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  1. Monoclonal gammopathies encompass a wide range of diseases characterized by the monoclonal expansion of a B-cell clone. Despite emerging therapeutic strategies, chances of survival of patients who are affected...

    Authors: Giovanni Cigliana, Eleonora Torti, Francesca Gulli, Elena De Santis, Maria Teresa Dell’Abate, Luigi Colacicco, Francesco Pisani, Laura Conti and Umberto Basile
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:37
    Content type: Research article Published on:

  2. Malignant melanoma’s (MM) incidence is rising faster than that of any other cancer in the US and the overall survival at 5 years is less than 10%. B cell associated protein 31 (BAP31) is overexpressed in most ...

    Authors: Shaojuan Yu, Fuli Wang, Li Fan, Yuying Wei, Haitao Li, Yuanjie Sun, Angang Yang, Boquan Jin, Chaojun Song and Kun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:36
    Content type: Research article Published on:

  3. Gastric cancer (GC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its metastasis is still largely unclear. MicroRNAs have emerged as important regulators of m...

    Authors: Jun Liu, Hui Xue, Jianjun Zhang, Tao Suo, Yijin Xiang, Wen Zhang, Jun Ma, Dingfang Cai and Xixi Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:35
    Content type: Research article Published on:

  4. Our previous studies have demonstrated that autophagosome-enriched vaccine (named DRibbles: DRiPs-containing blebs) induce a potent anti-tumor efficacy in different murine tumor models, in which DRibble-contai...

    Authors: Mohanad Aldarouish, Huzhan Wang, Meng Zhou, Hong-Ming Hu and Li-xin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:34
    Content type: Research article Published on:

  5. Metastatic spread of tumor cells remains a serious problem in cancer treatment. Gene-directed enzyme/prodrug therapy mediated by tumor-homing genetically engineered mesenchymal stromal cells (MSC) represents a...

    Authors: Miroslava Matuskova, Zuzana Kozovska, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Zuzana Cierna, Roman Bohovic and Lucia Kucerova
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:33
    Content type: Research article Published on:

  6. A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer research since they play a central role in regulation of gene-expression and miRNA aberrant expressio...

    Authors: Germana Falcone, Armando Felsani and Igea D’Agnano
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:32
    Content type: Review Published on:

  7. The anti-tumor activity of glucose analogs 2-deoxy-glucose (2-DG) and D-allose was investigated alone or in combination with p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190 or platinum analogs a...

    Authors: Scott W Malm, Neale T Hanke, Alexander Gill, Liliana Carbajal and Amanda F Baker
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:31
    Content type: Research article Published on:

  8. Nectin-4 belongs to the nectin family that has diverse physiological and pathological functions in humans. Recent studies have also suggested some roles for Nectin-4 in several human cancers. However, the prec...

    Authors: Satoshi Nishiwada, Masayuki Sho, Satoshi Yasuda, Keiji Shimada, Ichiro Yamato, Takahiro Akahori, Shoichi Kinoshita, Minako Nagai, Noboru Konishi and Yoshiyuki Nakajima
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:30
    Content type: Research article Published on:

  9. In 2009, treatment guidelines were updated to recommend KRAS testing at diagnosis for patients with metastatic colorectal cancer (mCRC). We investigated KRAS testing rates over time and compared characteristics o...

    Authors: Gebra Cuyun Carter, Pamela B Landsman-Blumberg, Barbara H Johnson, Paul Juneau, Steven J Nicol, Li Li and Veena Shankaran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:29
    Content type: Research article Published on:

  10. Increasing evidence showed that miRNAs serve as modulators of human cancer, either as oncogene or tumor suppressors. Cisplatin resistance is the most common cause of chemotherapy failure in gastric cancer (GC)...

    Authors: Xiaoying Zhou, Wujuan Jin, Hongyan Jia, Jin Yan and Guoxin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:28
    Content type: Research article Published on:

  11. miRNA-184 is an oncogene in human hepatocellular carcinoma but acts as a tumor suppressor in tongue squamous cell carcinoma. Studies have shown that miR-184 was down-regulated in glioma and TNFα-induced protei...

    Authors: Zhe Cheng, Hang Zhou Wang, Xuetao Li, Zhiwu Wu, Yong Han, Yanyan Li, Guilin Chen, Xueshun Xie, Yulun Huang, Ziwei Du and Youxin Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:27
    Content type: Research Published on:

  12. The role of chemotherapy in the treatment of metastatic male breast cancer patients remains unknown, and the only available evidence stem from small, retrospective series evaluating outdated drugs and/or regim...

    Authors: Luigi Di Lauro, Laura Pizzuti, Maddalena Barba, Domenico Sergi, Isabella Sperduti, Marcella Mottolese, Pietro Del Medico, Franca Belli, Patrizia Vici, Ruggero De Maria and Marcello Maugeri-Saccà
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:26
    Content type: Research article Published on:

  13. SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteogly...

    Authors: Carolina M Vicente, Marcelo A Lima, Helena B Nader and Leny Toma
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:25
    Content type: Research article Published on:

  14. Traditional subjective method for the analysis of time-intensity curves (TICs) from breast dynamic contrast enhanced MRI (DCE-MRI) presented a low specificity. Hence, a semi-automatic quantitative method was p...

    Authors: Jiandong Yin, Jiawen Yang, Lu Han, Qiyong Guo and Wei Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:24
    Content type: Research article Published on:

  15. Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that pred...

    Authors: Kai-Ming Gao, Xin-cheng Chen, Jun-xia Zhang, Yingyi Wang, Wei Yan and Yong-Ping You
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:23
    Content type: Research article Published on:

  16. Osteosarcoma is the most common malignancy of bone. HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic...

    Authors: Tu Hu, Nengbin He, Yunsong Yang, Chengqian Yin, Nianli Sang and Qingcheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:22
    Content type: Research article Published on:

  17. Huachansu (HCS), a class of toxic steroids extracted from toad venom, which has been shown to be a valuable anticancer drug in many kinds of cancers. However, the effect of HCS on bladder cancer has not been e...

    Authors: Tao Yang, Runlin Shi, Lei Chang, Kun Tang, Ke Chen, Gan Yu, Yuanfeng Tian, Yonglian Guo, Wei He, Xiaodong Song, Hua Xu and Zhangqun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:21
    Content type: Research article Published on:

  18. Aberrant insulin-like growth factor-binding protein 7 (IGFBP-7) expression has been found in various cancers such as prostate, breast, and colon. IGFBP-7 induced the apoptosis of tumor and potentially predicte...

    Authors: Li-Hsuen Chen, Dai-Wei Liu, Junn-Liang Chang, Peir-Rong Chen, Lee-Ping Hsu, Hon-Yi Lin, Yu-Fu Chou, Chia-Fong Lee, Miao-Chun Yang, Yu-Hsuan Wen, Wen-Lin Hsu and Ching-Feng Weng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:20
    Content type: Research article Published on:

  19. Colorectal cancers are significant causes of morbidity and mortality and existing therapies often perform poorly for individuals afflicted with advanced disease. Oncolytic virotherapy is an emerging therapeuti...

    Authors: Steven J Conrad, Mohamed El-Aswad, Esaw Kurban, David Jeng, Brian C Tripp, Charles Nutting, Robert Eversole, Charles Mackenzie and Karim Essani
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:19
    Content type: Research article Published on:

  20. Long noncoding RNAs (lncRNAs) have been identified as having functional roles in cancer biology and are deregulated in many cancers. The present study aimed to determine the expression, roles and functional me...

    Authors: Liang Deng, Shi-Bin Yang, Feng-Feng Xu and Ji-Hong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:18
    Content type: Research article Published on:

  21. Extranodal NK/T-cell lymphoma (ENKL) is an aggressive hematological malignancy associated with Epstein–Barr virus (EBV) infection. It is often resistant to conventional chemotherapy and has a poor prognosis. I...

    Authors: Ting Wu, Songmei Wang, Jinfeng Wu, Zhiguang Lin, Xianxian Sui, Xiaoping Xu, Norio Shimizu, Bobin Chen and Xuanyi Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:17
    Content type: Research article Published on:

  22. To detect genetic expression profile alterations after papillary thyroid carcinoma (PTC) cells transfected with chemokine receptor CXCR7 gene by gene microarray, and gain insights into molecular mechanisms of ...

    Authors: Hengwei Zhang, Xuyong Teng, Zhangyi Liu, Lei Zhang and Zhen Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:16
    Content type: Research article Published on:

  23. Prostate cancer (PCa) is the most common male cancer in Europe and the US. The early diagnosis relies on prostate specific antigen (PSA) serum test, even if it showed clear limits. Among the new tests currentl...

    Authors: Roberta Merola, Luigi Tomao, Anna Antenucci, Isabella Sperduti, Steno Sentinelli, Serena Masi, Chiara Mandoj, Giulia Orlandi, Rocco Papalia, Salvatore Guaglianone, Manuela Costantini, Giuseppe Cusumano, Giovanni Cigliana, Paolo Ascenzi, Michele Gallucci and Laura Conti
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:15
    Content type: Research article Published on:

  24. Glioblastoma (GBM) is the most common and malignant primary brain tumor. In contrast to some other tumor types, aberrant glucose metabolism is an important component of GBM growth and chemoresistance. Recent s...

    Authors: Han Shen, Stephanie Decollogne, Pierre J Dilda, Eric Hau, Sylvia A Chung, Peter P Luk, Philip J Hogg and Kerrie L McDonald
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:14
    Content type: Research article Published on:

  25. Kinesins play a key role in the development and progression of many human cancers. The present study investigated the expression and clinical significance of kinesin family member 26B (KIF26B) in colorectal ca...

    Authors: Jingtao Wang, Feifei Cui, Xiao Wang, Yingming Xue, Jian Chen, Yang Yu, Huijun Lu, Meng Zhang, Huamei Tang and Zhihai Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:13
    Content type: Research article Published on:

  26. Follicle-stimulating hormone receptor (FSHR) is expressed on the endothelial surface of blood vessels associated with solid tumor periphery, where angiogenesis is known to occur. The correlation between FSHR e...

    Authors: François Planeix, Mohammad-Ahsan Siraj, François-Clément Bidard, Blaise Robin, Christophe Pichon, Xavier Sastre-Garau, Martine Antoine and Nicolae Ghinea
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:12
    Content type: Research Published on:

  27. Agonistic CD40 antibodies have been demonstrated to activate antigen-presenting cells (APCs) and enhance antitumour T cell responses, thereby providing a new therapeutic option in cancer immunotherapy. In agon...

    Authors: Yong Zhang, Xiaoyan Hu, Yue Hu, Kai Teng, Kai Zhang, Yamei Zheng, Xiaohua Hong, Kunwu Yu, Yan Wang and Li Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:11
    Content type: Research Published on:

  28. Aim of this study was to investigate for the presence of existing prognostic factors in patients with bone metastases (BMs) from RCC since bone represents an unfavorable site of metastasis for renal cell carci...

    Authors: Matteo Santoni, Alessandro Conti, Giuseppe Procopio, Camillo Porta, Toni Ibrahim, Sandro Barni, Francesco Maria Guida, Andrea Fontana, Alfredo Berruti, Rossana Berardi, Francesco Massari, Bruno Vincenzi, Cinzia Ortega, Davide Ottaviani, Giacomo Carteni, Gaetano Lanzetta…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:10
    Content type: Research Published on:

  29. Authors: Angela Rizzo, Sara Iachettini, Pasquale Zizza, Chiara Cingolani, Manuela Porru, Simona Artuso, Malcolm Stevens, Marc Hummersone, Annamaria Biroccio, Erica Salvati and Carlo Leonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:9
    Content type: Erratum Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:81

  30. Evidence supports an important role for miR-203 in the regulation of the proliferation, migration and invasion of prostate cancer (PCa) cells. However, the exact mechanisms of miR-203 in PCa are not entirely c...

    Authors: Jun Xiang, Cuidong Bian, Hao Wang, Shengsong Huang and Denglong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:8
    Content type: Research Published on:

  31. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has been demonstrated to be an important player in various human malignancies; it is thought to promote tumor growth by cell cycle regulating. Ho...

    Authors: Liwen Hu, Yuanyuan Wu, Deli Tan, Hui Meng, Kai Wang, Yun Bai and Kang Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:7
    Content type: Research Published on:

  32. Transcription factor CP2 (TFCP2) is overexpressed in hepatocellular carcinoma(HCC) and correlated with the progression of the disease. Here we report the use of an integrated systems biology approach to identi...

    Authors: Xiao Xu, Zhikun Liu, Lin Zhou, Haiyang Xie, Jun Cheng, Qi Ling, Jianguo Wang, Haijun Guo, Xuyong Wei and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:6
    Content type: Research Published on:

  33. Aberrant methylation of genes is one of the most common epigenetic modifications involved in the development of urothelial carcinoma. However, it is unknown the predictive role of methylation to contralateral ...

    Authors: Lei Zhang, Gengyan Xiong, Dong Fang, Xuesong Li, Jin Liu, Weimin Ci, Wei Zhao, Nirmish Singla, Zhisong He and Liqun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:5
    Content type: Research Published on:

  34. Pediatric acute myeloid leukemia (AML) comprises up to 20% of all childhood leukemia. Recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. The epigenetic silencing ...

    Authors: Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Shao-Yan Hu, Fang Fang, Lan Cao, Pei-Fang Xiao, Xiao-Juan Du, Li-Chao Sun, Zhi-Heng Li, Na-Na Wang, Guang-Hao Su, Yan-Hong Li, Gang Li, He Zhao, Yi-Ping Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:4
    Content type: Research Published on:

  35. Epithelial-to mesenchymal transition (EMT) involves in metastasis, causing loss of epithelial polarity. Metastasis is the major cause of carcinoma-induced death, but mechanisms are poorly understood. Here we i...

    Authors: Xianliang Chen, Xiaoying Guan, Huiyu Zhang, Xiaobin Xie, Hongyan Wang, Jie Long, Tonghui Cai, Shuhua Li, Zhen Liu and Yajie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:3
    Content type: Research Published on:

  36. Ovarian malignancies are often diagnosed in advanced stage and at the same time resistance to treatment, both intrinsic and developed during treatment, is sometimes observed. These facts underscore the need fo...

    Authors: Karolina Tecza, Jolanta Pamula-Pilat, Zofia Kolosza, Natalia Radlak and Ewa Grzybowska
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:2
    Content type: Research Published on:

  37. Classical Kaposi’s Sarcoma (cKS) is a rare vascular tumor, which develops in subjects infected with Human Herpesvirus-8 (HHV-8). Beside the host predisposing factors, viral genetic variants might possibly be r...

    Authors: Paola Cordiali-Fei, Elisabetta Trento, Marta Giovanetti, Alessandra Lo Presti, Alessandra Latini, Massimo Giuliani, Giovanna D’Agosto, Valentina Bordignon, Eleonora Cella, Francesca Farchi, Carmela Ferraro, Ilaria Lesnoni La Parola, Carlo Cota, Isabella Sperduti, Antonella Vento, Antonio Cristaudo…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:1
    Content type: Research Published on:

  38. Metastasis have considered as an important clinical obstacle in the treatment of human cancer including bladder cancer. Post-transcriptional regulation has emerged as robust effectors of metastasis. MiRNAs are...

    Authors: Gan Yu, Weimin Yao, Wei Xiao, Heng Li, Hua Xu and Bin Lang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:779
    Content type: Research Published on:

  39. Identification of a gene expression signature in primary breast tumors that could classify patients by lymph node status would allow patients to avoid the morbidities of surgical disruption of the lymph nodes....

    Authors: Craig D Shriver, Matthew T Hueman and Rachel E Ellsworth
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:116
    Content type: Research Published on:

  40. Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrate...

    Authors: Xin Zhu, Jia-jie Xu, Si-si Hu, Jian-guo Feng, Lie-hao Jiang, Xiu-xiu Hou, Jun Cao, Jing Han, Zhi-qiang Ling and Ming-hua Ge
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:114
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:304

  41. MicroRNAs (miRNAs) have been reported to play crucial roles in regulating a variety of genes pivotal for tumor metastasis. MicroRNA-301a (miR-301a) is overexpressed and displays oncogenic activity in many canc...

    Authors: Wenpeng Zhang, Tao Zhang, Runsen Jin, Hongchao Zhao, Jin Hu, Bo Feng, Lu Zang, Minhua Zheng and Mingliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:113
    Content type: Research Published on:

  42. Carfilzomib (CFZ) is a proteasome inhibitor that selectively and irreversibly binds to its target and has been approved in the US for treatment of relapsed and refractory multiple myeloma. Phase 1B studies of ...

    Authors: Amanda F Baker, Neale T Hanke, Barbara J Sands, Liliana Carbajal, Janet L Anderl and Linda L Garland
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:111
    Content type: Research Published on:

  43. The Y-box binding protein 1 (YB-1) possesses pleiotropic functions through its interactions with various cellular proteins, and its high expression levels make it a potential useful prognostic biomarker for ca...

    Authors: Ying Wu, Ke-yong Wang, Zhi Li, Yun-peng Liu, Hiroto Izumi, Hidetaka Uramoto, Yoshifumi Nakayama, Ken-ichi Ito and Kimitoshi Kohno
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:112
    Content type: Research Published on:

  44. The choice of drugs for treatment of advanced gastric cancer (GC) is empirical. The purpose of the current study was to benchmark ex vivo the sensitivity of GC tumor cells from patients to standard cytotoxic a...

    Authors: Bo Hultman, Haile Mahteme, Magnus Sundbom, Martin Ljungman, Rolf Larsson and Peter Nygren
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:110
    Content type: Research Published on:

  45. The echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene rearrangements occur in approximately 5% of lung adenocarcimomas (ACA), leading to ALK overexpress...

    Authors: Jiandong Wang, Qin Shen, Qunli Shi, Bo Yu, Xuan Wang, Kai Cheng, Guangming Lu and Xiaojun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:109
    Content type: Research article Published on:

  46. Histone acetyltransferase (HAT) inhibitors can inhibit proliferation and induce apoptosis in cancer cell lines. The novel cell-permeable p300/CREB-binding protein (CBP)-selective HAT inhibitor HATi II can redu...

    Authors: Li-Xiao Xu, Zhi-Heng Li, Yan-Fang Tao, Rong-Hu Li, Fang Fang, He Zhao, Gang Li, Yan-Hong Li, Jian Wang, Xing Feng and Jian Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:108
    Content type: Research article Published on:

  48. In our previous study, parathyroid hormone-like hormone (PTHLH) which encodes parathyroid hormone-related protein (PTHrP) was revealed to be up-regulated in oral squamous cell carcinoma (OSCC) compared with pa...

    Authors: Zhongjing Lv, Xiangbing Wu, Wei Cao, ZongZe Shen, Lizhen Wang, FuRong Xie, JianJun Zhang, Tong Ji, Ming Yan and WanTao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:100
    Content type: Research Published on:

  49. Brachyury overexpression has been reported in various human malignant neoplasms, but its expression and function in hepatocellular carcinoma progression and metastasis remains unknown. The present study aimed ...

    Authors: Rui Du, Shanshan Wu, Xiaoning Lv, Henghu Fang, Sudong Wu and Jingbo Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:105
    Content type: Research Published on:

  50. Pancreatic ductal adenocarcinoma has proven to be one of the most chemo-resistant among all solid organ malignancies. Several mechanisms of resistance have been described, though few reports of strategies to o...

    Authors: Rouzbeh Daylami, Diego J Muilenburg, Subbulakshmi Virudachalam and Richard J Bold
    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:102
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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