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  1. Cholangiocarcinoma (CCA) is highly resistant to most of the known chemotherapeutic treatments. NAD(P)H-quinone oxidoreductase 1 (NQO1) is an antioxidant/detoxifying enzyme recently recognized as an important c...

    Authors: Ponsilp Zeekpudsa, Veerapol Kukongviriyapan, Laddawan Senggunprai, Banchob Sripa and Auemduan Prawan
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:11
  2. ErbB4 expression has been noted in various tumors, but its regulatory mechanism in esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to investigate whether miR-302b regulates...

    Authors: Mingxin Zhang, Qi Yang, Lingmin Zhang, Suna Zhou, Wenguang Ye, Qinglin Yao, Zongfang Li, Cheng Huang, Qinsheng Wen and Jingjie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:10
  3. Glioblastoma multiforme (GBM) is the most malignant type of glioma. Integrated classification based on mRNA expression microarrays and whole–genome methylation subdivides GBM into five subtypes: Classical, Mes...

    Authors: Rui Li, Kaiming Gao, Hui Luo, Xiefeng Wang, Yan Shi, Qingsheng Dong, WenKang Luan and Yongping You
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:9
  4. c-Jun NH2-terminal kinases (JNKs) are strongly activated by a stressful cellular environment, such as chemotherapy and oxidative stress. Autophagy is a protein-degradation system in which double-membrane vacuo...

    Authors: Guang Jia, Rui Kong, Zhi-Bin Ma, Bing Han, Yong-Wei Wang, Shang-Ha Pan, Ying-Hua Li and Bei Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:8
  5. The mechanism for inactivation of positive regulatory domain containing I (PRDM1), a newly identified tumour suppressor gene in extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT) has not been well defined....

    Authors: Li Liang, Lin Nong, Shuang Zhang, Jing Zhao, Hongjuan Ti, Ying Dong, Bo Zhang and Ting Li
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:7
  6. Hec1 (NDC80) is an integral part of the kinetochore and is overexpressed in a variety of human cancers, making it an attractive molecular target for the design of novel anticancer therapeutics. A highly potent...

    Authors: Lynn YL Huang, Ying-Shuan Lee, Jiann-Jyh Huang, Chia-chi Chang, Jia-Ming Chang, Shih-Hsien Chuang, Kuo-Jang Kao, Yung-Jen Tsai, Pei-Yi Tsai, Chia-Wei Liu, Her-Sheng Lin and Johnson YN Lau
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:6
  7. EGFR mutation detection has been widely applied in the prediction of TKIs therapy in Non-Small Cell Lung Cancer (NSCLC). Metastatic tumors rather than primary tumors were usually assayed for those patients in ...

    Authors: Bing Wei, Ke Yang, Jiuzhou Zhao, Yuxi Chang, Zihui Ma, Bing Dong, Yongjun Guo and Jie Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:5
  8. Colorectal cancer (CRC) arises as a consequence of genetic events such as gene mutation and epigenetic alteration. The aim of this study was to identify new hypermethylated candidate genes and methylation-base...

    Authors: Ji Wook Moon, Soo Kyung Lee, Jung Ok Lee, NamI Kim, Yong Woo Lee, Su Jin Kim, Ho Jin Kang, Jin Kim, Hyeon Soo Kim and Sun-Hwa Park
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:4
  9. Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate cancer stem cells such as leukemia stem cells, prostate tumor-initiating cells and so on. However, the mec...

    Authors: Xiaofei Zhao, Xiangguo Liu and Ling Su
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:3
  10. Gastric cancers have poor overall survival despite recent advancements in early detection methods, endoscopic resection techniques, and chemotherapy treatments. Vaccinia viral therapy has had promising therape...

    Authors: Kyong-Hwa Jun, Sepideh Gholami, Tae-Jin Song, Joyce Au, Dana Haddad, Joshua Carson, Chun-Hao Chen, Kelly Mojica, Pat Zanzonico, Nanhai G Chen, Qian Zhang, Aladar Szalay and Yuman Fong
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:2
  11. Several studies evaluated the prevalence of Lynch Syndrome (LS) in young onset colorectal cancer (CRC) patients and the results were extremely variable (5%-20%). Immunohistochemistry (IHC) for MMR proteins and...

    Authors: Vittoria Stigliano, Lupe Sanchez-Mete, Aline Martayan, Maria Diodoro, Beatrice Casini, Isabella Sperduti and Marcello Anti
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:1
  12. To assess the efficacy of intraoperative ultrasound-guided implantation of 125I seeds for the treatment of unresectable pancreatic carcinoma, and analyze the associated prognostic factors.

    Authors: Hao Wang, Junjie Wang, Yuliang Jiang, Jinna Li, Suqing Tian, Weiqiang Ran, Dianrong Xiu and Yang Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:106
  13. Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer. The purpose...

    Authors: Dong Yang, Min-Bin Chen, Li-Qiang Wang, Lan Yang, Chao-Ying Liu and Pei-Hua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:105
  14. Genome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) that located in the 8q24 was discovered. Single nu...

    Authors: Lijuan Li, Ruifen Sun, Yundan Liang, Xinmin Pan, Zhaohui Li, Peng Bai, Xiaofeng Zeng, Dongxian Zhang, Lin Zhang and Linbo Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:104
  15. To investigate the feasibility of dose escalation (86 Gy at 2 Gy/fraction) with intensity modulated radiation therapy (IMRT) in intermediate-risk prostate cancer without androgen deprivation therapy.

    Authors: Maria Grazia Petrongari, Valeria Landoni, Biancamaria Saracino, Sara Gomellini, Stefano Arcangeli, Giuseppe Iaccarino, Paola Pinnarò, Giorgio Arcangeli and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:103
  16. Both BRCA1 and epidermal growth factor receptor (EGFR) play a critical role in ovarian cancer progression. However, the crosstalk between BRCA1 and EGFR signaling pathways in ovarian cancer remains largely unk...

    Authors: Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Chun-Yan Li and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:102
  17. Recently, leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), a negative regulator of EGFR, was discovered is a novel agent for suppressing bladder cancer. The aim of this study was to investigate ...

    Authors: Lei Chang, Runlin Shi, Tao Yang, Fan Li, Guohao Li, Yonglian Guo, Bin Lang, Weimin Yang, Qianyuan Zhuang and Hua Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:101
  18. Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. The present treatment including surgery, chemotherapy and radiation, which have only 40% long-term cure rates, and usually cause tum...

    Authors: Xiao-Hong Tian, Wei-Jian Hou, Yan Fang, Jun Fan, Hao Tong, Shu-Ling Bai, Qu Chen, He Xu and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:100
  19. Paclitaxel, a widely used chemotherapeutic drug, can induce apoptosis in variety of cancer cells. A previous study has shown preferential toxicity of paclitaxel to FLCN-deficient kidney cancer cell line, UOK25...

    Authors: Qi Zhang, Shuhui Si, Sue Schoen, Jindong Chen, Xun-Bo Jin and Guan Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:99
  20. Mir-29 microRNA families are involved in regulation of various types of cancers. Although Mir-29 was shown to play an inhibitory role in tumorigenesis, the role of Mir-29 in breast cancer still remains obscure...

    Authors: Zhenglong Wu, Xiaona Huang, Xing Huang, Qiang Zou and Yujiang Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:98
  21. Interleukin-27 signaling is mediated by the JAK-STAT pathway via activation of STAT1 and STAT3, which have tumor suppressive and oncogenic activities, respectively. Epithelial–mesenchymal transition (EMT) and ...

    Authors: Puja Kachroo, Mi-Heon Lee, Ling Zhang, Felicita Baratelli, Gina Lee, Minu K Srivastava, Gerald Wang, Tonya C Walser, Kostyantyn Krysan, Sherven Sharma, Steven M Dubinett and Jay M Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:97
  22. Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modificati...

    Authors: Xiaolan Liu, Xiaoyan Chen, Xinfang Yu, Yongguang Tao, Ann M Bode, Zigang Dong and Ya Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:96
  23. Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is ...

    Authors: Maria Saveria Gilardini Montani, Andrea Prodosmo, Venturina Stagni, Dania Merli, Laura Monteonofrio, Veronica Gatti, Maria Pia Gentileschi, Daniela Barilà and Silvia Soddu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:95
  24. Although non muscle invasive bladder cancer (NMIBC) generally has a good long-term prognosis, up to 80% of patients will nevertheless experience local recurrence after the primary tumor resection. The search f...

    Authors: Valentina Casadio, Chiara Molinari, Daniele Calistri, Michela Tebaldi, Roberta Gunelli, Luigi Serra, Fabio Falcini, Chiara Zingaretti, Rosella Silvestrini, Dino Amadori and Wainer Zoli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:94
  25. Antiangiogenic treatment may change the tumor microenvironment and hence influence the effect of conventional therapies. The potential of diffusion weighted magnetic resonance imaging (DW-MRI) and dynamic cont...

    Authors: Jon-Vidar Gaustad, Viktoria Pozdniakova, Tord Hompland, Trude G Simonsen and Einar K Rofstad
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:93
  26. Fluoropyrimidines, oxaliplatin, irinotecan and biologic therapies (Bevacizumab, Panitumumab, and Cetuximab) represent the backbone of metastatic colorectal cancer (CRC) treatment. The improvement in survival f...

    Authors: Giuseppe Tonini, Marco Imperatori, Bruno Vincenzi, Anna Maria Frezza and Daniele Santini
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:92
  27. One of the key oncogenic pathways involved in melanoma aggressiveness, development and progression is the RAS/BRAF/MEK pathway, whose alterations are found in most patients. These molecular anomalies are promi...

    Authors: Giovanni Sette, Katia Fecchi, Valentina Salvati, Fiorenza Lotti, Emanuela Pilozzi, Enrico Duranti, Mauro Biffoni, Alfredo Pagliuca, Daniela Martinetti, Lorenzo Memeo, Michele Milella, Ruggero De Maria and Adriana Eramo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:91
  28. The principal Epstein–Barr virus (EBV) oncoprotein, latent membrane protein 1 (LMP1) is strongly associated with nasopharyngeal carcinoma (NPC), a prevalent cancer in China. The epidermal growth factor recepto...

    Authors: Yang Xu, Ying Shi, Qi Yuan, Xuli Liu, Bin Yan, Ling Chen, Yongguang Tao and Ya Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:90
  29. The effectiveness of different breast cancer follow-up procedures to decrease breast cancer mortality are still an object of debate, even if intensive follow-up by imaging modalities is not recommended by inte...

    Authors: Isabella Sperduti, Patrizia Vici, Nicola Tinari, Teresa Gamucci, Michele De Tursi, Giada Cortese, Antonino Grassadonia, Stefano Iacobelli and Clara Natoli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:89
  30. To investigate the potential dosimetric and clinical benefits of Deep Inspiration Breath-Hold (DIBH) technique during radiotherapy of breast cancer compared with Free Breathing (FB).

    Authors: Vicente Bruzzaniti, Armando Abate, Paola Pinnarò, Marco D’Andrea, Erminia Infusino, Valeria Landoni, Antonella Soriani, Carolina Giordano, Anna Maria Ferraro and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:88
  31. To evaluate the prognostic role of TAMs in patients affected by non-muscle invasive bladder cancer (NMIBC), undergone Trans Urethral Resection of Bladder (TURB) and Bacillus Calmette-Guerin (BCG) therapy.

    Authors: Francesca Suriano, Daniele Santini, Giuseppe Perrone, Michela Amato, Bruno Vincenzi, Giuseppe Tonini, Andrea Onetti Muda, Sara Boggia, Maurizio Buscarini and Francesco Pantano
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:87
  32. Altered gene methylation, regulated by DNA methyltransferases (DNMT) 1, 3a and 3b, contributes to tumorigenesis. However, the role of DNMT in pancreatic ductal adenocarcinoma (PDAC) remains unknown.

    Authors: Jun Gao, Lihua Wang, Jinkang Xu, Jianming Zheng, Xiaohua Man, Hongyu Wu, Jin Jin, Kaixuan Wang, Huasheng Xiao, Shude Li and Zhaoshen Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:86
  33. The SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Studies investigating the association between MDM2 SNP309 poly...

    Authors: Qiliu Peng, Cuiju Mo, Aiping Qin, Xianjun Lao, Zhiping Chen, Jingzhe Sui, Junrong Wu, Limin Zhai, Shi Yang, Xue Qin and Shan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:85
  34. According to the International Multidisciplinary Classification of Lung Adenocarcinoma (LAD) by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IA...

    Authors: Jiayuan Huang, Haizhu Song, Biao Liu, Bo Yu, Rui Wang and Longbang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:84
  35. Mammalian target of rapamycin (mTOR) inhibitors are associated with dermatological adverse events. The chief aim of this study was to examine the relation between the signal transducer and activator of transcr...

    Authors: Kazuhiro Yamamoto, Atsushi Uda, Akira Mukai, Kazuhiko Yamashita, Manabu Kume, Hiroo Makimoto, Toshinori Bito, Chikako Nishigori, Takeshi Hirano and Midori Hirai
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:83
  36. Patients with advanced melanoma are faced with a poor prognosis and, until recently, limited treatment options. Ipilimumab, a novel immunotherapy that blocks cytotoxic T-lymphocyte-associated antigen-4, was th...

    Authors: Maresa Altomonte, Anna Maria Di Giacomo, Paola Queirolo, Paolo Antonio Ascierto, Francesco Spagnolo, Emilio Bajetta, Luana Calabrò, Riccardo Danielli, Francesco de Rosa, Michela Maur, Vanna Chiarion-Sileni, Pier Francesco Ferrucci, Diana Giannarelli, Alessandro Testori, Ruggero Ridolfi and Michele Maio
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:82
  37. The purpose of this study is to evaluate the radiation dose in patients undergoing liver angiographic procedure and verify the usefulness of different dose measurements to prevent deterministic effects. Gafchr...

    Authors: Daniela D’Alessio, Claudia Giliberti, Antonella Soriani, Livio Carpanese, Giuseppe Pizzi, Giulio Eugenio Vallati and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:81
  38. Feasibility of whole breast hypofractionated radiotherapy schedules in breast conserving therapy is recognized however concerns remain about the role of the boost dose on the overall treatment’s potential toxi...

    Authors: Valeria Landoni, Carolina Giordano, Annelisa Marsella, Biancamaria Saracino, Maria Grazia Petrongari, Anna Maria Ferraro, Lidia Strigari and Paola Pinnarò
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:80
  39. Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway regulates multiple cellular processes such as cell proliferation, evasion from apoptosis, migration, glucose meta...

    Authors: Roberta Gonnella, Roberta Santarelli, Antonella Farina, Marisa Granato, Gabriella D’Orazi, Alberto Faggioni and Mara Cirone
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:79
  40. Three-dimensional (3D) minimally invasive video-assisted thyroidectomy (MIVAT) was carried out with a 4-mm, 3D 0-degree stereoscopic endoscope. The procedure was applied on 3 patients who underwent total thyro...

    Authors: Giuseppe Mercante, Paolo Battaglia, Valentina Manciocco, Giovanni Cristalli, Raul Pellini and Giuseppe Spriano
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:78
  41. Nucleobindin 2 (NUCB2) protein, a novel oncoprotein, is overexpressed in breast cancer. To date, there have been no published data regarding the role of NUCB2 protein expression in prostate cancer (PCa). There...

    Authors: Hongtuan Zhang, Can Qi, Andi Wang, Bing Yao, Liang Li, Yuzhuo Wang and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:77
  42. Metastasis is the major cause of cancer-related death in patients with gastric cancer, and aberrant expression of various microRNAs (miRNAs) is associated with cancer metastasis.

    Authors: Zishu Wang, Jin Wang, Yan Yang, Bo Hao, Rui Wang, Yumei Li and Qiong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:76

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:18

  43. Polyploid giant cancer cells (PGCCs) contribute to solid tumor heterogeneity. This study investigated the relationships among PGCCs numbers, vasculogenic mimicry (VM) formation, and tumor grades in glioma.

    Authors: Yang Qu, Li Zhang, Zhe Rong, Tao He and Sai Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:75
  44. Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidin...

    Authors: Kevin Marley, Stuart C Helfand, Jennifer Simpson, John E Mata, William G Tracewell, Lisa Brownlee, Shay Bracha and Bernard Séguin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:74
  45. Cutaneous melanoma is a malignant neoplasm with a constantly increasing incidence, the prognosis of which is largely dependent on early diagnosis. The appropriateness of requests for ultrasound (US) tests duri...

    Authors: Francesco M Solivetti, Fulvia Elia, Antonino Guerrisi, Flora Desiderio, Maria Giulia Santaguida, Isabella Sperduti, Claudia Cavallotti and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:73
  46. Mutations of the p53 oncosuppressor gene are amongst the most frequent aberration seen in human cancer. Some mutant (mt) p53 proteins are prone to loss of Zn(II) ion that is bound to the wild-type (wt) core, p...

    Authors: Alessia Garufi, Daniela Trisciuoglio, Manuela Porru, Carlo Leonetti, Antonella Stoppacciaro, Valerio D’Orazi, Maria Laura Avantaggiati, Alessandra Crispini, Daniela Pucci and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:72
  47. The diagnostic and prognostic value of microRNA (miRNA) expression aberrations in pancreatic ductal adenocarcinoma (PDAC) has been studied extensively in recent years. However, differences in measurement platf...

    Authors: Ming-Zhe Ma, Xiang Kong, Ming-Zhe Weng, Kun Cheng, Wei Gong, Zhi-Wei Quan and Cheng-Hong Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:71
  48. Inflammatory breast cancer (IBC) is the most metastatic variant of breast cancer with the poorest survival in all types of breast cancer patients and presently therapeutic targets for IBC are very limited. Enh...

    Authors: Zhaomei Mu, Hua Li, Sandra V Fernandez, Katherine R Alpaugh, Rugang Zhang and Massimo Cristofanilli
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:70
  49. Recently, we reported an association of a novel cancer testis (CT) antigen, sperm-associated antigen 9 (SPAG9) expression in breast cancer clinical samples, indicating its potential role in carcinogenesis. Aro...

    Authors: Abhilasha Sinha, Sumit Agarwal, Deepak Parashar, Archana Verma, Shikha Saini, Nirmala Jagadish, Abdul S Ansari, Nirmal K Lohiya and Anil Suri
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:69
  50. Quadruplexes DNA are present in telomeric DNA as well as in several cancer-related gene promoters and hence affect gene expression and subsequent biological processes. The conformations of G4 provide selective...

    Authors: Sara Iachettini, Malcolm FG Stevens, Mark Frigerio, Marc G Hummersone, Ian Hutchinson, Thomas P Garner, Mark S Searle, David W Wilson, Manoj Munde, Rupesh Nanjunda, Carmen D’Angelo, Pasquale Zizza, Angela Rizzo, Chiara Cingolani, Federica De Cicco, Manuela Porru…
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:68

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