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  1. Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utiliz...

    Authors: Jeffrey B Hoag, Aimel Azizi, Timothy J Doherty, Jason Lu, Rudolph E Willis and Mark E Lund
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:113
    Content type: Research Published on:

  2. Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. A number of studies have conducted on the association of TP53 codon 72 polymorphisms with susceptibility to bre...

    Authors: Wenlei Zhuo, Yunsong Zhang, Zhaolan Xiang, Lei Cai and Zhengtang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:115
    Content type: Research Published on:

  3. Recently, maintaining higher relative dose intensity (RDI) of chemotherapeutic drugs has become a widespread practice in an attempt to achieve better outcomes in the treatment of aggressive lymphoma. The addit...

    Authors: Yoshiki Terada, Hirohisa Nakamae, Ran Aimoto, Hiroshi Kanashima, Erina Sakamoto, Mizuki Aimoto, Eri Inoue, Hideo Koh, Takahiko Nakane, Yasunobu Takeoka, Masahiko Ohsawa, Ki-Ryang Koh, Takahisa Yamane, Yoshitaka Nakao, Kensuke Ohta, Atsuko Mugitani…
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:116
    Content type: Research Published on:

  4. Recently, the use of hypo-fractionated treatment schemes for the prostate cancer has been encouraged due to the fact that α/β ratio for prostate cancer should be low. However a major concern on the use of hypo...

    Authors: Simona Marzi, Biancamaria Saracino, Maria G Petrongari, Stefano Arcangeli, Sara Gomellini, Giorgio Arcangeli, Marcello Benassi and Valeria Landoni
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:117
    Content type: Research Published on:

  5. Vimentin is one of the cytoplasmic intermediate filament proteins which are the major component of the cytoskeleton. In our study we checked the usefulness of vimentin expression in identifying cases of breast...

    Authors: Renata U Kusinska, Radzislaw Kordek, Elzbieta Pluciennik, Andrzej K Bednarek, Janusz H Piekarski and Piotr Potemski
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:118
    Content type: Research Published on:

  6. This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb.

    Authors: Xiang-Yun Zong, Yang Yu and Hong-Jian Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:119
    Content type: Research Published on:

  7. Germ cell testicular tumors have survival rate that diminishes with high tumor marker levels, such as human chorionic gonadotropin (hCG). hCG may regulate vascular neoformation through vascular endothelial gro...

    Authors: Oscar Arrieta, Rosa Mayela Michel Ortega, Julián Ángeles-Sánchez, Cynthia Villarreal-Garza, Alejandro Avilés-Salas, José G Chanona-Vilchis, Elena Aréchaga-Ocampo, Arturo Luévano-González, Miguel Ángel Jiménez and José Luis Aguilar
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:120
    Content type: Research Published on:

  8. In cancer patients, MUC1 glycoprotein may carry Lewis y which could be involved in immune response. Purposes: 1- to evaluate the presence of Lewis y and MUC1 in circulating immune complexes (Lewis y/CIC and MU...

    Authors: Marina Isla Larrain, Sandra Demichelis, Marina Crespo, Ezequiel Lacunza, Alberto Barbera, Aldo Cretón, Francisco Terrier, Amada Segal-Eiras and María Virginia Croce
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:121
    Content type: Research Published on:

  9. Hepatocellular carcinoma (HCC), a major cause of cancer death in China, is preceded by chronic hepatitis and liver cirrhosis (LC). Although hepatitis B virus (HBV) has been regarded as a clear etiology of huma...

    Authors: Ning Li, Yunzhu Long, Xuegong Fan, Hongbo Liu, Cui Li, Lizhang Chen and Zhiming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:122
    Content type: Research Published on:

  10. Despite of the recent success of EGFR inhibitory agents, the primary drug-resistant becomes a major challenge for EGFR inhibitor therapies. PTEN gene is an important positive regulatory factor for response to ...

    Authors: Hong-Qing Zhuang, Jun Wang, Zhi-Yong Yuan, Lu-Jun Zhao, Ping Wang and Chang-Li Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:123
    Content type: Research Published on:

  11. Vasculogenic mimicry (VM) was increasingly recognized as a form of aggressive melanoma acquiring blood supply. Genistein had attracted much attention as a potential anticancer agent. Therefore, we examined the...

    Authors: Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng and Bin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:124
    Content type: Research Published on:

  12. The aim of this study was to determine the clinicopathological features of gastric cancers with loss of imprinting (LOI) of LIT1. Insulin-like growth factor 2 (IGF2) and H19 in Chinese patients.

    Authors: Yang Lu, Ping Lu, Zhi Zhu, Huimian Xu and Xike Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:125
    Content type: Research Published on:

  13. Although gastric caner (GC) remains the second cause of cancer-related death, useful biomarkers for prognosis are still unavailable. We present here the attempt of mining novel biomarkers for GC prognosis by u...

    Authors: Fu-Ming Qiu, Jie-Kai Yu, Yi-Ding Chen, Qi-Feng Jin, Mei-Hua Sui and Jian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:126
    Content type: Research Published on:

  15. Sexual dysfunction following surgery for rectal cancer may be frequent and often severe. The aim of the present study is to evaluate the occurrence of this complication from both a clinical point of view and b...

    Authors: Alberto Pietrangeli, Patrizia Pugliese, Maria Perrone, Isabella Sperduti, Maurizio Cosimelli and Bruno Jandolo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:128
    Content type: Case study Published on:

  16. Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we in...

    Authors: Alexandra Szalad, Mark Katakowski, Xuguang Zheng, Feng Jiang and Michael Chopp
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:129
    Content type: Research Published on:

  17. Polo-like kinase-1 (PLK-1) is reported to be upregulated in a variety of human tumors and is implicated in cell proliferation and survival. However, its importance in cervical carcinoma has not yet been fully ...

    Authors: Yuan Zhang, Yu Liu, Yuan-Xian Yang, Jia-Hong Xia, Hong-Xiu Zhang, Hua-Bin Li and Chun-Zhao Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:130
    Content type: Research Published on:

  18. This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine3(5-HT3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in ...

    Authors: Lijun Tan, Jiangtao Liu, Xiuli Liu, Jie Chen, Zhijun Yan, Huifen Yang and Daxin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:131
    Content type: Research Published on:

  19. Many studies have shown that colon cancer is an estrogen-dependent carcinoma. This study explored the efficacy of endocrine therapy in colon cancer cells with high metastatic potential (HT29). We investigated ...

    Authors: Yu-Jing Fang, Zhi-Zhong Pan, Li-Ren Li, Zhen-Hai Lu, Li-Yi Zhang and De-Sen Wan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:132
    Content type: Research Published on:

  20. The epidermal growth factor receptor variant III (EGFRvIII) is the most common variation of EGFR. Because it shows a high frequency in several different types of tumor and has not been detected in normal tissu...

    Authors: Xiao-yi Duan, Dong-gang Han, Ming-xin Zhang and Jian-sheng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:133
    Content type: Research Published on:

  21. Chromophobe renal cell carcinoma (ChRCC) is a subtype of renal cell carcinoma (RCC). ChRCC is diagnosed mainly in 6th decade of life. An incidence of ChRCC is similar in both men and woman. Eighty six percent ...

    Authors: Rafał Stec, Bartłomiej Grala, Michał Mączewski, Lubomir Bodnar and Cezary Szczylik
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:134
    Content type: Review Published on:

  22. To investigate prostate cancer (Pca) risk in relation to estrogen metabolism, expressed as urinary 2-hydroxyestrone (2-OHE1), 16α-hydroxyestrone (16α-OHE1) and 2-OHE1 to 16α-OHE1 ratio.

    Authors: Maddalena Barba, Li Yang, Holger J Schünemann, Francesca Sperati, Sara Grioni, Saverio Stranges, Kim C Westerlind, Giovanni Blandino, Michele Gallucci, Rossella Lauria, Luca Malorni and Paola Muti
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:135
    Content type: Review Published on:

  23. Apoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. 99mTc-HYNIC-annexinV has been reported as a promising agent fo...

    Authors: Ming-fang Guo, Yaqing Zhao, Rong Tian, Lin Li, Leiming Guo, Feng Xu, Yong-mei Liu, Yong-bo He, Sen Bai and Jin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:136
    Content type: Research Published on:

  24. Authors: Hyo-Jeong Lee, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Kwan-Hyun Kim, Sun-Hyung Kim, Keun-Sung Lee, Hee-Jae Jung and Sung-Hoon Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:137
    Content type: Retraction Note Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2009 28:102

  25. No single and thoroughly validated imaging method in monitoring of cryoablated renal cell carcinoma (RCC) is available. The purpose of our study was to determine the feasibility of dynamic contrast-enhanced pe...

    Authors: Ettore Squillaci, Guglielmo Manenti, Carmelo Cicciò, Francesca Nucera, Pierluigi Bove, Giuseppe Vespasiani, Laura Russolillo and Giovanni Simonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:138
    Content type: Research Published on:

  26. Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and...

    Authors: Qing-lei Wang, Bing-hui Li, Bin Liu, Ya-bin Liu, Yue-Ping Liu, Sui-Bing Miao, Yi Han, Jin-Kun Wen and Mei Han
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:139
    Content type: Research Published on:

  28. The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated.

    Authors: Zhaohui Wei, Naiyao Chen, Hongxing Guo, Xueming Wang, Fangyun Xu, Qian Ren, ShiHong Lu, Bin Liu, Lei Zhang and Hui Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:141
    Content type: Research Published on:

  29. Studies of treatment with octreotide of patients with hepatocellular carcinoma (HCC) gave conflicting results. We analyzed retrospectively the survival of our patients treated with octreotide monotherapy and c...

    Authors: Maximilian Schöniger-Hekele, Joachim Kettenbach, Markus Peck-Radosavljevic and Christian Müller
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:142
    Content type: Research Published on:

  30. Despite aggressive therapy, advanced stage neuroblastoma patients have poor survival rates. Although angiogenesis correlates with advanced tumour stage and plays an important role in determining the tumour res...

    Authors: Gordana Jakovljević, Srđana Čulić, Jasminka Stepan, Aleksandra Bonevski and Sven Seiwerth
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:143
    Content type: Research Published on:

  31. To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and th...

    Authors: Wen-Qing Hu, Chun-Wei Peng and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:144
    Content type: Research Published on:

  32. To establish a relationship between esophageal squamous cell diseases and the expression of human telomerase reverse transcriptase (hTERT) and Eyes absent 4 (EYA4) mRNA in peripheral blood mononuclear cells.

    Authors: Hao Li, Tao Yu Diao, Zhi Ying Zhou, Fang Yan Yang, Qing Ma and Qing Hui Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:145
    Content type: Review Published on:

  33. Carbohydrates embedded in the plasma membrane are one of the main actors involved in the communication of cells with the microenvironment. Neuraminic sialic acids are glycocalyx sugars that play important role...

    Authors: Mariano R Gabri, Laura L Otero, Daniel E Gomez and Daniel F Alonso
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:146
    Content type: Research Published on:

  34. Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are i...

    Authors: Sepideh Afshar, Tove Olafsen, Anna M Wu and Sherie L Morrison
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:147
    Content type: Research Published on:

  35. Carotid body tumours (CBTs) are very rare lesions which should be treated as soon as possible even when benign since small tumour size permits easier removal and lower incidence of perioperative complications ...

    Authors: Ombretta Martinelli, Luigi Irace, Rita Massa, Sara Savelli, Fabrizia Giannoni, Roberto Gattuso, Bruno Gossetti, Fabrizio Benedetti-Valentini and Luciano Izzo
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:148
    Content type: Research Published on:

  36. More studies based on gene expression data have been reported in great detail, however, one major challenge for the methodologists is the choice of classification methods. The main purpose of this research was...

    Authors: Desheng Huang, Yu Quan, Miao He and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:149
    Content type: Research Published on:

  37. Gene targeted therapy refers to any therapy focused on one of the many biological features of the tumor. Such features are mediated by specific genes that are involved in tumor metastasis, recurrence, poor res...

    Authors: Jun Wan, Jinben Ma, Ju Mei and Genfa Shan
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:150
    Content type: Research Published on:

  38. Many experimental data evidence that over-expression of various growth factors cause disorders in cell proliferation. The role of the Fibroblast Growth Factors (FGF) in growth control is indisputable: in parti...

    Authors: Gianfranco Risuleo, Marina Ciacciarelli, Mauro Castelli and Gaspare Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:151
    Content type: Research Published on:

  39. mTOR signaling pathway and its downstream serine/threonine kinase p70S6k were frequently activated in human cancers. The dysregulation of the mTOR pathway has been found to be a contributing factor of a variet...

    Authors: Li Xiao, Yi C Wang, Wu S Li and Yan Du
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:152
    Content type: Research Published on:

  40. Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are sus...

    Authors: Zhihua Yin, Meng Su, Xuelian Li, Mingchuan Li, Rui Ma, Qincheng He and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:153
    Content type: Research Published on:

  41. Lewis y antigen is difucosylated oligosaccharide and is carried by glycoconjugates at cell surface. Elevated expression of Lewis y has been found in 75% of ovarian tumor, and the high expression level is corre...

    Authors: Juanjuan Liu, Bei Lin, Yingying Hao, Yue Qi, Liancheng Zhu, Feifei Li, Dawo Liu, Jianping Cong, Shulan Zhang and Masao Iwamori
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:154
    Content type: Research Published on:

  42. Bladder cancer is the ninth most common malignancy in the world. Successful clinical management remains a challenge. In order To search for novel targeted and efficacious treatment, we sought to investigate an...

    Authors: Wei Tang, Yunfeng He, Shengcai Zhou, Yongping Ma and Geli Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:155
    Content type: Research Published on:

  43. CENP-E, one of spindle checkpoint proteins, plays a crucial role in the function of spindle checkpoint. Once CENP-E expression was interrupted, the chromosomes can not separate procedurally, and may result in ...

    Authors: Zijie Liu, Kang Ling, Xia Wu, Ju Cao, Bin Liu, Suyan Li, Qiong Si, Yan Cai, Chen Yan, Yan Zhang and Yaguang Weng
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:156
    Content type: Research Published on:

  44. Despite the fact that genetic counseling in oncology provides information regarding objective risks, it can be found a contrast between the subjective and objective risk.

    Authors: Anita Caruso, Cristina Vigna, Bruna Marozzo, Fabio M Sega, Isabella Sperduti, Francesco Cognetti and Antonella Savarese
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:157
    Content type: Research Published on:

  45. Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cad...

    Authors: Ken Sasaki, Shoji Natsugoe, Sumiya Ishigami, Masataka Matsumoto, Hiroshi Okumura, Tetsuro Setoyama, Yasuto Uchikado, Yoshiaki Kita, Kiyokazu Tamotsu, Akihiko Sakamoto, Tetsuhiro Owaki and Takashi Aikou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:158
    Content type: Research Published on:

  46. The results from the published studies on the association between hypoxia-inducible factor -1α (HIF-1α) polymorphisms and cancer risk are conflicting. In this meta-analysis, we aimed to investigate the associatio...

    Authors: Tongfeng Zhao, Jing Lv, Jiangpei Zhao and Marius Nzekebaloudou
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:159
    Content type: Research Published on:

  47. Epigenetic silencing of tumor suppressor genes associated with promoter methylation is considered to be a hallmark of oncogenesis. RASSF1A is a candidate tumor suppressor gene which was found to be inactivated...

    Authors: Tao Wang, Hongli Liu, Yeshan Chen, Wei Liu, Jing Yu and Gang Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:160
    Content type: Research Published on:

  48. The aim of this study is to examine the safety and distribution of Ad-EGFP-MDR1, an adenovirus encoding human multidurg resistance gene (human MDR1), in the mice colon carcinoma model.

    Authors: ZhenZhen Zhao, Wei Liu, YuXi Su, Jin Zhu, GaiHuan Zheng, Qing Luo and XianQing Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:1
    Content type: Research Published on:

  49. Renal cell carcinoma (RCC) is a cancer of increasing incidence and mortality. Currently, there are no immunohistochemical prognostic markers for RCCs in routine use. The aim of this study was to examine for th...

    Authors: Hanna Ronkainen, Saila Kauppila, Pasi Hirvikoski and Markku H Vaarala
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:2
    Content type: Research Published on:

  50. bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth. Correspondingly, gliomas have been shown to have reduced, or ...

    Authors: Biao Zhang, Xuequan Feng, Jinhuan Wang, Xinnu Xu, Hongsheng Liu and Na Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:3
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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