumei Li and Qiong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:76

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:18

  8. Polyploid giant cancer cells (PGCCs) contribute to solid tumor heterogeneity. This study investigated the relationships among PGCCs numbers, vasculogenic mimicry (VM) formation, and tumor grades in glioma.

    Authors: Yang Qu, Li Zhang, Zhe Rong, Tao He and Sai Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:75
  9. Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidin...

    Authors: Kevin Marley, Stuart C Helfand, Jennifer Simpson, John E Mata, William G Tracewell, Lisa Brownlee, Shay Bracha and Bernard Séguin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:74
  10. Cutaneous melanoma is a malignant neoplasm with a constantly increasing incidence, the prognosis of which is largely dependent on early diagnosis. The appropriateness of requests for ultrasound (US) tests duri...

    Authors: Francesco M Solivetti, Fulvia Elia, Antonino Guerrisi, Flora Desiderio, Maria Giulia Santaguida, Isabella Sperduti, Claudia Cavallotti and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:73
  11. Mutations of the p53 oncosuppressor gene are amongst the most frequent aberration seen in human cancer. Some mutant (mt) p53 proteins are prone to loss of Zn(II) ion that is bound to the wild-type (wt) core, p...

    Authors: Alessia Garufi, Daniela Trisciuoglio, Manuela Porru, Carlo Leonetti, Antonella Stoppacciaro, Valerio D’Orazi, Maria Laura Avantaggiati, Alessandra Crispini, Daniela Pucci and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:72
  12. The diagnostic and prognostic value of microRNA (miRNA) expression aberrations in pancreatic ductal adenocarcinoma (PDAC) has been studied extensively in recent years. However, differences in measurement platf...

    Authors: Ming-Zhe Ma, Xiang Kong, Ming-Zhe Weng, Kun Cheng, Wei Gong, Zhi-Wei Quan and Cheng-Hong Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:71
  13. Inflammatory breast cancer (IBC) is the most metastatic variant of breast cancer with the poorest survival in all types of breast cancer patients and presently therapeutic targets for IBC are very limited. Enh...

    Authors: Zhaomei Mu, Hua Li, Sandra V Fernandez, Katherine R Alpaugh, Rugang Zhang and Massimo Cristofanilli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:70
  14. Recently, we reported an association of a novel cancer testis (CT) antigen, sperm-associated antigen 9 (SPAG9) expression in breast cancer clinical samples, indicating its potential role in carcinogenesis. Aro...

    Authors: Abhilasha Sinha, Sumit Agarwal, Deepak Parashar, Archana Verma, Shikha Saini, Nirmala Jagadish, Abdul S Ansari, Nirmal K Lohiya and Anil Suri
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:69
  15. Quadruplexes DNA are present in telomeric DNA as well as in several cancer-related gene promoters and hence affect gene expression and subsequent biological processes. The conformations of G4 provide selective...

    Authors: Sara Iachettini, Malcolm FG Stevens, Mark Frigerio, Marc G Hummersone, Ian Hutchinson, Thomas P Garner, Mark S Searle, David W Wilson, Manoj Munde, Rupesh Nanjunda, Carmen D’Angelo, Pasquale Zizza, Angela Rizzo, Chiara Cingolani, Federica De Cicco, Manuela Porru…
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:68
  16. The role of second-line therapy in gastric cancer patients mostly stemmed from clinical trials with monochemotherapy carried out in Asian countries. Nevertheless, these results cannot be broadly generalized as...

    Authors: Marcello Maugeri-Saccà, Laura Pizzuti, Domenico Sergi, Maddalena Barba, Franca Belli, Silvia Ileana Fattoruso, Diana Giannarelli, Antonella Amodio, Sara Boggia, Patrizia Vici and Luigi Di Lauro
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:67
  17. L1 cell adhesion molecule (L1CAM) and epithelial cell adhesion molecule (EPCAM) have been implicated in the development and progression of gastric cancer. The present study investigated the clinical significan...

    Authors: Yuan-Yu Wang, Li Li, Zhong-Sheng Zhao, Yong-Xiang Wang, Zai-Yuan Ye and Hou-Quan Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:66
  18. To detect genes correlated with hepatocellular carcinoma (HCC), we developed a triple combination array consisting of methylation array, gene expression array and single nucleotide polymorphism (SNP) array ana...

    Authors: Yoshikuni Inokawa, Shuji Nomoto, Mitsuhiro Hishida, Masamichi Hayashi, Mitsuro Kanda, Yoko Nishikawa, Shin Takeda, Hiroyuki Sugimoto, Tsutomu Fujii, Suguru Yamada and Yasuhiro Kodera
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:65
  19. Among the numerous genetic defects associated with hepatocarcinogenesis, telomere abnormalities appear to play a role both in tumor promotion and maintenance. Telomeres, the chromosome extremities, are protect...

    Authors: Manale El Idrissi, Valérie Hervieu, Philippe Merle, Franck Mortreux and Eric Wattel
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:64
  20. Cellfood™ (CF) is a nutritional supplement containing deuterium sulphate, minerals, amino acids, and enzymes, with well documented antioxidant properties. Its organic and inorganic components are extracted fro...

    Authors: Simona Catalani, Valentina Carbonaro, Francesco Palma, Marselina Arshakyan, Rossella Galati, Barbara Nuvoli, Serafina Battistelli, Franco Canestrari and Serena Benedetti
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:63
  21. Increased motility and invasiveness of cancer cells are reminiscent of the epithelial-mesenchymal transition (EMT), which occurs during cancer progression and metastasis. Recent studies have indicated the expr...

    Authors: Masanobu Tsubaki, Makiko Komai, Shin-ichiro Fujimoto, Tatsuki Itoh, Motohiro Imano, Kotaro Sakamoto, Hirotaka Shimaoka, Tomoya Takeda, Naoki Ogawa, Kenji Mashimo, Daiichiro Fujiwara, Junji Mukai, Katsuhiko Sakaguchi, Takao Satou and Shozo Nishida
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:62
  22. There is no consensus regarding the secondary cytoreduction surgery (CRS) in recurrent ovarian cancer patients. The present study aims to determine the value of secondary CRS and the eligible subgroup for this...

    Authors: Xia Xu, Xiaoxiang Chen, Zhiqin Dai, Fei Deng, Junwei Qu and Jing Ni
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:61
  23. The deleted in liver cancer 1 (DLC1) and plasminogen activator inhibitor 1 (PAI-1) are known to be closely associated with tumor growth and metastasis in several kinds of human tumors. The aim of this study wa...

    Authors: Fang Ren, Huirong Shi, Gong Zhang and Ruitao Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:60
  24. To date, no prognostic microRNAs (miRNAs) for isocitrate dehydrogenase 1 (IDH1) wild-type glioblastoma multiformes (GBM) have been reported. The aim of the present study was to identify a miRNA signature of pr...

    Authors: Zheng Wang, Zhaoshi Bao, Wei Yan, Gan You, Yinyan Wang, Xuejun Li and Wei Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:59
  25. An External Quality Assessment (EQA) program was developed to investigate the state of the art of HER2 immunohistochemical determination in breast cancer (BC) in 16 Pathology Departments in the Lazio Region (I...

    Authors: Irene Terrenato, Vincenzo Arena, Sara Pizzamiglio, Ilaria Pennacchia, Letizia Perracchio, Simonetta Buglioni, Cristiana Ercolani, Francesca Sperati, Leopoldo Costarelli, Elena Bonanno, Daniela Baldini, Silvia Candia, Anna Crescenzi, Antonella Dal Mas, Claudio Di Cristofano, Vito Gomes…
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:58
  26. Renal cell carcinoma (RCC), the most common malignancy of the kidney, is refractory to standard therapy and has an incidence that continues to rise. Screening of plant extracts in search of new agents to treat...

    Authors: Richard T Williams, Alice L Yu, Mitchell B Diccianni, Emmanuel A Theodorakis and Ayse Batova
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:57

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:95

  27. Nucleobindin 2 (NUCB2) abnormal expression has been reported in gastric cancer and breast cancer. However, the role of NUCB2 in prostate cancer (PCa) remains unclear. The aim of the present study was to invest...

    Authors: Hongtuan Zhang, Can Qi, Liang Li, Fei Luo and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:56
  28. Neuroepithelial Transforming Gene 1 (NET1) is a well characterised oncoprotein and a proven marker of an aggressive phenotype in a number of cancers, including gastric adenocarcinoma. We aimed to investigate w...

    Authors: Conor Lahiff, Eoin Cotter, Rory Casey, Peter Doran, Graham Pidgeon, John Reynolds, Padraic MacMathuna and David Murray
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:55
  29. The prognostic value of metastasis-associated gene 1 (MTA1) in nasopharyngeal carcinoma (NPC) has been suggested. However, there is still no direct evidence that MTA1 promotes NPC growth in vivo. In this study...

    Authors: Qingcui Song, Hong Zhang, Min Wang, Wen Song, Min Ying, Yuan Fang, Yiyi Li, Yilan Chao and Xiaoxia Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:54
  30. The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relati...

    Authors: Yan Lin, Changjun Wang, Ying Zhong, Xin Huang, Li Peng, Guangliang Shan, Ke Wang and Qiang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:53
  31. RABEX-5, a guanine nucleotide exchange factor (GEF) for RAB-5, plays an important role in cell mobility and altered expression associated with tumor metastasis. This study aimed to investigate the role of RABE...

    Authors: Xiang Zhang, Jie Min, Yingjian Wang, Yan Li, Hongzhong Li, Qiang Liu, Xinjie Liang, Peng Mu and Hongyuan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:52
  32. It is well documented that cancer cells secrete angiogenic factors to recruit and sustain tumor vascular networks. However, little is known about the effects of endothelial cells on the behavior of tumor cells...

    Authors: Yao-Hui Wang, Yin-Ying Dong, Wei-Min Wang, Xiao-Ying Xie, Zhi-Ming Wang, Rong-Xin Chen, Jie Chen, Dong-Mei Gao, Jie-Feng Cui and Zheng-Gang Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:51
  33. Epidermal growth factor receptor (EGFR)-activating mutations are major determinants in predicting the tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC). Noninvasive test for ...

    Authors: Hye-Ryoun Kim, Sung Yong Lee, Dae-Sung Hyun, Min Ki Lee, Hyun-Kyung Lee, Chang-Min Choi, Sei-Hoon Yang, Young-Chul Kim, Yong Chul Lee, Sun Young Kim, Seung Hun Jang, Jae Cheol Lee and Kye Young Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:50
  34. Currently, no clearly superior management strategy exists for recurrent, platinum-resistant ovarian cancer. We tested the efficacy and safety of gemcitabine combined with oxaliplatin (GEMOX) in a multicentre p...

    Authors: Patrizia Vici, Domenico Sergi, Laura Pizzuti, Luciano Mariani, Maria Grazia Arena, Maddalena Barba, Marcello Maugeri-Saccà, Cristina Vincenzoni, Enrico Vizza, Giacomo Corrado, Giancarlo Paoletti, Federica Tomao, Silverio Tomao, Diana Giannarelli and Luigi Di Lauro
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:49
  35. In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in...

    Authors: Federica Tomao, Anselmo Papa, Luigi Rossi, Martina Strudel, Patrizia Vici, Giuseppe Lo Russo and Silverio Tomao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:48
  36. Completion lymph node dissection (CLND) is the gold standard treatment for patients with a positive sentinel lymph node (SLN) biopsy. Considering the morbidity associated with CLND it is important to identify ...

    Authors: Emilia Migliano, Barbara Bellei, Flavio Andrea Govoni, Giovanni Paolino, Caterina Catricalà, Stefania Bucher and Pietro Donati
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:47
  37. Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been cl...

    Authors: Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Hiroshi Okumura, Hiroshi Kurahara, Yasuto Uchikado, Tetsuro Setoyama, Yoshiaki Kita, Yuko Kijima, Yuka Nishizono, Akihiro Nakajo, Tetsuro Owaki, Shinichi Ueno and Shoji Natsugoe
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:46
  38. Osteopontin (OPN) plays important roles in the modulation of apoptosis, angiogenesis, immune response, and tumor invasion. Elevated osteopontin expression has been reported in the lung cancer tissues compared ...

    Authors: Yunzhen Chen, Haichun Liu, Wenliang Wu, Yi Li and Jianmin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:45
  39. Colonoscopy is widely regarded to be the gold standard for colorectal cancer (CRC) detection. Recent studies, however, suggest that the effectiveness of colonoscopy is mostly confined to tumors on the left sid...

    Authors: Samuel Chao, Jay Ying, Gailina Liew, Wayne Marshall, Choong-Chin Liew and Robert Burakoff
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:44
  40. N-Acetyl-Cysteine (NAC), a natural sulfur-containing amino acid derivative, and peroxisome proliferators activated receptor alpha (PPARα) ligand have been shown to have anticancer properties. However, the mech...

    Authors: Swei Sunny Hann, Fang Zheng and Shunyu Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:43
  41. Glioblastoma is the most common type of primary brain tumors. Cisplatin is a commonly used chemotherapeutic agent for Glioblastoma patients. Despite a consistent rate of initial responses, cisplatin treatment ...

    Authors: Yong Guo, Kuipo Yan, Jiasheng Fang, Qiang Qu, Ming Zhou and Fenghua Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:41
  42. Pegvisomant (PEGV) is widely used, alone or with somatostatin analogs (SSA), for GH-secreting pituitary tumors poorly controlled by SSAs alone. No information is available on specific indications for or relati...

    Authors: Antonio Bianchi, Ferdinando Valentini, Raffaella Iuorio, Maurizio Poggi, Roberto Baldelli, Marina Passeri, Antonella Giampietro, Linda Tartaglione, Sabrina Chiloiro, Marialuisa Appetecchia, Patrizia Gargiulo, Andrea Fabbri, Vincenzo Toscano, Alfredo Pontecorvi and Laura De Marinis
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:40
  43. Previous evidence has shown that the FOXP3 gene was involved in the pathogenesis of several tumors; however, the correlation between single nucleotide polymorphisms (SNPs) in the FOXP3 gene and the susceptibil...

    Authors: YanHui Chen, HengHui Zhang, WeiJia Liao, JinXue Zhou, GaiXia He, XingWang Xie, Ran Fei, LiLing Qin, Lai Wei and HongSong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:39
  44. Saquinavir, a protease inhibitor utilized in HIV infection, shows antitumor activity in various experimental models. In previous studies performed in our laboratory the drug was found to induce a substantial i...

    Authors: Riccardo Adamo, Alessandro Comandini, Angelo Aquino, Laura Bonmassar, Loredana Guglielmi, Enzo Bonmassar and Ornella Franzese
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:38
  45. Pulmonary carcinoma is the main cause of malignant pleural effusions (MPEs). However, there is no satisfactory marker for diagnosing MPEs caused by pulmonary carcinoma. The purpose of this study is to assess t...

    Authors: Ying Tang and Lijun Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:37
  46. This study investigates the expression of Lewis y antigen, integrin αv, β3 in epithelial ovarian cancer tissues. We further evaluate the relationship between their expression and chemotherapy resistance of ova...

    Authors: Jian Gao, Zhenhua Hu, Dawo Liu, Juanjuan Liu, Chuan Liu, Rui Hou, Song Gao, Danye Zhang, Shulan Zhang and Bei Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:36
  47. Ankyrin repeat domain 12 (ANKRD12), is encoding a 224 kDa nuclear protein and most conserved at its N-terminal ankyrin repeats region and the C-terminal co-activator interacting domain. The aim of this study w...

    Authors: Rui Bai, Dan Li, Zhong Shi, Xuefeng Fang, Weiting Ge and Shu Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:35
  48. The use of [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for detection of gastric cancer is often debated because FDG uptake varies for each patient. The purpose of this study was to ...

    Authors: Ryusuke Takebayashi, Kunihiko Izuishi, Yuka Yamamoto, Reiko Kameyama, Hirohito Mori, Tsutomu Masaki and Yasuyuki Suzuki
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:34
  49. The metastasis-associated gene 1 (MTA1) has been identified as one critical regulator of tumor metastasis. Previously, we identified miR-125b as a downregualted miRNA in non-small cell lung cancer (NSCLC) cell...

    Authors: Yiyi Li, Yilan Chao, Yuan Fang, Jian Wang, Min Wang, Hong Zhang, Min Ying, Xiaoxia Zhu and Haofei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:33

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