Skip to main content

Articles

Page 60 of 77

  1. Ovarian malignancies are often diagnosed in advanced stage and at the same time resistance to treatment, both intrinsic and developed during treatment, is sometimes observed. These facts underscore the need fo...

    Authors: Karolina Tecza, Jolanta Pamula-Pilat, Zofia Kolosza, Natalia Radlak and Ewa Grzybowska
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:2
  2. Metastasis have considered as an important clinical obstacle in the treatment of human cancer including bladder cancer. Post-transcriptional regulation has emerged as robust effectors of metastasis. MiRNAs are...

    Authors: Gan Yu, Weimin Yao, Wei Xiao, Heng Li, Hua Xu and Bin Lang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:779
  3. Identification of a gene expression signature in primary breast tumors that could classify patients by lymph node status would allow patients to avoid the morbidities of surgical disruption of the lymph nodes....

    Authors: Craig D Shriver, Matthew T Hueman and Rachel E Ellsworth
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:116
  4. Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrate...

    Authors: Xin Zhu, Jia-jie Xu, Si-si Hu, Jian-guo Feng, Lie-hao Jiang, Xiu-xiu Hou, Jun Cao, Jing Han, Zhi-qiang Ling and Ming-hua Ge
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:114

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:304

  5. MicroRNAs (miRNAs) have been reported to play crucial roles in regulating a variety of genes pivotal for tumor metastasis. MicroRNA-301a (miR-301a) is overexpressed and displays oncogenic activity in many canc...

    Authors: Wenpeng Zhang, Tao Zhang, Runsen Jin, Hongchao Zhao, Jin Hu, Bo Feng, Lu Zang, Minhua Zheng and Mingliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:113
  6. Carfilzomib (CFZ) is a proteasome inhibitor that selectively and irreversibly binds to its target and has been approved in the US for treatment of relapsed and refractory multiple myeloma. Phase 1B studies of ...

    Authors: Amanda F Baker, Neale T Hanke, Barbara J Sands, Liliana Carbajal, Janet L Anderl and Linda L Garland
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:111
  7. The Y-box binding protein 1 (YB-1) possesses pleiotropic functions through its interactions with various cellular proteins, and its high expression levels make it a potential useful prognostic biomarker for ca...

    Authors: Ying Wu, Ke-yong Wang, Zhi Li, Yun-peng Liu, Hiroto Izumi, Hidetaka Uramoto, Yoshifumi Nakayama, Ken-ichi Ito and Kimitoshi Kohno
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:112
  8. The choice of drugs for treatment of advanced gastric cancer (GC) is empirical. The purpose of the current study was to benchmark ex vivo the sensitivity of GC tumor cells from patients to standard cytotoxic a...

    Authors: Bo Hultman, Haile Mahteme, Magnus Sundbom, Martin Ljungman, Rolf Larsson and Peter Nygren
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:110
  9. The echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene rearrangements occur in approximately 5% of lung adenocarcimomas (ACA), leading to ALK overexpress...

    Authors: Jiandong Wang, Qin Shen, Qunli Shi, Bo Yu, Xuan Wang, Kai Cheng, Guangming Lu and Xiaojun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:109
  10. Histone acetyltransferase (HAT) inhibitors can inhibit proliferation and induce apoptosis in cancer cell lines. The novel cell-permeable p300/CREB-binding protein (CBP)-selective HAT inhibitor HATi II can redu...

    Authors: Li-Xiao Xu, Zhi-Heng Li, Yan-Fang Tao, Rong-Hu Li, Fang Fang, He Zhao, Gang Li, Yan-Hong Li, Jian Wang, Xing Feng and Jian Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:108
  11. In our previous study, parathyroid hormone-like hormone (PTHLH) which encodes parathyroid hormone-related protein (PTHrP) was revealed to be up-regulated in oral squamous cell carcinoma (OSCC) compared with pa...

    Authors: Zhongjing Lv, Xiangbing Wu, Wei Cao, ZongZe Shen, Lizhen Wang, FuRong Xie, JianJun Zhang, Tong Ji, Ming Yan and WanTao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:100
  12. Brachyury overexpression has been reported in various human malignant neoplasms, but its expression and function in hepatocellular carcinoma progression and metastasis remains unknown. The present study aimed ...

    Authors: Rui Du, Shanshan Wu, Xiaoning Lv, Henghu Fang, Sudong Wu and Jingbo Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:105
  13. Pancreatic ductal adenocarcinoma has proven to be one of the most chemo-resistant among all solid organ malignancies. Several mechanisms of resistance have been described, though few reports of strategies to o...

    Authors: Rouzbeh Daylami, Diego J Muilenburg, Subbulakshmi Virudachalam and Richard J Bold
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:102
  14. Epithelial–mesenchymal transition (EMT) contributes to the progression and metastasis of cancer cells and is associated with a more invasive phenotype of cancer. The Wnt/β-catenin signaling pathway is one of t...

    Authors: Lisha Qi, Baocun Sun, Zhiyong Liu, Runfen Cheng, Yixian Li and Xiulan Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:107
  15. The optimal laboratory assay for detecting KRAS mutations in different biospecimens from patients with metastatic colorectal cancer (mCRC), and the clinical relevance of these gene alterations is still in questio...

    Authors: Jian-Ming Xu, Xiao-Jing Liu, Fei-Jiao Ge, Li Lin, Yan Wang, Manish R Sharma, Ze-Yuan Liu, Stefania Tommasi and Angelo Paradiso
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:104
  16. Intrahepatic cholangiocarcinoma (IHCC) is the second most frequent primary malignant liver tumor following hepatocellular carcinoma. It is a highly fatal disease and has few therapeutics. The CXC chemokine lig...

    Authors: Shengqiang Zhao, Jing Wang and Chengyong Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:103
  17. Increasing evidences have documented that microRNAs (miRNAs) act as oncogenes or tumor suppressors in gastric cancer (GC). In this study, we aimed to investigate the expression of miR-133b in a large number of...

    Authors: Lihua Guo, Hua Bai, Dongling Zou, Tao Hong, Jie Liu, Jiaqiang Huang, Pengfei He, Qi Zhou and Jinsheng He
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:99

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:220

  18. The ubiquitous second messenger Ca2+ has been demonstrated to play an important role in cancer progression. Store-operated Ca2+ entry (SOCE) is the main Ca2+ entry pathway regulating intracellular Ca2+ concentrat...

    Authors: Meng Zhu, Lei Chen, Pengfei Zhao, Hua Zhou, Chen Zhang, Shengping Yu, Yu Lin and Xuejun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:98
  19. SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis in many cancers, but their association with survival in breast cancer has not been determined. The purpose of this study was to asses...

    Authors: Yu-Wen Cao, Wen-Qin Li, Guo-Xing Wan, Yi-Xiao Li, Xiao-Ming Du, Yu-Cong Li and Feng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:97
  20. Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosi...

    Authors: Francesco Maria Solivetti, Flora Desiderio, Antonino Guerrisi, Antonio Bonadies, Carlo Ludovico Maini, Simona Di Filippo, Valerio D’Orazi, Isabella Sperduti and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:96
  21. The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signal...

    Authors: Shulin Zhang, Yi-Lin Yang, Yucheng Wang, Bin You, Yuyuan Dai, Geraldine Chan, David Hsieh, Il-Jin Kim, Li Tai Fang, Alfred Au, Hubert J Stoppler, Zhidong Xu, David M Jablons and Liang You
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:93
  22. There has been a “rising tide” in mastectomy utilization that can be attributed to more skin-sparing mastectomies (SSMs) performed concurrently with immediate breast reconstruction. We report our experience of...

    Authors: Roy De Vita, Ernesto Maria Buccheri, Marcello Pozzi and Giovanni Zoccali
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:78
  23. The mechanism behind poor survival of acute myeloid leukemia (AML) patients with 1-barabinofuranosylcytosine (Ara-C) based treatment remains unclear. This study aimed to assess the pharmacogenomic effects of A...

    Authors: Haixia Wan, Jianyi Zhu, Fangyuan Chen, Fei Xiao, Honghui Huang, Xiaofeng Han, Lu Zhong, Hua Zhong, Lan Xu, Beiwen Ni and Jihua Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:90
  24. Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing compounds with good safety profiles which have been investigated for their benefits and application in health and disease for more than fif...

    Authors: Afshin Amini, Samar Masoumi-Moghaddam, Anahid Ehteda and David Lawson Morris
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:92
  25. Breast cancer patients with positive estrogen receptor (ER) have a better prognosis. However, no prognostic miRNA signature was reported in the ER-positive breast cancer. The aim of the study was to identify a...

    Authors: Xin Zhou, Xiaping Wang, Zebo Huang, Lei Xu, Wei Zhu and Ping Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:94
  26. Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. H...

    Authors: Mingxu Guan, Gaetano Romano, Roberta Coroniti and Earl E Henderson
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:91
  27. Poor prognosis of medullary thyroid cancer (MTC) with suspicious ultrasound (US) features has been reported. The aim of the study was to investigate the association between preoperative US presentation and agg...

    Authors: Pierpaolo Trimboli, Luca Giovanella, Stefano Valabrega, Massimiliano Andrioli, Roberto Baldelli, Nadia Cremonini, Fabio Rossi, Leo Guidobaldi, Agnese Barnabei, Francesca Rota, Antonella Paoloni, Laura Rizza, Giorgio Fattorini, Maurizio Latini, Claudio Ventura, Paolo Falasca…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:87
  28. Identification of novel molecular biomarkers will improve the management of patients with gastric cancer (GC). Prenyl diphosphate synthase subunit 2 (PDSS2) is required for coenzyme Q10 biosynthesis and acts a...

    Authors: Mitsuro Kanda, Shuji Nomoto, Hisaharu Oya, Ryoji Hashimoto, Hideki Takami, Dai Shimizu, Fuminori Sonohara, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Kenta Murotani, Michitaka Fujiwara…
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:88
  29. We aimed at investigating the outcomes of female patients with stage IIIB-IV adenocarcinoma of the lung according to EGFR and K-Ras mutational status.

    Authors: Virginia Rotella, Lorenzo Fornaro, Enrico Vasile, Carmelo Tibaldi, Laura Boldrini, Antonio Chella, Armida D'Incecco, Giovanna Cirigliano, Aldo Chioni, Cristiana Lupi, Elisa Sensi, Laura Ginocchi, Simona Giovannelli, Maria Cristina Pennucci, Gabriella Fontanini and Editta Baldini
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:77
  30. Resistance to Fas-mediated apoptosis limits the efficacy of currently available chemotherapy regimens. We identified CD74, which is known to be overexpressed in hematological malignancies, as one of the factor...

    Authors: Zuzana Berkova, Shu Wang, Xue Ao, Jillian F Wise, Frank K Braun, Abdol H Rezaeian, Lalit Sehgal, David M Goldenberg and Felipe Samaniego
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:80
  31. Many long non-coding RNAs(lncRNAs) have been found to be a good marker for several tumors. Using lncRNA-mining approach, we aimed to identify lncRNA expression signature that can predict breast cancer patient ...

    Authors: Jin Meng, Ping Li, Qing Zhang, Zhangru Yang and Shen Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:84
  32. The pentacyclic acridinium salt RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino [4,3,2-kl] acridinium methosulfate, compound 1) is one of the most interesting DNA G-quadruplex binding molecules due to its high eff...

    Authors: Angela Rizzo, Sara Iachettini, Pasquale Zizza, Chiara Cingolani, Manuela Porru, Simona Artuso, Malcolm Stevens, Marc Hummersone, Annamaria Biroccio, Erica Salvati and Carlo Leonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:81

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2015 34:9

  33. Unlike metastatic colorectal cancer (CRC) there are to date few reports concerning the predictive value of molecular biomarkers on the clinical outcome in stage II/III CRC patients receiving adjuvant chemother...

    Authors: Thomas Thomaidis, Annett Maderer, Andrea Formentini, Susanne Bauer, Mario Trautmann, Michael Schwarz, Wiebke Neumann, Jens Martin Kittner, Arno Schad, Karl-Heinrich Link, Johannes Wilhelm Rey, Arndt Weinmann, Arthur Hoffman, Peter Robert Galle, Marko Kornmann and Markus Moehler
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:83
  34. Human cancer cells can transfer signaling molecules to neighboring and distant cells predisposing them to malignant transformation. This process might contribute to tumor progression and invasion through deliv...

    Authors: Mohamed Abdouh, Shufeng Zhou, Vincenzo Arena, Manuel Arena, Anthoula Lazaris, Ronald Onerheim, Peter Metrakos and Goffredo Orazio Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:86
  35. We previously identified platelet-activating factor receptor (PAFR) as being overexpressed in ovarian cancer and found that its ligand PAF evoked EGFR phosphorylation using the phospho-antibody microarray. Epi...

    Authors: Yi Yu, Mingxing Zhang, Xiaoyan Zhang, Qingqing Cai, Zhiling Zhu, Wei Jiang and Congjian Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:85
  36. Previous studies investigating the association between EPHX1 polymorphisms (Tyr113His and His139Arg) and cancer risk have yielded inconsistent results. This meta-analysis was performed to derive a more precise...

    Authors: Xiaoqin Yang, Yubing Wang and Guiping Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:82
  37. MICA/B are major ligands for NK cell activating receptor NKG2D and previous studies showed that the serum level of soluble MICA (sMICA) is an independent prognostic factor for advanced human hepatocellular car...

    Authors: Liang Fang, Jiuyu Gong, Ying Wang, Rongrong Liu, Zengshan Li, Zhe Wang, Yun Zhang, Chunmei Zhang, Chaojun Song, Angang Yang, Jenny P -Y Ting, Boquan Jin and Lihua Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:76
  38. DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase I belongs to the family of poly(ADP-ribose)-binding proteins...

    Authors: Cinzia Tesauro, Grazia Graziani, Barbara Arnò, Laura Zuccaro, Alessia Muzi, Ilda D'Annessa, Elettra Santori, Lucio Tentori, Carlo Leonetti, Paola Fiorani and Alessandro Desideri
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:71
  39. Recent evidence suggests that aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas including gastric cancer. Speckle-type PO...

    Authors: Chunyan Zeng, Yao Wang, Quqin Lu, Jiang Chen, Junyan Zhang, Tao Liu, Nonghua Lv and Shiwen Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:75
  40. Conventional Sanger sequencing reliably detects the majority of genetic mutations associated with hereditary cancers, such as single-base changes and small insertions or deletions. However, detection of genomi...

    Authors: Debora Mancini-DiNardo, Thaddeus Judkins, Nick Woolstenhulme, Collin Burton, Jeremy Schoenberger, Matthew Ryder, Adam Murray, Natalia Gutin, Aaron Theisen, Jayson Holladay, Jonathan Craft, Christopher Arnell, Kelsey Moyes and Benjamin Roa
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:74
  41. Prostate cancer gene expression marker 1 (PCGEM1) is a long non-coding RNA (lncRNA) overexpressed in prostate cancer (PCa) cells that promotes PCa initiation and progression, and protects against chemotherapy-ind...

    Authors: Jin-Hua He, Jing-zhi Zhang, Ze-Ping Han, Li Wang, Yu Bing Lv and Yu-Guang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:72
  42. LKB1, also known as STK11, is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. Recent studies have indicated that LKB1 is related to breast tumorigenesis and ...

    Authors: Juan Li, Jie Liu, Pingping Li, Xiaona Mao, Wenjie Li, Jin Yang and Peijun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:70
  43. Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to human disease including cancer. Previous miRNA microarray analysis illustrated that miR-320c is down-regulated in ...

    Authors: Xiao Wang, Jian Wu, Yiwei Lin, Yi Zhu, Xianglai Xu, Xin Xu, Zhen Liang, Shiqi Li, Zhenghui Hu, Xiangyi Zheng and Liping Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:69
  44. Neoadjuvant treatment plays a crucial role in the therapy of advanced esophageal cancer. However, response to radiochemotherapy varies widely. Proton pump inhibitors (PPIs) have been demonstrated to impact on ...

    Authors: Kirsten Lindner, Christiane Borchardt, Maren Schöpp, Anja Bürgers, Christian Stock, Damian J Hussey, Jörg Haier and Richard Hummel
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:73
  45. The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and R...

    Authors: Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran and Chun-Meng Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:64
  46. PCDH8 is a novel tumor suppressor gene, and frequently inactivated by promoter methylation in human cancers. However, there is little information regarding PCDH8 methylation in non-muscle invasive bladder canc...

    Authors: Ying-Li Lin, Yan-Ling Wang, Jian-Guo Ma and Wen-Ping Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:68
  47. Laparoscopic prostatectomy (LRP) may activate clotting system influencing the risk of perioperative thrombosis in patients with prostate cancer. Moreover, different anaesthetic techniques can also modify coagu...

    Authors: Maria Sofra, Anna Antenucci, Michele Gallucci, Chiara Mandoj, Rocco Papalia, Claudia Claroni, Ilaria Monteferrante, Giulia Torregiani, Valeria Gianaroli, Isabella Sperduti, Luigi Tomao and Ester Forastiere
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:63

Annual Journal Metrics

  • 2022 Citation Impact
    11.3 - 2-year Impact Factor
    11.5 - 5-year Impact Factor
    1.870 - SNIP (Source Normalized Impact per Paper)
    2.413 - SJR (SCImago Journal Rank)

    2023 Speed
    4 days submission to first editorial decision for all manuscripts (Median)
    100 days submission to accept (Median)

    2023 Usage 
    3,003,080 downloads
    3,022 Altmetric mentions