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  1. Signal transducer and activator of transcription 3 (STAT3) is a key signaling molecule and a central cytoplasmic transcription factor, implicated in the regulation of growth. Its aberrant activation has been d...

    Authors: Diana David, Lakshmy M Rajappan, Krishna Balachandran, Jissa V Thulaseedharan, Asha S Nair and Radhakrishna M Pillai
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:56
    Content type: Research Published on:

  3. Although the addition of bevacizumab significantly improves the efficacy of chemotherapy for advanced breast cancer, regulatory concerns still exist with regard to the magnitude of the benefits and the overall...

    Authors: Federica Cuppone, Emilio Bria, Vanja Vaccaro, Fabio Puglisi, Alessandra Fabi, Isabella Sperduti, Paolo Carlini, Michele Milella, Cecilia Nisticò, Michelangelo Russillo, Paola Papaldo, Gianluigi Ferretti, Matti Aapro, Diana Giannarelli and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:54
    Content type: Research Published on:

  5. An advantage of the Intensity Modulated Radiotherapy (IMRT) technique is the feasibility to deliver different therapeutic dose levels to PTVs in a single treatment session using the Simultaneous Integrated Boo...

    Authors: Vicente Bruzzaniti, Armando Abate, Massimo Pedrini, Marcello Benassi and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:52
    Content type: Research Published on:

  6. The expression of chemokine receptors CCR7 has been studied in relation to tumor dissemination and poor prognosis in a limited number of cancers. No such studies have been done on CCR7 expression in non-Hodgki...

    Authors: Jing Yang, Shengyi Wang, Guofan Zhao and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:51
    Content type: Research Published on:

  7. Maintenance therapy is emerging as a treatment strategy in the management of advanced non small cell lung cancer (NSCLC). Initial trials addressing the question of duration of combination chemotherapy failed t...

    Authors: Silvia Novello, Michele Milella, Marcello Tiseo, Giuseppe Banna, Diego Cortinovis, Massimo Di Maio, Marina Garassino, Paolo Maione, Olga Martelli, Tiziana Vavalà and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:50
    Content type: Review Published on:

  8. The present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model in rats and to investigate...

    Authors: Mohamed T Abdel aziz, Mohamed F El Asmar, Hazem M Atta, Soheir Mahfouz, Hanan H Fouad, Nagwa K Roshdy, Laila A Rashed, Dina Sabry, Amira A Hassouna and Fatma M Taha
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:49
    Content type: Research Published on:

  9. To explore the potential role of CpG motif-containing oligonucleotides (CpG-ODN) in modulating the expression of FasL in HepG2 and Fas in Jurkat cells in vitro, and to examine the effect of CpG-ODN treatment on t...

    Authors: Jianfeng Zheng, Rongquan Fu, Jing Li and Xiaozhong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:48
    Content type: Research Published on:

  10. Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells ...

    Authors: Zhu Xishan, An Guangyu, Song Yuguang and Zhang Hongmei
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:47
    Content type: Research Published on:

  11. Vasculogenic mimicry (VM), as a new blood supply for tumor growth and hematogenous metastases, has been recently described in highly aggressive human melanoma cells, etc. We previously reported VM in human gal...

    Authors: Wei Sun, Yue Z Fan, Wen Z Zhang and Chun Y Ge
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:46
    Content type: Research Published on:

  12. Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. Our aim was to define whether alterations in putative progenitor popu...

    Authors: Simona Donatello, Lance Hudson, David C Cottell, Alfonso Blanco, Igor Aurrekoetxea, Martin J Shelly, Peter A Dervan, Malcolm R Kell, Maurice Stokes, Arnold DK Hill and Ann M Hopkins
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:45
    Content type: Research Published on:

  13. Silibinin, a natural polyphenolic flavonoid, has been reported to induce cell death in various cancer cell types. However, the molecular mechanism is not clearly defined. Our previous study showed that silibin...

    Authors: Ji C Jeong, Won Y Shin, Thae H Kim, Chae H Kwon, Jae H Kim, Yong K Kim and Ki H Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:44
    Content type: Research Published on:

  14. To conserve laryngeal function and elevate living quality of laryngeal squamous cell carcinoma (LSCC) patients, we designed antisense oligodeoxynucleotides (AS-ODNs) to reduce expression of ATM and to enhance ...

    Authors: Jun Feng, Jian Zou, Li Li, Yongsheng Zhao and Shixi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:43
    Content type: Research Published on:

  15. Fermented wheat germ extract (FWGE) is currently used as nutrition supplement for cancer patients. Limited recent data suggest antiproliferative, antimetastatic and immunological effects which were at least in...

    Authors: Thomas Mueller, Karin Jordan and Wieland Voigt
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:42
    Content type: Research Published on:

  16. Over-expressed in numerous cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1, also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring Associated) which is found only in the UHRF fam...

    Authors: Mahmoud Alhosin, Tanveer Sharif, Marc Mousli, Nelly Etienne-Selloum, Guy Fuhrmann, Valérie B Schini-Kerth and Christian Bronner
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:41
    Content type: Review Published on:

  17. Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, spec...

    Authors: Francesco M Solivetti, Fulvia Elia, Alessandra Latini, Carlo Cota, Paola Cordiali-Fei and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:40
    Content type: Research Published on:

  18. To evaluate activity and tolerability of two anthracycline-containing regimens as first-line treatment for anthracycline-naïve relapsed breast cancer patients.

    Authors: Patrizia Vici, Giuseppe Colucci, Francesco Giotta, Domenico Sergi, Gianfranco Filippelli, Pasquale Perri, Claudio Botti, Enrico Vizza, Armando Carpino, Laura Pizzuti, Agnese Latorre, Diana Giannarelli, Massimo Lopez and Luigi Di Lauro
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:39
    Content type: Research Published on:

  19. The human epidermal growth factor receptor 2 (HER2) and p53 pathways may be involved in chemotherapy sensitivity and/or resistance. We explore the value of HER2 and p53 status to foretell docetaxel sensitivity...

    Authors: Andrea Camerini, Sara Donati, Paolo Viacava, Olimpia Siclari, Cheti Puccetti, Gianna Tartarelli, Chiara Valsuani, Filomena De Luca, Leonardo Martini, Andrea Cavazzana and Domenico Amoroso
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:38
    Content type: Research Published on:

  20. Cancer cells are known to secrete the stress molecules MICA and MICB that activate cytotoxicity by lymphocytes and NK cells through their NKG2D receptor as a mechanism of immunological defense. This work was u...

    Authors: Benny Weiss-Steider, Isabel Soto-Cruz, Christian A Martinez-Campos and Jorge Flavio Mendoza-Rincon
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:37
    Content type: Research Published on:

  21. There has been insufficient examination of the factors affecting long-term survival of more than 5 years in patients with leukemia that is not in remission at transplantation.

    Authors: Hideo Koh, Hirohisa Nakamae, Kiyoyuki Hagihara, Takahiko Nakane, Masahiro Manabe, Yoshiki Hayashi, Mitsutaka Nishimoto, Yukari Umemoto, Mika Nakamae, Asao Hirose, Eri Inoue, Atsushi Inoue, Masahiro Yoshida, Masato Bingo, Hiroshi Okamura, Ran Aimoto…
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:36
    Content type: Research Published on:

  22. Iodine 125 (125I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we investigated the in...

    Authors: Jian-xia Ma, Zhen-dong Jin, Pei-ren Si, Yan Liu, Zheng Lu, Hong-yu Wu, Xue Pan, Luo-wei Wang, Yan-fang Gong, Jun Gao and Li Zhao-shen
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:35
    Content type: Research Published on:

  23. Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer ...

    Authors: Zhen Li, Hiroki Tanaka, Floyd Galiano and Jonathan Glass
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:34
    Content type: Research Published on:

  26. Various angiogenic regulators are involved in angiogenesis cascade. Transcription factor Ets-1 plays important role in angiogenesis, remodeling of extracellular matrix, and tumor metastasis. Ets-1 target genes...

    Authors: Zijing Lin, Yu Liu, Yuhui Sun and Xiuping He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:31
    Content type: Research Published on:

  27. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been widely used for the treatment of non-small cell lung cancer (NSCLC). KRAS and EGFR somatic mutations in NSCLC may predict resistanc...

    Authors: Leina Sun, Qiang Zhang, Huanling Luan, Zhongli Zhan, Changli Wang and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:30
    Content type: Research Published on:

  28. Ovarian cancer remains the leading cause of death from gynaecological malignancy. More than 60% of the patients are presenting the disease in stage III or IV. In spite of combination of chemotherapy and surger...

    Authors: Caroline van Haaften, Colin C Duke, Arij M Weerheim, Nico PM Smit, Paul MM van Haard, Firouz Darroudi and Baptist JMZ Trimbos
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:29
    Content type: Research Published on:

  29. To elucidate whether rapamycin, the inhibitor of mTOR (mammalian target of rapamycin), can potentiate the cytotoxic effect of docetaxel in lung cancer cells and to probe the mechanism underlying such enhancement.

    Authors: Huiyan Niu, Jiahe Wang, Hui Li and Ping He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:28
    Content type: Research Published on:

  30. To evaluate the expression of EGFR and COX-2 and their correlation with prognosis in NSCLC

    Authors: Feng Li, Yongmei Liu, Huijiao Chen, Dianying Liao, Yali Shen, Feng Xu and Jin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:27
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:32

  31. Cyclooxygenase2 (COX-2), one isoform of cyclooxygenase proinflammatory enzymes, is responsible for tumor development, invasion and metastasis. Due to its role and frequent overexpression in a variety of human ...

    Authors: Qinghua Zhao, Chuan Wang, Jiaxue Zhu, Lei Wang, Shuanghai Dong, Guoqiao Zhang and Jiwei Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:26
    Content type: Research Published on:

  32. As the expression of human sperm protein 17 (Sp17) in normal tissue is limited and the function is obscure, its aberrant expression in malignant tumors makes it to be a candidated molecular marker for tumor im...

    Authors: Fang-qiu Li, Shi-xin Zhang, Lian-xiao An and Yue-qing Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:25
    Content type: Research Published on:

  33. The immune factors heat shock protein (HSP)/peptides (HSP/Ps) can induce both adaptive and innate immune responses. Treatment with HSP/Ps in cancer cell-bearing mice and cancer patients revealed antitumor immu...

    Authors: Quan-Yi Guo, Mei Yuan, Jiang Peng, Xue-Mei Cui, Ge Song, Xiang Sui and Shi-Bi Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:24
    Content type: Research Published on:

  34. Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis.

    Authors: Burkhard HA von Rahden, Stefan Kircher, Maria Lazariotou, Christoph Reiber, Luisa Stuermer, Christoph Otto, Christoph T Germer and Martin Grimm
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:23
    Content type: Research Published on:

  35. This study investigated the effects of Ulinastatin (UTI) and docataxel (Taxotere, TAX) on tumor growth and expression of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in breas...

    Authors: Xiaoliang Zhao, Xin Sun, Feng Gao, Jie Luo and Zhijun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:22
    Content type: Research Published on:

  36. Epidemiological studies propose that obesity increases the risk of several cancers, including melanoma. Obesity increases the expression of leptin, a multifunctional peptide produced predominantly by adipocyte...

    Authors: Fatemehsadat Amjadi, Shaghaygh Haghjooy Javanmard, Hamid Zarkesh-Esfahani, Majid Khazaei and Manijeh Narimani
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:21
    Content type: Research Published on:

  37. Recently, miR-451 as a tumor suppressor has been reported in other studies. However, whether miR-451 can affect the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP) remains unclear. T...

    Authors: Hai-Bo Bian, Xuan Pan, Jin-Song Yang, Zhao-Xia Wang and Wei De
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:20
    Content type: Research Published on:

  39. Lung cancer is one of the most common human cancers and the leading cause of cancer death worldwide. The identification of lung cancer associated genes is essential for lung cancer diagnosis and treatment.

    Authors: Liangan Chen, Zhixin Liang, Qing Tian, Chunsun Li, Xiuqing Ma, Yu Zhang, Zhen Yang, Ping Wang and Yanqin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:18
    Content type: Research Published on:

  40. Bostrycin is a novel compound isolated from marine fungi that inhibits proliferation of many cancer cells. However, the inhibitory effect of bostrycin on lung cancers has not been reported. This study is to in...

    Authors: Wei-Sheng Chen, Jun-Na Hou, Yu-Biao Guo, Hui-Ling Yang, Can-Mao Xie, Yong-Cheng Lin and Zhi-Gang She
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:17
    Content type: Research Published on:

  41. This retrospective analysis is focused on the efficacy and safety of radioimmunotherapy (RIT) with Zevalin® in nine patients with recurrent follicular lymphoma (FL) who were treated in a consolidation setting aft...

    Authors: Francesco Pisani, Carlo Ludovico Maini, Rosa Sciuto, Laura Dessanti, Mariella D'Andrea, Daniela Assisi and Maria Concetta Petti
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:16
    Content type: Case report Published on:

  42. This study aimed to investigate the molecular structural relationship between cell adhesive molecule CD44 and Lewis y antigen, and determine the effects of Lewis y antigen on CD44-mediated adhesion and spreadi...

    Authors: Lili Gao, Limei Yan, Bei Lin, Jian Gao, Xiuyun Liang, Yanyan Wang, Juanjuan Liu, Shulan Zhang and Iwamori Masao
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:15
    Content type: Research Published on:

  43. Cyclooxygenase-2 (COX-2) has recently been considered to promote lymphangiogenesis by up-regulating vascular endothelial growth factor-C (VEGF-C) in breast and lung cancer. However, the impact of COX-2 on lymp...

    Authors: Hong-Feng Gou, Xin-Chuan Chen, Jiang Zhu, Ming Jiang, Yu Yang, Dan Cao and Mei Hou
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:14
    Content type: Research Published on:

  46. Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant...

    Authors: Ahmed S Abdulamir, Rand R Hafidh and Fatimah Abu Bakar
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:11
    Content type: Review Published on:

  47. To evaluate the therapeutic strategies commonly employed in the clinic for the management of brain metastases (BMs) and to correlate disease outcome with type of treatment and therapeutic resources available a...

    Authors: Alessandra Fabi, Alessandra Felici, Giulio Metro, Alessandra Mirri, Emilio Bria, Stefano Telera, Luca Moscetti, Michelangelo Russillo, Gaetano Lanzetta, Giovanni Mansueto, Andrea Pace, Marta Maschio, Antonello Vidiri, Isabella Sperduti, Francesco Cognetti and Carmine M Carapella
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:10
    Content type: Research Published on:

  48. Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. Th...

    Authors: Daniele Lodi, Tommaso Iannitti and Beniamino Palmieri
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:9
    Content type: Review Published on:

  49. Hedgehog (Hh) signaling pathway is involved in regulation of many tissues development and oncogenesis. Recently, Hh signaling has been identified as a required functional pathway for leukemia stem cells(LSCs),...

    Authors: Bing Long, Huanling Zhu, Cuixia Zhu, Ting Liu and Wentong Meng
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:8
    Content type: Research Published on:

  50. To implement a new cost efficacy internal Service for blood component irradiation, we carried out specific procedures and quality assurance reports using the linear accelerators (LINACs) of the Regina Elena In...

    Authors: Paola Pinnarò, Antonella Soriani, Daniela D'Alessio, Carolina Giordano, Maria Laura Foddai, Valentina Pinzi and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:7
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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